Discovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABAA receptor interaction via the benzodiazepine-binding site

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 57-73

  Pejović, Anka ^a   Denić, Marija S ^b   Stevanović, Dragana ^a   Damljanović, Ivan ^a   Vukićević, Mirjana ^a   Kostova, Kalina ^c   Tavlinova Kirilova, Maya ^c   Randjelović, Pavle ^b   Stojanović, Nikola M ^b   Bogdanović, Goran A ^d   Blagojević, Polina ^b   D'Hooghe, Matthias ^e   Radulović, Niko S ^b   Vukićević, Rastko D ^a  

^a UNIVERSITY OF KRAGUJEVAC   (Serbia)

^b UNIVERSITY OF NI   (Serbia)

^c INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^d UNIVERSITY OF BELGRADE   (Serbia)

^e GHENT UNIVERSITY   (Belgium)

Author keywords

2 Ferrocenyl 1,3 thiazolidin 4 ones; Anxiolytic agents; Ligand docking

Indexed keywords

2 FERROCENYL 3 (4 METHOXYPHENETHYL) 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 (M TOLYL) 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 (P TOLYL) 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 FURFURYL 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 HEXYL 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 OCTYL 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 PENTYL 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 PHENYL 1,3 THIAZOLIDIN 4 ONE; 2 FERROCENYL 3 THENYL 1,3 THIAZOLIDIN 4 ONE; 3 BENZYL 2 FERROCENYL 1,3 THIAZOLIDIN 4 ONE; 3 BUTYL 2 FERROCENYL 1,3 THIAZOLIDIN 4 ONE; 3 DODECYL 2 FERROCENYL 1,3 THIAZOLIDIN 4 ONE; 3 HEXADECYL 2 FERROCENYL 1,3 THIAZOLIDIN 4 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; BENZODIAZEPINE; DIAZEPAM; FERROCENE; FLUMAZENIL; UNCLASSIFIED DRUG; 2-FERROCENYL-2-THIAZOLINE; BENZODIAZEPINE DERIVATIVE; FERROUS ION; PROTEIN BINDING; FERROCENE DERIVATIVE; ISONIAZID; PENTETRAZOLE; PICROTOXIN; THIAZOLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG SYNTHESIS; ELECTROCHEMICAL ANALYSIS; IN VIVO STUDY; LIBRARY; MOLECULAR DOCKING; MOUSE; NONHUMAN; SPECTROSCOPY; SUBSTITUTION REACTION; ANIMAL; BINDING SITE; CHEMISTRY; DRUG DESIGN; ELECTROCHEMISTRY; MALE; METABOLISM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY; ANTICONVULSANT ACTIVITY; ANXIETY; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; CYCLIC POTENTIOMETRY; DRUG SCREENING; GABAERGIC SYSTEM; GEOMETRY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; INFRARED RADIATION; LIPOPHILICITY; LOCOMOTION; MASS SPECTROMETRY; MOTOR ACTIVITY; NUCLEAR OVERHAUSER EFFECT; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ELECTROCHEMISTRY; FERROUS COMPOUNDS; MALE; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, GABA-A;

EID: 84902679997     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.062     Document Type: Article

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