Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: Relevance in IBD

Mucosal Immunology

Volumn 7, Issue 4, 2014, Pages 929-938

  Ortiz Masia D ^a   Cosin Roger J ^a   Calatayud, S ^a   Hernandez C ^b   Alos R ^c   Hinojosa, J ^c   Apostolova, N ^d   Alvarez, A ^a   Barrachina, M D ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^c Hospital de Manises   (Spain)

^d UNIVERSITAT JAUME I   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BETA CATENIN; CD68 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESALAZINE; PROTEIN P62; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; WNT1 PROTEIN; TARGET OF RAPAMYCIN KINASE; WNT1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; INTESTINE CRYPT; MACROPHAGE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH MUCOSA LESION; ULCERATIVE COLITIS; UPREGULATION; CELL HYPOXIA; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASE; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; PATHOLOGY; WNT SIGNALING PATHWAY; YOUNG ADULT;

ADOLESCENT; ADULT; AUTOPHAGY; CELL HYPOXIA; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MACROPHAGES; MALE; MIDDLE AGED; TOR SERINE-THREONINE KINASES; WNT SIGNALING PATHWAY; WNT1 PROTEIN; YOUNG ADULT;

EID: 84902581011     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2013.108     Document Type: Article

References (40)

1. Maloy, K.J. & Powrie, F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474, 298-306 (2011
2. Khor, B., Gardet, A. & Xavier, R.J. Genetics and pathogenesis of inflammatory bowel disease. Nature 474, 307-317 (2011
3. Patel, K.K. & Stappenbeck, T.S. Autophagy and intestinal homeostasis. Annu. Rev. Physiol. 75, 241-262 (2013
4. Sokollik, C., Ang, M. & Jones, N. Autophagy: A primer for the gastroenterologist/hepatologist. Can. J. Gastroenterol. 25, 667-674 (2011
5. Benjamin, J.L., Sumpter,R. Jr., Levine, B.& Hooper, L.V. Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host. Microbe 13, 723-734 (2013
6. Kaser, A. & Blumberg, R.S. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 140, 1738-1747 (2011
7. Fritz, T., Niederreiter, L., Adolph, T., Blumberg, R.S. & Kaser, A. Crohn's disease: NOD2, autophagy and ER stress converge. Gut 60, 1580-1588 (2011
8. Cadwell, K., Patel, K.K., Komatsu, M., Virgin, H.W. & Stappenbeck, T.S. A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn Disease. Autophagy 5, 250-252 (2009
9. Baumgart, D.C. & Sandborn, W.J. Crohn's disease. Lancet 380, 1590-1605 (2012
10. Strober, W. & Watanabe, T. NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease. Mucosal. Immunol. 4, 484-495 (2011
11. Choi, A.M., Ryter, S.W. & Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 368, 651-662 (2013
12. Levine, B. & Kroemer, G. Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008
13. Wynn, T.A., Chawla, A. & Pollard, J.W. Macrophage biology in Development, homeostasis and disease. Nature 496, 445-455 (2013
14. Glover, L.E. & Colgan, S.P. Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology 140, 1748-1755 (2011
15. Lin, S.L. et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc. Natl Acad. Sci. USA 107, 4194-4199 (2010
16. Farin, H.F., van Es, J.H. & Clevers, H. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 143, 1518-1529 (2012
17. Pull, S.L., Doherty, J.M., Mills, J.C., Gordon, J.I. & Stappenbeck, T.S. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl. Acad. Sci. USA 102, 99-104 (2005
18. Mowat, A.M. & Bain, C.C. Mucosal macrophages in intestinal homeostasis and inflammation. J. Innate. Immun. 3, 550-564 (2011
19. Anderson, E.C. & Wong, M.H. Caught in the Akt: Regulation of Wnt signaling in the intestine. Gastroenterology 139, 718-722 (2010
20. Yeung, T.M., Chia, L.A., Kosinski, C.M. & Kuo, C.J. Regulation of selfrenewal and differentiation by the intestinal stem cell niche. Cell Mol. Life Sci. 68, 2513-2523 (2011
21. Nakamura, T., Tsuchiya, K. & Watanabe, M. Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J. Gastroenterol. 42, 705-710 (2007
22. Clevers, H. & Nusse, R. Wnt/beta-catenin signaling and disease. Cell 149, 1192-1205 (2012
23. Jin, T., George, F.,I. & Sun, J. Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of beta-catenin. Cell Signal. 20, 1697-1704 (2008
24. Inoki, K. et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-968 (2006
25. Ashton, G.H. et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev. Cell 19, 259-269 (2010
26. Valvezan, A.J. & Klein, P.S. GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder. Front Mol. Neurosci. 5, 1 (2012
27. Castilho, R.M., Squarize, C.H., Chodosh, L.A., Williams, B.O. & Gutkind, J.S. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 5, 279-289 (2009
28. Ortiz-Masia, D. et al. Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory Process. PLoS. ONE 7, e48535 (2012
29. Giatromanolaki, A. et al. Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease. J. Clin. Pathol. 56, 209-213 (2003
30. Koh, M.Y. & Powis, G. Passing the baton: The HIF switch. Trends Biochem. Sci. 37, 364-372 (2012
31. Karhausen, J. et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 114, 1098-1106 (2004
32. Hughes, K.R., Sablitzky, F. &Mahida,Y.R. Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Inflamm. Bowel. Dis. 17, 213-220 (2011
33. Gao, C. et al. Autophagy negatively regulates Wnt signalling by promoting dishevelled degradation. Nat. Cell Biol. 12, 781-790 (2010
34. Lee, G. et al. Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-881. 881 (2010
35. Brown, J.B. et al. Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology 138, 595-605. 605 (2010
36. Branka, J.E. et al. Early functional effects of Clostridium difficile toxin A on human colonocytes. Gastroenterology 112, 1887-1894 (1997
37. Mahida, Y.R.,Wu, K.C. & Jewell, D.P. Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease. Gut 30, 1362-1370 (1989
38. Ortiz-Masia, D. et al. iNOS-derived nitric oxide mediates the increase in TFF2 expression associated with gastric damage: Role of HIF-1. FASEB J. 24, 136-145 (2010
39. Hernandez, C. et al. Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: Implications for gastric mucosal healing. Br. J. Pharmacol. 156, 262-272 (2009
40. Riano, A. et al. Nitric oxide induces HIF-1alpha stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing. J. Gastroenterol. 46, 565-576 (2011.