Freezing-induced perturbation of tertiary structure of a monoclonal antibody

Journal of Pharmaceutical Sciences

Volumn 103, Issue 7, 2014, Pages 1979-1986

  Liu, Lu ^a   Braun, Latoya Jones ^a   Wang, Wei ^b   Randolph, Theodore W ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b PFIZER INC   (United States)

^c University of Colorado at Boulder   (United States)

Author keywords

excipients; formulation; liquid chromatography; monoclonal antibody; protein aggregation; proteins; stability; surfactants

Indexed keywords

EXCIPIENT; GUANIDINE; MONOCLONAL ANTIBODY; POLYSORBATE 80; POTASSIUM CHLORIDE; SUCROSE; BUFFER; IMMUNOGLOBULIN G;

ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; COOLING; DRUG FORMULATION; FLUORESCENCE SPECTROSCOPY; FREEZE THAWING; FREEZING; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SPECTROMETER; WARMING; CHEMISTRY; GEL CHROMATOGRAPHY; ISOELECTRIC POINT; SPECTROFLUOROMETRY;

ANTIBODIES, MONOCLONAL; BUFFERS; CHROMATOGRAPHY, GEL; EXCIPIENTS; FREEZING; IMMUNOGLOBULIN G; ISOELECTRIC POINT; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE;

EID: 84903216265     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24013     Document Type: Article

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