Silver nanoparticles: Therapeutical uses, toxicity, and safety issues

Journal of Pharmaceutical Sciences

Volumn 103, Issue 7, 2014, Pages 1931-1944

  Dos Santos, Carolina Alves ^a   Seckler, Marcelo Martins ^a   Ingle, Avinash P ^b   Gupta, Indarchand ^b,c   Galdiero, Stefania ^d   Galdiero, Massimiliano ^e   Gade, Aniket ^b,f   Rai, Mahendra ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SANT GADGE BABA AMRAVATI UNIVERSITY   (India)

^c Government Institute of Science   (India)

^d CNR   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f UTAH STATE UNIVERSITY   (United States)

Author keywords

antimicrobials; biomaterials; coating; drug delivery; nanotechnology; silver nanoparticles; synthesis; therapeutics; toxicity

Indexed keywords

CETUXIMAB; NANOMATERIAL; PHTHALAZINE DERIVATIVE; PYRIDAZINE DERIVATIVE; SILVER NANOPARTICLE; THIAZOLIDINE DERIVATIVE; METAL NANOPARTICLE; SILVER;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIVIRAL ACTIVITY; ATOM; BIOMEDICINE; DRUG DELIVERY SYSTEM; DRUG INTOXICATION; DRUG SAFETY; HUMAN; NANOTECHNOLOGY; NONHUMAN; PARASITOSIS; REVIEW; ANIMAL; CHEMISTRY; PHYSICAL CHEMISTRY; PRODUCT SAFETY; TOXICITY;

ANIMALS; CONSUMER PRODUCT SAFETY; HUMANS; METAL NANOPARTICLES; NANOTECHNOLOGY; PHYSICOCHEMICAL PHENOMENA; SILVER;

EID: 84902996575     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24001     Document Type: Article

References (149)

1. Jana S, Pal T,. 2007. Synthesis, characterization and catalytic application of silver nanoshell coated functionalized polystyrene beads. J Nanosci Nanotechnol 7: 2151-2156.
2. Leopold N, Lendl B,. 2003. A new method for fast preparation of highly surface-enhanced Raman scattering (SERS) active silver colloids at room temperature by reduction of silver nitrate with hydroxylamine hydrochloride. J Phys Chem B 107: 5723-5727.
3. Szmacinski H, Lakowicz JR, Catchmark JM, Eid K, Anderson JP, Middendorf L,. 2008. Correlation between scattering properties of silver particle arrays and fluorescence enhancement. Appl Spectrosc 62: 733-738.
4. Marambio-Jones C, Hoek EMV,. 2010. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res 12: 1531-1551.
5. Chen X, Schluesener HJ,. 2008. Nanosilver: A nanoproduct in medical application. Toxicol Lett 176: 1-12. (Pubitemid 350251066)
6. Devi P, Patil D, Jeevanandam P, Navani N, Singla M,. 2014. Synthesis, characterization and bactericidal activity of silica/silver core-shell nanoparticles. J Mater Sci Mater Med 25: 1267-1273.
7. Santos CA, Jozala AF, Pessoa A Jr, Seckler M,. 2012. Antimicrobial effectiveness of silver nanoparticles. J Nanobiotechnol 10: 1-6.
8. Dos Santos CA, Knirsch MC, Borghesan G, Pessoa A Jr, Penna TCV,. 2011. Influence of pluronic F68 on ceftazidime biological activity in parenteral solutions. J Pham Sci 100: 715-720.
9. Dwyer A,. 2008. Surface-treated catheters-A review. Semin Dial 21: 542-546.
10. Maki DG,. 2010. In vitro studies of a novel antimicrobial luer-activated needleless connector for prevention of catheter-related bloodstream infection. Clin Infect Dis 50: 1580-1587.
11. Roe D, Karandikar B, Bonn-Savage N, Gibbins B, Roullet JB,. 2008. Antimicrobial surface functionalization of plastic catheters by silver nanoparticles. J Antimicrob Chemother 61: 869-876. (Pubitemid 351426072)
12. Kvitek L, Kvitek L, Panacek A, Prucek R, Soukupova J, Vanickova M, Kolar M, Zboril R,. 2011. Antibacterial activity and toxicity of silver-nanosilver versus ionic silver. J Phys Conf Ser 304: 012029.
