Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 506-520

  Ragab, F A ^a   Yahya, T A A ^b   El Naa, M M ^c   Arafa, R K ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b SANA A UNIVERSITY   (Yemen)

^c October University for Modern Sciences and Arts   (Egypt)

Author keywords

Cytotoxicity; Furoaurones; Furochalcones; Furoflavones; Furostyrylfurochromones; Kinase inhibition

Indexed keywords

1 (6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (2 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (SUBSTITUTED)PHENYLPROP 2 EN 1 ONE; 1 (7 ALLYL 6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (4 CHLOROPHENYL) PROP 2 EN 1 ONE; 1 (7 ALLYL 6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (SUBSTITUTED)PHENYL PROP 2 EN 1 ONE; 1 (7 ALLYL 6 HYDROXY 4 METHOXYBENZOFURAN 5 YL) 3 (2METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (7 BROMO 6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (2 METHOXY PHENYL)PROP 2 EN 1 ONE; 1 (7 BROMO 6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (4 METHOXY PHENYL)PROP 2 EN 1 ONE; 1 (7 BROMO 6 HYDROXY 4 METHOXY 1 BENZOFURAN 5 YL) 3 (CHLOROPHENYL)PROP 2 EN 1 ONE; 1 (7 BROMO 6 HYDROXY 4 METHOXY 1 BENZOFURAN-5 YL) 3 PHENYLPROP 2 EN 1 ONE; 1 (7 BROMO 6 HYDROXY 4 METHOXY 1 BENZOFURAN-5 YL) 3 SUBSTITUTED PHENYLPROP 2 EN 1 ONE; 3 (4 METHOXY 5 OXO 7 (SUBSTITUTED)PHENYL 5H FURO[3,2 G]CHROMEN 9 YL)ACRYLALDEHYDE; 3 (4 METHOXY 5 OXO 7 PHENYL 5H FURO[3,2 G]CHROMEN 9 YL) ACRYLALDEHYDE; 3 [4 METHOXY 7 (4 METHOXYPHENYL) 5 OXO 5H FURO[3,2 G] CHROMEN 9 YL]ACRYL ALDEHYDE; 3 [7 (4 CHLOROPHENYL) 4 METHOXY 5 OXO 5H FURO[3,2 G] CHROMEN 9 YL]ACRYLALDEHYDE; 4 METHOXY 7 (2 METHOXYPHENYL) 5H FURO[3,2 G]CHROMEN 5 ONE; 4 METHOXY 7 (SUBSTITUTED)PHENYL FURO[3,2 G]CHROMEN 5 ONE; 4,9 DIMETHOXY 7 [2 (4 DIMETHYLAMINOPHENYL)VINYL] 6 (MORPHOLIN 4 YLMETHYL) 5H FURO [3,2 G]CHROMEN 5 ONE; 9 BROMO 4 METHOXY 7 (2 METHOXYPHENYL) 5H FURO[3,2 G] CHROMEN 5 ONE; 9 BROMO 4 METHOXY 7 (4 METHOXYPHENYL) 5H FURO[3,2 G] CHROMEN 5 ONE; 9 BROMO 4 METHOXY 7 (SUBSTITUTED)PHENYL FURO[3,2 G]CHROMEN 5 ONE; 9 BROMO 4 METHOXY 7 PHENYL 5H FURO[3,2 G]CHROMEN 5 ONE; 9 BROMO 7 (4 CHLOROPHENYL) 4 METHOXY 5H FURO[3,2 G]CHROMEN 5 ONE; ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; FLAVONOID; GLYCOGEN SYNTHASE KINASE 3BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER SIZE; COLON CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG MEGADOSE; DRUG SCREENING; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY CANCER; LEUKEMIA; LOW DRUG DOSE; LUNG NON SMALL CELL CANCER; MELANOMA; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, EHRLICH TUMOR; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FEMALE; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLAVONOIDS; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902657942     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.007     Document Type: Article

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