Common therapeutic targets in cardiometabolic disease

Science Translational Medicine

Volumn 6, Issue 239, 2014, Pages

  Fredman, Gabrielle ^a   Ozcan, Lale ^a   Tabas, Ira ^a  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; CALCIUM; TAUROURSODEOXYCHOLIC ACID;

ATHEROSCLEROSIS; BARIATRIC SURGERY; CALCIUM SIGNALING; CARDIOMETABOLIC DISEASE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CELL TYPE; CORONARY ARTERY THROMBOSIS; DISEASE ASSOCIATION; DRUG RESEARCH; DRUG SAFETY; DYSLIPIDEMIA; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERINSULINEMIA; INFLAMMATION; INSULIN RESISTANCE; MECHANICAL STRESS; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; MOLECULARLY TARGETED THERAPY; PATHOLOGY;

ANIMALS; CALCIUM SIGNALING; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; HUMANS; INFLAMMATION; MOLECULAR TARGETED THERAPY;

EID: 84903118813     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3008908     Document Type: Review

References (39)

1. S. Mottillo, K. B. Filion, J. Genest, L. Joseph, L. Pilote, P. Poirier, S. Rinfret, E. L. Schiffrin, M. J. Eisenberg, The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J. Am. Coll. Cardiol. 56, 1113-1132 (2010).
2. S. Kotla, N. K. Singh, M. R. Heckle, G. J. Tigyi, G. N. Rao, The transcription factor CREB enhances interleukin-17A production and infl ammation in a mouse model of atherosclerosis. Sci. Signal. 6, ra83 (2013).
3. O. Bergmann, R. D. Bhardwaj, S. Bernard, S. Zdunek, F. Barnabé-Heider, S. Walsh, J. Zupicich, K. Alkass, B. A. Buchholz, H. Druid, S. Jovinge, J. Frisén, Evidence for cardiomyocyte renewal in humans. Science 324, 98-102 (2009).
4. J. C. Cohen, J. D. Horton, H. H. Hobbs, Human fatty liver disease: Old questions and new insights. Science 332, 1519-1523 (2011).
5. J.-W. Yoon, C.-S. Yoon, H.-W. Lim, Q. Q. Huang, Y. Kang, K. H. Pyun, K. Hirasawa, R. S. Sherwin, H.-S. Jun, Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells. Science 284, 1183-1187 (1999).
6. K. E. Bornfeldt, I. Tabas, Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 14, 575-585 (2011).
7. P. Libby, P. M. Ridker, G. K. Hansson, Progress and challenges in translating the biology of atherosclerosis. Nature 473, 317-325 (2011).
8. K. J. Moore, I. Tabas, Macrophages in the pathogenesis of atherosclerosis. Cell 145, 341-355 (2011).
9. D. Ron, P. Walter, Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529 (2007).
10. I. Tabas, D. Ron, Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011).
11. M. Myoishi, H. Hao, T. Minamino, K. Watanabe, K. Nishihira, K. Hatakeyama, Y. Asada, K. Okada, H. Ishibashi-Ueda, G. Gabbiani, M. L. Bochaton-Piallat, N. Mochizuki, M. Kitakaze, Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation 116, 1226-1233 (2007).
12. -/- mice lacking CHOP. Cell Metab. 9, 474-481 (2009).
13. G. S. Hotamisligil, Endoplasmic reticulum stress and atherosclerosis. Nat. Med. 16, 396-399 (2010).
14. M. F. Gregor, L. Yang, E. Fabbrini, B. S. Mohammed, J. C. Eagon, G. S. Hotamisligil, S. Klein, Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 58, 693-700 (2009).
15. L. Ozcan, J. Cristina de Souza, A. A. Harari, J. Backs, E. N. Olson, I. Tabas, Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. Cell Metab. 18, 803-815 (2013).
16. U. Ozcan, E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vaillancourt, R. O. Smith, C. Z. Görgün, G. S. Hotamisligil, Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006).
17. D. Ai, J. M. Baez, H. Jiang, D. M. Conlon, A. Hernandez-Ono, M. Frank-Kamenetsky, S. Milstein, K. Fitzgerald, A. J. Murphy, C. W. Woo, A. Strong, H. N. Ginsberg, I. Tabas, D. J. Rader, A. R. Tall, Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J. Clin. Invest. 122, 1677-1687 (2012).
18. F. R. Papa, Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Cold Spring Harb. Perspect. Med. 2, a007666 (2012).
