Signatures of cardioembolic and large-vessel ischemic stroke

Annals of Neurology

Volumn 68, Issue 5, 2010, Pages 681-692

  Jickling, Glen C ^a   Xu, Huichun ^a   Stamova, Boryana ^a   Ander, Bradley P ^a   Zhan, Xinhua ^a   Tian, Yingfang ^a   Liu, Dazhi ^a   Turner, Renée J ^a   Mesias, Matthew ^a   Verro, Piero ^a   Khoury, Jane ^b   Jauch, Edward C ^c   Pancioli, Arthur ^d   Broderick, Joseph P ^d   Sharp, Frank R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; B LYMPHOCYTE RECEPTOR; EPTIFIBATIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; THROMBOPOIETIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR NFAT;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CARDIOEMBOLIC STROKE; CELL PROLIFERATION; CLINICAL TRIAL; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HEART ATRIUM FIBRILLATION; HUMAN; INFLAMMATION; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PREDICTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA ISOLATION; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; STROKE; T LYMPHOCYTE; VALIDATION PROCESS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; BIOLOGICAL MARKERS; BRAIN ISCHEMIA; EMBOLISM; FEMALE; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; STROKE;

EID: 78249266887     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22187     Document Type: Article

References (25)

1. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35 - 41.
2. Goldstein LB, Jones MR, Matchar DB, et al. Improving the reliability of stroke subgroup classification using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria. Stroke 2001; 32: 1091 - 1098.
3. Ay H, Benner T, Arsava EM, et al. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke 2007; 38: 2979 - 2984.
4. Ionita CC, Xavier AR, Kirmani JF, et al. What proportion of stroke is not explained by classic risk factors? Prev Cardiol 2005; 8: 41 - 46.
5. Laskowitz DT, Kasner SE, Saver J, et al. Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study. Stroke 2009; 40: 77 - 85.
6. Shibazaki K, Kimura K, Iguchi Y, et al. Plasma brain natriuretic peptide can be a biological marker to distinguish cardioembolic stroke from other stroke types in acute ischemic stroke. Intern Med 2009; 48: 259 - 264.
7. Montaner J, Perea-Gainza M, Delgado P, et al. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke 2008; 39: 2280 - 2287.
8. Hassan A, Hunt BJ, O-sullivan M, et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 2003; 126: 424 - 432.
9. Xu H, Tang Y, Liu DZ, et al. Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab 2008; 28: 1320 - 1328.
10. Tang Y, Xu H, Du X, et al. Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab 2006; 26: 1089 - 1102.
11. Du X, Tang Y, Xu H, et al. Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics 2006; 87: 693 - 703.
12. Pancioli AM, Broderick J, Brott T, et al. The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial. Stroke 2008; 39: 3268 - 3276.
13. Stamova BS, Apperson M, Walker WL, et al. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Med Genomics 2009; 2: 49.
14. Tibshirani RJ, Efron B., Pre-validation and inference in microarrays. Stat Appl Genet Mol Biol 2002; 1:Article1.
15. Schulze A, Downward J., Navigating gene expression using microarrays-a technology review. Nat Cell Biol 2001; 3: E190 - E195.
16. Hedenfalk I, Duggan D, Chen Y, et al. Gene-expression profiles in hereditary breast cancer. N Engl J Med 2001; 344: 539 - 548.
17. Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004; 350: 1617 - 1628.
18. Tayal AH, Tian M, Kelly KM, et al. Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke. Neurology 2008; 71: 1696 - 1701.
19. Ziegler PD, Glotzer TV, Daoud EG, et al. Incidence of newly detected atrial arrhythmias via implantable devices in patients with a history of thromboembolic events. Stroke 2010; 41: 256 - 260.
20. Harloff A, Handke M, Reinhard M, et al. Therapeutic strategies after examination by transesophageal echocardiography in 503 patients with ischemic stroke. Stroke 2006; 37: 859 - 864.
21. Sacco RL, Prabhakaran S, Thompson JL, et al. Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study. Cerebrovasc Dis 2006; 22: 4 - 12.
22. Mohr JP, Thompson JL, Lazar RM, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med 2001; 345: 1444 - 1451.
23. Elijovich L, Josephson SA, Fung GL, Smith WS., Intermittent atrial fibrillation may account for a large proportion of otherwise cryptogenic stroke: a study of 30-day cardiac event monitors. J Stroke Cerebrovasc Dis 2009; 18: 185 - 189.
24. Gaillard N, Deltour S, Vilotijevic B, et al. Detection of paroxysmal atrial fibrillation with transtelephonic EKG in TIA or stroke patients. Neurology 2010; 74: 1666 - 1670.
25. Tang TY, Muller KH, Graves MJ, et al. Iron oxide particles for atheroma imaging. Arterioscler Thromb Vasc Biol 2009; 29: 1001 - 1008.