MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Jickling, Glen C ^a   Ander, Bradley P ^a   Zhan, Xinhua ^a   Noblett, Dylan ^a   Stamova, Boryana ^a   Liu, Dazhi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MICRORNA 122; MICRORNA 148A; MICRORNA 19A; MICRORNA 320D; MICRORNA 363; MICRORNA 4429; MICRORNA 487B; MICRORNA LET 7I; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; MESSENGER RNA;

ADULT; AFRICAN AMERICAN; ARTICLE; ASIAN; BLOOD CELL; BRAIN ISCHEMIA; CARDIOEMBOLIC STROKE; CARDIOVASCULAR RISK; CAUCASIAN; CLINICAL ARTICLE; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; LARGE VESSEL STROKE; LEUKOCYTE; LEUKOCYTE EXTRAVASATION SIGNALING; MALE; MICROARRAY ANALYSIS; PREDICTION; PROTHROMBIN ACTIVATOR; PROTHROMBIN TIME; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMALL VESSEL LACUNAR STROKE; AGED; CASE CONTROL STUDY; CEREBROVASCULAR ACCIDENT; COMORBIDITY; GENE REGULATORY NETWORK; GENETICS; METABOLISM; MIDDLE AGED; RISK FACTOR; RNA INTERFERENCE;

AGED; BLOOD CELLS; CASE-CONTROL STUDIES; COMORBIDITY; FEMALE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NF-KAPPA B; RISK FACTORS; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STROKE; TOLL-LIKE RECEPTORS;

EID: 84902668890     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099283     Document Type: Article

References (33)

1. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, et al. (2002) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 99: 15524-15529. (Pubitemid 35403967)
2. Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, et al. (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 10: R101.
3. Du C, Liu C, Kang J, Zhao G, Ye Z, et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol 10: 1252-1259.
4. O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D (2010) Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10: 111-122.
5. Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, et al. (2010) Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab 30: 92-101.
6. Jeyaseelan K, Lim KY, Armugam A (2008) MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 39: 959-966. (Pubitemid 351619577)
7. Dharap A, Bowen K, Place R, Li LC, Vemuganti R (2009) Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab 29: 675-687.
8. Im H-I, Kenny PJ (2012) MicroRNAs in neuronal function and dysfunction. Trends Neurosci 35: 325-334.
9. Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, et al. (2012) Ischemic transient neurological events identified by immune response to cerebral ischemia. Stroke 43: 1006-1012.
10. Stamova B, Xu H, Jickling G, Bushnell C, Tian Y, et al. (2010) Gene expression profiling of blood for the prediction of ischemic stroke. Stroke 41: 2171-2177.
11. Jickling GC, Xu H, Stamova B, Ander BP, Zhan X, et al. (2010) Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol 68: 681-692.
12. Tang Y, Xu H, Du X, Lit L, Walker W, et al. (2006) Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab 26: 1089-1102. (Pubitemid 44134079)
13. O'Carroll D, Schaefer A (2012) General Principals of miRNA Biogenesis and Regulation in the Brain. Neuropsychopharmacology.
14. Koutsis G, Siasos G, Spengos K (2013) The emerging role of microRNA in stroke. Curr Top Med Chem 13: 1573-1588.
15. Tsai PC, Liao YC, Wang YS, Lin HF, Lin RT, et al. (2013) Serum microRNA-21 and microRNA-221 as potential biomarkers for cerebrovascular disease. J Vasc Res 50: 346-354.
16. Gan CS, Wang CW, Tan KS (2012) Circulatory microRNA-145 expression is increased in cerebral ischemia. Genet Mol Res 11: 147-152.
17. Zeng L, Liu J, Wang Y, Wang L, Weng S, et al. (2011) MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia. Front Biosci (Elite Ed) 3: 1265-1272.
18. Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, et al. (2009) Expression profile of MicroRNAs in young stroke patients. PLoS One 4: e7689.
19. Zhang M, Liu F, Jia H, Zhang Q, Yin L, et al. (2011) Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1. J Immunol 187: 1674-1683.
20. Chen XM, Splinter PL, O'Hara SP, LaRusso NF (2007) A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem 282: 28929-28938. (Pubitemid 47610421)
21. Diao S, Zhang JF, Wang H, He ML, Lin MC, et al. (2010) Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma. Proteomics 10: 3723-3731.
22. Liu X, Zhan Z, Xu L, Ma F, Li D, et al. (2010) MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIalpha. J Immunol 185: 7244-7251.
23. Pan W, Zhu S, Yuan M, Cui H, Wang L, et al. (2010) MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184: 6773-6781.
24. Philippe L, Alsaleh G, Suffert G, Meyer A, Georgel P, et al. (2012) TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes. J Immunol 188: 454-461.
25. O'Neill LA, Sheedy FJ, McCoy CE (2011) MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 11: 163-175.
26. Liu Y, Lai L, Chen Q, Song Y, Xu S, et al. (2012) MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN. J Immunol 188: 5500-5510.
27. Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, et al. (2011) Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol 31: 4760-4774.
28. Ren XP, Wu J, Wang X, Sartor MA, Qian J, et al. (2009) MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 119: 2357-2366.
29. Sharp FR, Xu H, Lit L, Walker W, Apperson M, et al. (2006) The future of genomic profiling of neurological diseases using blood. Arch Neurol 63: 1529-1536. (Pubitemid 44748794)
30. Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, et al. (2012) Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol 14: 159-167.
31. Doebele C, Bonauer A, Fischer A, Scholz A, Reiss Y, et al. (2010) Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 115: 4944-4950.
32. Camaioni C, Gustapane M, Cialdella P, Della Bona R, Biasucci LM (2013) Microparticles and microRNAs: new players in the complex field of coagulation. Intern Emerg Med 8: 291-296.
33. Dangwal S, Thum T (2013) MicroRNAs in platelet physiology and pathology. Hamostaseologie 33: 17-20.