-
1
-
-
84887611976
-
Targeting the ubiquitin proteasome system in haematological malignancies
-
Crawford LJ, Irvine AE. Targeting the ubiquitin proteasome system in haematological malignancies. Blood Rev 2013;27:297-304.
-
(2013)
Blood Rev
, vol.27
, pp. 297-304
-
-
Crawford, L.J.1
Irvine, A.E.2
-
2
-
-
84875231510
-
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?
-
Nathan JA, Kim HT, Ting L, Gygi SP, Goldberg AL. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J 2013;32:552-65.
-
(2013)
EMBO J
, vol.32
, pp. 552-565
-
-
Nathan, J.A.1
Kim, H.T.2
Ting, L.3
Gygi, S.P.4
Goldberg, A.L.5
-
3
-
-
63649113699
-
Origin and function of ubiquitin-like proteins
-
Hochstrasser M. Origin and function of ubiquitin-like proteins. Nature 2009;458:422-9.
-
(2009)
Nature
, vol.458
, pp. 422-429
-
-
Hochstrasser, M.1
-
4
-
-
84875981508
-
Role of ubiquitin ligases and the proteasome in oncogenesis: Novel targets for anticancer therapies
-
Micel LN, Tentler JJ, Smith PG, Eckhardt GS. Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies. J Clin Oncol 2013;31:1231-8.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1231-1238
-
-
Micel, L.N.1
Tentler, J.J.2
Smith, P.G.3
Eckhardt, G.S.4
-
5
-
-
34748860356
-
Epidermal growth factor receptor degradation: An alternative view of oncogenic pathways
-
DOI 10.1016/j.biocel.2007.07.012, PII S1357272507002506
-
Kirisits A, Pils D, Krainer M. Epidermal growth factor receptor degradation: an alternative view of oncogenic pathways. Int J Biochem Cell Biol 2007;39:2173-82. (Pubitemid 47484288)
-
(2007)
International Journal of Biochemistry and Cell Biology
, vol.39
, Issue.12
, pp. 2173-2182
-
-
Kirisits, A.1
Pils, D.2
Krainer, M.3
-
6
-
-
0032135131
-
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation
-
Desterro JM, Rodriguez MS, Hay RT. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell 1998;2:233-9. (Pubitemid 128373648)
-
(1998)
Molecular Cell
, vol.2
, Issue.2
, pp. 233-239
-
-
Desterro, J.M.P.1
Rodriguez, M.S.2
Hay, R.T.3
-
7
-
-
84878579784
-
Sumoylation in neurodegenerative diseases
-
Krumova P, Weishaupt JH. Sumoylation in neurodegenerative diseases. Cell Mol Life Sci 2013;70:2123-38.
-
(2013)
Cell Mol Life Sci
, vol.70
, pp. 2123-2138
-
-
Krumova, P.1
Weishaupt, J.H.2
-
8
-
-
84888617317
-
Control of nuclear activities by substrate-selective and protein-group SUMOylation
-
Jentsch S, Psakhye I. Control of nuclear activities by substrate-selective and protein-group SUMOylation. Annu Rev Genet 2013;47:167-86.
-
(2013)
Annu Rev Genet
, vol.47
, pp. 167-186
-
-
Jentsch, S.1
Psakhye, I.2
-
9
-
-
84887850498
-
Sumoylation in gene regulation, human disease, and therapeutic action
-
Yang XJ, Chiang CM. Sumoylation in gene regulation, human disease, and therapeutic action. F1000Prime Rep 2013;5:45.
-
(2013)
F1000Prime Rep
, vol.5
, pp. 45
-
-
Yang, X.J.1
Chiang, C.M.2
-
10
-
-
84888016188
-
The antiviral activities of ISG15
-
Morales DJ, Lenschow DJ. The antiviral activities of ISG15. J Mol Biol 2013;425:4995-5008.
-
(2013)
J Mol Biol
, vol.425
, pp. 4995-5008
-
-
Morales, D.J.1
Lenschow, D.J.2
-
11
-
-
77953114765
-
The ISG15 conjugation system broadly targets newly synthesized proteins: Implications for the antiviral function of ISG15
-
Durfee LA, Lyon N, Seo K, Huibregtse JM. The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15. Mol Cell 2010;38:722-32.
