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Volumn 36, Issue 6, 2014, Pages 830-846

Diagnostic and prognostic potential of extracellular vesicles in peripheral blood

Author keywords

Diagnostics; Enumeration; Exosomes; Extracellular vesicles; Microvesicles; Phenotyping; RNA cargo

Indexed keywords

BIOLOGICAL MARKER; LIPID; MICRORNA; PROTEIN; RNA;

EID: 84902823826     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2014.05.008     Document Type: Review
Times cited : (213)

References (126)
  • 1
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • Akers JC, Gonda D, Kim R, et al. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol. 2013;113:1-11.
    • (2013) J Neurooncol. , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3
  • 2
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: Biology and emerging therapeutic opportunities
    • Andaloussi SEL, Mager I, Breakefield XO, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12:347-357.
    • (2013) Nat Rev Drug Discov. , vol.12 , pp. 347-357
    • Andaloussi, S.E.L.1    Mager, I.2    Breakefield, X.O.3
  • 3
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200:373-383.
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 4
    • 79960944057 scopus 로고    scopus 로고
    • Membrane vesicles, current state-of-The-art: Emerging role of extracellular vesicles
    • Gyorgy B, Szabo TG, Pasztoi M, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011;68:2667-2688.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 2667-2688
    • Gyorgy, B.1    Szabo, T.G.2    Pasztoi, M.3
  • 6
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581-593.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 7
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: Extracellular organelles important in intercellular communication
    • Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73:1907-1920.
    • (2010) J Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 8
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • Vlassov AV, Magdaleno S, Setterquist R, et al. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820:940-948.
    • (2012) Biochim Biophys Acta. , vol.1820 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3
  • 9
    • 84859515309 scopus 로고    scopus 로고
    • The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities
    • Pant S, Hilton H, Burczynski ME. The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem Pharmacol. 2012;83:1484-1494.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1484-1494
    • Pant, S.1    Hilton, H.2    Burczynski, M.E.3
  • 10
    • 33845702611 scopus 로고    scopus 로고
    • Microparticles as mediators of cellular cross-talk in inflammatory disease
    • DOI 10.1080/08916930601061538, PII Q313873077168150
    • Distler JH, Huber LC, Gay S, et al. Microparticles as mediators of cellular cross-talk in inflammatory disease. Autoimmunity. 2006;39:683-690. (Pubitemid 44964371)
    • (2006) Autoimmunity , vol.39 , Issue.8 , pp. 683-690
    • Distler, J.H.W.1    Huber, L.C.2    Gay, S.3    Distler, O.4    Pisetsky, D.S.5
  • 11
  • 12
    • 61849179182 scopus 로고    scopus 로고
    • Activated T cells recruit exosomes secreted by dendritic cells via LFA-1
    • Noltet Hoen EN, Buschow SI, Anderton SM, et al. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood. 2009;113:1977-1981.
    • (2009) Blood , vol.113 , pp. 1977-1981
    • Noltet Hoen, E.N.1    Buschow, S.I.2    Anderton, S.M.3
  • 13
    • 0032910979 scopus 로고    scopus 로고
    • + T cells
    • Arnold PY, Mannie MD. Vesicles bearing MHC class II molecules mediate transfer of antigen from antigen-presenting cells to CD4 T cells. Eur J Immunol. 1999;29:1363- 1373. (Pubitemid 29164183)
    • (1999) European Journal of Immunology , vol.29 , Issue.4 , pp. 1363-1373
    • Arnold, P.Y.1    Mannie, M.D.2
  • 14
    • 84895891752 scopus 로고    scopus 로고
    • Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse
    • Choudhuri K, Llodra J, Roth EW, et al. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature. 2014;507:118-123.
    • (2014) Nature , vol.507 , pp. 118-123
    • Choudhuri, K.1    Llodra, J.2    Roth, E.W.3
  • 15
    • 79955070767 scopus 로고    scopus 로고
    • Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
    • Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Com-mun. 2011;2:282.
    • (2011) Nat Com-mun. , vol.2 , pp. 282
    • Mittelbrunn, M.1    Gutierrez-Vazquez, C.2    Villarroya-Beltri, C.3
  • 16
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • DOI 10.1038/ncb1596, PII NCB1596
    • Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654-659. (Pubitemid 47214727)
    • (2007) Nature Cell Biology , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 17
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10:1470-1476.
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3
  • 18
    • 77952365658 scopus 로고    scopus 로고
    • Microvesicles: Mediators of extracellular communication during cancer progression
    • Muralidharan-Chari V, Clancy JW, Sedgwick A, et al. Microvesicles: mediators of extracellular communication during cancer progression. J Cell Sci. 2010;123(pt 10):1603- 1611 .
    • (2010) J Cell Sci , vol.123 , Issue.PART 10 , pp. 1603-1611
    • Muralidharan-Chari, V.1    Clancy, J.W.2    Sedgwick, A.3
  • 19
    • 33947289003 scopus 로고    scopus 로고
    • Plasma mi-croparticles and vascular disorders
    • Lynch SF, Ludlam CA. Plasma mi-croparticles and vascular disorders. Br J Haematol. 2 007;137:36-48.
    • (2007) Br J Haematol. , vol.137 , pp. 36-48
    • Lynch, S.F.1    Ludlam, C.A.2
  • 20
    • 3042614111 scopus 로고    scopus 로고
    • Antigenic characterization of endothelial cell-derived microparticles and their detection ex vivo
    • Abid Hussein MN, Meesters EW, Osmanovic N, et al. Antigenic characterization of endothelial cell-derived microparticles and their detection ex vivo. J Thromb Haemost. 2003;1:2434-2443.