13. Stevens KN, Crespo-Biel O, van den Bosch EE, Dias AA, Knetsch ML, Aldenhoff YB, van der Veen FH, Maessen JG, Stobberingh EE, Koole LH,. 2009. The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood. Biomaterials 30: 3682-3690.
14. Cao H, Liu X,. 2010. Silver nanoparticles-modified films versus biomedical device-associated infections. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2: 670-684.
15. Sharma VK, Yngard RA, Lin Y,. 2009. Silver nanoparticles: Green synthesis and their antimicrobial activities. Adv Colloid Interface Sci 145: 83-96.
16. Tran HV, Tran LD, Ba CT, Vu HD, Nguyen TN, Pham DG, Nguyen PX,. 2010. Synthesis, characterization, antibacterial and antiproliferative activities of monodisperse chitosan-based silver nanoparticles. Colloids Surf A Physicochem Eng Aspects 360: 32-40.
17. Krishnaraj C, Jagan EG, Rajasekar S, Selvakumar P, Kalaichelvan PT, Mohan N,. 2010. Synthesis of silver nanoparticles using Acalypha indica leaf extracts and its antibacterial activity against water borne pathogens. Colloids Sur B: Biointerfaces 76: 50-56.
18. Ershov BG, Janata E, Henglein A,. 1993. Growth of silver particles in aqueous solution: Long-lived "magic" clusters and ionic strength effects. J Phys Chem 97: 339-343.
19. Lazarus LL, Riche CT, Malmstad N, Brutchey RL,. 2012. Effect of ionic liquid impurities on the synthesis of silver nanoparticles. Langmuir 28: 15987-15993.
20. Gentry ST, Fredericks SJ, Krchnavek R,. 2009. Controlled particle growth of silver sols through the use of hydroquinone as a selective reducing agent. Langmuir 25: 2613-2621.
21. Shirtcliffe N, Nickel U, Schneider S,. 1999. Reproducible preparation of silver sols with small particle size using borohydride reduction: For use as nuclei for preparation of larger particles. J Colloid Interface Sci 211: 122-129. (Pubitemid 29394465)
22. Dong X, Ji X, Jing J, Li M, Li J, Yang W,. 2010. Synthesis of triangular silver nanoprisms by stepwise reduction of sodium borohydride and trisodium citrate. J Phys Chem 114: 2070-2074.
23. Silvert PY, Herrera-Urbina R, Tekaia-Elhsissen K,. 1997. Preparation of colloidal silver dispersions by the polyol process. Part 2. Mechanism of particle formation. J Mater Chem 7: 293-299.
24. Sidhaye DS, Prasad BLV,. 2011. Many manifestations of digestive ripening: Monodispersity, superlattices and nanomachining. New J Chem 35: 755-763.
25. Tang Y, Ouyang M,. 2007. Tailoring properties and functionalities of metal nanoparticles through crystallinity engineering. Nat Mater 6: 754-759. (Pubitemid 47515310)
26. Kohler JM, Abahmane L, Wagner J, Albert J, Mayer G,. 2008. Preparation of metal nanoparticles with varied composition for catalytical applications in microreactors. Chem Eng Sci 63: 5048-5055.
27. Dahl JA, Maddux BLS, Hutchison JE,. 2007. Toward reener nanosynthesis. Chem Rev 107: 2228-2269.
28. Gade A, Gaikwad S, Duran N, Rai Mahendra,. 2013. Screening of different species of Phoma for synthesis of silver nanoparticles. Biotechnol Appl Biochem 60: 482-493.
29. Dar M, Ingle A, Rai M,. 2013. Enhanced antimicrobial activity of silver nanoparticles synthesized by Cryphonectria sp. evaluated singly and in combination with antibiotics. Nanomedicine 9: 105-110.
30. Sondi I, Salopek-Sondi B,. 2004. Silver nanoparticles as antimicrobial agent: A case study on E. coli as a model for gram-negative bacteria. J Colloid Interface Sci 275: 177-182. (Pubitemid 38670216)
31. Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramírez JT, Yacaman MJ,. 2005. The bactericidal effect of silver nanoparticles. Nanotechnology 16: 2346-2353. (Pubitemid 41376178)
32. Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, Kim SH, Park YK, Park YH, Hwang CY, Kim YK, Lee YS, Jeong DH, Cho MH,. 2007. Antimicrobial effects of silver nanoparticles. Nanomedicine 3: 95-101. (Pubitemid 46428190)
33. Wei D, Sun W, Qian W, Ye Y, Ma X,. 2009. The synthesis of chitosan-based silver nanoparticles and their antibacterial activity. Carbohydr Res 344: 2375-2382.
