Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration - Effects of α-linolenic acid and N-acetylcysteine

Chemico-Biological Interactions

Volumn 219, Issue , 2014, Pages 143-150

  Steinritz, Dirk ^a,b   Schmidt, Annette ^a,c   Simons, Thilo ^a   Ibrahim, Marwa ^c   Morguet, Christian ^c   Balszuweit, Frank ^a   Thiermann, Horst ^a   Kehe, Kai ^a,b   Bloch, Wilhelm ^c   Bölck, Birgit ^c  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Chlorambucil; Endothelial cell; Migration; Mitochondrial membrane potential; Nitrogen mustard; ROS scavenger

Indexed keywords

3 NITROTYROSINE; 8 ISOPROSTANE; ACETYLCYSTEINE; CHLORAMBUCIL; CHLORMETHINE; LINOLENIC ACID; REACTIVE OXYGEN METABOLITE; SCAVENGER; SULFUR; ALKYLATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; GOLGI COMPLEX; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; VASCULAR ENDOTHELIUM; WOUND HEALING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; CYTOLOGY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; METABOLISM; PHYSIOLOGY;

ACETYLCYSTEINE; ALPHA-LINOLENIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL MOVEMENT; CELL POLARITY; CHLORAMBUCIL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; REACTIVE OXYGEN SPECIES;

EID: 84903200088     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.05.015     Document Type: Article

References (46)

