Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

International Journal of Occupational Medicine and Environmental Health

Volumn 24, Issue 2, 2011, Pages 115-141

  Jurewicz, Joanna ^a   Hanke, Wojciech ^a  

^a NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

Author keywords

Children health; Exposure to phthalates; Reproductive outcome

Indexed keywords

PHTHALIC ACID DERIVATIVE;

CHILD; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; POLLUTANT; REPRODUCTION; REVIEW;

CHILD; ENVIRONMENTAL POLLUTANTS; GROWTH AND DEVELOPMENT; HUMANS; PHTHALIC ACIDS; REPRODUCTION;

EID: 79960044917     PISSN: 12321087     EISSN: None     Source Type: Journal    
DOI: 10.2478/s13382-011-0022-2     Document Type: Review

References (90)

1. R.J. Kavlock G.P. Daston C. DeRosa P. Fenner-Crisp L.E. Gray, et al. 1996 Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the US EPA-sponsored workshop Environ Health Perspect 104 715 740 8880000 10.2307/3432708 (Pubitemid 26290301)
2. A.M. Api 2001 Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients Food Chem Toxicol 39 97 108 11267702 10.1016/S0278-6915(00)00124-1 1:CAS:528:DC%2BD3MXhvFKisrc%3D (Pubitemid 32239347)
3. F.A. Arcadi C. Costa C. Imperatore A. Marchese A. Rapisarda M. Salemi, et al. 1998 Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in the Long-Evans rat Food Chem Toxicol 36 963 970 9771559 10.1016/S0278-6915(98)00065-9 1:CAS:528:DyaK1cXms1Kqt7g%3D (Pubitemid 28526549)
4. Foster PM, Mylchreest E, Gaido KW, Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update 2001;231-235. (Pubitemid 32440285)
5. L.E. Gray Jr J. Ostby J. Furr M. Price D.N. Veeramachaneni L. Parks 2000 Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat Toxicol Sci 58 350 365 11099647 10.1093/toxsci/58.2.350 1:CAS:528:DC%2BD3cXovFynsLY%3D (Pubitemid 32042433)
6. R.W. Moore T.A. Rudy T.M. Lin K. Ko R.E. Peterson 2001 Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer di(2-ethylhexyl) phthalate Environ Health Perspect 109 229 237 11333183 10.1289/ehp.01109229 1:CAS:528:DC%2BD3MXivVOjsb0%3D (Pubitemid 32331513)
7. R. Tandon P.K. Seth S.P. Srivastava 1991 Effect of in utero exposure to di(2-ethylhexyl)phthalate on rat testes Indian J Exp Biol 29 1044 1046 1816082 1:CAS:528:DyaK38Xhs12rtA%3D%3D
8. S.H. Swan K.M. Main F. Liu S.L. Stewart S.L. Kruse A.M. Calafat, et al. 2005 Decrease in anogenital distance among male infants with prenatal phthalate exposure Environ Health Perspect 113 1056 1061 16079079 10.1289/ehp.8100 1:CAS:528:DC%2BD2MXpslSku74%3D (Pubitemid 41149638)
9. M. Welsh P.T. Saunders M. Fisken H.M. Scott G.R. Hutchison L.B. Smith, et al. 2008 Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism J Clin Invest 118 1479 1490 18340380 10.1172/JCI34241 1:CAS:528: DC%2BD1cXkt1CnurY%3D (Pubitemid 351500441)
10. P.M. Foster 2006 Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters Int J Androl 29 140 147 16102138 10.1111/j.1365-2605.2005.00563.x 1:CAS:528:DC%2BD28XjslWitrg%3D