34. Shameli K, Ahmad MB, Jazayeri SD, Shabanzadeh P, Sangpour P, Jahangirian H, Gharayebi Y,. 2012. Investigation of antibacterial properties silver nanoparticles prepared via green method. Chem Cent J 6: 73.
35. Shrivastava S, Bera T, Roy A, Singh G, Ramchandrarao P, Dash D,. 2007. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology 18: 225103.
36. Xiang DX, Chen Q, Pang L, Zheng CL,. 2011. Inhibitory effect of silver nanoparticles on H1N1 influenza A virus in vitro. J Virol Methods 178: 137-142.
37. Elechiguerra JL, Burt JL, Morones JR, Camacho-Bragado A, Gao X, Lara HH, Yacaman MJ,. 2005. Interaction of silver nanoparticles with HIV-1. J Nanobiotechnol 3: 6.
38. Lara HH, Ixtepan-Turrent L, Garza-Trevino EN, Rodriguez-Padilla C,. 2010b. PVP-coated silver nanoparticles block the transmission of cell-free and cell-associated HIV-1 in human cervical culture. J Nanobiotechnol 8: 15.
39. Gaikwad S, Ingle A, Gade A, Rai M, Falanga A, Incoronato N, Russo L, Galdiero S, Galdiero M,. 2013. Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. Int J Nanomed 8: 4303-4314.
40. Baram-Pinto D, Shukla S, Perkas N, Gedanken A, Sarid R,. 2009. Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate. Bioconjug Chem 20: 1497-1502.
41. Mehrbod P, Motamed N, Tabatabaian M, Soleimani Estyar R, Amini E, Shahidi M, Kheiri MT,. 2009. In vitro antiviral effect of "nanosilver" on influenza virus. DARU 17: 88-93.
42. Rogers JV, Parkinson CV, Choi YW, Speshock JL, Hussain SM,. 2008. A preliminary assessment of silver nanoparticles inhibition of monkeypox virus plaque formation. Nanoscale Res Lett 3: 129-133.
43. Trefry JC, Wooley DP,. 2013. Silver nanoparticles inhibit vaccinia virus infection by preventing viral entry through a macropinocytosis-dependent mechanism. J Biomed Nanotechnol 9: 1624-1635.
44. Speshock JL, Murdock RC, Braydich-Stolle LK, Schrand AM, Hussain SM,. 2010. Interaction of silver nanoparticles with Tacaribe virus. J Nanobiotechnol 8: 19.
45. Gherbawy YA, Shalaby IM, Abd El-sadek MS, Elhariry HM, Banaja AA,. 2013. The anti-fasciolasis properties of silver nanoparticles produced by Trichoderma harzianum and their improvement of the anti-fasciolasis drug triclabendazole. Int J Mol Sci 14: 21887-21898.
46. Allahverdiyev AM, Abamor ES, Bagirova M, Ustundag CB, Kaya C, Kaya F, Rafailovich M,. 2011. Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light. Int J Nanomed 6: 2705-2714.
47. Panneerselvam C, Ponarulselvam S, Murugan K,. 2011. Potential anti-plasmodial activity of synthesized silver nanoparticle using Andrographis paniculata Nees (Acanthaceae). Archives App Sci Res 3: 208-217.
48. NIOSH. 2009. Approaches to safe nanotechnology managing the health and safety concerns associated with engineered nanomaterials. Accessed, at: http://www.cdc.gov/niosh/docs/2009 - 125/.; last accessed on May 01, 2014.
49. Coulter JA, Hyland WB, Nicol J, Currell FJ,. 2013. Radiosensitising nanoparticles as novel cancer therapeutics-Pipe dream or realistic prospect? Clin Oncol (R Coll Radiol) 25: 593-603.
50. Brown SB, Brown EA, Walker I,. 2004. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol 5: 497-508. (Pubitemid 39069400)
51. Begg AC, Stewart FA, Vens C,. 2011. Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 11: 239-253.
52. Kleinauskas A, Rocha S, Sahu S, Sun YP, Juzenas P,. 2013. Carbon-core silver-shell nanodots as sensitizers for phototherapy and radiotherapy. Nanotechnology 24: 325103.
53. Boca-Farcau S, Potara M, Simon T, Juhem A, Baldeck P, Astilean S,. 2014. Folic acid-conjugated, SERS-labelled silver nanotriangles for multimodal detection and targeted photothermal treatment on human ovarian cancer cells. Mol Pharm 11: 391-399.
