New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 7, 2014, Pages 4242-4245

  Zhu, Weixing ^a   Haupenthal, Jörgm ^a   Groh, Matthias ^a   Fountain, Michelle ^c   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL RNA; CBR 703; DOXORUBICIN; RIFAMPICIN; RNA DIRECTED RNA POLYMERASE INHIBITOR; RNA POLYMERASE; UNCLASSIFIED DRUG; AMIDINE; DNA DIRECTED RNA POLYMERASE; ENZYME INHIBITOR; HYDROXYLAMINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; ARTIFACT; BACILLUS SUBTILIS; BIOFILM; CYTOTOXICITY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION;

AMIDINES; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; CELL LINE; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; ESCHERICHIA COLI; HEK293 CELLS; HUMANS; HYDROXYLAMINES; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; RNA, BACTERIAL; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 84903130018     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02600-14     Document Type: Article

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