Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by streptococcus pneumoniae

Journal of Innate Immunity

Volumn 6, Issue 4, 2014, Pages 542-552

  Blok, Dana C ^a,e   Van Lieshout, Miriam H P ^a   Hoogendijk, Arie J ^a   Florquin, Sandrine ^b   De Boer, Onno J ^b   Garlanda, Cecilia ^c   Mantovani, Alberto ^c,d   Van'T Veer, Cornelis ^a   De Vos, Alex F ^a   Van Der Poll, Tom ^a,b  

^a Center of Experimental and Molecular Medicine Center of Infection and Immunity   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Humanitas Clinical and Research Center Department of Inflammation and Immunology   (Colombia)

^d UNIVERSITY OF MILAN   (Italy)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Gram positive bacterial infections; Innate immunity; Pneumococcal pneumonia; Sepsis; Toll like receptors

Indexed keywords

CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; SINGLE IMMUNOGLOBULIN INTERLEUKIN 1 RECEPTOR RELATED MOLECULE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; TIR8 PROTEIN, MOUSE; TOLL LIKE RECEPTOR; KERATINOCYTE DERIVED CHEMOKINE; REGULATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL LOAD; BACTERIAL OVERGROWTH; CYTOKINE PRODUCTION; GENOTYPE; HOST RESISTANCE; INFLAMMATION; INNATE IMMUNITY; LOWER RESPIRATORY TRACT INFECTION; LUNG ALVEOLUS MACROPHAGE; MORTALITY; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEPSIS; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; ANIMAL; BACTERIAL PNEUMONIA; C57BL MOUSE; CELL CULTURE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; MACROPHAGE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; STREPTOCOCCUS INFECTION; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; COLONY FORMING UNIT; CONTROLLED STUDY; HISTOPATHOLOGY; LUNG EDEMA; LUNG HOMOGENATE; SURVIVAL; WILD TYPE MOUSE;

ANIMALS; BACTERIAL LOAD; CELLS, CULTURED; LUNG; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PHAGOCYTOSIS; PNEUMONIA, BACTERIAL; RECEPTORS, INTERLEUKIN-1; SEPSIS; SIGNAL TRANSDUCTION; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; TOLL-LIKE RECEPTORS;

EID: 84902773460     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000358239     Document Type: Article

References (40)