54. 4/Ag enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy. Acta Biochim Biophys Sin 44: 678-684.
55. Pan J, Kong L, Lin S, Chen G, Chen Q, Lu JJ,. 2008. The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma. Laryngoscope 118: 1970-1975.
56. Xu R, Ma J, Sun X, Chen Z, Jiang X, Guo Z, Huang L, Li Y, Wang M, Wang C, Liu J, Fan X, Gu J, Chen X, Zhang Y, Gu N,. 2009. Ag nanoparticles sensitize IR-induced killing of cancer cells. Cell Res 19: 1031-1034.
57. Asharani PV, Hande MP, Valiyaveettil S,. 2009a. Anti-proliferative activity of silver nanoparticles. BMC Cell Biol 10: 65.
58. Asharani PV, Mun GLK, Hande MP, Valiyaveettil S,. 2009b. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3: 279-290.
59. Cheng LC, Chen HM, Lai TC, Chan YC, Liu RS, Sung JC, Hsiao M, Chen CH, Her LJ, Tsai DP,. 2013. Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cells. Nanoscale 5: 3931-3940.
60. Lin J, Chen R, Feng S, Pan J, Li Y, Chen G, Cheng M, Huang Z, Yu Y, Zeng H,. 2011. A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection. Nanomedicine 7: 655-663.
61. Tse C, Zohdy MJ, Ye JY, O'Donnell M, Lesniak W, Balogh L,. 2011. Enhanced optical breakdown in KB cells labelled with folate-targeted silver-dendrimer composite nanodevices. Nanomedicine 7: 97-106.
62. Wang R, Chen C, Yang W, Shi S, Wang C, Chen J,. 2013. Enhancement effect of cytotoxicity response of silver nanoparticles combined with thermotherapy on C6 rat glioma cells. J Nanosci Nanotechnol 13: 3851-3854.
63. Guo D, Zhu L, Huang Z, Zhou H, Ge Y, Ma W, Wu J, Zhang X, Zhou X, Zhang Y, Zhao Y, Gu N,. 2013. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 34: 7884-7894.
64. Ranjitham AM, Suja R, Caroling G, Tiwari S,. 2013. In vitro evaluation of antioxidant, antimicrobial, anticancer activities and characterisation of Brassica oleracea. var. Bortrytis. L synthesized silver nanoparticles. Int J Pharm Pharm Sci 5: 239-251.
65. Chen M, Yang Z, Wu H, Pan X, Xie X, Wu C,. 2011. Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel. Int J Nanomed 6: 2873-2877.
66. Kalishwaralal K, Barath-Manikanth S, Pandian SR, Deepak V, Gurunathan S,. 2010. Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis. Colloids Surf B Biointerfaces 79: 340-344.
67. Jefferson KK, Cerca N,. 2006. Bacterial-bacterial cell interactions in biofilms: Detection of polysaccharide intercellular adhesions by blotting and confocal microscopy. Methods Mol Biol 341: 119-126.
68. Yen HJ, Hsu SH, Tsai CL,. 2009. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 5: 1553-1561.
69. Pal S, Tak YK, Song JM,. 2007. Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli. Appl Environ Microbiol 73: 1712-1720. (Pubitemid 46449051)
70. Hwang ET, Lee JH, Chae YJ, Kim YS, Kim BC, Sang BI, Gu MB,. 2008. Analysis of the toxic mode of action of silver nanoparticles using stress-specific bioluminescent bacteria. Small 4: 746-750. (Pubitemid 352007136)
71. Klueh U, Wagner V, Kelly S, Johnson A, Bryers JD,. 2000. Efficacy of silver-coated fabric to prevent bacterial colonization and subsequent device-based biofilm formation. J Biomed Mater 53: 621-631.
72. Gajbhiye MB, Kesharwani JG, Ingle AP, Gade AK, Rai MK,. 2009. Fungus mediated synthesis of silver nanoparticles and its activity against pathogenic fungi in combination of fluconazole. Nanomedicine NBM 5 (4): 282-286.
73. Roy S, Mukherjee T, Chakraborty S, Das TK,. 2013. Biosynthesis, characterization & antifungal activity of silver nanoparticles synthesized by the fungus Aspergillus foetidus MTCC-8876. Dig J Nanomat Bios 8: 197-205.
