The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

Nucleic Acids Research

Volumn 42, Issue 10, 2014, Pages 6511-6522

  Mukherjee, Sucheta ^a   Wright, William Douglass ^a   Ehmsen, Kirk Tevebaugh ^a,b   Heyer, Wolf Dietrich ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; DOUBLE STRANDED DNA; EME1 DNA ENDONUCLEASE; HETERODIMER; THIOL GROUP; UNCLASSIFIED DRUG;

3' FLAP SUBSTRATE; ARTICLE; BASE PAIRING; CATALYSIS; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; DNA JUNCTION FLEXIBILITY; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HOLLIDAY JUNCTION; MICHAELIS MENTEN KINETICS; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUS81 MMS4 YEAST; NONBIOLOGICAL MODEL; NONHUMAN; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; STRUCTURE ACTIVITY RELATION; YEAST;

DNA; DNA CLEAVAGE; DNA, CRUCIFORM; DNA-BINDING PROTEINS; ENDONUCLEASES; FLAP ENDONUCLEASES; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84903173997     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku265     Document Type: Article

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