Identification and analysis of circulating exosomal microRNA in human body fluids

Methods in Molecular Biology

Volumn 1024, Issue , 2013, Pages 109-128

  Lässer, Cecilia ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Body fluids; Exosomes; Extracellular vesicles; miRNA; Protocols; RNA

Indexed keywords

MICRORNA; DIAGNOSTIC KIT; TUMOR MARKER;

ARTICLE; BODY FLUID; CELL CULTURE; CELL FRACTIONATION; CELL ISOLATION; CELL VACUOLE; CULTURE MEDIUM; ELECTRON MICROSCOPY; EXOSOME; EXOSOME ISOLATION METHOD; HUMAN; ISOLATION PROCEDURE; PRIORITY JOURNAL; RNA ANALYSIS; RNA ISOLATION; BLOOD; CHEMISTRY; DIAGNOSTIC KIT; GENETICS; ISOLATION AND PURIFICATION; NEOPLASM; PATHOLOGY; ULTRACENTRIFUGATION; ULTRASTRUCTURE; URINE;

BODY FLUIDS; EXOSOMES; HUMANS; MICRORNAS; MICROSCOPY, ELECTRON; NEOPLASMS; REAGENT KITS, DIAGNOSTIC; TUMOR MARKERS, BIOLOGICAL; ULTRACENTRIFUGATION;

EID: 84924839639     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-453-1_9     Document Type: Article

References (63)

