N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine

Clinical Toxicology

Volumn 51, Issue 4, 2013, Pages 216-224

  Jugg, B ^a   Fairhall, S ^a   Smith, A ^a   Rutter, S ^a   Mann, T ^a   Perrott, R ^a   Jenner, J ^a   Salguero, J ^b   Shute, J ^c   Sciuto, A M ^d  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^d US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Acute lung injury; Inflammation; Inhalation; Mono sulfoxide; Porcine physiology; Thiol

Indexed keywords

ACETYLCYSTEINE; BICARBONATE; CARBON DIOXIDE; HEMOGLOBIN; MUCOLYTIC AGENT; MUSTARD GAS;

ACCURACY; ALKALOSIS; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTERIAL BLOOD; ARTERIAL PH; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD GAS ANALYSIS; BLOOD OXYGEN TENSION; BLOOD OXYGENATION; BREATHING; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; EXPOSURE; FEMALE; HEART RATE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; INFLAMMATORY CELL; INTOXICATION; LEUKOCYTE ACTIVATION; LUNG COMPLIANCE; LUNG EDEMA; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; LUNG PROTECTION; LUNG RESISTANCE; NEUTROPHIL; NONHUMAN; OXYGEN SATURATION; PROTECTION; REPRODUCIBILITY; RESPIRATORY ACIDOSIS; RESPIRATORY TRACT PARAMETERS; SWINE; TIDAL VOLUME; TRACHEA MUCOSA; URINALYSIS; VAPOR;

ACETYLCYSTEINE; ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANTIDOTES; ANTIOXIDANTS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICAL WARFARE AGENTS; DISEASE MODELS, ANIMAL; EXPECTORANTS; FEMALE; GAS POISONING; LUNG; LUNG DISEASES; MUSTARD GAS; NEUTROPHIL INFILTRATION; RANDOM ALLOCATION; RESPIRATORY INSUFFICIENCY; SURVIVAL ANALYSIS; SUS SCROFA;

ANIMALIA; SUIDAE; SUS;

EID: 84876502340     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2013.780208     Document Type: Article

References (36)