1. van der Poll T, Opal SM: Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet 2009; 374:1543-1556.
2. Dockrell DH, Whyte MK, Mitchell TJ: Pneu-mococcal pneumonia: mechanisms of infection and resolution. Chest 2012; 142:482-491.
3. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Re-comm Rep 1997; 46:1-24.
4. Welte T, Torres A, Nathwani D: Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax 2012; 67:71-79.
5. Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S: Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe 2008; 3:352-363.
6. Kawai T, Akira S: Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011; 34:637-650.
7. Knapp S, Wieland CW, van 't Veer C, Takeu-chi O, Akira S, Florquin S, van der Poll T: Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumo-coccal pneumonia but does not contribute to antibacterial defense. J Immunol 2004; 172: 3132-3138.
8. Mogensen TH, Paludan SR, Kilian M, Oster-gaard L: Live Streptococcus pneumoniae, Hae-mophilus influenzae, and Neisseria meningiti-dis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. J Leukoc Biol 2006; 80: 267-277.
9. Dessing MC, Schouten M, Draing C, Levi M, von Aulock S, van der Poll T: Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation. J Infect Dis 2008; 197:245-252.
10. Malley R, Henneke P, Morse SC, Cieslewicz MJ, Lipsitch M, Thompson CM, Kurt-Jones E, Paton JC, Wessels MR, Golenbock DT: Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci USA 2003; 100:1966-1971.
11. Srivastava A, Henneke P, Visintin A, Morse SC, Martin V, Watkins C, Paton JC, Wessels MR, Golenbock DT, Malley R: The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococ-cal disease. Infect Immun 2005; 73:6479-6487.
12. Branger J, Knapp S, Weijer S, Leemans JC, Pater JM, Speelman P, Florquin S, van der Poll T: Role of Toll-like receptor 4 in Gram-positive and Gram-negative pneumonia in mice. Infect Immun 2004; 72:788-794.
13. Albiger B, Dahlberg S, Sandgren A, Wartha F, Beiter K, Katsuragi H, Akira S, Normark S, Henriques-Normark B: Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol 2007; 9:633-644.
14. Dessing MC, Florquin S, Paton JC, van der Poll T: Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci. Cell Microbiol 2008; 10: 237-246.
15. Dinarello CA: Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009; 27:519-550.
16. Albiger B, Sandgren A, Katsuragi H, Meyer-Hoffert U, Beiter K, Wartha F, Hornef M, Normark S, Normark BH: Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice. Cell Microbiol 2005; 7:1603-1615.
17. Kondo T, Kawai T, Akira S: Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol 2012; 33:449-458.
18. Riva F, Bonavita E, Barbati E, Muzio M, Man-tovani A, Garlanda C: TIR8/SIGIRR is an in-terleukin-1 receptor/Toll like receptor family member with regulatory functions in inflammation and immunity. Front Immunol 2012; 3:322.
19. Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C: Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect Immun 2012; 80: 100-109.
20. Garlanda C, Di Liberto D, Vecchi A, La Manna MP, Buracchi C, Caccamo N, Salerno A, Dieli F, Mantovani A: Damping excessive inflammation and tissue damage in Mycobacte-rium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. J Immunol 2007; 179:3119-3125.
21. Chen X, Zhao Y, Wu X, Qian G: Enhanced expression of single immunoglobulin IL-1 receptor-related molecule ameliorates LPS-in-duced acute lung injury in mice. Shock 2011; 35:198-204.
22. Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, De Bortoli M, Muzio M, Bergot-tini R, Scanziani E, Vecchi A, Hirsch E, Man-tovani A: Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci USA 2004; 101:3522-3526.
23. van der Windt GJ, Blok DC, Hoogerwerf JJ, Lammers AJ, de Vos AF, Van't Veer C, Flo-rquin S, Kobayashi KS, Flavell RA, van der Poll T: Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia. J Infect Dis 2012; 205:1849-1857.
24. van der Windt GJ, Hoogendijk AJ, Schouten M, Hommes TJ, de Vos AF, Florquin S, van der Poll T: Osteopontin impairs host defense during pneumococcal pneumonia. J Infect Dis 2011; 203:1850-1858.
25. Hoogendijk AJ, Roelofs JJ, Duitman J, van Lieshout MH, Blok DC, van der Poll T, Wieland CW: R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae. Mol Med 2012; 18: 1086-1095.
26. Blok DC, van der Sluijs KF, Florquin S, de Boer OJ, van 't Veer C, de Vos AF, van der Poll T: Limited anti-inflammatory role for inter-leukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococ-cal pneumonia. PLoS One 2013; 8:e58191.
27. Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JC, Levi M, Van't Veer C, van der Poll T: Plas-minogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis). J Thromb Haemost 2011; 9:2020-2028.
28. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X: SIGIRR, a negative regulator of Toll-like re-ceptor-interleukin 1 receptor signaling. Nat Immunol 2003; 4:920-927.
29. Rijneveld AW, Florquin S, Branger J, Speel-man P, Van Deventer SJ, van der Poll T: TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia. J Immunol 2001; 167:5240-5246.
30. Lauw FN, Branger J, Florquin S, Speelman P, van Deventer SJ, Akira S, van der Poll T: IL-18 improves the early antimicrobial host response to pneumococcal pneumonia. J Immunol 2002; 168:372-378.
31. van der Poll T, Keogh CV, Buurman WA, Lowry SF: Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice. Am J Respir Crit Care Med 1997; 155: 603-608.
32. Skerrett SJ, Martin TR, Chi EY, Peschon JJ, Mohler KM, Wilson CB: Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeru-ginosa. Am J Physiol 1999; 276:L715-L727.
33. Schultz MJ, Knapp S, Florquin S, Pater J, Takeda K, Akira S, van der Poll T: Interleu-kin-18 impairs the pulmonary host response to Pseudomonas aeruginosa. Infect Immun 2003; 71:1630-1634.
34. Schultz MJ, Rijneveld AW, Florquin S, Edwards CK, Dinarello CA, van der Poll T: Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 2002; 282:L285-L290.
35. Huang X, Hazlett LD, Du W, Barrett RP: SIGIRR promotes resistance against Pseudo-monas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. J Immunol 2006; 177:548-556.
36. Bozza S, Zelante T, Moretti S, Bonifazi P, De-Luca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L: Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J Immunol 2008; 180:4022-4031.
37. Leemans JC, Butter LM, Teske GJ, Stroo I, Pulskens WP, Florquin S: The Toll interleu-kin-1 receptor (IL-1R) 8/single Ig domain IL-1R-related molecule modulates the renal response to bacterial infection. Infect Immun 2012; 80:3812-3820.
38. Doyle SE, O'Connell RM, Miranda GA, Vaid-ya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G: Tolllike receptors induce a phagocytic gene program through p38. J Exp Med 2004; 199:81-90.
39. Ferreira R, Santos T, Viegas M, Cortes L, Bernardino L, Vieira OV, Malva JO: Neuropep-tide Y inhibits interleukin-1beta-induced phagocytosis by microglial cells. J Neuroin-flammation 2011; 8:169.
40. Henan X, Toyota N, Yanjiang X, Fujita Y, Zh-ijun H, Touma M, Qiong W, Sugimoto K: Enhancement of phagocytosis and cytotoxicity in macrophages by tumor-derived IL-18 stimulation. BMB Rep 2013, Epub ahead of print.