    • (2003) J Thromb Haemost , vol.1 , pp. 2434-2443
    • Abid Hussein, M.N.1    Meesters, E.W.2    Osmanovic, N.3
  • 21
    • 85014919682 scopus 로고    scopus 로고
    • A flow cytometric method for characterization of circulating cell-derived microparticles in plasma
    • Feb 24. Epub ahead of print
    • Nielsen MH, Beck-Nielsen H, Andersen MN, et al. A flow cytometric method for characterization of circulating cell-derived microparticles in plasma. J Extracell Vesicles. 2014 Feb 24. [Epub ahead of print].
    • (2014) J Extracell Vesicles
    • Nielsen, M.H.1    Beck-Nielsen, H.2    Andersen, M.N.3
  • 22
    • 77952074366 scopus 로고    scopus 로고
    • The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib
    • Connor DE, Exner T, Ma DD, et al. The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb Haemost. 2010;103:1044-1052.
    • (2010) Thromb Haemost , vol.103 , pp. 1044-1052
    • Connor, D.E.1    Exner, T.2    Ma, D.D.3
  • 23
    • 0037709857 scopus 로고    scopus 로고
    • Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis
    • DOI 10.1016/S0049-3848(03)00064-1
    • Jimenez JJ, Jy W, Mauro LM, et al. Endothelial cells release phenotypi-cally and quantitatively distinct microparticles in activation and apoptosis. Thromb Res. 2003;109: 175 -180. (Pubitemid 36712905)
    • (2003) Thrombosis Research , vol.109 , Issue.4 , pp. 175-180
    • Jimenez, J.J.1    Jy, W.2    Mauro, L.M.3    Soderland, C.4    Horstman, L.L.5    Ahn, Y.S.6
  • 24
    • 33846828571 scopus 로고    scopus 로고
    • Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: Studies using a new digital flow cytometer
    • DOI 10.1002/cyto.a.20354
    • Perez-Pujol S, Marker PH, Key NS. Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytometry A. 2007;71:38-45. (Pubitemid 46207382)
    • (2007) Cytometry Part A , vol.71 , Issue.1 , pp. 38-45
    • Perez-Pujol, S.1    Marker, P.H.2    Key, N.S.3
  • 25
    • 70450170492 scopus 로고    scopus 로고
    • ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles
    • Muralidharan-Chari V, Clancy J, Plou C, et al. ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr Biol. 2009;19:1875-1885.
    • (2009) Curr Biol , vol.19 , pp. 1875-1885
    • Muralidharan-Chari, V.1    Clancy, J.2    Plou, C.3
  • 26
    • 84855504820 scopus 로고    scopus 로고
    • Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1alpha
    • Berda-Haddad Y, Robert S, Salers P, et al. Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1alpha. Proc Natl Acad Sci U S A. 2011;108:20684-20689.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 20684-20689
    • Berda-Haddad, Y.1    Robert, S.2    Salers, P.3
  • 27
    • 7244221520 scopus 로고    scopus 로고
    • Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro
    • DOI 10.1182/blood-2003-10-3614
    • Hristov M, Erl W, Linder S, et al. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood. 2004;104:2761-2766. (Pubitemid 39434959)
    • (2004) Blood , vol.104 , Issue.9 , pp. 2761-2766
    • Hristov, M.1    Erl, W.2    Linder, S.3    Weber, P.C.4
  • 28
    • 3042753858 scopus 로고    scopus 로고
    • Apoptosis, subcellular particles, and autoim-munity
    • Cline AM, Radic MZ. Apoptosis, subcellular particles, and autoim-munity. Clin Immunol. 2004;112: 175 -182.
    • (2004) Clin Immunol , vol.112 , pp. 175-182
    • Cline, A.M.1    Radic, M.Z.2
  • 29
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
    • Pan BT, Johnstone RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell. 1983;33:967-978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 30
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulo-cytes
    • Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulo-cytes. J Cell Biol. 1983;97:329-339.
    • (1983) J Cell Biol , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 31
    • 33746238574 scopus 로고    scopus 로고
    • Direct exosome stimulation of peripheral human T cells detected by ELISPOT
    • DOI 10.1002/eji.200535615
    • Admyre C, Johansson SM, Paulie S, et al. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur J Immunol. 2006;36:1772-1781. (Pubitemid 44089044)
    • (2006) European Journal of Immunology , vol.36 , Issue.7 , pp. 1772-1781
    • Admyre, C.1    Johansson, S.M.2    Paulie, S.3    Gabrielsson, S.4
  • 32
    • 78650722735 scopus 로고    scopus 로고
    • Exosomes communicate protective messages during oxidative stress; Possible role of exosomal shuttle RNA
    • Eldh M, Ekstrom K, Valadi H, et al. Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA. PLoS One. 2010;5: e15353.
    • (2010) PLoS One , vol.5
    • Eldh, M.1    Ekstrom, K.2    Valadi, H.3
  • 33
    • 50949130683 scopus 로고    scopus 로고
    • Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor
    • Saunderson SC, Schuberth PC, Dunn AC, et al. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J Immunol. 2008;180:8146-8152.
    • (2008) J Immunol , vol.180 , pp. 8146-8152
    • Saunderson, S.C.1    Schuberth, P.C.2    Dunn, A.C.3
  • 34
    • 69249223795 scopus 로고    scopus 로고
    • Nolte-'t Hoen EN, van Niel G, et al. MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways
    • Buschow SI, Nolte-'t Hoen EN, van Niel G, et al. MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Tra f fi c. 2009;10:1528-1542.
