Phthalate metabolites in urine and asthma, allergic rhinoconjunctivitis and atopic dermatitis in preschool children

International Journal of Hygiene and Environmental Health

Volumn 217, Issue 6, 2014, Pages 645-652

  Callesen, Michael ^a   Bekö, Gabriel ^b   Weschler, Charles J ^b,c   Langer, Sarka ^d   Brive, Lena ^e   Clausen, Geo ^b   Toftum, Jørn ^b   Sigsgaard, Torben ^f   Høst, Arne ^a   Jensen, Tina Kold ^g  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c RUTGERS UNIVERSITY   (United States)

^d IVL SWEDISH ENVIRONMENTAL RESEARCH INSTITUTE   (Sweden)

^e SP TECHNICAL RESEARCH INSTITUTE OF SWEDEN   (Sweden)

^f AARHUS UNIVERSITY   (Denmark)

^g UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Allergic diseases; Clinical examination; Eczema; Exposure pathways; Wheeze

Indexed keywords

PHTHALIC ACID DERIVATIVE; POLLUTANT;

ALLERGIC CONJUNCTIVITIS; ANALYSIS; ASTHMA; ATOPIC DERMATITIS; CASE CONTROL STUDY; CROSS-SECTIONAL STUDY; DENMARK; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; INFANT; MALE; POLLUTANT; PRESCHOOL CHILD; RHINITIS; URINE;

ASTHMA; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; CONJUNCTIVITIS, ALLERGIC; CROSS-SECTIONAL STUDIES; DENMARK; DERMATITIS, ATOPIC; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INFANT; MALE; PHTHALIC ACIDS; RHINITIS;

EID: 84902827573     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2013.12.001     Document Type: Article

References (59)

