Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice

Journal of Clinical Investigation

Volumn 122, Issue 12, 2012, Pages 4727-4731

  Zhou, Guangjin ^a   Hamik, Anne ^a   Nayak, Lalitha ^a   Tian, Hongmei ^a   Shi, Hong ^a   Lu, Yuan ^a   Sharma, Nikunj ^a   Liao, Xudong ^a   Hale, Andrew ^a   Boerboom, Lauren ^b   Feaver, Ryan E ^c   Gao, Huiyun ^a   Desai, Amar ^d   Schmaier, Alvin ^c   Gerson, Stanton L ^d   Wang, Yunmei ^a   Atkins, G Brandon ^a   Blackman, Brett R ^b,c   Simon, Daniel I ^a   Jain, Mukesh K ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Virginia   (United States)

^c HemoShear LLC   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E1A ASSOCIATED P300 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KRUPPEL LIKE FACTOR 4; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; SMALL INTERFERING RNA; UVOMORULIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; ATHEROGENESIS; CELL ISOLATION; CONTROLLED STUDY; EX VIVO STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE SILENCING; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOSIS;

ANIMALS; ATHEROSCLEROSIS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; THROMBOSIS; VASCULITIS;

EID: 84870542457     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66056     Document Type: Article

References (10)

1. Lin Z, et al. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005;96(5):e48-e57.
2. Hamik A, et al. Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem. 2007;282(18):13769-13779. (Pubitemid 47100499)
3. Fang Y, Davies PF. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol. 2012;32(4):979-987.
4. Liao X, et al. Kruppel-like factor 4 regulates macrophage polarization. J Clin Invest. 2011; 121(7):2736-2749.
5. Mas C, et al. Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci U S A. 2011;108(26):10484-10489.
6. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest. 1973;52(11):2745-2756.
7. Atkins GB, et al. Hemizygous deficiency of Kruppel- like factor 2 augments experimental atherosclerosis. Circ Res. 2008;103(7):690-693.
8. Katz JP, et al. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002; 129(11):2619-2628. (Pubitemid 34874246)
9. Nieman MT, et al. The preparation and characterization of novel peptide antagonists to thrombin and factor VIIa and activation of protease-activated receptor 1. J Pharmacol Exp Ther. 2004;311(2):492-501. (Pubitemid 39391533)
10. Feaver RE, Hastings NE, Pryor A, Blackman BR. GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells. Arterioscler Thromb Vasc Biol. 2008;28(8):1534-1541.