1. Pan BT, Teng K, Wu C et al (1985) Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol 101:942-948
2. Harding C, Heuser J, Stahl P (1983) Receptormediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol 97:329-339
3. Raposo G, Nijman HW, Stoorvogel W et al (1996) B lymphocytes secrete antigen-presenting vesicles. J Exp Med 183:1161-1172
4. Zitvogel L, Regnault A, Lozier A et al (1998) Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes. Nat Med 4:594-600
5. Thery C, Regnault A, Garin J et al (1999) Molecular characterization of dendritic cellderived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol 147:599-610
6. Escola JM, Kleijmeer MJ, Stoorvogel W et al (1998) Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem 273:20121-20127
7. Andre F, Schartz NE, Movassagh M et al (2002) Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360:295-305
8. Valadi H, Ekstrom K, Bossios A et al (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654-659
9. Lim LP, Lau NC, Garrett-Engele P et al (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:769-773
10. Krek A, Grun D, Poy MN et al (2005) Combinatorial microRNA target predictions. Nat Genet 37:495-500
11. Skog J, Wurdinger T, van Rijn S et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470-1476
12. Taylor DD, Gercel-Taylor C (2008) MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110:13-21
13. Lässer C, O'Neil SE, Ekerljung L et al (2011) RNA-containing exosomes in human nasal secretions. Am J Rhinol Allergy 25:89-93
14. Caby MP, Lankar D, Vincendeau-Scherrer C et al (2005) Exosomal-like vesicles are present in human blood plasma. Int Immunol 17:879-887
15. Vella LJ, Greenwood DL, Cappai R et al (2008) Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid. Vet Immunol Immunopathol 124:385-393
16. Pisitkun T, Shen RF, Knepper MA (2004) Identi fication and proteomic pro filing of exosomes in human urine. Proc Natl Acad Sci USA 101:13368-13373
17. Admyre C, Grunewald J, Thyberg J et al (2003) Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J 22:578-583
18. Keller S, Rupp C, Stoeck A et al (2007) CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int 72:1095-1102
19. Skriner K, Adolph K, Jungblut PR et al (2006) Association of citrullinated proteins with synovial exosomes. Arthritis Rheum 54:3809-3814
20. Admyre C, Johansson SM, Qazi KR et al (2007) Exosomes with immune modulatory features are present in human breast milk. J Immunol 179:1969-1978
21. Ogawa Y, Kanai-Azuma M, Akimoto Y et al (2008) Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. Biol Pharm Bull 31:1059-1062
22. Prado N, Marazuela EG, Segura E et al (2008) Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction. J Immunol 181:1519-1525
23. Qazi KR, Torregrosa Paredes P, Dahlberg B et al (2010) Proin flammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. Thorax 65:1016-1024
24. Keller S, Konig AK, Marme F et al (2009) Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes. Cancer Lett 278:73-81
25. Rabinowits G, Gercel-Taylor C, Day JM et al (2009) Exosomal microRNA: A diagnostic marker for lung cancer. Clin Lung Cancer 10:42-46
26. Michael A, Bajracharya SD, Yuen PS et al (2010) Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis 16:34-38
27. Nilsson J, Skog J, Nordstrand A et al (2009) Prostate cancer-derived urine exosomes: A novel approach to biomarkers for prostate cancer. Br J Cancer 100:1603-1607
28. Merchant ML, Powell DW, Wilkey DW et al (2010) Micro filtration isolation of human urinary exosomes for characterization by MS. Proteomics Clin Appl 4:84-96
29. Cheruvanky A, Zhou H, Pisitkun T et al (2007) Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultra filtration concentrator. Am J Physiol Renal Physiol 292:F1657-F1661
30. Rood IM, Deegens JK, Merchant ML et al (2010) Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome. Kidney Int 78:810-816
31. Zhou Q, Li M, Wang X et al (2012) Immunerelated microRNAs are abundant in breast milk exosomes. Int J Biol Sci 8:118-123
32. Ogawa Y, Miura Y, Harazono A et al (2011) Proteomic analysis of two types of exosomes in human whole saliva. Biol Pharm Bull 34:13-23
33. Eldh M, Lotvall J, Malmhall C et al (2012) Importance of RNA isolation methods for analysis of exosomal RNA: Evaluation of different methods. Mol Immunol 50:278-286
34. Moon PG, Lee JE, You S et al (2011) Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Proteomics 11:2459-2475
35. Zhang Y, Li Y, Qiu F et al (2010) Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip- MS/MS. Electrophoresis 31:3797-3807
36. Gonzales PA, Pisitkun T, Hoffert JD et al (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol 20:363-379
37. Zhou H, Yuen PS, Pisitkun T et al (2006) Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int 69:1471-1476
38. Fernandez-Llama P, Khositseth S, Gonzales PA et al (2010) Tamm-Horsfall protein and urinary exosome isolation. Kidney Int 77:736-742
39. Gonzalez-Begne M, Lu B, Han X et al (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identi fication technology (MudPIT). J Proteome Res 8:1304-1314
40. Hiemstra TF, Charles PD, Hester SS et al (2011) Uromodulin exclusion list improves urinary exosomal protein identi fication. J Biomol Tech 22:136-145
41. Lässer C, Alikhani VS, Ekström K et al (2011) Human saliva, plasma and breast milk exosomes contain RNA: Uptake by macrophages. J Transl Med 9:9
42. Miranda KC, Bond DT, McKee M et al (2010) Nucleic acids within urinary exosomes/ microvesicles are potential biomarkers for renal disease. Kidney Int 78:191-199
43. Keller S, Ridinger J, Rupp AK et al (2011) Body fluid derived exosomes as a novel template for clinical diagnostics. J Transl Med 9:86
44. Hata T, Murakami K, Nakatani H et al (2010) Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs. Biochem Biophys Res Commun 396:528-533
45. Street JM, Barran PE, Mackay CL et al (2012) Identi fication and proteomic pro filing of exosomes in human cerebrospinal fluid. J Transl Med 10:5
46. Lässer C, Eldh M, Lötvall J (2012) Isolation and characterization of RNA-containing exosomes. J Vis Exp (59):e3037
47. Hoen EN, van der Vlist EJ, Aalberts M et al (2012) Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles. Nanomedicine 8(5):712-720
48. Berckmans RJ, Sturk A, van Tienen LM et al (2011) Cell-derived vesicles exposing coagulant tissue factor in saliva. Blood 117:3172-3180
49. Palanisamy V, Sharma S, Deshpande A et al (2010) Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS One 5:e8577
50. Zhong H, Yang Y, Ma S et al (2011) Induction of a tumour-speci fic CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients. Int J Hyperthermia 27:604-611
51. Saman S, Kim W, Raya M et al (2012) Exosomeassociated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease. J Biol Chem 287:3842-3849
52. Choi DS, Park JO, Jang SC et al (2011) Proteomic analysis of microvesicles derived from human colorectal cancer ascites. Proteomics 11:2745-2751
53. Runz S, Keller S, Rupp C et al (2007) Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM. Gynecol Oncol 107:563-571
54. Asea A, Jean-Pierre C, Kaur P et al (2008) Heat shock protein-containing exosomes in mid-trimester amniotic fluids. J Reprod Immunol 79:12-17
55. Gallo A, Tandon M, Alevizos I et al (2012) The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes. PLoS One 7:e30679
56. Gutwein P, Stoeck A, Riedle S et al (2005) Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. Clin Cancer Res 11:2492-2501
57. Dai S, Wei D, Wu Z et al (2008) Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther 16:782-790
58. Bhatnagar S, Shinagawa K, Castellino FJ et al (2007) Exosomes released from macrophages infected with intracellular pathogens stimulate a proin flammatory response in vitro and in vivo. Blood 110:3234-3244
59. Li QL, Bu N, Yu YC et al (2008) Exvivo experiments of human ovarian cancer ascitesderived exosomes presented by dendritic cells derived from umbilical cord blood for immunotherapy treatment. Clin Med Oncol 2:461-467
60. Bard MP, Hegmans JP, Hemmes A et al (2004) Proteomic analysis of exosomes isolated from human malignant pleural effusions. Am J Respir Cell Mol Biol 31:114-121
61. Li Y, Zhang Y, Qiu F et al (2011) Proteomic identi fication of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. Electrophoresis 32:1976-1983
62. Sharma S, Rasool HI, Palanisamy V et al (2010) Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano 4:1921-1926
63. Zhang L, Hou D, Chen X et al (2012) Exogenous plant MIR168a speci fically targets mammalian LDLRAP1: Evidence of crosskingdom regulation by microRNA. Cell Res 22:107-126