Artemisinin protects against dextran sulfate-sodium-induced inflammatory bowel disease, which is associated with activation of the pregnane X receptor

European Journal of Pharmacology

Volumn 738, Issue , 2014, Pages 273-284

  Hu, Donghua ^a   Wang, Yuguang ^b   Chen, Zhiwu ^a   Ma, Zengchun ^b   You, Qing ^b   Zhang, Xianxie ^b   Zhou, Tao ^b   Xiao, Yong ^b   Liang, Qiande ^b   Tan, Hongling ^b   Xiao, Chengrong ^b   Tang, Xianglin ^b   Zhang, Boli ^c   Gao, Yue ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Artemisinin; Cytochrome 3A; Dextran sodium sulfate; Inflammatory bowel disease; Pregnane X receptor

Indexed keywords

ARTEMISININ; CYTOCHROME P450 3A4; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PREGNANE X RECEPTOR; ARTEMISININ DERIVATIVE; CYTOCHROME P450 3A; LIGAND; MESSENGER RNA; STEROID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYP3A4 GENE; DISEASE SEVERITY; DRUG EFFICACY; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; GENE; GENE INDUCTION; HUMAN; HUMAN CELL; INFLAMMATORY BOWEL DISEASE; MALE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; PXR MRNA GENE; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; ANIMAL; CHEMICALLY INDUCED; COLON; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; INFLAMMATORY BOWEL DISEASES; METABOLISM; PATHOLOGY; TIME; TUMOR CELL LINE;

ANIMALS; ARTEMISININS; CELL LINE, TUMOR; COLITIS; COLON; CYTOCHROME P-450 CYP3A; DEXTRAN SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HUMANS; INFLAMMATORY BOWEL DISEASES; LIGANDS; MALE; MICE; NF-KAPPA B; RECEPTORS, STEROID; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84902749224     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.04.050     Document Type: Article

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