1. Asher M.I., Keil U., Anderson H.R., Beasley R., Crane J., Martinez F., Mitchell E.A., Pearce N., Sibbald B., Stewart A.W. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur. Respir. J. 1995, 8:483-491.
2. Bateman E.D., Hurd S.S., Barnes P.J., Bousquet J., Drazen J.M., FitzGerald M., Gibson P., Ohta K., O'Byrne P., Pedersen S.E., Pizzichini E., Sullivan S.D., Wenzel S.E., Zar H.J. Global strategy for asthma management and prevention: GINA executive summary. Eur. Respir. J. 2008, 31(1):143-178.
3. Bekö G., Weschler C.J., Langer S., Callesen M., Toftum J., Clausen G. Children's phthalate intakes and resultant cumulative exposures estimated from urine compared with estimates from dust ingestion, inhalation and dermal absorption in their homes and daycare centers. PLoS ONE 2013, 8(4):e62442.
4. Beydon D., Payan J.P., Grandclaude M.C. Comparison of percutaneous absorption and metabolism of di-n-butylphthalate in various species. Toxicol. In Vitro 2010, 24:71-78.
5. Boas M., Frederiksen H., Feldt-Rasmussen U., Skakkebaek N.E., Hegedus L., Hilsted L., Juul A., Main K.M. Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth. Environ. Health Perspect. 2010, 118(10):1458-1464.
6. Bornehag C.G., Nanberg E. Phthalate exposure and asthma in children. Int. J. Androl. 2010, 33(2):333-345.
7. Bornehag C.G., Sundell J., Weschler C.J., Sigsgaard T., Lundgren B., Hasselgren M., Hägerhed-Engman L. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ. Health Perspect. 2004, 112(14):1393-1397.
8. Bornehag C.G., Sundell J., Sigsgaard T. Dampness in buildings and health (DBH): report from an ongoing epidemiological investigation on the association between indoor environmental factors and health effects among children in Sweden. Indoor Air 2004, 14(Suppl. 7):59-66.
9. Bornehag C.G., Lundgren B., Weschler C.J., Sigsgaard T., Hagerhed-Engman L., Sundell J. Phthalates in indoor dust and their association with building characteristics. Environ. Health Perspect. 2005, 113(10):1399-1404.
10. Bornehag C.G., Sundell J., Hagerhed-Engman L., Sigsgaard T., Janson S., Aberg N. Dampness at home and its association with airway, nose, and skin symptoms among 10,851 preschool children in Sweden: a cross sectional study. Indoor Air 2005, 15(S10):48-55. the DBH study group.
11. Bosgra S., Bos P.M., Vermeire T.G., Luit R.J., Slob W. Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate. Regul. Toxicol. Pharmacol. 2005, 43(1):104-113.
12. Bousquet J., Khaltaev N., Cruz A.A., Denburg J., Fokkens W.J., Togias A., et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008, 63(Suppl. 86):8-160.
13. Callesen M., Bekö G., Weschler C.J., Sigsgaard T., Jensen T.K., Clausen G., Toftum J., Norberg L.A., Høst A. Associations between selected allergens, phthalates, nicotine, PAHs and bedroom ventilation and clinically confirmed asthma, rhinoconjunctivitis and atopic dermatitis in preschool children. Indoor Air 2014, (in press). 10.1111/ina.12060.
14. Carlstedt F., Jönsson B.A.G., Bornehag C.-G. PVC flooring is related to human uptake of phthalates in infants. Indoor Air 2013, 23:32-39.
15. Clausen G., Høst A., Toftum J., Bekö G., Weschler C., Callesen M., Buhl S., Ladegaard M.B., Langer S., Andersen B., Sundell J., Bornehag C.G., Sigsgaard T. Children's health and its association with indoor environments in Danish homes and daycare centres - methods. Indoor Air 2012, 22:467-475.
16. Dodson R.E., Nishioka M., Standley L.J., Perovich L.J., Brody J.G., Rudel R.A. Endocrine disruptors and asthma-associated chemicals in consumer products. Environ. Health Perspect. 2012, 120(7):935-943.
17. Dye J.A., Venier M., Zhu L., Ward C.R., Hites R.A., Birnbaum L.S. Elevated PBDE levels in pet cats: sentinels for humans?. Environ. Sci. Technol. 2007, 41(18):6350-6356.
18. Ferguson K.K., Loch-Caruso R., Meeker J.D. Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999-2006. Environ. Res. 2011, 111:718-726.
19. Frederiksen H., Sorensen K., Mouritsen A., Aksglaede L., Hagen C.P., Petersen J.H., Skakkebaek N.E., Andersson A.M., Juul A. High urinary phthalate concentration associated with delayed pubarche in girls. Int. J. Androl. 2012, 35:216-226.
20. Fromme H., Bolte G., Koch H.M., Angerer J., Boehmer S., Drexler H., Mayer R., Liebl B. Occurrence and daily variation of phthalate metabolites in the urine of an adult population. Int. J. Hyg. Environ. Health 2007, 210(1):21-33.
21. Fromme H., Gruber L., Schlummer M., Wolz G., Bohmer S., Angerer J., Mayer R., Liebl B., Bolte G. Intake of phthalates and di(2-ethylhexyl)adipate: results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data. Environ. Int. 2007, 33(8):1012-1020.
22. Guo Y., Kannan K. Comparative assessment of human exposure to phthalate esters from house dust in China and the United States. Environ. Sci. Technol. 2011, 45(8):3788-3794.
23. Hansen E.J. Danskernes Levekår - 1986 sammenholdt med 1976 1986, Hans Reitzels Forlag, Copenhagen.
24. Hauser R., Meeker J.D., Park S., Silva M.J., Calafat A.M. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ. Health Perspect. 2004, 112(17):1734-1740.
25. Hsu N.Y., Lee C.C., Wang J.Y., Li Y.C., Chang H.W., Chen C.Y., Bornehag C.G., Wu P.C., Sundell J., Su H.J. Predicted risk of childhood allergy, asthma and reported symptoms using measured phthalate exposure in dust and urine. Indoor Air 2012, 22:186-199.
26. Huang P.C., Kuo P.L., Guo Y.L., Liao P.C., Lee C.C. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum. Reprod. 2007, 22(10):2715-2722.
27. Jaakkola J.J., Oie L., Nafstad P., Botten G., Samuelsen S.O., Magnus P. Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway. Am. J. Public Health 1999, 89(2):188-192.
28. Jaakkola J.J., Parise H., Kislitsin V., Lebedeva N.I., Spengler J.D. Asthma, wheezing, and allergies in Russian schoolchildren in relation to new surface materials in the home. Am. J. Public Health 2004, 94(4):560-562.
29. Jaakkola J.J., Verkasalo P.K., Jaakkola N. Plastic wall materials in the home and respiratory health in young children. Am. J. Public Health 2000, 90(5):797-799.
