메뉴 건너뛰기




Volumn 140, Issue 1, 2012, Pages 46-54

Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract

Author keywords

Achillea millefolium; Anti anxiety agents; Anxiety; Apigenin; Flumazenil; GABA antagonist; Picrotoxin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACHILLEA MILLEFOLIUM EXTRACT; ALCOHOL; APIGENIN; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; PICROTOXIN;

EID: 84857116235     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.047     Document Type: Article
Times cited : (72)

References (55)
  • 1
    • 0035661051 scopus 로고    scopus 로고
    • Tratamento farmacológico do transtorno de ansiedade generalizada: Perspectivas futuras
    • R. Andreatini, R. Boerngen-Lacerda, and D. Zorzetto Filho Tratamento farmacológico do transtorno de ansiedade generalizada: perspectivas futuras Pharmacological treatment of generalized anxiety disorder: future perspectives Revista Brasileira de Psiquiatria 23 2001 233 242 (Pubitemid 34015369)
    • (2001) Revista Brasileira de Psiquiatria , vol.23 , Issue.4 , pp. 233-242
    • Andreatini, R.1    Boerngen-Lacerda, R.2    Filho, D.Z.3
  • 2
    • 79958155497 scopus 로고    scopus 로고
    • Yarrow (Achillea millefolium L.): A neglected panacea? A review of ethnobotany, bioactivity, and biomedical research
    • W.L. Applequist, and D.E. Moerman Yarrow (Achillea millefolium L.): a neglected panacea? A review of ethnobotany, bioactivity, and biomedical research Economic Botany 65 2011 209 225
    • (2011) Economic Botany , vol.65 , pp. 209-225
    • Applequist, W.L.1    Moerman, D.E.2
  • 3
    • 0034213864 scopus 로고    scopus 로고
    • Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla
    • DOI 10.1016/S0006-2952(00)00264-1, PII S0006295200002641
    • R. Avallone, P. Zanoli, G. Puia, M. Kleinschnitz, P. Schreier, and M. Baraldi Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla Biochemical Pharmacology 59 2000 1387 1394 (Pubitemid 30177355)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.11 , pp. 1387-1394
    • Avallone, R.1    Zanoli, P.2    Puia, G.3    Kleinschnitz, M.4    Schreier, P.5    Baraldi, M.6
  • 4
    • 58049130013 scopus 로고    scopus 로고
    • GABA-A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts
    • D. Benke, A. Barberis, S. Kopp, K.H. Altmann, M. Schubiger, K.E. Vogt, U. Rudolph, and H. Möhler GABA-A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts Neuropharmacology 56 2009 174 181
    • (2009) Neuropharmacology , vol.56 , pp. 174-181
    • Benke, D.1    Barberis, A.2    Kopp, S.3    Altmann, K.H.4    Schubiger, M.5    Vogt, K.E.6    Rudolph, U.7    Möhler, H.8
  • 5
    • 0036053186 scopus 로고    scopus 로고
    • Do animal models of anxiety predict anxiolytic-like effects of antidepressants?
