Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1

Journal of Immunology

Volumn 187, Issue 4, 2011, Pages 1674-1683

  Zhang, Maomao ^a   Liu, Fang ^a   Jia, Haibo ^a   Zhang, Qi ^a   Yin, Li ^a   Liu, Wei ^a   Li, Hulun ^a   Yu, Bo ^a   Wu, Jian ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; MICRORNA; MICRORNA LET 7I; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL EXPANSION; CELL FUNCTION; CELL MATURATION; CELL STIMULATION; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSFECTION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TRANSLATION REGULATION;

ANIMALS; ANTIGENS, CD80; ANTIGENS, CD86; CELL PROLIFERATION; DENDRITIC CELLS; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MICRORNAS; RATS; RATS, WISTAR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES;

EID: 80051925149     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001937     Document Type: Article

References (41)

1. Steinman, R. M. 2003. The control of immunity and tolerance by dendritic cell. Pathol. Biol. (Paris) 51: 59-60. (Pubitemid 36427570)
2. Li, Y. P., V. Latger-Canard, L. Marchal, N. Li, J. P. Ou-Yang, and J. F. Stoltz. 2006. The regulatory role of dendritic cells in the immune tolerance. Biomed. Mater. Eng. 16(4, Suppl.): S163-S170. (Pubitemid 43953686)
3. Koval'chuk, L. V., L. V. Gankovskaia, and E. A. Akimova. 2009. Role of microRNA in regulation of innate immunity mechanisms. Zh. Mikrobiol. Epidemiol. Immunobiol. 3: 100-104.
4. Bartel, D. P. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
5. Lim, L. P., N. C. Lau, P. Garrett-Engele, A. Grimson, J. M. Schelter, J. Castle, D. P. Bartel, P. S. Linsley, and J. M. Johnson. 2005. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773. (Pubitemid 40292988)
6. Liston, A., M. Linterman, and L. F. Lu. 2010. MicroRNA in the adaptive immune system, in sickness and in health. J. Clin. Immunol. 30: 339-346.
7. Lu, L. F., and A. Liston. 2009. MicroRNA in the immune system, microRNA as an immune system. Immunology 127: 291-298.
8. Homey, B. 2007. MicroRNA: New level of immune regulation. Hautarzt 58: 553-554. (Pubitemid 46917398)
9. Reinhart, B. J., F. J. Slack, M. Basson, A. E. Pasquinelli, J. C. Bettinger, A. E. Rougvie, H. R. Horvitz, and G. Ruvkun. 2000. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901-906. (Pubitemid 30130993)
10. Slack, F. J., M. Basson, Z. Liu, V. Ambros, H. R. Horvitz, and G. Ruvkun. 2000. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol. Cell 5: 659-669.
11. Johnson, S. M., H. Grosshans, J. Shingara, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K. L. Reinert, D. Brown, and F. J. Slack. 2005. RAS is regulated by the let-7 microRNA family. Cell 120: 635-647. (Pubitemid 40343076)
12. Shi, G., M. A. Perle, K. Mittal, H. Chen, X. Zou, M. Narita, E. Hernando, P. Lee, and J. J. Wei. 2009. let-7 Repression leads to HMGA2 overexpression in uterine leiomyosarcoma. J. Cell. Mol. Med. 13: 3898-3905.
13. Lee, Y. S., and A. Dutta. 2007. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 21: 1025-1030. (Pubitemid 46686471)
14. Legesse-Miller, A., O. Elemento, S. J. Pfau, J. J. Forman, S. Tavazoie, and H. A. Coller. 2009. let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. J. Biol. Chem. 284: 6605-6609.
15. Yoshimura, A., T. Naka, and M. Kubo. 2007. SOCS proteins, cytokine signalling and immune regulation. Nat. Rev. Immunol. 7: 454-465. (Pubitemid 46834848)
16. Dalpke, A., K. Heeg, H. Bartz, and A. Baetz. 2008. Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins. Immunobiology 213: 225-235. (Pubitemid 351479858)
17. Fletcher, J., and R. Starr. 2005. The role of suppressors of cytokine signalling in thymopoiesis and T cell activation. Int. J. Biochem. Cell Biol. 37: 1774-1786. (Pubitemid 40961663)
18. Naka, T., M. Fujimoto, H. Tsutsui, and A. Yoshimura. 2005. Negative regulation of cytokine and TLR signalings by SOCS and others. Adv. Immunol. 87: 61-122. (Pubitemid 41135899)