    • (2009) Tra F Fi C. , vol.10 , pp. 1528-1542
    • Buschow, S.I.1
  • 35
    • 84866411048 scopus 로고    scopus 로고
    • Extracellular vesicles and their convergence with viral pathways
    • Wurdinger T, Gatson NN, Balaj L, et al. Extracellular vesicles and their convergence with viral pathways. Adv Virol. 2012;2012:767694.
    • (2012) Adv Virol. , vol.2012 , pp. 767694
    • Wurdinger, T.1    Gatson, N.N.2    Balaj, L.3
  • 37
    • 36148959342 scopus 로고    scopus 로고
    • Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo
    • DOI 10.1182/blood-2007-03-079152
    • Bhatnagar S, Shinagawa K, Castel-lino FJ, et al. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood. 2007;110: 3234-3244. (Pubitemid 350106316)
    • (2007) Blood , vol.110 , Issue.9 , pp. 3234-3244
    • Bhatnagar, S.1    Shinagawa, K.2    Castellino, F.J.3    Schorey, J.S.4
  • 38
    • 84861228574 scopus 로고    scopus 로고
    • Extracellular vesicles - Vehicles that spread cancer genes
    • Rak J, Guha A. Extracellular vesicles - vehicles that spread cancer genes. Bioessays. 2012;34:489-497.
    • (2012) Bioessays , vol.34 , pp. 489-497
    • Rak, J.1    Guha, A.2
  • 40
    • 70349315105 scopus 로고    scopus 로고
    • Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8 T lymphocytes
    • Wieckowski EU, Visus C, Szajnik M, et al. Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8 T lymphocytes. J Immunol. 2009;183: 3720-3730.
    • (2009) J Immunol , vol.183 , pp. 3720-3730
    • Wieckowski, E.U.1    Visus, C.2    Szajnik, M.3
  • 41
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik M, Czystowska M, Szcze-panski MJ, et al. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One. 2010;5:e11469.
    • (2010) PLoS One. , vol.5
    • Szajnik, M.1    Czystowska, M.2    Szcze-Panski, M.J.3
  • 42
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • DOI 10.1038/ncb1725, PII NCB1725
    • Al-Nedawi K, Meehan B, Micallef J, et al. Intercellular transfer of the oncogenic receptor EGFRvIII by mi-crovesicles derived from tumour cells. Nat Cell Biol. 2008;10:619-624. (Pubitemid 351627382)
    • (2008) Nature Cell Biology , vol.10 , Issue.5 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6    Rak, J.7
  • 43
    • 84892674862 scopus 로고    scopus 로고
    • Exosomes in plasma of patients with ovarian carcinoma: Potential biomarkers of tumor progression and response to therapy
    • Szajnik M, Derbis M, Lach M, et al. Exosomes in plasma of patients with ovarian carcinoma: potential biomarkers of tumor progression and response to therapy. Gynecol Obstet (Sunnyvale). 2013;(Suppl 4):3.
    • (2013) Gynecol Obstet (Sunnyvale). , Issue.SUPPL.4 , pp. 3
    • Szajnik, M.1    Derbis, M.2    Lach, M.3
  • 44
    • 77953097955 scopus 로고    scopus 로고
    • Circulating tumour-derived microvesicles in plasma of gastric cancer patients
    • Baran J, Baj-Krzyworzeka M, Weglarczyk K, et al. Circulating tumour-derived microvesicles in plasma of gastric cancer patients. Cancer Immunol Immunother. 2009; 59:841-850.
    • (2009) Cancer Immunol Immunother , vol.59 , pp. 841-850
    • Baran, J.1    Baj-Krzyworzeka, M.2    Weglarczyk, K.3
  • 45
    • 0037220119 scopus 로고    scopus 로고
    • Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: Possible role of a metastasis predictor
    • DOI 10.1016/S0959-8049(02)00596-8, PII S0959804902005968
    • Kim HK, Song KS, Park YS, et al. Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. Eur J Cancer. 2003;39:184-191. (Pubitemid 36057068)
    • (2003) European Journal of Cancer , vol.39 , Issue.2 , pp. 184-191
    • Kim, H.K.1    Song, K.S.2    Park, Y.S.3    Kang, Y.H.4    Lee, Y.J.5    Lee, K.R.6    Kim, H.K.7    Ryu, K.W.8    Bae, J.M.9    Kim, S.10
  • 46
    • 62549125455 scopus 로고    scopus 로고
    • Exosomal microRNA: A diagnostic marker for lung cancer
    • Rabinowits G, Gercel-Taylor C, Day JM, et al. Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer. 2009;10:42-46.
    • (2009) Clin Lung Cancer , vol.10 , pp. 42-46
    • Rabinowits, G.1    Gercel-Taylor, C.2    Day, J.M.3
  • 47
    • 0001644020 scopus 로고    scopus 로고
    • The human plasma proteome: History, character, and diagnostic prospects
    • Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1 (11):845-867.
    • (2002) Mol Cell Proteomics , vol.1 , Issue.11 , pp. 845-867
    • Anderson, N.L.1    Anderson, N.G.2
  • 48
    • 72149100726 scopus 로고    scopus 로고
    • The dynamic range problem in the analysis of the plasma proteome
    • Hortin GL, Sviridov D. The dynamic range problem in the analysis of the plasma proteome. J Proteomics. 2010;73:629-636.
