Role of c-Src activity in the regulation of gastric cancer cell migration

Oncology Reports

Volumn 32, Issue 1, 2014, Pages 45-49

  Yang, Yun ^a   Bai, Zhi Gang ^a   Yin, Jie ^a   Wu, Guo Cong ^a   Zhang, Zhong Tao ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

c Src; Cell migration; Furin; Gastric cancer; MT1 MMP; VEGF C

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; C SRC PROTEIN; FURIN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN C; CSK TYROSINE-PROTEIN KINASE; FURIN PROTEIN, HUMAN; INDOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STOMACH CANCER; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE; TUMOR INVASION;

CELL LINE, TUMOR; CELL MOVEMENT; FURIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; MATRIX METALLOPROTEINASE 14; NEOPLASM INVASIVENESS; PYRIMIDINES; SRC-FAMILY KINASES; STOMACH NEOPLASMS; SULFONAMIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84903150411     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3188     Document Type: Article

References (28)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Namikawa T and Hanazaki K: Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surg Today: Jul 30, 2013 (Epub ahead of print).
3. He CZ and Zhang KH: Serum protein and genetic tumor markers of gastric carcinoma. Asian Pac J Cancer Prev 14: 3437-3442, 2013.
4. Vey M, Schafer W, Berghofer S, Klenk HD and Garten W: Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation. J Cell Biol 127: 1829-1842, 1994.
5. Anderson ED, VanSlyke JK, Thulin CD, Jean F and Thomas G: Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage. EMBO J 16: 1508-1518, 1997. (Pubitemid 27151946)
6. de Lartigue J, Polson H, Feldman M, et al: PIKfyve regulation of endosome-linked pathways. Traffic 10: 883-893, 2009.
7. Kappert K, Meyborg H, Fritzsche J, et al: Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. PLoS One 8: e70542, 2013.
8. Lopez de Cicco R, Bassi DE, Zucker S, et al: Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res 65: 4162-4171, 2005. (Pubitemid 40775654)
9. Komiyama T, Coppola JM, Larsen MJ, et al: Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules. J Biol Chem 284: 15729-15738, 2009.
10. Hilbig A: Src kinase and pancreatic cancer. Recent Results Cancer Res 177: 179-185, 2008.
11. Okamoto W, Okamoto I, Yoshida T, et al: Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. Mol Cancer Ther 9: 1188-1197, 2010.
12. Nam HJ, Im SA, Oh DY, et al: Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer. Mol Cancer Ther 12: 16-26, 2013.
13. Summy JM and Gallick GE: Treatment for advanced tumors: SRC reclaims center stage. Clin Cancer Res 12: 1398-1401, 2006.
14. Lee M, Choy WC and Abid MR: Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src. PLoS One 6: e28454, 2011.
15. Tekedereli I, Alpay SN, Tavares CD, et al: Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. PLoS One 7: e41171, 2012.
16. Demidyuk IV, Shubin AV, Gasanov EV, et al: Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. PLoS One 8: e55752, 2013.
17. Page RE, Klein-Szanto AJ, Litwin S, et al: Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell Oncol 29: 289-299, 2007. (Pubitemid 47037242)
18. Thomas G: Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3: 753-766, 2002.
19. Bassi DE, Mahloogi H, Lopez De Cicco R, et al: Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol 162: 439-447, 2003. (Pubitemid 36267851)
20. Strongin AY: Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy. Biochim Biophys Acta 1803: 133-141, 2010.
21. Suboj P, Babykutty S, Valiyaparambil G, Nair RS, Srinivas P and Gopala S: Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB. Eur J Pharm Sci 45:581-591, 2012.
22. Stacker SA, Caesar C and Baldwin ME: VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 7: 186-191, 2001. (Pubitemid 32148485)
23. Tolde O, Rosel D, Mierke CT, et al: Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP. Int J Oncol 36: 833-839, 2010.
24. Iravani O, Tay BW, Chua PJ, Yip GW and Bay BH: Claudins and gastric carcinogenesis. Exp Biol Med (Maywood) 238: 344-349, 2013.
25. Zucker S, Pei D, Cao J and Lopez-Otin C: Membrane type-matrix metalloproteinases (MT-MMP). Curr Top Dev Biol 54: 1-74, 2003. (Pubitemid 137639464)
26. Nakanishi Y, Ohara M, Domen H, Shichinohe T, Hirano S and Ishizaka M: Differences in risk factors between patterns of recurrence in patients after curative resection for advanced gastric carcinoma. World J Surg Oncol 11: 98, 2013.
27. Parker MW, Hellman LM, Xu P, et al: Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin. Biochemistry 49: 4068-4075, 2010.
28. s6-kinase activation in vascular smooth muscle cells. Hypertension 39: 399-406, 2002.