-
(2010)
Mol Cell
, vol.38
, pp. 722-732
-
-
Durfee, L.A.1
Lyon, N.2
Seo, K.3
Huibregtse, J.M.4
-
13
-
-
77951651753
-
The family of ubiquitin-conjugating enzymes (E2s): Deciding between life and death of proteins
-
van Wijk SJ, Timmers HT. The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins. FASEB J 2010;24:981-93.
-
(2010)
FASEB J
, vol.24
, pp. 981-993
-
-
Van Wijk, S.J.1
Timmers, H.T.2
-
14
-
-
44949231368
-
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling
-
Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, et al. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE 2008;3:e1487.
-
(2008)
PLoS ONE
, vol.3
-
-
Li, W.1
Bengtson, M.H.2
Ulbrich, A.3
Matsuda, A.4
Reddy, V.A.5
Orth, A.6
-
15
-
-
84860496378
-
The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis
-
Lau AW, Fukushima H, Wei W. The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed) 2012;17:2197-212.
-
(2012)
Front Biosci (Landmark Ed)
, vol.17
, pp. 2197-2212
-
-
Lau, A.W.1
Fukushima, H.2
Wei, W.3
-
16
-
-
0030602813
-
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
-
DOI 10.1016/S0092-8674(00)80098-7
-
Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 1996;86:263-74. (Pubitemid 26286109)
-
(1996)
Cell
, vol.86
, Issue.2
, pp. 263-274
-
-
Chang, B.1
Partha, S.2
Hofmann, K.3
Lei, M.4
Goebl, M.5
Harper, J.W.6
Elledge, S.J.7
-
17
-
-
78049264771
-
The 26S proteasome: Assembly and function of a destructive machine
-
Gallastegui N, Groll M. The 26S proteasome: assembly and function of a destructive machine. Trends Biochem Sci 2010;35:634-42.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 634-642
-
-
Gallastegui, N.1
Groll, M.2
-
18
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
19
-
-
84883590611
-
Pirh2: An E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation
-
Halaby MJ, Hakem R, Hakem A. Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation. Cell Cycle 2013;12:2733-7.
-
(2013)
Cell Cycle
, vol.12
, pp. 2733-2737
-
-
Halaby, M.J.1
Hakem, R.2
Hakem, A.3
-
20
-
-
10744221485
-
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
-
DOI 10.1126/science.1092472
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8. (Pubitemid 38174664)
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
21
-
-
80053504901
-
A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors
-
Tabernero J, Dirix L, Schoffski P, Cervantes A, Lopez-Martin JA, Capdevila J, et al. A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors. Clin Cancer Res 2011;17:6313-21.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6313-6321
-
-
Tabernero, J.1
Dirix, L.2
Schoffski, P.3
Cervantes, A.4
Lopez-Martin, J.A.5
Capdevila, J.6
-
22
-
-
80053941516
-
Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts
-
Chargari C, Leteur C, Angevin E, Bashir T, Schoentjes B, Arts J, et al. Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts. Cancer Lett 2011;312:209-18.
-
(2011)
Cancer Lett
, vol.312
, pp. 209-218
-
-
Chargari, C.1
Leteur, C.2
Angevin, E.3
Bashir, T.4
Schoentjes, B.5
Arts, J.6
-
23
-
-
72549094296
-
An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals
-
Mohammad RM, Wu J, Azmi AS, Aboukameel A, Sosin A, Wu S, et al. An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals. Mol Cancer 2009;8:115.
-
(2009)
Mol Cancer
, vol.8
, pp. 115
-
-
Mohammad, R.M.1
Wu, J.2
Azmi, A.S.3
Aboukameel, A.4
Sosin, A.5
Wu, S.6
-
24
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
DOI 10.1038/nature737
-
Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002;416:648-53. (Pubitemid 34406767)
-
(2002)
Nature
, vol.416
, Issue.6881
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
Luo, J.4
Nikolaev, A.Y.5
Qin, J.6
Gu, W.7
-
25
-
-
75749132016
-
USP10 regulates p53 localization and stability by deubiquitinating p53
-
Yuan J, Luo K, Zhang L, Cheville JC, Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 2010;140:384-96.
-
(2010)
Cell
, vol.140
, pp. 384-396
-
-
Yuan, J.1
Luo, K.2
Zhang, L.3
Cheville, J.C.4
Lou, Z.5
-
26
-
-
84866021069
-
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
-
Chauhan D, Tian Z, Nicholson B, Kumar KG, Zhou B, Carrasco R, et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell 2012;22:345-58.