    • (2010) J Proteomics , vol.73 , pp. 629-636
    • Hortin, G.L.1    Sviridov, D.2
  • 49
    • 73349111961 scopus 로고    scopus 로고
    • Claudin-containing exo-somes in the peripheral circulation of women with ovarian cancer
    • Li J, Sherman-Baust CA, Tsai-Turton M, et al. Claudin-containing exo-somes in the peripheral circulation of women with ovarian cancer. BMC Cancer. 2009;9:244.
    • (2009) BMC Cancer , vol.9 , pp. 244
    • Li, J.1    Sherman-Baust, C.A.2    Tsai-Turton, M.3
  • 50
    • 84874755851 scopus 로고    scopus 로고
    • Clinical impact of serum exosomal microRNA21 as a clinical biomarker in human esophageal squamous cell carcinoma
    • Tanaka Y, Kamohara H, Kinoshita K, et al. Clinical impact of serum exosomal microRNA21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer. 2013;119:1159-1167 .
    • (2013) Cancer. , vol.119 , pp. 1159-1167
    • Tanaka, Y.1    Kamohara, H.2    Kinoshita, K.3
  • 51
    • 77950498821 scopus 로고    scopus 로고
    • Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer
    • Hu Z, Chen X, Zhao Y, et al. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol. 2010;28:1721-1726.
    • (2010) J Clin Oncol , vol.28 , pp. 1721-1726
    • Hu, Z.1    Chen, X.2    Zhao, Y.3
  • 52
    • 77649106091 scopus 로고    scopus 로고
    • MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma
    • Satzger I, Mattern A, Kuettler U, et al. MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. Int J Cancer.
    • Int J Cancer.
    • Satzger, I.1    Mattern, A.2    Kuettler, U.3
  • 53
    • 66049112674 scopus 로고    scopus 로고
    • Differential expression of microRNAs in plasma of patients with colorectal cancer: A potential marker for color-ectal cancer screening
    • Ng EK, Chong WW, Jin H, et al. Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for color-ectal cancer screening. Gut. 2009;58: 1375 -1381 .
    • (2009) Gut. , vol.58 , pp. 1375-1381
    • Ng, E.K.1    Chong, W.W.2    Jin, H.3
  • 55
    • 57649091633 scopus 로고    scopus 로고
    • The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform
    • Resnick KE, Alder H, Hagan JP, et al. The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol. 2009;112:55-59.
    • (2009) Gynecol Oncol , vol.112 , pp. 55-59
    • Resnick, K.E.1    Alder, H.2    Hagan, J.P.3
  • 56
    • 53349177819 scopus 로고    scopus 로고
    • Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases
    • Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008;18:997- 1006.
    • (2008) Cell Res , vol.18 , pp. 997-1006
    • Chen, X.1    Ba, Y.2    Ma, L.3
  • 57
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008;105:10513-10518.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3
  • 58
    • 72449180374 scopus 로고    scopus 로고
    • Circulating microRNAs in breast cancer and healthy subjects
    • Zhu W, Qin W, Atasoy U, et al. Circulating microRNAs in breast cancer and healthy subjects. BMC Res Notes. 2009;2:89.
    • (2009) BMC Res Notes. , vol.2 , pp. 89
    • Zhu, W.1    Qin, W.2    Atasoy, U.3
  • 59
    • 60549112361 scopus 로고    scopus 로고
    • Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
    • Segura MF, Hanniford D, Menen-dez S, et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A. 2009;106:1814-1819.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1814-1819
    • Segura, M.F.1    Hanniford, D.2    Menen-Dez, S.3
  • 60
    • 63649092087 scopus 로고    scopus 로고
    • Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
    • Keller S, Konig AK, Marme F, et al. Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes. Cancer Lett. 2009;278:73-81.
    • (2009) Cancer Lett , vol.278 , pp. 73-81
    • Keller, S.1    Konig, A.K.2    Marme, F.3
  • 61
    • 84870931536 scopus 로고    scopus 로고
    • Protein typing of circulating micro-vesicles allows real-time monitoring of glioblastoma therapy
    • Shao H, Chung J, Balaj L, et al. Protein typing of circulating micro-vesicles allows real-time monitoring of glioblastoma therapy. Nat Med. 2012;18:1835-1840.
    • (2012) Nat Med , vol.18 , pp. 1835-1840
    • Shao, H.1    Chung, J.2    Balaj, L.3
  • 62
    • 65449117971 scopus 로고    scopus 로고
    • High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients
    • Logozzi M, De Milito A, Lugini L, et al. High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS One. 2009;4:e5219.
    • (2009) PLoS One. , vol.4
    • Logozzi, M.1    De Milito, A.2    Lugini, L.3
  • 63
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim JW, Wieckowski E, Taylor DD, et al. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res. 2005;11: 1010-1020. (Pubitemid 40175748)
    • (2005) Clinical Cancer Research , vol.11 , Issue.3 , pp. 1010-1020
    • Jeong, W.K.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4    Watkins, S.5    Whiteside, T.L.6
  • 66
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • 27 May, Epub ahead of print
    • Witwer KW, Buzas EI, Bemis LT, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. 27 May 2013. [Epub ahead of print].
    • (2013) J Extracell Vesicles
    • Witwer, K.W.1    Buzas, E.I.2    Bemis, L.T.3
  • 67
    • 84888103828 scopus 로고    scopus 로고
    • Current methods for the isolation of extracellular vesicles
    • Momen-Heravi F, Balaj L, Alian S, et al. Current methods for the isolation of extracellular vesicles. Biol Chem. 2013;394:1253-1262.