1. K. Kehe, F. Balszuweit, D. Steinritz, and H. Thiermann Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering Toxicology 263 2009 12 19
2. T.C. Marrs, R.L. Maynard, F.R. Sidell, and T.C. Marrs Chemical Warfare Agents: Toxicology and Treatment 2nd ed. 2007 Wiley Chichester, West Sussex, England; Hoboken, NJ
3. T.S.S. Dikshith Handbook of Chemicals and Safety 2011 CRC Press Boca Raton, FL
4. N. Tewari-Singh, A.K. Jain, D.J. Orlicky, C.W. White, and R. Agarwal Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice PLoS ONE 9 2014 e85402
5. H.R. Bierman, M.B. Shimkin, S.R. Mettier, J. Weaver, W.C. Berry, and S.P. Wise Methyl-bis (beta-chloroethyl)amine in large doses in the treatment of neoplastic diseases Calif. Med. 71 1949 117 125
6. F. Trautinger, R. Knobler, R. Willemze, K. Peris, R. Stadler, L. Laroche, M. D'Incan, A. Ranki, N. Pimpinelli, P. Ortiz-Romero, R. Dummer, T. Estrach, and S. Whittaker EORTC consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome Eur. J. Cancer 42 2006 1014 1030
7. T. Weberschock, R. Strametz, M. Lorenz, C. Rollig, C. Bunch, A. Bauer, and J. Schmitt Interventions for mycosis fungoides Cochrane Database Syst. Rev. 9 2012 CD008946
8. R. Houot, S. Le Gouill, M. Ojeda Uribe, C. Mounier, S. Courby, C. Dartigeas, K. Bouabdallah, M. Alexis Vigier, M.P. Moles, O. Tournilhac, N. Arakelyan, P. Rodon, A. El Yamani, L. Sutton, L. Fornecker, D. Assouline, J.L. Harousseau, H. Maisonneuve, S. Caulet-Maugendre, and R. Gressin Combination of rituximab, bortezomib, doxorubicin, dexamethasone and chlorambucil (RiPAD + C) as first-line therapy for elderly mantle cell lymphoma patients: results of a phase II trial from the GOELAMS Ann. Oncol. 23 2012 1555 1561
9. W.X. Li, X. Yan, C.R. Shi, and A.P. Zhang Chlorambucil for patients with primary biliary cirrhosis Cochrane Database Syst. Rev. 9 2012 CD008714
10. Chlorambucil, in: a.-t. Arzneimitteldatenbank, (Ed.), W. Becker-Brüser, Berlin, 2014.
11. P. Rice Sulphur mustard injuries of the skin. Pathophysiology and management Toxicol. Rev. 22 2003 111 118
12. J.S. Graham, K.T. Schomacker, R.D. Glatter, C.M. Briscoe, E.H. Braue Jr., and K.S. Squibb Efficacy of laser debridement with autologous split-thickness skin grafting in promoting improved healing of deep cutaneous sulfur mustard burns Burns 28 2002 719 730
13. S.M. Bauer, R.J. Bauer, and O.C. Velazquez Angiogenesis, vasculogenesis, and induction of healing in chronic wounds Vasc. Endovascular Surg. 39 2005 293 306
14. J.M. Reinke, and H. Sorg Wound repair and regeneration Eur. Surg. Res. 49 2012 35 43
15. A. Schmidt, B. Bölck, M. Jedig, D. Steinritz, F. Balszuweit, K. Kehe, and W. Bloch Nitrogen mustard (Chlorambucil) has a negative influence on early vascular development Toxicology 263 2009 32 40
16. D. Steinritz, B. Bölck, J. Schwarz, F. Balszuweit, S. Dühr, M. Ibrahim, W. Bloch, H. Thiermann, and K. Kehe Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation Toxicol. Sci. 118 2010 521 529
17. A. Schmidt, D. Wenzel, I. Ferring, S. Kazemi, T. Sasaki, J. Hescheler, R. Timpl, K. Addicks, B.K. Fleischmann, and W. Bloch Influence of endostatin on embryonic vasculo- and angiogenesis Dev. Dyn. 230 2004 468 480
18. M. Shohrati, J. Aslani, M. Eshraghi, F. Alaedini, and M. Ghanei Therapeutics effect of N-acetyl cysteine on mustard gas exposed patients: evaluating clinical aspect in patients with impaired pulmonary function test Respir. Med. 102 2008 443 448
19. B. Jugg, S. Fairhall, A. Smith, S. Rutter, T. Mann, R. Perrott, J. Jenner, J. Salguero, J. Shute, and A.M. Sciuto N-acetyl-l-cysteine protects against inhaled sulfur mustard poisoning in the large swine Clin. Toxicol. (Phila.) 51 2013 216 224
20. M.B. Dainiak, A. Kumar, I.Y. Galaev, and B. Mattiasson Methods in cell separations Adv. Biochem. Eng. Biotechnol. 106 2007 1 18
21. W.F. Marei, D.C. Wathes, and A.A. Fouladi-Nashta The effect of linolenic acid on bovine oocyte maturation and development Biol. Reprod. 81 2009 1064 1072
22. M.L. Bajt, T.R. Knight, J.J. Lemasters, and H. Jaeschke Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine Toxicol. Sci. 80 2004 343 349
23. J. Muller-Ehmsen, A. Schmidt, B. Krausgrill, R.H. Schwinger, and W. Bloch Role of erythropoietin for angiogenesis and vasculogenesis: from embryonic development through adulthood Am. J. Physiol. Heart Circ. Physiol. 290 2006 H331 H340