30. Jurewicz J., Hanke W. Exposure to phthalates: reproductive outcome and children health. a review of epidemiological studies. Int. J. Occup. Med. Environ. Health 2011, 24:115-141.
31. Just A.C., Whyatt R.M., Perzanowski M.S., Calafat A.M., Perera F.P., Goldstein I.F., Chen Q., Rundle A.G., Miller R.L. Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohort. Environ. Health Perspect. 2012, 120:1475-1480.
32. Kimber I., Dearman R.J. An assessment of the ability of phthalates to influence immune and allergic responses. Toxicology 2010, 271(3):73-82.
33. Kjaer H.F., Eller E., Host A., Andersen K.E., Bindslev-Jensen C. The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. Pediatr. Allergy Immunol. 2008, 19(8):737-745.
34. Kluwe W.M. Overview of phthalate ester pharmacokinetics in mammalian species. Environ. Health Perspect. 1982, 45:3-9.
35. Koch H., Lorber M., Christensen K.L.Y., Pälmke C., Koslitz S., Brüning T. Identifying sources of phthalate exposure with human biomonitoring: results of a 48h fasting study with urine collection and personal activity patterns. Int. J. Hyg. Environ. Health 2013, 213:672-681.
36. Koch H., Christensen K.L.Y., Harth V., Lorber M., Brüning T. Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses. Arch. Toxicol. 2012, 86:1829-1839.
37. Kolarik B., Naydenov K., Larsson M., Bornehag C.G., Sundell J. The association between phthalates in dust and allergic diseases among Bulgarian children. Environ. Health Perspect. 2008, 116(1):98-103.
38. Koniecki D., Wang R., Moody R.P., Zhu J. Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ. Res. 2011, 111:329-336.
39. Langer S., Weschler C.J., Fischer A., Bekö G., Toftum J., Clausen G. Phthalate and PAH concentrations in dust collected from Danish homes and daycare centers. Atmos. Environ. 2010, 44(19):2294-2301.
40. Langer S., Bekö G., Weschler C.J., Brive L., Toftum J., Callesen M., Clausen G. Phthalate metabolites in urine samples from Danish children and correlations with phthalates in dust samples from their homes and daycare centers. Int. J. Hyg. Environ. Health 2014, 217:78-87.
41. Larsson M., Hägerhed-Engman L., Kolarik B., James P., Lundin F., Janson S., Sundell J., Bornehag C.G. PVC - as flooring material - and its association with incident asthma in a Swedish child cohort study. Indoor Air 2010, 20:494-501.
42. Meeker J.D., Sathyanarayana S., Swan S.H. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364(1526):2097-2113.
43. Nielsen G.D., Larsen S.T., Olsen O., Lovik M., Poulsen L.K., Glue C., Wolkoff P. Do indoor chemicals promote development of airway allergy?. Indoor Air 2007, 17(3):236-255.
44. Niggemann B., Jacobsen L., Dreborg S., Ferdousi H.A., Halken S., Host A., Koivikko A., Koller D., Norberg L.A., Urbanek R., Valovirta E., Wahn U., Moller C. Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy 2006, 61(7):855-859.
45. Oie L., Nafstad P., Botten G., Magnus P., Jaakkola J.K. Ventilation in homes and bronchial obstruction in young children. Epidemiology 1999, 10(3):294-299.
46. Peat J.K., Dickerson J., Li J. Effects of damp and mould in the home on respiratory health: a review of the literature. Allergy 1998, 53(2):120-128.
47. Pekkanen J., Pearce N. Defining asthma in epidemiological studies. Eur. Respir. J. 1999, 14(4):951-957.
48. Platt S.D., Martin C.J., Hunt S.M., Lewis C.W. Damp housing, mould growth, and symptomatic health state. Br. Med. J. 1989, 298(6689):1673-1678.
49. Romero-Franco M., Hernandez-Ramirez R.U., Calafat A.M., Cebrian M.E., Needham L.L., Teitelbaum S., Wolff M.S., Lopez-Carrillo L. Personal care product use and urinary levels of phthalate metabolites in Mexican women. Environ. Int. 2011, 37:867-871.
50. Roth B., Herkenrath P., Lehmann H.J., Ohles H.D., Homig H.J., Benz-Bohm G., Kreuder J., Younossiharteinstein A. Di-(2-ethylhexyl)-phthalate as plasticizer in PVC respiratory tubing systems: indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants. Eur. J. Pediatr. 1988, 147(1):41-46.
51. Rudel R.A., Camann D.E., Spengler J.D., Korn L.R., Brody J.G. Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Environ. Sci. Technol. 2003, 37(20):4543-4553.
52. Rudel R.A., Gray J.M., Engel C.L., Rawsthorne T.W., Dodson R.E., Ackerman J.M., Rizzo J., Nudelman J.L., Brody J.G. Food packaging and bisphenol A and bis(2-ethylhexyl) phthalate exposure: findings from a dietary intervention. Environ. Health Perspect. 2011, 119(7):914-920.
53. Soto-Martinez M.E., Avila L., Soto-Quiros M.E. New criteria for the diagnosis and management of asthma in children under 5 years old: GINA Guidelines 2009. An Pediatr 2009, 71(2):91-94.
54. Weschler C.J., Nazaroff W.W. Semivolatile organic compounds in indoor environments. Atmos. Environ. 2008, 42(40):9018-9040.
55. Whyatt R.M., Liu X., Rauh V.A., Calafat A.M., Just A.C., Hoepner L., Diaz D., Quinn J., Adibi J., Perera F.P., Factor-Litvak P. Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age. Environ. Health Perspect. 2012, 120:290-295.
56. Whyatt R., Miller R., Rundle A., Perzanowski M., Calafat A.M., Just A.C., Donohue K., Hoepner L., Perera F. Interactions between prenatal and early life exposures to butylbenzyl phthalate and bisphenol-A on risk of asthma and other respiratory symptoms. Environ. Health Perspect. 2013, Available at: http://ehp.niehs.nih.gov/ehbasel13/wp-content/uploads/2013/09/EHB13-Abstracts.pdf (accessed 10.10.2013). 10.1289/ehp.ehbasel13.
57. Wigle D.T., Arbuckle T.E., Turner M.C., Berube A., Yang Q., Liu S., Krewski D. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J. Toxicol. Environ. Health B: Crit. Rev. 2008, 11(5-6):373-517.
58. Wittassek M., Koch H., Angerer J., Brüning T. Assessing exposure to phthalates - the human biomonitoring approach. Mol. Nutr. Food Res. 2011, 55:7-31.
59. Wormuth M., Scheringer M., Vollenweider M., Hungerbuhler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26(3):803-824.