    • (2013) Biol Chem , vol.394 , pp. 1253-1262
    • Momen-Heravi, F.1    Balaj, L.2    Alian, S.3
  • 68
    • 84930483835 scopus 로고    scopus 로고
    • Classification, functions, and clinical relevance of extracellular vesicles
    • van der Pol E, Boing AN, Harrison P, et al. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev. 2012;64: 676-705.
    • (2012) Pharmacol Rev , vol.64 , pp. 676-705
    • Van Der Pol, E.1    Boing, A.N.2    Harrison, P.3
  • 69
    • 79251591623 scopus 로고    scopus 로고
    • Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters
    • Gyorgy B, Modos K, Pallinger E, et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters. Blood. 2011;117:e39-e48.
    • (2011) Blood. , vol.117
    • Gyorgy, B.1    Modos, K.2    Pallinger, E.3
  • 70
    • 84924845177 scopus 로고    scopus 로고
    • Analyzing the circulating mi-croRNAs in exosomes/extracellular vesicles from serum or plasma by qRT-PCR
    • Moldovan L, Batte K, Wang Y, et al. Analyzing the circulating mi-croRNAs in exosomes/extracellular vesicles from serum or plasma by qRT-PCR. Methods Mol Biol. 2013;1024:129-145.
    • (2013) Methods Mol Biol , vol.1024 , pp. 129-145
    • Moldovan, L.1    Batte, K.2    Wang, Y.3
  • 71
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracen-trifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • Tauro BJ, Greening DW, Mathias RA, et al. Comparison of ultracen-trifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods. 2012;56:293- 304.
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3
  • 72
    • 0026034448 scopus 로고
    • Segregation of MHC class II molecules from MHC class i molecules in the Golgi complex for transport to lysosomal compartments
    • Peters PJ, Neefjes JJ, Oorschot V, et al. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature. 1991;349:669-676. (Pubitemid 21912130)
    • (1991) Nature , vol.349 , Issue.6311 , pp. 669-676
    • Peters, P.J.1    Neefjes, J.J.2    Oorschot, V.3    Ploegh, H.L.4    Geuze, H.J.5
  • 73
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • DOI 10.1074/jbc.273.32.20121
    • Escola JM, Kleijmeer MJ, Stoorvo-gel W, et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endo-somes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998;273:20121-20127. (Pubitemid 28377568)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 20121-20127
    • Escola, J.-M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 74
    • 84902835800 scopus 로고    scopus 로고
    • Extracellular Vesicle (EV) Array: Microarray capturing of exo-somes and other extracellular vesicles for multiplexed phenotyp-ing
    • June 18 Epub ahead of print
    • Joergensen M, Baek R, Pedersen S, et al. Extracellular Vesicle (EV) Array: microarray capturing of exo-somes and other extracellular vesicles for multiplexed phenotyp-ing. J Extracell Vesicles. 2013 June 18. [Epub ahead of print].
    • (2013) J Extracell Vesicles
    • Joergensen, M.1    Baek, R.2    Pedersen, S.3
  • 75
    • 0024371915 scopus 로고
    • Relations between the intracellular pathways of the receptors for transferrin, asialoglycoprotein, and mannose 6-phosphate in human hepatoma cells
    • Stoorvogel W, Geuze HJ, Griffith JM, et al. Relations between the intracellular pathways of the receptors for transferrin, asialoglycopro-tein, and mannose 6-phosphate in human hepatoma cells. J Cell Biol. 1989;108:2137-2148. (Pubitemid 19168907)
    • (1989) Journal of Cell Biology , vol.108 , Issue.6 , pp. 2137-2148
    • Stoorvogel, W.1    Geuze, H.J.2    Griffith, J.M.3    Schwartz, A.L.4    Strous, G.J.5
  • 76
    • 0030047961 scopus 로고    scopus 로고
    • A novel class of clathrin-coated vesicles budding from endosomes
    • Stoorvogel W, Oorschot V, Geuze HJ. A novel class of clathrin-coated vesicles budding from endosomes. J Cell Biol. 1996;132:21-33. (Pubitemid 26035072)
    • (1996) Journal of Cell Biology , vol.132 , Issue.1-2 , pp. 21-33
    • Stoorvogel, W.1    Oorschot, V.2    Geuze, H.J.3
  • 78
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo G, Nijman HW, Stoorvogel W, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996;183:1161-1172 .
    • (1996) J Exp Med. , vol.183 , pp. 1161-1172
    • Raposo, G.1    Nijman, H.W.2    Stoorvogel, W.3
  • 79
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: Micro-vesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules
    • Heijnen HF, Schiel AE, Fijnheer R, et al. Activated platelets release two types of membrane vesicles: micro-vesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood. 1999;94:3791-37.
    • (1999) Blood. , vol.94 , pp. 3791-3747
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3
  • 80
    • 84857011554 scopus 로고    scopus 로고
    • Isolation and characterization of RNA-containing exosomes
    • Lasser C, Eldh M, Lotvall J. Isolation and characterization of RNA-containing exosomes. J Vis Exp. 2012(59):e3037.