19. Ryo, A., F. Suizu, Y. Yoshida, K. Perrem, Y. C. Liou, G. Wulf, R. Rottapel, S. Yamaoka, and K. P. Lu. 2003. Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/ RelA. Mol. Cell 12: 1413-1426. (Pubitemid 38037011)
20. Gingras, S., E. Parganas, A. De Pauw, J. N. Ihle, and P. J. Murray. 2004. Reexamination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of Toll-like receptor signaling. J. Biol. Chem. 279: 54702-54707. (Pubitemid 40053214)
21. Kimura, A., T. Naka, T. Muta, O. Takeuchi, S. Akira, I. Kawase, and T. Kishimoto. 2005. Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. Proc. Natl. Acad. Sci. USA 102: 17089-17094. (Pubitemid 41692688)
22. Mansell, A., R. Smith, S. L. Doyle, P. Gray, J. E. Fenner, P. J. Crack, S. E. Nicholson, D. J. Hilton, L. A. O'Neill, and P. J. Hertzog. 2006. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 7: 148-155. (Pubitemid 43135880)
23. Zhang, M., Q. Wang, Y. Liu, Y. Sun, G. Ding, Z. Fu, Z. Min, Y. Zhu, and X. Cao. 2004. Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to prolongation of allograft survival. J. Mol. Med. 82: 240-249. (Pubitemid 38553652)
24. + T-cells expressing Foxp3. Diabetes 54: 1040-1047.
25. + regulatory T cells through downregulating toll like receptor 2-mediated activation of NF-κB. Cell. Physiol. Biochem. 25: 649-656.
26. Schmittgen, T. D., J. Jiang, Q. Liu, and L. Yang. 2004. A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res. 32: e43.
27. Chen, X.-M., P. L. Splinter, S. P. O'Hara, and N. F. LaRusso. 2007. A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J. Biol. Chem. 282: 28929-28938. (Pubitemid 47610421)
28. + T-cell tolerance induced by steady-state dendritic cells. Proc. Natl. Acad. Sci. USA 107: 199-203.
29. Coquerelle, C., and M. Moser. 2008. Are dendritic cells central to regulatory T cell function? Immunol. Lett. 119: 12-16.
30. Holmstrøm, K., A. W. Pedersen, M. H. Claesson, M. B. Zocca, and S. S. Jensen. 2010. Identification of a microRNA signature in dendritic cell vaccines for cancer immunotherapy. Hum. Immunol. 71: 67-73.
31. Lu, L. F., T. H. Thai, D. P. Calado, A. Chaudhry, M. Kubo, K. Tanaka, G. B. Loeb, H. Lee, A. Yoshimura, K. Rajewsky, and A. Y. Rudensky. 2009. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 30: 80-91.
32. Ceppi, M., P. M. Pereira, I. Dunand-Sauthier, E. Barras, W. Reith, M. A. Santos, and P. Pierre. 2009. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc. Natl. Acad. Sci. USA 106: 2735-2740.
33. Liu, X., Z. Zhan, L. Xu, F. Ma, D. Li, Z. Guo, N. Li, and X. Cao. 2010. MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIa. J. Immunol. 185: 7244-7251.
34. Jurkin, J., Y. M. Schichl, R. Koeffel, T. Bauer, S. Richter, S. Konradi, B. Gesslbauer, and H. Strobl. 2010. miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation. J. Immunol. 184: 4955-4965.
35. Chen, T., Z. Li, J. Tu, W. Zhu, J. Ge, X. Zheng, L. Yang, X. Pan, H. Yan, and J. Zhu. 2011. MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated dendritic cells. FEBS Lett. 585: 657-663.
36. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767-811. (Pubitemid 30365397)
37. Starr, R., and D. J. Hilton. 2003. Defining control: Regulation of dendritic cell activation and immune homeostasis by SOCS1. Immunity 19: 308-309. (Pubitemid 37153408)
38. Hanada, T., H. Yoshida, S. Kato, K. Tanaka, K. Masutani, J. Tsukada, Y. Nomura, H. Mimata, M. Kubo, and A. Yoshimura. 2003. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19: 437-450. (Pubitemid 37153419)
39. Evel-Kabler, K., X. T. Song, M. Aldrich, X. F. Huang, and S. Y. Chen. 2006. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J. Clin. Invest. 116: 90-100. (Pubitemid 43121794)
40. Shen, L., K. Evel-Kabler, R. Strube, and S. Y. Chen. 2004. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat. Biotechnol. 22: 1546-1553. (Pubitemid 40039457)
41. Fu, H., S. Song, F. Liu, Z. Ni, Y. Tang, X. Shen, L. Xiao, G. Ding, and Q. Wang. 2009. Dendritic cells transduced with SOCS1 gene exhibit regulatory DC properties and prolong allograft survival. Cell. Mol. Immunol. 6: 87-95.