11. R.M. Shape J.S. Fisher M.M. Millar S. Jobling J.P. Sumpter 1995 Gestational and lactation exposure of rats to xenoestrogens results in reduced testicular size and sperm production Environ Health Perspect 103 1136 1143 10.1289/ehp.951031136 (Pubitemid 26141419)
12. T. Tanaka 2005 Reproductive and neurobehavioral effects of bis(2-ethylhexyl) phthalate (DEHP) in a cross-mating toxicity study of mice Food Chem Toxicol 43 581 589 15721206 10.1016/j.fct.2005.01.001 1:CAS:528: DC%2BD2MXhtlOlsrc%3D (Pubitemid 40255294)
13. K.M. Shea 2003 Pediatric exposure and potential toxicity of phthalate plasticizers Pediatrics 111 1467 1474 12777573 10.1542/peds.111.6.1467 (Pubitemid 36682291)
14. S.M. Duty A.M. Calafat M.J. Silva L. Ryan R. Hauser 2005 Phthalate exposure and reproductive hormones in adult men Hum Reprod 20 3 604 610 15591081 10.1093/humrep/deh656 1:CAS:528:DC%2BD2MXhsFSgsbs%3D (Pubitemid 40425483)
15. R. Hauser J.D. Meeker S. Duty M.J. Silva A.M. Calafat 2006 Altered Semen Quality in Relation to Urinary Concentrations of Phthalate Monoester and Oxidative Metabolites Epidemiol 17 682 691 10.1097/01.ede.0000235996.89953.d7 (Pubitemid 44655605)
16. M.A. Kamrin 2009 Phthalate risks, phthalate regulation, and public health: a review J Toxicol Environ Health B Crit Rev 12 157 174 19235623 1:CAS:528:DC%2BD1MXjsVWrtrk%3D
17. S. Sathyanarayana C.J. Karr P. Lozano E. Brown A.M. Calafat F. Liu, et al. 2008 Baby Care Products: Possible Sources of Infant Phthalate Exposure Pediatrics 121 2 e260 268 18245401 10.1542/peds.2006-3766 (Pubitemid 351198431)
18. M.S. Wolff S.M. Engel G.S. Berkowitz X. Ye M.J. Silva C. Zhu, et al. 2008 Prenatal phenol and phthalate exposures and birth outcomes Environ Health Perspect 116 1092 1097 18709157 10.1289/ehp.11007 1:CAS:528:DC%2BD1cXhtVOkt7fI
19. A.M. Lottrup H. Eersson G.K. Leffers J. Mortensen N.E. Toppari N.E. Skakkebaek, et al. 2006 Possible impact of phthalates on infant reproductive health Int J Androl 29 172 180 16466537 10.1111/j.1365-2605.2005.00642.x 1:CAS:528:DC%2BD28XjslWit74%3D
20. M. Chalubinski M.L. Kowalski 2006 Endocrine disrupters - potential modulators of the immune system and allergic response Allergy 61 1326 1335 17002710 10.1111/j.1398-9995.2006.01135.x 1:CAS:528:DC%2BD28Xht1OjurfN (Pubitemid 44465594)
21. J.J. Jaakkola L. Oie P. Nafstad G. Botten S.O. Samuelsen P. Magnus 1999 Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway Am J Pub Health 89 188 192 10.2105/AJPH.89.2.188 1:STN:280:DyaK1M7jsV2jtA%3D%3D (Pubitemid 29282795)
22. L. ∅ie L.-G. Hersoug J. Madsen 1997 Residential exposure to plasticizers and its possible role in the pathogenesis of asthma Environ Health Perspect 105 972 978 9374082 10.1289/ehp.97105972 (Pubitemid 27503630)
23. C.G. Bornehag J. Sundell C.J. Weschler T. Sigsgaard B. Lundgren M. Hasselgren, et al. 2004 The association between asthma and allergic symptoms in children and phthalates in house dust: A nested case-control study Environ Health Perspect 112 1393 1397 15471731 10.1289/ehp.7187 1:CAS:528: DC%2BD2cXpsVGgs70%3D (Pubitemid 39386556)
