Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Lee, Monica ^a,b   Choy, Wing C ^a,c   Abid, Md Ruhul ^a  

^a BROWN UNIVERSITY   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE P60; RAC1 PROTEIN DEPENDENT REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE PROTEIN P47PHOX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; THIOL; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; NEUTROPHIL CYTOSOLIC FACTOR 1;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; OXIDATION; OXIDATION REDUCTION STATE; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CELL CULTURE; CORONARY BLOOD VESSEL; CYTOLOGY; DRUG ANTAGONISM; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; ONCOGENE SRC; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

BLOTTING, WESTERN; CELLS, CULTURED; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FLUORESCENT ANTIBODY TECHNIQUE; GENES, SRC; HUMANS; IMMUNOPRECIPITATION; NADPH OXIDASE; OXIDATION-REDUCTION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 82455174396     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028454     Document Type: Article

References (41)

1. Ray R, Shah AM, (2005) NADPH oxidase and endothelial cell function. Clin Sci (Lond) 109: 217-226.
2. Fichtlscherer S, Dimmeler S, Breuer S, Busse R, Zeiher AM, et al. (2004) Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. Circulation 109: 178-183.
3. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, et al. (2002) Prognostic value of coronary vascular endothelial dysfunction. Circulation 106: 653-658.
4. Irani K, (2000) Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res 87: 179-183.
5. Kunsch C, Medford RM, (1999) Oxidative stress as a regulator of gene expression in the vasculature. Circ Res 85: 753-766.
6. Patterson C, Ruef J, Madamanchi NR, Barry-Lane P, Hu Z, et al. (1999) Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo. J Biol Chem 274: 19814-19822.
7. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW, (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148.
8. Marumo T, Schini-Kerth VB, Fisslthaler B, Busse R, (1997) Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Circulation 96: 2361-2367.
9. Baas AS, Berk BC, (1995) Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells. Circ Res 77: 29-36.
10. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK, (1998) p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chem 273: 15022-15029.
11. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, et al. (1999) Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem 274: 22699-22704.
12. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK, (1996) p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271: 23317-23321.
13. Zafari AM, Ushio-Fukai M, Akers M, Yin Q, Shah A, et al. (1998) Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy. Hypertension 32: 488-495.
14. Abid MR, Kachra Z, Spokes KC, Aird WC, (2000) NADPH oxidase activity is required for endothelial cell proliferation and migration. FEBS Lett 486: 252-256.
15. Abid MR, Tsai JC, Spokes KC, Deshpande SS, Irani K, et al. (2001) Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism. Faseb J 15: 2548-2550.
16. Colavitti R, Pani G, Bedogni B, Anzevino R, Borrello S, et al. (2002) Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. J Biol Chem 277: 3101-3108.
17. Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, et al. (2002) Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis. Circ Res 91: 1160-1167.
18. Ferrara N, (2001) Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 280: C1358-1366.
19. Dvorak HF, Brown LF, Detmar M, Dvorak AM, (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039.
20. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L, (2006) VEGF receptor signalling- in control of vascular function. Nat Rev Mol Cell Biol 7: 359-371.
21. Veikkola T, Karkkainen M, Claesson-Welsh L, Alitalo K, (2000) Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res 60: 203-212.
22. Abid MR, Kachra Z, Spokes KC, Aird WC, (2000) NADPH oxidase activity is required for endothelial cell proliferation and migration. FEBS Lett 486: 252-256.
23. Abid MR, Spokes KC, Shih SC, Aird WC, (2007) NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem 282: 35373-35385.
24. Feng J, Damrauer SM, Lee M, Sellke FW, Ferran C, et al. (2010) Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol 30: 1703-1710.
25. Meng TC, Fukada T, Tonks NK, (2002) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9: 387-399.
26. Meng TC, Buckley DA, Galic S, Tiganis T, Tonks NK, (2004) Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J Biol Chem 279: 37716-37725.
27. Boivin B, Zhang S, Arbiser JL, Zhang ZY, Tonks NK, (2008) A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A 105: 9959-9964.
28. Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, et al. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell 18: 713-724.
29. Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, et al. (2010) Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice. PLoS One 5: e10189.
30. Giannoni E, Buricchi F, Raugei G, Ramponi G, Chiarugi P, (2005) Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth. Mol Cell Biol 25: 6391-6403.
31. Chou MT, Wang J, Fujita DJ, (2002) Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells. BMC Biochem 3: 32.
32. Akhand AA, Pu M, Senga T, Kato M, Suzuki H, et al. (1999) Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism. J Biol Chem 274: 25821-25826.
33. Oo ML, Senga T, Thant AA, Amin AR, Huang P, et al. (2003) Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase. Oncogene 22: 1411-1417.
34. Pu M, Akhand AA, Kato M, Hamaguchi M, Koike T, et al. (1996) Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation. Oncogene 13: 2615-2622.
35. Rahman MA, Senga T, Ito S, Hyodo T, Hasegawa H, et al. S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion. J Biol Chem 285: 3806-3814.
36. Dansen TB, Smits LM, van Triest MH, de Keizer PL, van Leenen D, et al. (2009) Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol 5: 664-672.
37. Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E, (2006) Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol 174: 593-604.
38. Ewan LC, Jopling HM, Jia H, Mittar S, Bagherzadeh A, et al. (2006) Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells. Traffic 7: 1270-1282.
39. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, et al. (2004) Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol 24: 294-300.
40. Ehrlich M, Shmuely A, Henis YI, (2001) A single internalization signal from the di-leucine family is critical for constitutive endocytosis of the type II TGF-beta receptor. J Cell Sci 114: 1777-1786.
41. Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL, (2003) Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 5: 410-421.