74. Rajarathinam M, Kalaichelvan PT,. 2013. Biogenic nanosilver as a potential antibacterial and antifungal additive to commercially available dish wash and hand wash for an enhanced antibacterial and antifungal activity against selected pathogenic strains. Int Res J Pharma 4: 68-75.
75. Monteiro DR, Gorup LF, Silva S, Negri M, de Camargo ER, Oliveira R, Barbosa DB, Henriques M,. 2011. Silver colloidal nanoparticles: Antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata. Biofouling 27: 711-719.
76. Kandile NG, Zaky HT, Mohamed MI, Mohamed HM,. 2010. Silver nanoparticles effect on antimicrobial and antifungal activity of new heterocycles. Bull Korean Chem Soc 3: 3530-3538.
77. Georgea C, Kuriakosea S, Georgea S, Mathew T,. 2011. Antifungal activity of silver nanoparticle-encapsulated b-cyclodextrin against human opportunistic pathogens. Supramol Chem 23: 593-597.
78. Kaur P, Thakur R, Choudhary A,. 2012. An in vitro study of the antifungal activity of silver/chitosan nanoformulations against important seed borne pathogens. Int J Scientific Technol Res 1: 83-86.
79. Khadri H, Alzohairy M, Janardhan A, Kumar AP, Narasimha G,. 2013. Green synthesis of silver nanoparticles with high fungicidal activity from olive seed extract. Adv Nanopart 2: 241-246.
80. Qian Y, Yu H, He D, Yang H, Wang W, Wan X, Wang L,. 2013. Biosynthesis of silver nanoparticles by the endophytic fungus Epicoccum nigrum and their activity against pathogenic fungi. Bioprocess Biosyst Eng 36: 1613-1619.
81. Kumar P, Selvi SS, Govindaraju M,. 2013. Seaweed-mediated biosynthesis of silver nanoparticles using Gracilaria corticata for its antifungal activity against Candida spp. Appl Nanosci 3: 495-500.
82. Rout Y, Behera A, Ojha AK, Nayak PL,. 2012. Green synthesis of silver nanoparticles using Ocimum sanctum (Tulashi) and study of their antibacterial and antifungal activities. J Microbiol Antimicrob 4: 103-109.
83. Galdiero S, Falanga A, Vitiello M, Cantisani M, Marra V, Galdiero M,. 2011. Silver nanoparticles as potential antiviral agents. Molecules 16: 8894-8918.
84. Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M,. 2013. Peptide inhibitors against herpes simplex virus infections. J Pept Sci 19: 148-158.
85. Lu L, Sun RW, Chen R, Hui CK, Ho CM, Luk JM, Lau GK, Che CM,. 2008. Silver nanoparticles inhibit hepatitis B virus replication. Antivir Ther 13: 253-262.
86. Sun RW, Chen R, Chung NP, Ho CM, Lin CL, Che CM,. 2005. Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem Commun 40: 5059-5061. (Pubitemid 41566432)
87. Salem ANB, Zyed R, Lassoued MA, Nidhal S, Sfar S, Mahjoub A,. 2012. Plant-derived nanoparticles enhance antiviral activity against Coxsakie virus B3 by acting on virus particles and vero cells. Dig J Nanomater Bios 7: 737-744.
88. Lara HH, Ayala-Nunez NV, Ixtepan-Turrent L, Rodriguez-Padilla C,. 2010a. Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnol 8: 1.
89. Fayaz AM, Ao Z, Girilal M, Chen L, Xiao X, Kalaichelvan PT, Yao X,. 2012. Inactivation of microbial infectiousness by silver-nanoparticles coated condoms: A new approach to inhibit HIV- and HVS transmitted infection. Int J Nanomed 7: 5007-5018.
90. Sun L, Singh AK, Vig K, Pillai S, Shreekumar R, Singh SR,. 2008. Silver nanoparticles inhibit replication of respiratory sincitial virus. J Biomed Biotech 4: 149-158.
91. Santhoshkumar T, Rahuman AA, Rajakumar G, Marimuthu S, Bagavan A, Jayaseelan C, Zahir AA, Elango G, Kamaraj C,. 2011. Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors. Parasitol Res 108: 693-702.
92. Soni N, Prakash S,. 2013. Possible mosquito control by silver nanoparticles synthesized by soil fungus (Aspergillus niger-2587). Adv Nanopart 2: 125-132.
93. De-Jong WH, Van Der Ven LTM, Sleijffers A, Park MVDZ, Jansen EHJM, Loveren HV, Vandebriel RJ,. 2013. Systemic and immuno-toxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats. Biomaterials 34: 8333-8343.