    • DOI 10.1007/s00213-002-1155-6
    • F. Borsini, J. Podhorna, and D. Marazziti Do animal models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology (Berlin) 163 2002 121 141 (Pubitemid 35013604)
    • (2002) Psychopharmacology , vol.163 , Issue.2 , pp. 121-141
    • Borsini, F.1    Podhorna, J.2    Marazziti, D.3
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Analytical Biochemistry 72 1976 248 254
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 9
    • 0043199852 scopus 로고    scopus 로고
    • Plants and the central nervous system
    • DOI 10.1016/S0091-3057(03)00112-6
    • E.A. Carlini Plants and the central nervous system Pharmacology Biochemistry and Behavior 75 2003 501 512 (Pubitemid 36936886)
    • (2003) Pharmacology Biochemistry and Behavior , vol.75 , Issue.3 , pp. 501-512
    • Carlini, E.A.1
  • 10
    • 26844489352 scopus 로고    scopus 로고
    • Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on
    • DOI 10.1016/j.neubiorev.2005.04.017, PII S0149763405000680
    • A.P. Carobrez, and L.J. Bertoglio Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on Neuroscience and Biobehavioral Reviews 29 2005 1193 1205 (Pubitemid 41446895)
    • (2005) Neuroscience and Biobehavioral Reviews , vol.29 , Issue.8 , pp. 1193-1205
    • Carobrez, A.P.1    Bertoglio, L.J.2
  • 11
    • 0020360344 scopus 로고
    • Herbal remedies of the maritime Indians: Sterols and triterpenes of Achillea millefolium L. (Yarrow)
    • DOI 10.1002/jps.2600710621
    • R.F. Chandler, S.N. Hooper, D.L. Hooper, W.D. Jamieson, C.G. Flinn, and L.M. Safe Herbal remedies of the Maritime Indians: sterols and triterpenes of A. millefolium L. (Yarrow) Journal of Pharmaceutical Sciences 71 1982 690 693 (Pubitemid 13228325)
    • (1982) Journal of Pharmaceutical Sciences , vol.71 , Issue.6 , pp. 690-693
    • Chandler, R.F.1    Hooper, S.N.2    Hooper, D.L.3
  • 12
    • 0027139227 scopus 로고
    • An ethological analysis of the effects of chlordiazepoxide and bretazenil (Ro 16-6028) in the murine elevated plus-maze
    • J.C. Cole, and R.J. Rodgers An ethological analysis of the effects of chlordiazepoxide and bretazenil (Ro 16-6028) in the murine elevated plus-maze Behavioural Pharmacology 4 1993 573 580 (Pubitemid 24002272)
    • (1993) Behavioural Pharmacology , vol.4 , Issue.6 , pp. 573-580
    • Cole, J.C.1    Rodgers, R.J.2
  • 13
    • 80052035823 scopus 로고    scopus 로고
    • The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass)
    • C.A. Costa, D.O. Kohn, V.M. de Lima, A.C. Gargano, J.C. Flório, and M. Costa The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass) Journal of Ethnopharmacology 137 2011 828 836
    • (2011) Journal of Ethnopharmacology , vol.137 , pp. 828-836
    • Costa, C.A.1    Kohn, D.O.2    De Lima, V.M.3    Gargano, A.C.4    Flório, J.C.5    Costa, M.6
  • 14
    • 0027932914 scopus 로고
    • Ethopharmacological analysis of rat behavior on the elevated plus-maze
    • DOI 10.1016/0091-3057(94)90472-3
    • A.P. Cruz, F. Frei, and F.G. Graeff Ethopharmacological analysis of rat behavior on the elevated plus-maze Pharmacology, Biochemistry and Behavior 49 1994 171 176 (Pubitemid 24297273)
    • (1994) Pharmacology Biochemistry and Behavior , vol.49 , Issue.1 , pp. 171-176
    • Cruz, A.P.M.1    Frei, F.2    Graeff, F.G.3
  • 15
    • 3342889700 scopus 로고    scopus 로고
    • Reproductive evaluation of aqueous crude extract of Achillea millefolium L. (Asteraceae) in Wistar rats
    • DOI 10.1016/j.reprotox.2004.04.011, PII S089062380400098X
    • P.R. Dalsenter, A.M. Cavalcanti, A.J. Andrade, S.L. Araujo, and M.C. Marques Reproductive evaluatioin of aqueous crude extract of A. millefolium L. (Asteraceae) in Wistar rats Reproductive Toxicology 18 2004 819 823 (Pubitemid 38987969)
    • (2004) Reproductive Toxicology , vol.18 , Issue.6 , pp. 819-823
    • Dalsenter, P.R.1    Cavalcanti, A.M.2    Andrade, A.J.M.3    Araujo, S.L.4    Marques, M.C.A.5
  • 16