-
(2012)
Cancer Cell
, vol.22
, pp. 345-358
-
-
Chauhan, D.1
Tian, Z.2
Nicholson, B.3
Kumar, K.G.4
Zhou, B.5
Carrasco, R.6
-
27
-
-
33847212425
-
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
-
Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J 2007;26:976-86.
-
(2007)
EMBO J
, vol.26
, pp. 976-986
-
-
Stevenson, L.F.1
Sparks, A.2
Allende-Vega, N.3
Xirodimas, D.P.4
Lane, D.P.5
Saville, M.K.6
-
28
-
-
84881290170
-
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway
-
Dar A, Shibata E, Dutta A. Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway. Mol Cell Biol 2013;33:3309-20.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 3309-3320
-
-
Dar, A.1
Shibata, E.2
Dutta, A.3
-
29
-
-
48949116102
-
FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias
-
Song JH, Schnittke N, Zaat A, Walsh CS, Miller CW. FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. Leuk Res 2008;32:1751-5.
-
(2008)
Leuk Res
, vol.32
, pp. 1751-1755
-
-
Song, J.H.1
Schnittke, N.2
Zaat, A.3
Walsh, C.S.4
Miller, C.W.5
-
30
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
DOI 10.1158/0008-5472.CAN-07-1320
-
Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, Maljukova A, et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 2007;67:9006-12. (Pubitemid 47535882)
-
(2007)
Cancer Research
, vol.67
, Issue.19
, pp. 9006-9012
-
-
Akhoondi, S.1
Sun, D.2
Von Der, L.N.3
Apostolidou, S.4
Klotz, K.5
Maljukova, A.6
Cepeda, D.7
Fiegl, H.8
Dofou, D.9
Marth, C.10
Mueller-Holzner, E.11
Corcoran, M.12
Dagnell, M.13
Nejad, S.Z.14
Nayer, B.N.15
Zali, M.R.16
Hansson, J.17
Egyhazi, S.18
Petersson, F.19
Sangfelt, P.20
Nordgren, H.21
Grander, D.22
Reed, S.I.23
Widschwendter, M.24
Sangfelt, O.25
Spruck, C.26
more..
-
31
-
-
84860208090
-
Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
-
Wang G, Chan CH, Gao Y, Lin HK. Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chin J Cancer 2012;31:169-77.
-
(2012)
Chin J Cancer
, vol.31
, pp. 169-177
-
-
Wang, G.1
Chan, C.H.2
Gao, Y.3
Lin, H.K.4
-
32
-
-
62549108186
-
Inhibitor of apoptosis proteins in hematological malignancies
-
Fulda S. Inhibitor of apoptosis proteins in hematological malignancies. Leukemia 2009;23:467-76.
-
(2009)
Leukemia
, vol.23
, pp. 467-476
-
-
Fulda, S.1
-
33
-
-
84892758212
-
Molecular pathways: Targeting inhibitor of apoptosis proteins in cancer-from molecular mechanism to therapeutic application
-
Fulda S. Molecular pathways: targeting inhibitor of apoptosis proteins in cancer-from molecular mechanism to therapeutic application. Clin Cancer Res 2014;20:289-95.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 289-295
-
-
Fulda, S.1
-
34
-
-
84856173058
-
Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study
-
Schimmer AD, Herr W, Hanel M, Borthakur G, Frankel A, Horst HA, et al. Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study. Clin Lymphoma Myeloma Leuk 2011;11:433-8.
-
(2011)
Clin Lymphoma Myeloma Leuk
, vol.11
, pp. 433-438
-
-
Schimmer, A.D.1
Herr, W.2
Hanel, M.3
Borthakur, G.4
Frankel, A.5
Horst, H.A.6
-
35
-
-
84878847999
-
Phase I trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma
-
Mahadevan D, Chalasani P, Rensvold D, Kurtin S, Pretzinger C, Jolivet J, et al. Phase I trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma. Am J Clin Oncol 2013;36:239-43.
-
(2013)
Am J Clin Oncol
, vol.36
, pp. 239-243
-
-
Mahadevan, D.1
Chalasani, P.2
Rensvold, D.3
Kurtin, S.4
Pretzinger, C.5
Jolivet, J.6
-
36
-
-
84877095096
-
MorseMA, DeviGR.Smacmimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-alpha-independent mechanism
-
Allensworth JL, Sauer SJ, LyerlyHK,MorseMA, DeviGR.Smacmimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-alpha-independent mechanism. Breast Cancer Res Treat 2013;137:359-71.