94. Trop M, Novak M, Rodl S, Hellbom B, Kroell W, Goessler W,. 2006. Silver coated dressing acticoat caused raised liver enzymes and argyria like symptoms in burn patient. J Trauma 60: 648-652.
95. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE,. 2006. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 8: 1794-1807. (Pubitemid 44327550)
96. Hussain SM, Javorina MK, Schrand AM, Duhart HM, Ali SF, Schlager JJ,. 2006. The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. Toxicol Sci 92: 456-463. (Pubitemid 44018962)
97. Cha K, Hong HW, Choi YG, Lee MJ, Park JH, Chae HK, Ryu G, Myung H,. 2008. Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles. Biotechnol Lett 30: 1893-1899.
98. Lee YS, Kim DW, Lee YH, Oh JH, Yoon S, Choi MS, Lee SK, Kim JW, Lee K, Song CW,. 2011. Silver nanoparticles induce apoptosis and G2/M arrest via PKCz-dependent signalling in A549 lung cells. Arch Toxicol 85: 1529-1540.
99. Wang W, Kirsch T,. 2006. Annexin V/b5 integrin interactions regulate apoptosis of growth plate chondrocytes. J Biol Chem 281: 30848-30856. (Pubitemid 44582139)
100. Almofti MR, Ichikawa T, Yamashita K, Terada H, Shinohara Y,. 2003. Silver ion induces a cyclosporine a-insensitive permeability transition in rat liver mitochondria and release of apoptogenic cytochrome. C J Biochem 134: 43-49. (Pubitemid 37071178)
101. Rahman MF, Wang J, Patterson TA, Saini UT, Robinson BL, Newport GD, Murdock RC, Schlager JJ, Hussain SM, Ali SF,. 2009. Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles. Toxicol Lett 187: 15-21.
102. Gupta I, Duran N, Rai M,. 2012. Nano-silver toxicity: Emerging concerns and consequences in human health. In Nano-antimicrobials: Progress and prospects;, Rai M, Cioffi N, Eds. Germany: Springer Verlag, pp 525-548.
103. Navarro E, Piccapietra F, Wagner B, Marconi F, Kaegi R, Odzak N, Sigg L, Behra R,. 2008. Toxicity of silver nanoparticles to Clamydomonas reinhardtii. Environ Sci Technol 42: 8959-8964.
104. Xiu ZM, Zhang QB, Puppala HL, Colvin VL, Alvarez PJ,. 2012. Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Lett. 12 (8): 4271-4275.
105. Hatchett DW, White HS,. 1996. Electrochemistry of sulfur adlayers on the low-index faces of silver. J Phys Chem 100: 9854-9859. (Pubitemid 126788720)
106. Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramirez JT, Yacaman MJ,. 2005. The bactericidal effect of silver nanoparticles. Nanotechnology 16: 2346-2353. (Pubitemid 41376178)
107. Park S, Lee YK, Jung M, Kim KH, Chung N, Ahn EK, Lim Y, Lee KH,. 2007. Cellular toxicity of various inhalable metal nanoparticles on human alveolar epithelial cells. Inhal Toxicol 19 Suppl 1: 59-65. (Pubitemid 47450698)
108. Bar-Ilan O, Albrecht RM, Fako VE, Furgeson DV,. 2009. Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos. Small 5: 1897-1910.
109. Pauksch L, Hartmann S, Rohnke M, Szalay G, Alt V, Schnettler R, Lips KS,. 2014. Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts. Acta Biomaterialia 10: 439-449.
110. Silva T, Pokhrel LR, Dubey B, Tolaymat TM, Maier KJ, Liud X,. 2014. Particle size, surface charge and concentration dependent ecotoxicity of three organo-coated silver nanoparticles: Comparison between general linear model-predicted and observed toxicity. Sci Total Environ 468-469: 968-976.
111. Levard C, Hotze EM, Colman BP, Dale AL, Truong L, Yang XY, Bone AJ, Brown GE Jr, Tanguay RL, Di Giulio RT, Bernhardt ES, Meyer JN, Wiesner MR, Lowry GV,. 2013. Sulfidation of silver nanoparticles: Natural antidote to their toxicity. Environ Sci Technol 47: 13440-13448.
112. Pokhrel LR, Dubey B, Scheuerman PR,. 2013. Impacts of select organic ligands on the colloidal stability, dissolution dynamics, and toxicity of silver nanoparticles. Environ Sci Technol 47: 12877-12885.