    • (2012) J Vis Exp. , vol.59
    • Lasser, C.1    Eldh, M.2    Lotvall, J.3
  • 81
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 83
    • 0010254593 scopus 로고
    • Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: A method for studying antibody specificity and antigen structure
    • DOI 10.1073/pnas.76.7.3116
    • Renart J, Reiser J, Stark GR. Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure. Proc Natl Acad Sci U S A. 1979;76:3116-3120. (Pubitemid 9233242)
    • (1979) Proceedings of the National Academy of Sciences of the United States of America , vol.76 , Issue.7 , pp. 3116-3120
    • Renart, J.1    Reiser, J.2    Stark, G.R.3
  • 84
    • 84865558992 scopus 로고    scopus 로고
    • Elevated serum antibodies against insulinlike growth factor-binding protein-2 allow detecting early-stage cancers: Evidences from glioma and colorectal carcinoma studies
    • Li Y, Jiang T, Zhang J, et al. Elevated serum antibodies against insulinlike growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. Ann Oncol. 2012;23:2415-2422.
    • (2012) Ann Oncol , vol.23 , pp. 2415-2422
    • Li, Y.1    Jiang, T.2    Zhang, J.3
  • 86
    • 67649365976 scopus 로고    scopus 로고
    • Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: A possible role in innate defense
    • Kesimer M, Scull M, Brighton B, et al. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 2009;23:1858-1868.
    • (2009) FASEB J , vol.23 , pp. 1858-1868
    • Kesimer, M.1    Scull, M.2    Brighton, B.3
  • 87
    • 77149127065 scopus 로고    scopus 로고
    • A multicolor flow cytometric assay for measurement of platelet-derived microparticles
    • Mobarrez F, Antovic J, Egberg N, et al. A multicolor flow cytometric assay for measurement of platelet-derived microparticles. Thromb Res. 2010;125:e110-e116.
    • (2010) Thromb Res. , vol.125
    • Mobarrez, F.1    Antovic, J.2    Egberg, N.3
  • 88
    • 77952704204 scopus 로고    scopus 로고
    • Flow cyto-metric analysis of circulating mi-croparticles in plasma
    • Orozco AF, Lewis DE. Flow cyto-metric analysis of circulating mi-croparticles in plasma. Cytometry A. 2010;77:502-514.
    • (2010) Cytometry A , vol.77 , pp. 502-514
    • Orozco, A.F.1    Lewis, D.E.2
  • 90
    • 84856775465 scopus 로고    scopus 로고
    • Analysis of exosome release and its prognostic value in human colorectal cancer
    • Silva J, Garcia V, Rodriguez M, et al. Analysis of exosome release and its prognostic value in human colorectal cancer. Genes Chromosomes Cancer. 2012;51:409-418.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 409-418
    • Silva, J.1    Garcia, V.2    Rodriguez, M.3
  • 91
    • 78149326412 scopus 로고    scopus 로고
    • Overcoming limitations of microparticle measurement by flow cytometry
    • Lacroix R, Robert S, Poncelet P, et al. Overcoming limitations of microparticle measurement by flow cytometry. Semin Thromb Hemost. 2010;36:807-818.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 807-818
    • Lacroix, R.1    Robert, S.2    Poncelet, P.3
  • 92
    • 60349099201 scopus 로고    scopus 로고
    • Flow cytometric analysis of cell membrane microparticles
    • Gelderman MP, Simak J. Flow cytometric analysis of cell membrane microparticles. Methods Mol Biol. 2008;484:79-93.
    • (2008) Methods Mol Biol , vol.484 , pp. 79-93
    • Gelderman, M.P.1    Simak, J.2
  • 93
    • 19944434048 scopus 로고    scopus 로고
    • Measuring circulating cell-derived microparticles
    • Shet AS, Key NS, Hebbel RP. Measuring circulating cell-derived microparticles. J Thromb Haemost. 2004;2:1848-1850.
    • (2004) J Thromb Haemost , vol.2 , pp. 1848-1850
    • Shet, A.S.1    Key, N.S.2    Hebbel, R.P.3
  • 94
    • 57749190349 scopus 로고    scopus 로고
    • Standardization of platelet-derived microparticle counting using calibrated beads and a Cytom-ics FC500 routine flow cytometer: A first step towards multicenter studies?
    • Robert S, Poncelet P, Lacroix R, et al. Standardization of platelet-derived microparticle counting using calibrated beads and a Cytom-ics FC500 routine flow cytometer: a first step towards multicenter studies? J Thromb Haemost. 2009; 7:190-197.
    • (2009) J Thromb Haemost , vol.7 , pp. 190-197
    • Robert, S.1    Poncelet, P.2    Lacroix, R.3
  • 95
    • 49149122934 scopus 로고    scopus 로고
    • Chip-NMR biosensor for detection and molecular analysis of cells
    • Lee H, Sun E, Ham D, et al. Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med. 2008;14:869-874.
    • (2008) Nat Med , vol.14 , pp. 869-874
    • Lee, H.1    Sun, E.2    Ham, D.3
  • 96
    • 79958830224 scopus 로고    scopus 로고
    • Miniature magnetic resonance system for point-of-care diagnostics
    • Issadore D, Min C, Liong M, et al. Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip. 2011;11:2282-2287.
    • (2011) Lab Chip , vol.11 , pp. 2282-2287
    • Issadore, D.1    Min, C.2    Liong, M.3
  • 97
    • 79952204045 scopus 로고    scopus 로고
    • Micro-NMR for rapid molecular analysis of human tumor samples
    • Haun JB, Castro CM, Wang R, et al. Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med. 2011;3. 7116.
    • (2011) Sci Transl Med. , vol.3 , pp. 7116
    • Haun, J.B.1    Castro, C.M.2    Wang, R.3
  • 98
    • 2342633297 scopus 로고    scopus 로고
    • Protein arrays: Proteo-mics in multiplex
    • Melton L. Protein arrays: proteo-mics in multiplex. Nature. 2004; 429:101-107.
