Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae

Journal of Bacteriology

Volumn 194, Issue 20, 2012, Pages 5504-5512

  Buurman, Ed T ^a   Foulk, Melinda A ^a   Gao, Ning ^a   Laganas, Valerie A ^a   McKinney, David C ^a   Moustakas, Demetri T ^a   Rose, Jonathan A ^a   Shapiro, Adam B ^a   Fleming, Paul R ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORALLOPYRONIN; DNA; FATTY ACID; FIDAXOMICIN; MYXOPYRONIN; PEPTIDOGLYCAN; PROTEIN; RIFAMPICIN; RIPOSTATIN; RNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CRYSTAL STRUCTURE; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; DNA-DIRECTED RNA POLYMERASES; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HIGH-THROUGHPUT SCREENING ASSAYS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RIFAMPIN;

ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; THERMUS THERMOPHILUS;

EID: 84868586462     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.01103-12     Document Type: Article

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