113. Ramirez-Lee MA, Rosas-Hernandez H, Salazar-Garcia S, Gutierrez-Hernandez JM, Espinosa-Tanguma R, Gonzalez FJ, Ali SF, Gonzalez C,. 2014. Silver nanoparticles induce anti-proliferative effects on airway smooth muscle cells. Role of nitric oxide and muscarinic receptor signalling pathway. Toxicol Lett 224:2 46-256.
114. Munger MA, Radwanski P, Hadlock GC, Stoddard G, Shaaban A, Falconer J, Grainger DW, Deering-Rice CE,. 2014. In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine 10: 1-9.
115. Feldheim DL, Keating CD,. 1998. Self-assembly of single electron transistors and related devices. Chem Soc Rev 27: 1-12.
116. Rai M, Gade A, Yadav A,. 2011. Biogenic nanoparticles: An introduction to what they, how they are synthesized and their applications. In metal nanoparticles In Microbiology;, Rai MK, Duran N, Eds. Berlin Heidelberg, Germany: Springer-Verlag, pp 1-16.
117. http://www.bourneresearch.com, last accessed on April 25, 2014.
118. Chen J, Han CM, Lin XW, Tang ZJ, Su SJ,. 2006. Effect of silver nanoparticle dressing on second degree burn wound. Zhonghua Wai Ke Za Zhi 44: 50-52.
119. Muangman P, Chuntrasakul C, Silthram S, Suvanchote S, Benjathanung R, Kittidacha S, Rueksomtawin S,. 2006. Comparison of efficacy of 1% silver sulfadiazine and acticoat for treatment of partial-thickness burn wounds. J Med Assoc Thailand 89: 953-958. (Pubitemid 44099138)
120. Cohen MS, Stern JM, Vanni AJ, Kelley RS, Baumgart E, Field D, Libertino JA, Summerhayes IC,. 2007. In vitro analysis of a nanocrystalline silver-coated surgical mesh. Surg Infect 8: 397-403. (Pubitemid 47186310)
121. Zhang W, Qiao X, Chen J,. 2007. Formation of silver nanoparticles in SDS microemulsion. Mater Chem Phys 109: 411-416.
122. http://www.nanotechproject.org/news, Nanotech-enabled Consumer Products Continue to Rise, last accessed on May 01, 2014.
123. http://www.epa.gov/nanoscience/quickfinder/green.htm, Research Advancing Green Manufacturing of Nanotechnology Products, last accessed on May 01, 2014
124. Gade AK, Rai MK, Kulkarni SK,. 2011. Phoma sorghina: A phytopathogen mediated synthesis of unique silver rods. Int J Green Nanotechnol 3: 153-159.
125. Thakkar KN, Mhatre SS, Parikh RY,. 2010. Biological synthesis of metallic nanoparticles. Nanomedicine 6: 257-262.
126. Baldwin AD, Kiick KL,. 2010. Polysaccharide-modified synthetic polymeric biomaterialspolysaccharide-modified synthetic polymeric biomaterials polysaccharide modified synthetic polymeric biomaterials. Biopolymers 94: 128-140.
127. Rai MK, Deshmukh SD, Ingle AP, Gade AK,. 2012. Silver nanoparticles: The powerful nanoweapon against multidrug-resistant bacteria. J Appl Microbiol 112: 841-852.
128. Gade A, Gaikwad S, Duran N, Rai M,. 2013. Screening of different species of Phoma for the synthesis of silver nanoparticles. Biotechnol Appl Biochem 60: 482-493.
129. Gade A, Gaikwad S, Duran N, Rai M,. 2014. Green synthesis of silver nanoparticles by Phoma glomerata. Micron 59: 52-59.
130. Raheman F, Deshmukh S, Ingle A, Gade A, Rai, M,. 2011. Silver nanoparticles: Novel antimicrobial agent synthesized from a endophytic fungus Pestalotia sp. isolated from leaves of Syzygium cumini (L.). Nano Biomed Eng 3: 174-178.
131. Gupta A, Ingle A, Gade A, Gaikwad S, Bonde SR, Rai M,. 2013. Lawsonia inermis-mediated synthesis of silver nanoparticles: Activity against human pathogenic fungi and bacteria with special reference to formulation of an antimicrobial nanogel. IET Nanobiotechnol 1: 7.