    • (2004) Nature , vol.429 , pp. 101-107
    • Melton, L.1
  • 99
    • 33846051527 scopus 로고    scopus 로고
    • Protein microarray technology
    • DOI 10.1016/j.mad.2006.11.021, PII S0047637406002545, Functional Genomics of Aging III
    • Hall DA, Ptacek J, Snyder M. Protein microarray technology. Mech Ageing Dev. 2007;128:161-167. (Pubitemid 46073070)
    • (2007) Mechanisms of Ageing and Development , vol.128 , Issue.1 , pp. 161-167
    • Hall, D.A.1    Ptacek, J.2    Snyder, M.3
  • 100
    • 84860252219 scopus 로고    scopus 로고
    • Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells
    • Soo CY, Song Y, Zheng Y, et al. Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology. 2012;136:192-197.
    • (2012) Immunology , vol.136 , pp. 192-197
    • Soo, C.Y.1    Song, Y.2    Zheng, Y.3
  • 101
    • 85024962766 scopus 로고    scopus 로고
    • Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis
    • Feb 15., Epub ahead of print
    • Gardiner C, Ferreira YJ, Dragovic RA, et al. Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis. J Extracell Vesicles. 2013 Feb 15. [Epub ahead of print].
    • (2013) J Extracell Vesicles
    • Gardiner, C.1    Ferreira, Y.J.2    Dragovic, R.A.3
  • 102
    • 84867126923 scopus 로고    scopus 로고
    • Alternative methods for characterization of extracellular vesicles
    • Momen-Heravi F, Balaj L, Alian S, et al. Alternative methods for characterization of extracellular vesicles. Front Physiol. 2012;3:354.
    • (2012) Front Physiol. , vol.3 , pp. 354
    • Momen-Heravi, F.1    Balaj, L.2    Alian, S.3
  • 103
    • 80055118968 scopus 로고    scopus 로고
    • Sizing and phenotyping of cellular vesicles using Nanopar-ticle Tracking Analysis
    • Dragovic RA, Gardiner C, Brooks AS, et al. Sizing and phenotyping of cellular vesicles using Nanopar-ticle Tracking Analysis. Nanomedi-cine. 2011;7:780-788.
    • (2011) Nanomedi-cine , vol.7 , pp. 780-788
    • Dragovic, R.A.1    Gardiner, C.2    Brooks, A.S.3
  • 104
    • 77953291167 scopus 로고    scopus 로고
    • Critical evaluation of Nanoparticle Tracking Analysis (NTA) by Nano-Sight for the measurement of nanoparticles and protein aggregates
    • Filipe V, Hawe A, Jiskoot W. Critical evaluation of Nanoparticle Tracking Analysis (NTA) by Nano-Sight for the measurement of nanoparticles and protein aggregates. Pharm Res. 2010;27:796-810.
    • (2010) Pharm Res , vol.27 , pp. 796-810
    • Filipe, V.1    Hawe, A.2    Jiskoot, W.3
  • 105
    • 78650835871 scopus 로고    scopus 로고
    • Portable nanoparticle quantization using a resizable nanopore instrument - The IZON qNano
    • Garza-Licudine E, Deo D, Yu S, et al. Portable nanoparticle quantization using a resizable nanopore instrument - the IZON qNano. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:5736-5739.
    • (2010) Conf Proc IEEE Eng Med Biol Soc. , vol.2010 , pp. 5736-5739
    • Garza-Licudine, E.1    Deo, D.2    Yu, S.3
  • 106
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • Kosaka N, Iguchi H, Yoshioka Y, et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem. 2010; 285:17442-17452.
    • (2010) J Biol Chem , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3
  • 107
    • 80053309537 scopus 로고    scopus 로고
    • Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth
    • Kogure T, Lin WL, Yan IK, et al. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology. 2011;54:1237-1248.
    • (2011) Hepatology , vol.54 , pp. 1237-1248
    • Kogure, T.1    Lin, W.L.2    Yan, I.K.3
  • 108
    • 85009840654 scopus 로고    scopus 로고
    • Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells
    • Apr 16, Epub ahead of print
    • Ekstrom K, Valadi H, Sjostrand M, et al. Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells. J Extracell Vesicles. 2012 Apr 16. [Epub ahead of print].
    • (2012) J Extracell Vesicles
    • Ekstrom, K.1    Valadi, H.2    Sjostrand, M.3
  • 109
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 110
    • 33645294070 scopus 로고    scopus 로고
    • On-comirs: MicroRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ. On-comirs: microRNAs with a role in cancer. Nat Rev Cancer. 2006;6: 259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 111
    • 0036691045 scopus 로고    scopus 로고
    • Relative quantification of mRNA levels in Jurkat T cells with RT-real time-PCR (RT-rt-PCR): New possibilities for the screening of anti-inflammatory and cytotoxic compounds
    • Gertsch J, Guttinger M, Sticher O, et al. Relative quantification of mRNA levels in Jurkat T cells with RT-real time-PCR (RT-rt-PCR): new possibilities for the screening of anti-inflammatory and cytotoxic compounds. Pharm Res. 2002;19
    • (2002) Pharm Res. , pp. 19
    • Gertsch, J.1    Guttinger, M.2    Sticher, O.3
  • 112
    • 84858330248 scopus 로고    scopus 로고
    • Importance of RNA isolation methods for analysis of exosomal RNA: Evaluation of different methods
    • Eldh M, Lotvall J, Malmhall C, et al. Importance of RNA isolation methods for analysis of exosomal RNA: evaluation of different methods. Mol Immunol. 2012;50:278-286.