24. B. Kolarik K. Naydenov M. Larsson C.G. Bornehag J. Sundell 2008 The association between phthalates in dust and allergic diseases among Bulgarian children Environ Health Perspect 116 98 103 18197306 10.1289/ehp.10498 1:CAS:528:DC%2BD1cXhs12ns7k%3D
25. G. Latini C.D. Felice G. Presta A. Del Vecchio I. Paris F. Ruggieri, et al. 2003 In utero exposure to di-(2-ethylhexyl) phthalate and duration of human pregnancy Environ Health Perspect 111 1783 1785 14594632 10.1289/ehp.6202 1:CAS:528:DC%2BD3sXps1art78%3D (Pubitemid 37419903)
26. National Research Council. Committee on the Health Risks of Phthalates. Phthalates and Cumulative Risk Assessment: The Task Ahead. Washington: National Academies Press; 2008.
27. C.G. Bornehag J. Sundell L. Hagerhed-Engman T. Sigsgaard S. Janson N. Aberg, et al. 2005 "Dampness" at home and its association with airway, nose and skin symptoms among 10 851 preschool children in Sweden: A cross sectional study Indoor Air 15 48 55 15926944 10.1111/j.1600-0668.2005.00306.x (Pubitemid 40825118)
28. R.A. Rudel D.E. Camann J.D. Spengler R.L. Korn J.G. Brody 2003 Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust Environ Sci Technol 37 4543 453 14594359 10.1021/es0264596 1:CAS:528:DC%2BD3sXnt1OksL4%3D (Pubitemid 37266368)
29. M. Wormuth M. Scheringer M. Vollenweider K. Hungerbühler 2006 What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? Risk Anal 26 803 824 16834635 10.1111/j.1539-6924.2006.00770.x (Pubitemid 43948196)
30. K.L. Howdeshell V.S. Wilson J. Furr R.C. Lambright C.V. Rider R.C. Blystone A.K. Hotchkiss, et al. 2008 A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner Toxicol Sci 105 1 153 165 18411233 10.1093/toxsci/kfn077 1:CAS:528:DC%2BD1cXps12iuro%3D
31. R.M. Sharpe 2001 Hormones and testis development and the possible adverse effects of environmental chemicals Toxicol Lett 120 221 232 11323180 10.1016/S0378-4274(01)00298-3 1:CAS:528:DC%2BD3MXivFejsbg%3D (Pubitemid 32375089)
32. M. Ablake M. Itoh H. Terayama S. Hayashi S. Shoji M. Naito, et al. 2004 Di-(2-ethylhexyl) phthalate induces severe aspermatogenesis in mice, however, subsequent antioxidant vitamins supplementation accelerates regeneration of the seminiferous epithelium Int J Androl 27 274 281 15379967 10.1111/j.1365-2605. 2004.00482.x 1:CAS:528:DC%2BD2cXpvFajsLc%3D (Pubitemid 39371850)
33. G. Latini C.D. Felice A. Verrotti 2004 Plasticizers, infant nutrition and reproductive health Reprod Toxicol 19 27 33 15336709 10.1016/j.reprotox.2004. 05.011 1:CAS:528:DC%2BD2cXntFSltrY%3D (Pubitemid 39164874)
34. A.M. Calafat J.W. Brock M.J. Silva L.E. Gray J.A. Reidy D.B. Barr, et al. 2006 Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di-(2-ethylhexyl) phthalate and di-n-butyl phthalate Toxicology 217 22 30 16171919 10.1016/j.tox.2005.08.013 1:CAS:528: DC%2BD2MXhtlSjsr%2FL (Pubitemid 41758389)
35. R. Kavlock K. Boekelheide R. Chapin M. Cunningham E. Faustman P. Foster, et al. 2002 Phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate Reprod Toxicol 16 721 734 12406498 10.1016/S0890-6238(02)00031-X 1:CAS:528:DC%2BD38Xot1ahtb8%3D (Pubitemid 35291347)