1. Laskin JD, Black AT, Jan Y-H, Sinko PJ, Heindel ND, Sunil V, et al. Oxidants and antioxidants in sulfur mustard-induced injury. Ann N Y Acad Sci 2010; 1203:92-100.
2. Weinberger B, Laskin JD, Sunil VR, Sinko PJ, Heck DE, Laskin DL. Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther 2011; 24:92-99.
3. Anderson DR, Taylor SL, Fetterer DP, Holmes WW. Evaluation of protease inhibitors and an anti-oxidant for treatment of sulfur mustard-induced toxic lung injury. Toxicology 2009; 263:41-46.
4. Prentiss AM. Vesicant agents. In: Prentiss AM, ed. Chemicals in War: A Treatise on Chemical Warfare. 1st ed. New York: McGraw-Hill Book Co. Inc. and London: Maple Press Co.; 1937: 177-200.
5. Stockholm International Peace Research Institute (SIPRI). The Problem of Chemical and Biological Warfare. Volume I: The Rise of CB Weapons. Stockholm: Almqvist and Wiksell; 1971.
6. Hefazi M, Attaran D, Mahmoudi M, Balali-Mood M. Late respiratory complications of mustard gas poisoning in Iranian veterans. Inhal Toxicol. 2005; 17:587-592. (Pubitemid 41161312)
7. Parrish JS, Bradshaw DA. Toxic inhalational injury: gas, vapour and vesicant exposure. Respir Care Clin 2004; 10:43-58. (Pubitemid 38248164)
8. Ghanei M, Akhlaghpoor S, Moahammad MM, Aslani J. Tracheobron-chial stenosis following sulfur mustard inhalation. Inhal Tox 2004; 16:845-849. (Pubitemid 39447340)
9. Emad A, Rezaian GR. The diversity of effects of sulfur mustard gas inhalation on respiratory system 10 years after a single, heavy exposure: analysis of 197 cases. Chest 1997; 112:734-738. (Pubitemid 27410711)
10. Vedder EB. Pulmonary irritants-chlorine, phosgene, chlorpicrin etc. 1st 1925:77-124.
11. Russell D, Blaine PG, Rice P. Clinical management of casualties exposed to lung damaging agents: a critical review. Emerg Med J 2006; 23:421-424. (Pubitemid 44376955)
12. Deveci F, Turgut T, Ilhan N, Kirkil G, Muz MH. Effect of inhaled N-acetyl-L-cysteine treatment on induced sputum glutathione and nitrite. Firat Tip Dergisi 2008; 13:43-48.
13. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorus acid. Free Radic Biol Med 1989; 6:593-597. (Pubitemid 19147809)
14. Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respiratory Med 1998; 92: 609-623. (Pubitemid 28174829)
15. Brown RFR, Jugg BJA, Harban FMJ, Ashley Z. Pathophysiological responses following phosgene exposure in the anaesthetised pig. J Appl Toxicol 2002; 22:263-269. (Pubitemid 34835654)
16. Brown RFR, Jugg BJA, Jenner J. The use of large animals in inhalation toxicology. In: Brown RFR, Jugg BJA, Jenner J, eds. Inhalation Toxicology. 2nd ed. Boca Raton, Florida, USA: Taylor and Francis; 2006:119-136.
17. Fairhall SJ, Brown RFR, Jugg BJA, Smith AJ, Mann TM, Jenner J, Sciuto AM. Preliminary studies of sulfur mustard-induced lung injury in the terminally anaesthetized pig: exposure system and methodology. Toxicol Mech Methods 2008; 18:355-362. (Pubitemid 351892731)
18. Fairhall SJ, Jugg BJA, Read RW, Stubbs SJ, Rutter SJ, Smith AJ, et al. Exposure-response effects of inhaled sulfur mustard in a large porcine model: a 6-h study. Inhal Toxicol 2010; 22: 1135-1143.
19. Anderson DR, Byers SL, Vesely KR. Treatment of sulfur mustard (HD)-induced lung injury. J Appl Tox 2000; 20:S129-S132.
20. Grainge C, Jugg BJ, Smith AJ, Brown RFR, Jenner J, Parkhouse DA, Rice P. Delayed low-dose supplemental oxygen improves survival following phosgene-induced acute lung injury. Inhal Toxicol 2010; 22:552-560.
21. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
22. Read RW, Black RM. Analysis of β-lyase metabolites of sulfur mustard in urine by electrospray liquid chromatography-tandem mass spectrometry. J Anal Toxicol 2004; 28:346-351. (Pubitemid 38949848)
23. Laurent P, Magne L, De Palmas J, Bignon J, Jaurand M-C. Quantitation of elastin in human urine and rat pleural mesothelial cell matrix by a sensitive avidin-biotin ELISA for desmosine. J Immunol Methods 1988; 107:1-11. (Pubitemid 18060360)
24. Hilliard TN, Regamey N, Shute JK, Nicholson A, Alton EW, Bush A, Davies JC. Airway remodelling in children with cystic fbrosis. Thorax 2007; 62:1074-1080. (Pubitemid 350206200)
25. Hess C, Sadallah S, Hefti A, Landmann R, Schifferli JA. Ectosomes released by human neutrophils are specialized functional units. J Immunol 1999; 163: 4564-4573. (Pubitemid 29474527)
26. Pittet JF, Mackersie RC, Martin TR, Matthay MA. Biological markers of acute lung injury: prognostic and pathogenetic signifcance. Am J Respir Crit Care Med 1997; 155:1187-1205. (Pubitemid 27172758)
27. Wiener-Kronish JP, Gropper MA, Matthay MA. The adult respiratory distress syndrome: def nition and prognosis, pathogenesis and treatment. Br J Anaesth 1990; 65:107-129. (Pubitemid 20218883)
28. Allon N, Amir A, Manisterski E, Rabinovitz I, Dachir S, Kadar T. Inhalation exposure to sulfur mustard in the guinea pig model: clinical, biochemical and histopathological characterization of respiratory injuries. Toxicol Appl Pharmacol 2009; 241:154-162.
29. Pechura CM, Rall DP. Nonmalignant respiratory effects of mustard agents and lewisite. In: Pechura CM, Rall DP, eds. Veterans at Risk: The Health Effects of Mustard Gas and Lewisite. Institute of medicine. Washington DC, USA: National Academic Press; 1993:112-118.
30. Willems JL. Clinical management of mustard gas casualties. Ann Med Milit 1989; 3:1-61.
31. Papirmeister B, Feister AJ, Robinson SI, Ford RD. Medical Defense Against Mustard Gas: Toxic Mechanisms and Pharmacological Implications. Boca Raton, Florida, USA: CRC Press; 1991.
32. Pohl C, Paoritz M, Moisch M, Wubbeke C, Hermanns MI, Uboldi C, et al. Acute morphological and toxicological effects in a human bronchial coculture model after sulfur mustard exposure. Toxicol Sci 2009; 112:482-489.
33. Mukhopadhyay S, Mukherjee S, Stone WL, Smith M, Das SK. Role of MAPK/AP-1 signalling pathway in the protection of CEES-induced lung injury by antioxidant liposome. Toxicology 2009; 261: 143-151.
34. Ghanei M, Shohrati M, Jafari M, Ghaderi S, Alaeddini F, Aslani J. N-acetylcysteine improves the clinical conditions of mustard gas-exposed patients with normal pulmonary function test. Basic Clin Pharmacol Toxicol 2008; 103:428-432.
35. Balali-Mood M, Hefazi M. The pharmacology, toxicology and medical treatment of sulfur mustard poisoning. Fundam Clin Pharmacol 2005; 19:297-315. (Pubitemid 40769451)
36. Black RM, Read RW. Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography electron capture negative ion chemical ionization mass spectrometry. J Chromatogr 1988; 449:261-270.