-
(2013)
Breast Cancer Res Treat
, vol.137
, pp. 359-371
-
-
Allensworth, J.L.1
Sauer, S.J.2
Lyerly, H.K.3
-
37
-
-
84877087238
-
The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells
-
Krepler C, Chunduru SK, Halloran MB, He X, Xiao M, Vultur A, et al. The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells. Clin Cancer Res 2013;19:1784-94.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1784-1794
-
-
Krepler, C.1
Chunduru, S.K.2
Halloran, M.B.3
He, X.4
Xiao, M.5
Vultur, A.6
-
38
-
-
73849083434
-
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
-
Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, et al. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010;463:103-7.
-
(2010)
Nature
, vol.463
, pp. 103-107
-
-
Schwickart, M.1
Huang, X.2
Lill, J.R.3
Liu, J.4
Ferrando, R.5
French, D.M.6
-
39
-
-
78549247880
-
Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis
-
Kapuria V, Peterson LF, Fang D, Bornmann WG, Talpaz M, Donato NJ. Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res 2010;70:9265-76.
-
(2010)
Cancer Res
, vol.70
, pp. 9265-9276
-
-
Kapuria, V.1
Peterson, L.F.2
Fang, D.3
Bornmann, W.G.4
Talpaz, M.5
Donato, N.J.6
-
40
-
-
84869217978
-
The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
-
Peddaboina C, Jupiter D, Fletcher S, Yap JL, Rai A, Tobin RP, et al. The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition. BMC Cancer 2012;12:541.
-
(2012)
BMC Cancer
, vol.12
, pp. 541
-
-
Peddaboina, C.1
Jupiter, D.2
Fletcher, S.3
Yap, J.L.4
Rai, A.5
Tobin, R.P.6
-
41
-
-
0033034120
-
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation
-
DOI 10.1073/pnas.96.11.6273
-
Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A 1999;96:6273-8. (Pubitemid 29256655)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.11
, pp. 6273-6278
-
-
Liu, C.1
Kato, Y.2
Zhang, Z.3
Do, V.M.4
Yankner, B.A.5
He, X.6
-
42
-
-
0035947083
-
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
-
DOI 10.1016/S1097-2765(01)00241-6
-
Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, et al. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 2001;7:927-36. (Pubitemid 32525740)
-
(2001)
Molecular Cell
, vol.7
, Issue.5
, pp. 927-936
-
-
Liu, J.1
Stevens, J.2
Rote, C.A.3
Yost H.Joseph4
Hu, Y.5
Neufeld, K.L.6
White, R.L.7
Matsunami, N.8
-
43
-
-
84865712651
-
Fas-associated factor 1 is a scaffold protein that promotes beta-transducin repeat-containing protein (beta-TrCP)-mediated beta-catenin ubiquitination and degradation
-
Zhang L, Zhou F, Li Y, Drabsch Y, Zhang J, van Dam H, et al. Fas-associated factor 1 is a scaffold protein that promotes beta-transducin repeat-containing protein (beta-TrCP)-mediated beta-catenin ubiquitination and degradation. J Biol Chem 2012;287:30701-10.
-
(2012)
J Biol Chem
, vol.287
, pp. 30701-30710
-
-
Zhang, L.1
Zhou, F.2
Li, Y.3
Drabsch, Y.4
Zhang, J.5
Van Dam, H.6
-
44
-
-
84864749507
-
Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin
-
Gerard B, Sanders MA, Visscher DW, Tait L, Shekhar MP. Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin. Biochim Biophys Acta 2012;1823:1686-96.