36. S. Tabacova L. Balabaeva R.E. Little 1997 Maternal exposure to exogenous nitrogen compounds and complications of pregnancy Arch Environ Health 52 341 347 9546756 10.1080/00039899709602209 1:CAS:528:DyaK1cXisFGrs7k%3D (Pubitemid 28133629)
37. B.C. Gladen S. Tabacova D.D. Baird R.E. Little L. Balabaeva 1999 Variability of lipid hydroperoxides in pregnant and nonpregnant women Reprod Toxicol 13 41 44 10080298 10.1016/S0890-6238(98)00054-9 1:CAS:528: DyaK1MXhsFSmtr8%3D (Pubitemid 29122174)
38. K.M. Mein G.K. Mortensen M.M. Kaleva K.A. Boisen I.N. Damgaard M. Chellakooty, et al. 2006 Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age Environ Health Perspect 114 270 276 10.1289/ehp.8075 (Pubitemid 43193651)
39. P. Palanza S. Parmigiani F.S. vom Saal 1995 Urinemarking and maternal aggression of wild female mice in relation to anogenital distance at birth Physiol Behav 58 827 835 8577877 10.1016/0031-9384(95)00107-T 1:CAS:528:DyaK2MXptFGksb4%3D
40. C.L. Hughes 1992 Anogenital distance at birth as a predictor of volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus and pituitary responsiveness in castrated adult rats Biol Reprod 46 101 104 1547306 10.1095/biolreprod46.1.101
41. R.H. Gallavan J.F. Holson D.G. Stump J.F. Knapp V.L. Reynolds 1999 Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights Reprod Toxicol 13 383 390 10560587 10.1016/S0890-6238(99)00036-2 1:CAS:528:DyaK1MXmvVyitb4%3D (Pubitemid 29508428)
42. A.J. Andrade S.W. Grande C.E. Talsness K. Grote I. Chahoud 2006 A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity Toxicology 27 185 192 10.1016/j.tox.2006.07.022 (Pubitemid 44429936)
43. S.H. Swan 2008 Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans Environ Res 108 2 174 184 10.1016/j.envres.2008.08.007
44. L.P. Bustamente-Montes M.A. Hernandez-Valero M. Garcia-Fabila E. Halley-Castillo M.A. Karam-Calderon V.H. Borja-Aburto 2008 Prenatal phthalate exposure and decrease in anogenital distance in Mexican male newborns Epidemiol 19 60 270 275
45. P.-C. Huang P.-L. Kuo Y.-Y. Chou S.-J. Lin C.-C. Lee 2009 Association between prenatal exposure to phthalates and the health of newborns Environ International 35 14 20 10.1016/j.envint.2008.05.012
46. R.S. Ge G.R. Chen C. Tanrikut M.P. Hardy 2007 Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations Reprod Toxicol 23 3 366 373 17258888 10.1016/j.reprotox.2006.12.006 1:CAS:528:DC%2BD2sXksFegtb8%3D (Pubitemid 46602931)
47. J. Borch M. Axelstad A.M. Vinggaard M. Dalgaard 2006 Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis Toxicol Lett 163 3 183 190 16458459 10.1016/j.toxlet.2005.10.020 1:CAS:528:DC%2BD28XjtFajsb8%3D
48. S.M. Duty M.J. Silva D.B. Barr J.W. Brock L. Ryan Z. Chen, et al. 2003 Phthalate Exposure and Human Semen Parameters Epidemiol 14 269 277 (Pubitemid 40417077)
49. A.G. Jönsson J. Richthoff L. Rylander A. Giwercman H. Lars 2005 Urinary phthalate metabolities and biomarkers of reproductive function in young men Epidemiol 16 4 487 493 10.1097/01.ede.0000164555.19041.01 (Pubitemid 40847832)
50. J.J. Wirth M.G. Rossano R. Potter E. Puscheck D.C. Daly N. Paneth, et al. 2008 A pilot study associating urinary concentrations of phthalate metabolities and semen quality Sys Biol Reprod Med 54 3 143 154 10.1080/19396360802055921 1:CAS:528:DC%2BD1cXnsFejs7k%3D