    • 34248208273 scopus 로고    scopus 로고
    • Possible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental models
    • DOI 10.1002/ptr.2079
    • P.C. de Castro, A. Hoshino, J.C. da Silva, and F.R. Mendes Possible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental models Phytotherapy Research 21 2007 481 484 (Pubitemid 46715092)
    • (2007) Phytotherapy Research , vol.21 , Issue.5 , pp. 481-484
    • De Castro, P.C.F.1    Hoshino, A.2    Da Silva, J.C.3    Mendes, F.R.4
  • 18
    • 43149095155 scopus 로고    scopus 로고
    • Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: In vitro and in vivo interactions with benzodiazepine binding sites
    • F.S. Duarte, M. Marder, A.A. Hoeller, M. Duzzioni, B.G. Mendes, M.G. Pizzolatti, and T.C. De Lima Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites Psychopharmacology (Berlin) 197 2008 351 360
    • (2008) Psychopharmacology (Berlin) , vol.197 , pp. 351-360
    • Duarte, F.S.1    Marder, M.2    Hoeller, A.A.3    Duzzioni, M.4    Mendes, B.G.5    Pizzolatti, M.G.6    De Lima, T.C.7
  • 19
    • 33646489170 scopus 로고    scopus 로고
    • Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze
    • P.A. Dombrowski, L.H. Fernandes, and R. Andreatini Picrotoxin blocks the anxiolytic- and panicolytic-like effects of sodium valproate in the rat elevated T-maze European Journal of Pharmacology 537 2006 72 76
    • (2006) European Journal of Pharmacology , vol.537 , pp. 72-76
    • Dombrowski, P.A.1    Fernandes, L.H.2    Andreatini, R.3
  • 20
    • 84857117395 scopus 로고    scopus 로고
    • European Medicines Agency EMA/HMPC/149343/2010. Available at: (accessed 10.11.11)
    • European Medicines Agency, 2011. Assessment report on Achillea millefolium L.; EMA/HMPC/149343/2010. Available at: http://www.ema.europa.eu/ docs/en-GB/document-library/Herbal-HMPC-assessment-report/2011/09/WC500115467. pdf (accessed 10.11.11).
    • (2011) Assessment Report on Achillea Millefolium L.
  • 21
    • 79851486426 scopus 로고    scopus 로고
    • Plantas medicinais no tratamento do transtorno de ansiedade generalizada: Uma revisão dos estudos clínicos controlados
    • Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies
    • T.T. Faustino, R.B. Almeida, and R. Andreatini Plantas medicinais no tratamento do transtorno de ansiedade generalizada: uma revisão dos estudos clínicos controlados Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies Revista Brasileira de Psiquiatria 32 2010 429 436
    • (2010) Revista Brasileira de Psiquiatria , vol.32 , pp. 429-436
    • Faustino, T.T.1    Almeida, R.B.2    Andreatini, R.3
  • 24
    • 0033063823 scopus 로고    scopus 로고
    • The scientific basis for the reputed activity of valerian
    • DOI 10.1211/0022357991772772
    • P.J. Houghton The scientific basis for the reputed activity of Valerian Journal of Pharmacy and Pharmacology 51 1999 505 512 (Pubitemid 29319774)
    • (1999) Journal of Pharmacy and Pharmacology , vol.51 , Issue.5 , pp. 505-512
    • Houghton, P.J.1
  • 25
    • 0038005574 scopus 로고    scopus 로고
    • 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties
    • DOI 10.1016/S0006-2952(03)00233-8
    • M.S. Huen, J.W. Leung, W. Ng, W.S. Lui, M.N. Chan, J.T. Wong, and H. Xue 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties Biochemical Pharmacology 66 2003 125 132 (Pubitemid 36724906)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.1 , pp. 125-132
    • Huen, M.S.Y.1    Leung, J.W.C.2    Ng, W.3    Lui, W.S.4    Chan, M.N.S.5    Wong, J.T.-F.6    Xue, H.7
  • 27
    • 0023255981 scopus 로고
    • The use of a plus-maze to measure anxiety in the mouse
    • R.G. Lister The use of a plus maze to measure anxiety in the mouse Psychopharmacology (Berlin) 92 1987 180 185 (Pubitemid 17072893)
    • (1987) Psychopharmacology , vol.92 , Issue.2 , pp. 180-185
    • Lister, R.G.1
  • 28
    • 34147093036 scopus 로고    scopus 로고
    • A-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice
    • DOI 10.1016/j.jep.2006.11.021, PII S0378874106006246
    • L.F. Lolli, C.M. Sato, C.V. Romanini, B. Villas-Boas L. de, C.A. Santos, and R.M. de Oliveira Possible involvement of GABA A-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice Journal of Ethnopharmacology 111 2007 308 314 (Pubitemid 46553717)
    • (2007) Journal of Ethnopharmacology , vol.111 , Issue.2 , pp. 308-314
    • Lolli, L.F.1    Sato, C.M.2    Romanini, C.V.3    Villas-Boas, L.D.B.4    Santos, C.A.M.5    Oliveira, R.M.W.D.6
  • 29
    • 0031926310 scopus 로고    scopus 로고
    • Investigative burying by laboratory mice may involve non-functional, compulsive, behaviour
    • DOI 10.1016/S0166-4328(97)00162-9, PII S0166432897001629
    • T. Londei, A.M. Valentini, and V.G. Leone Investigative burying by laboratory mice may involve non-functional, compulsive, behaviour Behavioural Brain Research 94 1998 249 254 (Pubitemid 28352825)
    • (1998) Behavioural Brain Research , vol.94 , Issue.2 , pp. 249-254
    • Londei, T.1    Valentini, A.M.V.2    G. Leone, V.3
  • 31
    • 15444365574 scopus 로고    scopus 로고
    • A meta-analytic review of the efficacy of drug treatment in generalized anxiety disorder
    • DOI 10.1097/01.jcp.0000155821.74832.f9
    • K. Mitte, P. Noack, R. Steil, and M. Hautzinger A meta-analytic review of the efficacy of drug treatment in generalized anxiety disorder Journal of Clinical Psychopharmacology 25 2005 141 150 (Pubitemid 40395092)
    • (2005) Journal of Clinical Psychopharmacology , vol.25 , Issue.2 , pp. 141-150
    • Mitte, K.1    Noack, P.2    Steil, R.3    Hautzinger, M.4
  • 32
    • 11144222613 scopus 로고    scopus 로고
    • Anticonflict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats
    • DOI 10.1002/ptr.1578
    • M. Molina-Hernandez, N.P. Tellez-Alcantara, M.A. Diaz, J. Perez Garcia, J.I. Olivera Lopez, and M.T. Jaramillo Anticonflict actions of aqueous extracts of flowers of A. millefolium L. vary according to the estrous cycle phases in Wistar rats Phytotherapy Research 18 2004 915 920 (Pubitemid 40052770)
    • (2004) Phytotherapy Research , vol.18 , Issue.11 , pp. 915-920
    • Molina-Hernandez, M.1    Tellez-Alcantara, N.P.2    Diaz, M.A.3    Perez Garcia, J.4    Olivera Lopez, J.I.5    Jaramillo, M.T.6
  • 33
    • 33748572264 scopus 로고    scopus 로고
    • A combined marble burying-locomotor activity test in mice: A practical screening test with sensitivity to different classes of anxiolytics and antidepressants
    • DOI 10.1016/j.ejphar.2006.07.015, PII S0014299906007655
    • L.B. Nicolas, Y. Kolb, and E.P. Prinssen A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants Europena Journal of Pharmacology 547 2006 106 115 (Pubitemid 44373902)
    • (2006) European Journal of Pharmacology , vol.547 , Issue.1-3 , pp. 106-115
    • Nicolas, L.B.1    Kolb, Y.2    Prinssen, E.P.M.3
  • 34
    • 0025866052 scopus 로고
    • Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; A putative test for anxiolytic agents
    • K. Njung'e, and S.L. Handley Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents British Journal of Pharmacology 104 1991 105 112
    • (1991) British Journal of Pharmacology , vol.104 , pp. 105-112
    • Njung'E, K.1    Handley, S.L.2
  • 35
    • 0033029485 scopus 로고    scopus 로고
    • Flavonoids and the central nervous system: From forgotten factors to potent anxiolytic compounds
    • DOI 10.1211/0022357991772790
    • A.C. Paladini, M. Marder, H. Viola, C. Wolfman, C. Wasowski, and J.H. Medina Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds Journal of Pharmacy and Pharmacology 51 1999 519 526 (Pubitemid 29319776)
    • (1999) Journal of Pharmacy and Pharmacology , vol.51 , Issue.5 , pp. 519-526
    • Paladini, A.C.1    Marder, M.2    Viola, H.3    Wolfman, C.4    Wasowski, C.5    Medina, J.H.6
  • 36
    • 0022620470 scopus 로고
    • Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat
    • S. Pellow, and S.E. File Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat Pharmacology Biochemistry and Behavior 24 1986 525 529 (Pubitemid 16145187)
    • (1986) Pharmacology Biochemistry and Behavior , vol.24 , Issue.3 , pp. 525-529
    • Pellow, S.1    File, S.E.2
  • 37
    • 59449106529 scopus 로고    scopus 로고
    • Antinociceptive peripheral effect of A. millefolium L. and Artemisia vulgaris L.: Both plants known popularly by brand names of analgesic drugs
    • J.M. Pires, F.R. Mendes, G. Negri, J.M. Duarte-Almeida, and E.A. Carlini Antinociceptive peripheral effect of A. millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs Phytotherapy Research 23 2009 212 219
    • (2009) Phytotherapy Research , vol.23 , pp. 212-219
    • Pires, J.M.1    Mendes, F.R.2    Negri, G.3    Duarte-Almeida, J.M.4    Carlini, E.A.5
  • 40
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • DOI 10.1096/fj.07-9574LSF
    • S. Reagan-Shaw, M. Nihal, and N. Ahmad Dose translation from animal to human studies revisited FASEB Journal 22 2008 659 661 (Pubitemid 351348146)
    • (2008) FASEB Journal , vol.22 , Issue.3 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 41
    • 0029852005 scopus 로고    scopus 로고
    • Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti stress activity of neurosteroids in mice
    • DOI 10.1007/s002130050136
    • D.S. Reddy, and S.K. Kulkarni Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice Psychopharmacology (Berlin) 128 1996 280 292 (Pubitemid 26403124)
    • (1996) Psychopharmacology , vol.128 , Issue.3 , pp. 280-292
    • Reddy, D.S.1    Kulkarni, S.K.2
  • 42
    • 0002358097 scopus 로고
    • The elevated plus-maze: Pharmacology, methodology and ethology
    • S.J. Cooper, C.A. Hendrie, J. Wiley & Sons Ltd. Chichester
    • R.J. Rodgers, and J.C. Cole The elevated plus-maze: pharmacology, methodology and ethology S.J. Cooper, C.A. Hendrie, Ethology and Psychopharmacology 1994 J. Wiley & Sons Ltd. Chichester 9 44
    • (1994) Ethology and Psychopharmacology , pp. 9-44
    • Rodgers, R.J.1    Cole, J.C.2
  • 44
    • 0030782744 scopus 로고    scopus 로고
    • Anxiety, defence and the elevated plus-maze
    • DOI 10.1016/S0149-7634(96)00058-9, PII S0149763496000589
    • R.J. Rodgers, and A. Dalvi Anxiety, defence and the elevated plus-maze Neuroscience Biobehavioral Reviews 21 1997 801 810 (Pubitemid 27524775)
    • (1997) Neuroscience and Biobehavioral Reviews , vol.21 , Issue.6 , pp. 801-810
    • Rodgers, R.J.1    Dalvi, A.2
  • 45
    • 0029083245 scopus 로고
    • Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety
    • R.J. Rodgers, and N.J. Johnson Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety Pharmacology Biochemical and Behavior 52 1995 297 303
    • (1995) Pharmacology Biochemical and Behavior , vol.52 , pp. 297-303
    • Rodgers, R.J.1    Johnson, N.J.2
  • 46
    • 2942625690 scopus 로고    scopus 로고
    • Effect of Hypericum perforatum on marble-burying by mice
    • DOI 10.1002/ptr.1450
    • L.L. Skalisz, V. Beijamini, and R. Andreatini Effect of Hypericum perforatum on marble-burying by mice Phytotherapy Research 18 2004 399 402 (Pubitemid 38758244)
    • (2004) Phytotherapy Research , vol.18 , Issue.5 , pp. 399-402
    • Skalisz, L.L.1    Beijamini, V.2    Andreatini, R.3
  • 47
  • 48
  • 54
    • 0038223755 scopus 로고    scopus 로고
    • Millefolii herba
    • M. Wichtl, fouth ed. Wiss. Verlagsgesellschaft Stuttgart
    • G. Willuhn Millefolii herba M. Wichtl, Teedrogen und Phytopharmaka fouth ed. 2002 Wiss. Verlagsgesellschaft Stuttgart 399 403
    • (2002) Teedrogen und Phytopharmaka , pp. 399-403
    • Willuhn, G.1
  • 55
    • 0034255092 scopus 로고    scopus 로고
    • Behavioral characterisation of the flavonoids apigenin and chrysin
    • P. Zanoli, R. Avallone, and M. Baraldi Behavioral characterisation of the flavonoids apigenin and chrysin Fitoterapia 71 2000 S117 S123
    • (2000) Fitoterapia , vol.71
    • Zanoli, P.1    Avallone, R.2    Baraldi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.