    • (2012) Mol Immunol. , vol.50 , pp. 278-286
    • Eldh, M.1    Lotvall, J.2    Malmhall, C.3
  • 113
    • 84886094578 scopus 로고    scopus 로고
    • Detection methods for microRNAs in clinic practice
    • de Planell-Saguer M, Rodicio MC. Detection methods for microRNAs in clinic practice. Clin Biochem. 2013;46:869-878.
    • (2013) Clin Biochem , vol.46 , pp. 869-878
    • De Planell-Saguer, M.1    Rodicio, M.C.2
  • 114
    • 29144470346 scopus 로고    scopus 로고
    • Real-time quantification of microRNAs by stem-loop RT-PCR
    • Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005;33:e179.
    • (2005) Nucleic Acids Res. , vol.33
    • Chen, C.1    Ridzon, D.A.2    Broomer, A.J.3
  • 115
    • 85026337731 scopus 로고    scopus 로고
    • Distinct RNA profiles in sub-populations of extracellular vesicles: Apoptotic bodies, microvesicles and exosomes
    • Sep 12, Epub ahead of print
    • Crescitelli R, Lasser C, Szabo TG, et al. Distinct RNA profiles in sub-populations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell Vesicles. 2013 Sep 12. [Epub ahead of print].
    • (2013) J Extracell Vesicles
    • Crescitelli, R.1    Lasser, C.2    Szabo, T.G.3
  • 116
    • 84924839639 scopus 로고    scopus 로고
    • Identification and analysis of circulating exosomal microRNA in human body fluids
    • Lasser C. Identification and analysis of circulating exosomal microRNA in human body fluids. Methods Mol Biol. 2013;1024:109-128.
    • (2013) Methods Mol Biol , vol.1024 , pp. 109-128
    • Lasser, C.1
  • 117
    • 84878629272 scopus 로고    scopus 로고
    • Proteomics, transcriptomics and lip-idomics of exosomes and ectosomes
    • Choi DS, Kim DK, Kim YK, et al. Proteomics, transcriptomics and lip-idomics of exosomes and ectosomes. Proteomics. 2013;13:1554-1571 .
    • (2013) Proteomics , vol.13 , pp. 1554-1571
    • Choi, D.S.1    Kim, D.K.2    Kim, Y.K.3
  • 118
    • 84930540275 scopus 로고    scopus 로고
    • Proteomics of extracellular vesicles: Exosomes and ectosomes
    • Jan 14 Epub ahead of print
    • Choi DS, Kim DK, Kim YK, et al. Proteomics of extracellular vesicles: exosomes and ectosomes. Mass Spectrom Rev. 2014 Jan 14. [Epub ahead of print].
    • (2014) Mass Spectrom Rev
    • Choi, D.S.1    Kim, D.K.2    Kim, Y.K.3
  • 119
    • 84888026332 scopus 로고    scopus 로고
    • ExoCarta as a resource for exo-somal research
    • Apr 16. Epub ahead of print
    • Simpson RJ, Kalra H, Mathivanan S. ExoCarta as a resource for exo-somal research. J Extracell Vesicles. 2012 Apr 16. [Epub ahead of print].
    • (2012) J Extracell Vesicles
    • Simpson, R.J.1    Kalra, H.2    Mathivanan, S.3
  • 120
    • 84884932216 scopus 로고    scopus 로고
    • EVpedia: An integrated database of high-throughput data for systemic analyses of extracellular vesicles
    • Mar: 19. Epub ahead of print
    • Kim DK, Kang B, Kim OY, et al. EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles. J Extracell Vesicles. 2013 Mar:19. [Epub ahead of print].
    • (2013) J Extracell Vesicles
    • Kim, D.K.1    Kang, B.2    Kim, O.Y.3
  • 121
    • 84871702725 scopus 로고    scopus 로고
    • Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation
    • Kalra H, Simpson RJ, Ji H, et al. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012;10:e1001450.
    • (2012) PLoS Biol. , vol.10
    • Kalra, H.1    Simpson, R.J.2    Ji, H.3
  • 122
    • 84867666610 scopus 로고    scopus 로고
    • MiRandola: Extracellular circulating microRNAs database
    • Russo F, Di Bella S, Nigita G, et al. miRandola: extracellular circulating microRNAs database. PLoS One. 2012;7:e47786.
    • (2012) PLoS One. , vol.7
    • Russo, F.1    Di Bella, S.2    Nigita, G.3
  • 123
    • 84902817518 scopus 로고    scopus 로고
    • The launch of journal of extracellular vesicles (JEV), the official journal of the international society for extracellular vesicles -about microvesicles, exosomes, ec-tosomes and other extracellular vesicles
    • Apr 16 Epub ahead of print
    • Lotvall J, Rajendran L, Gho YS, et al. The launch of Journal of Extracellular Vesicles (JEV), the official journal of the International Society for Extracellular Vesicles -about microvesicles, exosomes, ec-tosomes and other extracellular vesicles. J Extracell Vesicles. 2012 Apr 16. [Epub ahead of print].
    • (2012) J Extracell Vesicles
    • Lotvall, J.1    Rajendran, L.2    Gho, Y.S.3
  • 124
    • 84896475773 scopus 로고    scopus 로고
    • Exosomes derived from mesenchymal stem cells
    • Yu B, Zhang X, Li X. Exosomes derived from mesenchymal stem cells. Int J Mol Sci. 2014;15:4142-4157.
    • (2014) Int J Mol Sci , vol.15 , pp. 4142-4157
    • Yu, B.1    Zhang, X.2    Li, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.