51. N. Pant M. Shukla K.D. Patel Y. Shukla N. Mathur Y.K. Gupta D.K. Saxena 2008 Correlation of phthalate exposures with semen quality Toxicol App Pharmacology 231 112 116 10.1016/j.taap.2008.04.001 1:CAS:528: DC%2BD1cXps1Gnurc%3D
52. Y. Zhang L. Zheng B. Chen 2006 Phthalate exposure and human semen quality in Shanghai: a cross-sectional study Biomed Environ Sci 19 3 205 209 16944777 1:CAS:528:DC%2BD28XnsFGgu74%3D
53. R. Hauser J.D. Meeker N.P. Singh M.J. Silva L. Ryan S. Duty, et al. 2007 DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites Hum Reprod 22 688 695 17090632 10.1093/humrep/del428 1:CAS:528:DC%2BD2sXksVCqsbs%3D
54. S.M. Duty N.P. Singh M.J. Silva D.B. Barr J.W. Brock L. Ryan, et al. 2003 The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay Environ Health Perspect 111 1164 1169 12842768 10.1289/ehp.5756 1:CAS:528:DC%2BD3sXmsVektLo%3D (Pubitemid 36939396)
55. J.S. Brown Jr 2009 Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia Schizophr Bull 35 256 278 18245062 10.1093/schbul/sbm147
56. Y. Masuo M. Morita S. Oka M. Ishido 2004 Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: A study inspired by the physiological roles of PACAP in the brain Regul Pept 15 225 234 10.1016/j.regpep.2004.05.010 (Pubitemid 39424171)
57. S.M. Engel C. Zhu G.S. Berkowitz A.M. Calafat M.J. Silva A. Miodovnik M.S. Wolff 2009 Prenatal phthalate exposure and performance on Neonatal Behavioral Assessment Scale in multiethnic birth cohort NeuroToxicol 30 522 528 10.1016/j.neuro.2009.04.001 1:CAS:528:DC%2BD1MXptVSjs7Y%3D
58. B.N. Kim S.C. Cho Y. Kim M.S. Shin H.J. Yoo J.W. Kim, et al. 2009 Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children Biol Psychiatry 66 10 958 963 19748073 10.1016/j.biopsych.2009.07.034 1:CAS:528:DC%2BD1MXhtlCmt73O
59. S.C. Cho S.Y. Bhang Y.C. Hong M.S. Shin B.N. Kim J.W. Kim 2010 Relationship between environmental phthalate exposure and the intelligence of school-age children Environ Health Perspect 118 7 1027 1032 20194078 10.1289/ehp.0901376 1:CAS:528:DC%2BC3cXpvFaisb4%3D
60. S.M. Engel A. Miodovnik R.L. Canfield C. Zhu M.J. Silva A.M. Calafat, et al. 2010 Prenatal phthalate exposure is associated with childhood behavior and executive functioning Environ Health Perspect 118 4 565 571 20106747 10.1289/ehp.0901470 1:CAS:528:DC%2BC3cXls1ajtL4%3D
61. S.H. Swan F. Liu R.L. Kruse C. Wang J.B. Redmon A. Sparks, et al. 2009 Prenatal phthalate exposure and reduced masculine play in boys Int J Androl 32 1 9 10.1111/j.1365-2605.2008.00924.x
62. P.C. Huang P.L. Kuo Y.L. Guo P.C. Liao C.C. Lee 2007 Associations between urinary phthalate monoesters and thyroid hormones in pregnant women Hum Reprod 22 10 2715 2722 17704099 10.1093/humrep/dem205 1:CAS:528:DC%2BD2sXhtlekt77O (Pubitemid 47434218)
63. J.D. Meeker A.M. Calafat R. Hauser 2007 Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men Environ Health Perspect 115 7 1029 1034 17637918 10.1289/ehp.9852 1:CAS:528:DC%2BD2sXosFSjsr0%3D (Pubitemid 47317067)