132. Rai M, Yadav A,. 2013. Plants as potential synthesiser of precious metal nanoparticles: Progress and prospects. IET Nanobiotechnol 7: 117-123.
133. Bonde SR, Rathod DP, Ingle AP, Ade RB, Gade AK, Rai MK,. 2012. First report of Murraya koenigii mediated synthesis of silver nanoparticles and its activity against three human pathogenic bacteria. Nanosci Meth 1: 25-36.
134. Sudha SS, Rajamanickam K, Rengaramanujam J,. 2013. Microalgae mediated synthesis of silver nanoparticles and their antibacterial activity against pathogenic bacteria. Ind J Exp Biol 51: 393-399.
135. Manivasagan P, Venkatesan J, Senthilkumar K, Sivakumar K, Kim SK,. 2013. Biosynthesis, antimicrobial and cytotoxic effect of silver nanoparticles using a novel Nocardiopsis sp. MBRC-1. Biomed Res Int 2013: 287638.
136. Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB,. 2000. Intra tracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations. J Toxicol Sci 55: 24-35. (Pubitemid 30252432)
137. Quadros ME, Marr LC,. 2010. Environmental and human health risks of aerosolized silver nanoparticles. J Air Waste Man Assoc 60: 770-781.
138. Ji JH, Jung JH, Kim SS, Yoon JU, Park JD, Choi BS, Chung YH, Kwon IH, Jeong J, Han BS,. 2007. Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol 19: 857-871. (Pubitemid 47237748)
139. Kim Y, Kim J, Cho H, Rha D, Kim J, Park J, Choi B, Lim R, Chang H, Chung Y, Kwon I, Jeong J, Han B, Yu I,. 2008. Twenty-eight-day oral toxicity, genotoxicity, and gender related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol 20: 575-583. (Pubitemid 351601408)
140. Handy RD, Owen R, Valsami-Jones E,. 2008. The ecotoxicology of nanoparticles and nanomaterials: Current status, knowledge gaps, challenges, and future needs. Ecotoxicology 17: 315-325.
141. Klaine SJ, Alvarez PJJ, Batley GE, Fernandes TF, Handy RD, Lyon DY, Mahendra S, Mclaughlin MJ, Lead JR,. 2008. Nanomaterials in the environment: Behavior, fate, bioavailability and effects. Environ Toxicol Chem 27: 1825-1851.
142. Savolainen K, Alenius H, Norppa H, Pylkkänen L, Tuomi L, Kasper G,. 2010. Risk assessment of engineered nanomaterials and nanotechnologies: A review. Toxicology 269: 92-104.
143. Schulte PA, Schubauer-Berigan MK, Mayweather C, Geraci CL, Zumwalde R, McKernan JL,. 2009. Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles. J Occup Environ Med 51: 323-335.
144. Kim KJ, Sung WS, Suh BK, Moon SK, Choi JS, Kim J, Lee DG,. 2009. Antifungal activity and mode of action of silver nanoparticles on Candida albicans. Biometals 22: 235-242.
145. Yin L, Cheng S, Espinasse B, Colman BP, Auffan M, Wiesner M, Rose J, Liu J, Bernhardt ES,. 2011. More than the ions: The effects of silver nanoparticles on Lolium multiflorum. Environ Sci Technol 45: 2360-2367.
146. Navarro E, Piccapietra F, Wagner B, Marconi F, Kaegi R, Odzak N, Sigg L, Behra R,. 2008. Toxicity of silver nanoparticles to Chlamydomonas reinhardtii. Environ Sci Technol 42: 8959-8964.
147. Bone AJ, Colman BP, Gondikas AP, Newton KM, Harrold K H, Cory RM, Unrine JM, Klaine SJ, Matson CW, Di Giulio RT,. 2012. Biotic and abiotic interactions in aquatic microcosms determine fate and toxicity of Ag nanoparticles: Part 2-toxicity and Ag speciation. Environ Sci Technol 46: 6925-6933.
148. Shoults-Wilson WA, Zhurbich OI, McNear DH, Tsyusko OV, Bertsch PM, Unrine JM,. 2011. Evidence for avoidance of Ag nanoparticles by earthworms (Eisenia fetida). Ecotoxicology 20: 385-396.
149. Ma R, Levard C, Judy JD, Unrine JM, Durenkamp M, Martin B, Jefferson B, Lowry GV,. 2014. Fate of zinc oxide and silver nanoparticles in a pilot wastewater treatment plant and in processed biosolids. Environ Sci Technol 48: 104-112.