RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6

Cell Reports

Volumn 4, Issue 6, 2013, Pages 1224-1234

  Demir, Kubilay ^a   Kirsch, Nadine ^b   Beretta, Carlo A ^a   Erdmann, Gerrit ^a   Ingelfinger, Dierk ^a   Moro, Enrico ^c   Argenton, Francesco ^c   Carl, Matthias ^a   Niehrs, Christof ^b,d   Boutros, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF PADOVA   (Italy)

^d INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CAVEOLIN; DICKKOPF 1 PROTEIN; DISHEVELLED 1; DYNAMIN; GUANOSINE TRIPHOSPHATASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; RAB8B PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN;

ARTICLE; CAVEOLA; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; LIGAND BINDING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; XENOPUS LAEVIS; ZEBRA FISH;

DANIO RERIO; VERTEBRATA; XENOPUS LAEVIS;

ANIMALS; ENDOCYTOSIS; HEK293 CELLS; HELA CELLS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; ONCOGENE PROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSFECTION; WNT PROTEINS; XENOPUS; ZEBRAFISH;

EID: 84884594963     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.08.008     Document Type: Article

References (42)

1. Abramoff M.D., Magalhaes P.J., Ram S.J. Image Processing with ImageJ. Biophotonics International 2004, 11:36-42.
2. Ahn S., Kim J., Lucaveche C.L., Reedy M.C., Luttrell L.M., Lefkowitz R.J., Daaka Y. Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J.Biol. Chem. 2002, 277:26642-26651.
3. Behrens J., von Kries J.P., Kühl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996, 382:638-642.
4. Bilic J., Huang Y.-L., Davidson G., Zimmermann T., Cruciat C.-M., Bienz M., Niehrs C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007, 316:1619-1622.
5. Bolte S., Cordelières F.P. A guided tour into subcellular colocalization analysis in light microscopy. J.Microsc. 2006, 224:213-232.
6. Boutros M., Brás L.P., Huber W. Analysis of cell-based RNAi screens. Genome Biol. 2006, 7:R66.
7. Buechling T., Bartscherer K., Ohkawara B., Chaudhary V., Spirohn K., Niehrs C., Boutros M. Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr. Biol. 2010, 20:1263-1268.
8. Chen M., Philipp M., Wang J., Premont R.T., Garrison T.R., Caron M.G., Lefkowitz R.J., Chen W. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J.Biol. Chem. 2009, 284:35040-35048.
9. Cruciat C.M., Ohkawara B., Acebron S.P., Karaulanov E., Reinhard C., Ingelfinger D., Boutros M., Niehrs C. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 2010, 327:459-463.
10. Da Q., Yang X., Xu Y., Gao G., Cheng G., Tang H. TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I. J.Immunol. 2011, 186:3023-3030.
11. Davidson G., Wu W., Shen J., Bilic J., Fenger U., Stannek P., Glinka A., Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 2005, 438:867-872.
12. Emery G., Hutterer A., Berdnik D., Mayer B., Wirtz-Peitz F., Gaitan M.G., Knoblich J.A. Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell 2005, 122:763-773.
13. Evans T.M., Ferguson C., Wainwright B.J., Parton R.G., Wicking C. Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic 2003, 4:869-884.
14. Gilbert D.F., Erdmann G., Zhang X., Fritzsche A., Demir K., Jaedicke A., Muehlenberg K., Wanker E.E., Boutros M. A novel multiplex cell viability assay for high-throughput RNAi screening. PLoS ONE 2011, 6:e28338.
15. Gurkan C., Lapp H., Alory C., Su A.I., Hogenesch J.B., Balch W.E. Large-scale profiling of Rab GTPase trafficking networks: the membrome. Mol. Biol. Cell 2005, 16:3847-3864.
16. Hassler C., Cruciat C.M., Huang Y.L., Kuriyama S., Mayor R., Niehrs C. Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling. Development 2007, 134:4255-4263.
17. Hattula K., Furuhjelm J., Arffman A., Peränen J. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Mol. Biol. Cell 2002, 13:3268-3280.