64. M. Boas U. Feldt-Rasmussen N.E. Skakkebaek K.M. Main 2006 Environmental chemicals and thyroid function Eur J Endocrinol 154 599 611 16645005 10.1530/eje.1.02128 1:CAS:528:DC%2BD28XltV2js7Y%3D (Pubitemid 43810844)
65. Liwnicz BH, Liwnicz RG. On endocrine function. In: Kaplan LA, editor. Clinical Chemistry: Theory, Analysis and Correlation. 2nd ed. St. Lewis, MO: CV Mosby Company; 1989. p. 607-619.
66. C.J. Partsch W.G. Sippell 2001 Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens Hum Reprod Update 7 292 302 11392376 10.1093/humupd/7.3.292 1:CAS:528:DC%2BD3MXkt1Okurw%3D (Pubitemid 32440291)
67. T.J. Key P.K. Verkasalo E. Banks 2001 Epidemiology of breast cancer Lancet Oncol 2 133 140 11902563 10.1016/S1470-2045(00)00254-0 1:STN:280:DC%2BD387ntFelsw%3D%3D (Pubitemid 33585924)
68. L. Lopez-Carillo R.U. Hernandez-Ramirez A.M. Calafat L. Tores-Sanches M. Galvan-Portillo L.L. Needham, et al. 2010 Exposure to phthalates and breast cancer risk in Northen Mexico Environ Health Perspect 118 4 539 544 10.1289/ehp.0901091
69. M. Nydick J. Butos J.H. Dale R.W. Rawson 1961 Gynecomastia in adolescent boys JAMA 178 449 454 14480779 1:STN:280:DyaF38%2Fot1aqtg%3D%3D
70. E. Durmaz N.E. Özmert P. Erkekoglu B. Giray O. Derman F. Hincal, et al. 2010 Plasma Phthalate Levels in Pubertal Gynecomastia Pediatrics 125 122 129 10.1542/peds.2009-0724
71. I. Colón D. Caro C.J. Bourdony O. Rosario 2000 Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development Environ Health Perspect 108 895 900 11017896 10.1289/ehp.00108895
72. L. Qiao L. Zheng D. Cai 2007 Study of the di-n-butyl phthalate and di-2-ethylhexyl-phthalate level of girls serum related with precocious puberty in Shanghai Wei Shen Yan Jiu 36 1 93 95 1:CAS:528:DC%2BD2sXnvVGlt7s%3D
73. J.P. Lomenick A.M. Calafat M.S. Melguizo Castro R. Mier P. Stenger M.B. Foster, et al. 2010 Phthalate exposure and precocious puberty in females J Pediatr 156 2 221 225 19892364 10.1016/j.jpeds.2009.09.047 1:CAS:528: DC%2BC3cXpslCrsg%3D%3D
74. S. Brasche W. Bischof 2005 Daily time spent indoors in German homes - baseline data for the assessment of indoor exposure of German occupants Int J Hyg Environ Health 208 4 247 253 16078638 10.1016/j.ijheh.2005.03.003 (Pubitemid 40828893)
75. M.K. Selgrade R.F. Lemanske Jr M.I. Gilmour L.M. Neas M.D. Ward P.K. Henneberger, et al. 2006 Induction of asthma and the environment: what we know and need to know Environ Health Perspect 114 615 619 16581555 10.1289/ehp.8376
76. J.J. Jaakkola P.K. Verkasalo N. Jaakkola 2000 Plastic wall ma terials in the home and respiratory health in young children Am J Pub Health 90 797 799 10.2105/AJPH.90.5.797 1:STN:280:DC%2BD3c3mtVahug%3D%3D (Pubitemid 30246388)
77. J.J. Jaakkola H. Parise V. Kislitsin N.I. Lebedeva J.D. Spengler 2004 Asthma, wheezing, and allergies in Russian schoolchildren in relation to new surface materials in the home Am J Pub Health 94 560 562 10.2105/AJPH.94.4.560 (Pubitemid 38436496)