19. E. Erbay, V. R. Babaev, J. R. Mayers, L. Makowski, K. N. Charles, M. E. Snitow, S. Fazio, M. M. Wiest, S. M. Watkins, M. F. Linton, G. S. Hotamisligil, Reducing endoplasmic reticulum stress through a macrophage lipid chaper-one alleviates atherosclerosis. Nat. Med. 15, 1383-1391 (2009).
20. Y. Dong, M. Zhang, B. Liang, Z. Xie, Z. Zhao, S. Asfa, H. C. Choi, M. H. Zou, Reduction of AMP-activated protein kinase α2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 121, 792-803 (2010).
21. M. Kars, L. Yang, M. F. Gregor, B. S. Mohammed, T. A. Pietka, B. N. Finck, B. W. Patterson, J. D. Horton, B. Mittendorfer, G. S. Hotamisligil, S. Klein, Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 59, 1899-1905 (2010).
22. G. Li, M. Mongillo, K. T. Chin, H. Harding, D. Ron, A. R. Marks, I. Tabas, Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J. Cell Biol. 186, 783-792 (2009).
23. Y. Li, M. Ge, L. Ciani, G. Kuriakose, E. J. Westover, M. Dura, D. F. Covey, J. H. Freed, F. R. Maxfield, J. Lytton, I. Tabas, Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. J. Biol. Chem. 279, 37030-37039 (2004).
24. J. M. Timmins, L. Ozcan, T. A. Seimon, G. Li, C. Malagelada, J. Backs, T. Backs, R. Bassel-Duby, E. N. Olson, M. E. Anderson, I. Tabas, Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J. Clin. Invest. 119, 2925-2941 (2009).
25. L. Ozcan, C. C. Wong, G. Li, T. Xu, U. Pajvani, S. K. Park, A. Wronska, B. X. Chen, A. R. Marks, A. Fukamizu, J. Backs, H. A. Singer, J. R. Yates, 3rd, D. Accili, I. Tabas, Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab. 15, 739-751 (2012).
26. Y. Wang, G. Li, J. Goode, J. C. Paz, K. Ouyang, R. Screaton, W. H. Fischer, J. Chen, I. Tabas, M. Montminy, Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132 (2012).
27. S. Fu, L. Yang, P. Li, O. Hofmann, L. Dicker, W. Hide, X. Lin, S. M. Watkins, A. R. Ivanov, G. S. Hotamisligil, Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473, 528-531 (2011).
28. E. D. Luczak, M. E. Anderson, CaMKII oxidative activation and the pathogenesis of cardiac disease. J. Mol. Cell. Cardiol. 10.1016/j.yjmcc.2014.02. 004 (2014).
29. K. Jagavelu, U. J. Tietge, M. Gaestel, H. Drexler, B. Schieffer, U. Bavendiek, Systemic defi ciency of the MAP kinaseactivated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice. Circ. Res. 101, 1104-1112 (2007).
30. J. M. Streicher, S. Ren, H. Herschman, Y. Wang, MAPKactivated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. Circ. Res. 106, 1434-1443 (2010).
31. C. N. Serhan, S. D. Brain, C. D. Buckley, D. W. Gilroy, C. Haslett, L. A. O'Neill, M. Perretti, A. G. Rossi, J. L. Wallace, Resolution of infl ammation: State of the art, defi nitions and terms. FASEB J. 21, 325-332 (2007).
32. I. Tabas, Macrophage death and defective inflammation resolution in atherosclerosis. Nat. Rev. Immunol. 10, 36-46 (2010).
33. G. Fredman, M. Spite, Recent advances in the role of immunity in atherosclerosis. Circ. Res. 113, e111-e114 (2013).
34. M. Spite, J. Clària, C. N. Serhan, Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 19, 21-36 (2014).
35. I. Tabas, C. K. Glass, Anti-infl ammatory therapy in chronic disease: challenges and opportunities. Science 339, 166-172 (2013).
36. M. Spite, L. V. Norling, L. Summers, R. Yang, D. Cooper, N. A. Petasis, R. J. Flower, M. Perretti, C. N. Serhan, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461, 1287-1291 (2009).
37. N. Kamaly, G. Fredman, M. Subramanian, S. Gadde, A. Pesic, L. Cheung, Z. A. Fayad, R. Langer, I. Tabas, O. C. Farokhzad, Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Proc. Natl. Acad. Sci. U.S.A. 110, 6506-6511 (2013).
38. J. Hellmann, Y. Tang, M. Kosuri, A. Bhatnagar, M. Spite, Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obesediabetic mice. FASEB J. 25, 2399-2407 (2011).
39. Y. Tang, M. J. Zhang, J. Hellmann, M. Kosuri, A. Bhatnagar, M. Spite, Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes 62, 618-627 (2013).