18. Irie N., Kuratani S. Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis. Nature communications 2011, 2:248.
19. Klaus A., Birchmeier W. Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 2008, 8:387-398.
20. Ladher R.K., Anakwe K.U., Gurney A.L., Schoenwolf G.C., Francis-West P.H. Identification of synergistic signals initiating inner ear development. Science 2000, 290:1965-1967.
21. Lekven A.C., Thorpe C.J., Waxman J.S., Moon R.T. Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev. Cell 2001, 1:103-114.
22. MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 2009, 17:9-26.
23. Macdonald R., Xu Q., Barth K.A., Mikkola I., Holder N., Fjose A., Krauss S., Wilson S.W. Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron 1994, 13:1039-1053.
24. Miaczynska M., Christoforidis S., Giner A., Shevchenko A., Uttenweiler-Joseph S., Habermann B., Wilm M., Parton R.G., Zerial M. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 2004, 116:445-456.
25. Moro E., Ozhan-Kizil G., Mongera A., Beis D., Wierzbicki C., Young R.M., Bournele D., Domenichini A., Valdivia L.E., Lum L., et al. Invivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev. Biol. 2012, 366:327-340.
26. Nickles D., Falschlehner C., Metzig M., Boutros M. A genome-wide RNAi screen identifies CASP4 as a factor required for TNF-alpha signaling. Mol. Cell. Biol. 2012, 32:3372-3381.
27. Niehrs C. The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell Biol. 2012, 13:767-779.
28. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:e45.
29. Pilli M., Arko-Mensah J., Ponpuak M., Roberts E., Master S., Mandell M.A., Dupont N., Ornatowski W., Jiang S., Bradfute S.B., et al. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity 2012, 37:223-234.
30. Progida C., Cogli L., Piro F., De Luca A., Bakke O., Bucci C. Rab7b controls trafficking from endosomes to the TGN. J.Cell Sci. 2010, 123:1480-1491.
31. Sakane H., Yamamoto H., Kikuchi A. LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse. J.Cell Sci. 2010, 123:360-368.
32. Schindelin J., Arganda-Carreras I., Frise E., Kaynig V., Longair M., Pietzsch T., Preibisch S., Rueden C., Saalfeld S., Schmid B., et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 2012, 9:676-682.
33. Schneider C.A., Rasband W.S., Eliceiri K.W. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 2012, 9:671-675.
34. Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat. Rev. Mol. Cell Biol. 2009, 10:513-525.
35. Taelman V.F., Dobrowolski R., Plouhinec J.-L., Fuentealba L.C., Vorwald P.P., Gumper I., Sabatini D.D., De Robertis E.M. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 2010, 143:1136-1148.
36. Thisse, B., and Thisse, C. (2004). Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission. http://zfin.org.
37. Tomic M., Sunjevaric I., Savtchenko E.S., Blumenberg M. A rapid and simple method for introducing specific mutations into any position of DNA leaving all other positions unaltered. Nucleic Acids Res. 1990, 18:1656.
38. Westerfield M. The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio) 1995, University of Oregon Press, Eugene, OR.
39. Wu X., Tu X., Joeng K.S., Hilton M.J., Williams D.A., Long F. Rac1 activation controls nuclear localization of β-catenin during canonical Wnt signaling. Cell 2008, 133:340-353.
40. Yamamoto H., Komekado H., Kikuchi A. Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 2006, 11:213-223.
41. Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J., He X. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005, 438:873-877.
42. Zhang J., Schulze K.L., Hiesinger P.R., Suyama K., Wang S., Fish M., Acar M., Hoskins R.A., Bellen H.J., Scott M.P. Thirty-one flavors of Drosophila rab proteins. Genetics 2007, 176:1307-1322.