78. M. Larsson L. Hagerhed-Engman B. Kolarik P. James F. Lundin J. Sundell, et al. 2010 PVC flooring and its association with incident asthma in Swedish children Indoor Air 20 494 501 21070375 10.1111/j.1600-0668.2010.00671.x 1:CAS:528:DC%2BC3cXhs1ansbbL
79. H.A. Dirven P.H. van den Broek A.M. Arends H.H. Nordkamp A.J. de Lepper P.T. Henderson, et al. 1993 Metabolites of the plasticizer di(2-ethylhexyl) phthalate in urine samples of workers in polyvinyl chloride processing industries Int Arch Occup Environ Health 64 549 554 8314612 10.1007/BF00517699 1:CAS:528:DyaK2cXhtFGlsbs%3D (Pubitemid 23218121)
80. H.M. Koch H.M. Bolt J. Angerer 2004 Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labeled DEHP Arch Toxicol 78 123 130 14576974 10.1007/s00204-003-0522- 3 1:CAS:528:DC%2BD2cXitFCms74%3D (Pubitemid 38657193)
81. R. Hauser J.D. Meeker S. Park M.J. Silva A.M. Calafat 2004 Temporal variability of urinary phthalate metabolite levels in men of reproductive age Environ Health Perspect 112 1734 1740 15579421 10.1289/ehp.7212 1:CAS:528:DC%2BD2MXmt1Crsg%3D%3D (Pubitemid 40017296)
82. M.J. Silva J.A. Reidy A.R. Herbert J.L. Preau Jr L.L. Needham A.M. Calafat 2004 Detection of phthalate metabolites in human amniotic fluid Bull Environ Contam Toxicol 72 1226 1231 15362453 10.1007/s00128-004-0374-4 1:CAS:528:DC%2BD2cXkvVyltrs%3D (Pubitemid 38691464)
83. S.L. Teitelbaum J.A. Britton A.M. Calafat X. Ye M.J. Silva J.A. Reidy, et al. 2008 Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States Environ Res 106 2 257 269 17976571 10.1016/j.envres.2007.09.010 1:CAS:528:DC%2BD1cXhsVCmur4%3D (Pubitemid 351162979)
84. Moore KL, Persaued TV. The developing human: clinically oriented embryology. Philadelphia: W.B. Saunders; 1998. p. 157-165.
85. James DK, Steer PJ, Weiner CP, Gonik B. High risk pregnancy: management options. Third Edition. Philadelphia, PA: Elsevier-Saunders; 2005.
86. M.L. Lewis J.W. Worobey D.S. Ramsay M.K. McCormack 1992 Prenatal exposure to heavy metals: effect on childhood cognitive skills and health status Pediatrics 89 1010 1015 1594339 1:STN:280:DyaK383nvVyrtQ%3D%3D
87. M.P. Longnecker B.C. Gladen L.A. Cupul-Uicab S.P. Romano-Riquer J.P. Weber R.E. Chapin, et al. 2007 In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, Mexico Am J Epidemiol 165 1015 1022 17272288 10.1093/aje/kwk109 (Pubitemid 46598831)
88. F. Dallaire E. Dewailly G. Muckle P. Ayotte 2003 Time trends of persistent organic pollutants and heavy metals in umbilical cord blood of Inuit infants born in Nunavik (Québec, Canada) between 1994 and 2001 Environ Health Perspect 111 1660 1664 14527847 10.1289/ehp.6269 1:CAS:528: DC%2BD3sXovVGiur0%3D (Pubitemid 37265979)
89. S.L. Wang P.H. Su S.B. Jong Y.L. Guo W.L. Chou O. Päpke 2005 In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns Environ Health Perspect 113 1645 1650 16263525 10.1289/ehp.7994 1:CAS:528:DC%2BD2MXht12isbnM (Pubitemid 41614925)
90. L.H. Engman C.G. Bornehag J. Sundell 2007 How valid are parents questionnaire responses regarding building characteristics, mouldy odour, and signs of moisture problems in Swedish homes? Scand J Publ Health 35 125 132 10.1080/14034940600975658 (Pubitemid 46567456)