Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-like factor 4 promoter in vitro and in vivo

Circulation Research

Volumn 115, Issue 1, 2014, Pages 32-43

  Jiang, Yi Zhou ^a   Jiménez, Juan M ^a   Ou, Kristy ^b   McCormick, Margaret E ^a   Zhang, Ling Di ^a   Davies, Peter F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

atherosclerosis; DNA methylation; epigenetics; hemodynamics

Indexed keywords

BISULFITE; DNA METHYLTRANSFERASE 3A; ENDOTHELIAL NITRIC OXIDE SYNTHASE; KRUPPEL LIKE FACTOR 4; MONOCYTE CHEMOTACTIC PROTEIN 1; MYOCYTE ENHANCER FACTOR 2; THROMBOMODULIN;

ADULT; ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; BINDING SITE; BLOOD FLOW; CONTROLLED STUDY; CPG ISLAND; DISEASE PREDISPOSITION; DNA METHYLATION; ENDOTHELIUM CELL; EPIGENETICS; HEMODYNAMIC DISTURBED FLOW; HEMODYNAMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PYROSEQUENCING; SWINE; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ATHEROSCLEROSIS; DNA METHYLATION; EPIGENETICS; HEMODYNAMICS;

ANIMALS; ATHEROSCLEROSIS; BLOOD CIRCULATION; CELLS, CULTURED; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENDOTHELIUM, VASCULAR; HEMODYNAMICS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEF2 TRANSCRIPTION FACTORS; NITRIC OXIDE SYNTHASE TYPE III; PROMOTER REGIONS, GENETIC; SWINE;

EID: 84903118705     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.303883     Document Type: Article

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