The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease

Journal of Hematology and Oncology

Volumn 7, Issue 1, 2014, Pages

  Gustafsson, Karin ^a   Jamalpour, Maria ^a   Trinh, Camilla ^a   Kharas, Michael G ^b   Welsh, Michael ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

BCR ABL; Chronic myeloid leukemia; Focal adhesion kinase; Neutrophilia; Shb

Indexed keywords

ANGIOPOIETIN 2; BCR ABL PROTEIN; CASPASE 3; CHEMOKINE RECEPTOR CXCR4; COLONY STIMULATING FACTOR; FOCAL ADHESION KINASE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; METHYLCELLULOSE; PROTEIN SH2; SRC HOMOLOGY 2 DOMAIN PROTEIN B; STAT5 PROTEIN; STROMAL CELL DERIVED FACTOR 1; THROMBOPOIETIN; UNCLASSIFIED DRUG; CYTOKINE; RETROVIRUS VECTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD CELL; BLOOD CELL COUNT; BONE MARROW CELL; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DISEASE COURSE; FLOW CYTOMETRY; GRANULOCYTE; LEUKEMOGENESIS; LEUKOCYTE; MOUSE; MYELOPROLIFERATIVE DISORDER; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; WEIGHT REDUCTION; WESTERN BLOTTING; CANCER GROWTH; CELL EXPANSION; CHRONIC MYELOID LEUKEMIA; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE INACTIVATION; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR PROMOTION; WILD TYPE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; DISEASE PROGRESSION; FLOW CYTOMETRY; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION; GRANULOCYTE COLONY-STIMULATING FACTOR; INTERLEUKIN-6; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOPROLIFERATIVE DISORDERS; NEUTROPENIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84902735692     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-7-45     Document Type: Article

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