24. J.C. Yarrow, Z.E. Perlman, N.J. Westwood, and T.J. Mitchison A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods BMC Biotechnol. 4 2004 21
25. K. Mitra, and J. Lippincott-Schwartz Analysis of mitochondrial dynamics and functions using imaging approaches Curr. Protoc. Cell Biol. 4 2010 1 21 Chapter 4, Unit 4.25
26. C. Pott, D. Steinritz, B. Bölck, U. Mehlhorn, K. Brixius, R.H. Schwinger, and W. Bloch ENOS translocation but not eNOS phosphorylation is dependent on intracellular Ca2+ in human atrial myocardium Am. J. Physiol. Cell Physiol. 290 2006 C1437 C1445
27. K. Aase, M. Ernkvist, L. Ebarasi, L. Jakobsson, A. Majumdar, C. Yi, O. Birot, Y. Ming, A. Kvanta, D. Edholm, P. Aspenstrom, J. Kissil, L. Claesson-Welsh, A. Shimono, and L. Holmgren Angiomotin regulates endothelial cell migration during embryonic angiogenesis Genes Dev. 21 2007 2055 2068
28. A. Kupfer, D. Louvard, and S.J. Singer Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound Proc. Natl. Acad. Sci. U.S.A. 79 1982 2603 2607
29. S. Yadav, and A.D. Linstedt Golgi positioning Cold Spring Harb. Perspect. Biol. 3 2011 a005322
30. R. Radi Nitric oxide, oxidants, and protein tyrosine nitration Proc. Natl. Acad. Sci. U.S.A. 101 2004 4003 4008
31. L.G. Wood, P.G. Gibson, and M.L. Garg Biomarkers of lipid peroxidation, airway inflammation and asthma Eur. Respir. J. 21 2003 177 186
32. H. Ishida, R. Ray, J. Amnuaysirikul, K. Ishida, and P. Ray Nitric oxide synthase gene transfer overcomes the inhibition of wound healing by sulfur mustard in a human keratinocyte in vitro model ISRN Toxicol. 2012 2012 190429
33. S. Dachir, M. Cohen, D. Kamus-Elimeleh, E. Fishbine, R. Sahar, R. Gez, R. Brandeis, V. Horwitz, and T. Kadar Characterization of acute and long-term pathologies of superficial and deep dermal sulfur mustard skin lesions in the hairless guinea pig model Wound Repair Regen. 20 2012 852 861
34. V. Paromov, Z. Suntres, M. Smith, and W.L. Stone Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy J. Burns Wounds 7 2007 e7
35. V. Paromov, M. Qui, H. Yang, M. Smith, and W.L. Stone The influence of N-acetyl-l-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue BMC Cell Biol. 9 2008 33
36. D. Steinritz, A. Elischer, F. Balszuweit, S. Gonder, A. Heinrich, W. Bloch, H. Thiermann, and K. Kehe Sulphur mustard induces time- and concentration-dependent regulation of NO-synthesizing enzymes Toxicol. Lett. 188 2009 263 269
37. L. Moldovan, K. Mythreye, P.J. Goldschmidt-Clermont, and L.L. Satterwhite Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1 Cardiovasc. Res. 71 2006 236 246
38. C. Darido, and S.M. Jane Golgi feels its own wound Adv. Wound Care (New Rochelle) 2 2013 87 92
39. M. Yamaoka-Tojo, M. Ushio-Fukai, L. Hilenski, S.I. Dikalov, Y.E. Chen, T. Tojo, T. Fukai, M. Fujimoto, N.A. Patrushev, N. Wang, C.D. Kontos, G.S. Bloom, and R.W. Alexander IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species - dependent endothelial migration and proliferation Circ. Res. 95 2004 276 283
40. Y. Wang, Q.S. Zang, Z. Liu, Q. Wu, D. Maass, G. Dulan, P.W. Shaul, L. Melito, D.E. Frantz, J.A. Kilgore, N.S. Williams, L.S. Terada, and F.E. Nwariaku Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species Am. J. Physiol. Cell Physiol. 301 2011 C695 C704
41. N. Tewari-Singh, A.K. Jain, S. Inturi, D.A. Ammar, C. Agarwal, P. Tyagi, U.B. Kompella, R.W. Enzenauer, J.M. Petrash, and R. Agarwal Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries Toxicol. Appl. Pharmacol. 264 2012 23 31
42. N.S. Gould, C.W. White, and B.J. Day A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection J. Pharmacol. Exp. Ther. 328 2009 732 739
43. K.B. Atkins, I.J. Lodhi, L.L. Hurley, and D.B. Hinshaw N-acetylcysteine and endothelial cell injury by sulfur mustard J. Appl. Toxicol. 20 Suppl 1 2000 S125 S128
44. A.A. Brimfield, S.D. Soni, K.A. Trimmer, M.A. Zottola, R.E. Sweeney, and J.S. Graham Metabolic activation of sulfur mustard leads to oxygen free radical formation Free Radic. Biol. Med. 52 2012 811 817
45. A. Korkmaz, H. Yaren, T. Topal, and S. Oter Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation Arch. Toxicol. 80 2006 662 670
46. L.S. Wong, and M. Martins-Green Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing Wound Repair Regen. 12 2004 471 484