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 1686-1696
-
-
Gerard, B.1
Sanders, M.A.2
Visscher, D.W.3
Tait, L.4
Shekhar, M.P.5
-
45
-
-
33750582313
-
Essential role of T-cell factor/beta-catenin in regulation of Rad6B: A potential mechanism for Rad6B overexpression in breast cancer cells
-
DOI 10.1158/1541-7786.MCR-06-0136
-
Shekhar MP, Tait L, Gerard B. Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. Mol Cancer Res 2006;4:729-45. (Pubitemid 44683313)
-
(2006)
Molecular Cancer Research
, vol.4
, Issue.10
, pp. 729-745
-
-
Shekhar, M.P.V.1
Tait, L.2
Gerard, B.3
-
46
-
-
84876494247
-
Novel inhibitors of Rad6 ubiquitin conjugating enzyme: Design, synthesis, identi fication, and functional characterization
-
Sanders MA, Brahemi G, Nangia-Makker P, Balan V, Morelli M, Kothayer H, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identi fication, and functional characterization. Mol Cancer Ther 2013;12:373-83.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 373-383
-
-
Sanders, M.A.1
Brahemi, G.2
Nangia-Makker, P.3
Balan, V.4
Morelli, M.5
Kothayer, H.6
-
47
-
-
84881425239
-
c-Cbl, a ubiquitin E3 ligase that targets active beta-catenin: A novel layer of Wnt signaling regulation
-
Chitalia V, Shivanna S, Martorell J, Meyer R, Edelman E, Rahimi N. c-Cbl, a ubiquitin E3 ligase that targets active beta-catenin: a novel layer of Wnt signaling regulation. J Biol Chem 2013;288:23505-17.
-
(2013)
J Biol Chem
, vol.288
, pp. 23505-23517
-
-
Chitalia, V.1
Shivanna, S.2
Martorell, J.3
Meyer, R.4
Edelman, E.5
Rahimi, N.6
-
48
-
-
79956128376
-
The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling
-
Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, et al. The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling. Mol Cell Biol 2011;31:2053-65.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2053-2065
-
-
Lui, T.T.1
Lacroix, C.2
Ahmed, S.M.3
Goldenberg, S.J.4
Leach, C.A.5
Daulat, A.M.6
-
49
-
-
0037709883
-
Von Hippel-Lindau disease
-
DOI 10.1016/S0140-6736(03)13643-4
-
Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, et al. von Hippel-Lindau disease. Lancet 2003;361:2059-67. (Pubitemid 36695052)
-
(2003)
Lancet
, vol.361
, Issue.9374
, pp. 2059-2067
-
-
Lonser, R.R.1
Glenn, G.M.2
Walther, M.3
Chew, E.Y.4
Libutti, S.K.5
Linehan, W.M.6
Oldfield, E.H.7
-
50
-
-
80052717417
-
Ubiquitylation and the Fanconi anemia pathway
-
Garner E, Smogorzewska A. Ubiquitylation and the Fanconi anemia pathway. FEBS Lett 2011;585:2853-60.
-
(2011)
FEBS Lett
, vol.585
, pp. 2853-2860
-
-
Garner, E.1
Smogorzewska, A.2
-
51
-
-
84870475682
-
Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma
-
Smetsers S, Muter J, Bristow C, Patel L, Chandler K, Bonney D, et al. Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma. Fam Cancer 2012;11:661-5.
-
(2012)
Fam Cancer
, vol.11
, pp. 661-665
-
-
Smetsers, S.1
Muter, J.2
Bristow, C.3
Patel, L.4
Chandler, K.5
Bonney, D.6
-
53
-
-
33947356281
-
+ anaplastic large cell lymphoma [16]
-
DOI 10.1038/sj.leu.2404528, PII 2404528
-
Bonvini P, Zorzi E, Basso G, Rosolen A. Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia 2007;21:838-42. (Pubitemid 46444582)
-
(2007)
Leukemia
, vol.21
, Issue.4
, pp. 838-842
-
-
Bonvini, P.1
Zorzi, E.2
Basso, G.3
Rosolen, A.4
-
54
-
-
84868614577
-
Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)
-
Hajek R, Bryce R, Ro S, Klencke B, Ludwig H. Design and rationale of FOCUS (PX-171-011): a randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM). BMC Cancer 2012;12:415.
-
(2012)
BMC Cancer
, vol.12
, pp. 415
-
-
Hajek, R.1
Bryce, R.2
Ro, S.3
Klencke, B.4
Ludwig, H.5
-
55
-
-
77950421253
-
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
-
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 2010;115:2251-9.
-
(2010)
Blood
, vol.115
, pp. 2251-2259
-
-
Xu, G.W.1
Ali, M.2
Wood, T.E.3
Wong, D.4
Maclean, N.5
Wang, X.6
-
56
-
-
84863448875
-
AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer
-
Brunckhorst MK, Lerner D, Wang S, Yu Q. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biol Ther 2012;13:804-11.
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 804-811
-
-
Brunckhorst, M.K.1
Lerner, D.2
Wang, S.3
Yu, Q.4
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