UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation

Leukemia

Volumn 23, Issue 3, 2009, Pages 610-614

  Szpurka, H ^a   Gondek, L P ^a   Mohan, S R ^a   Hsi, E D ^b   Theil, K S ^b   Maciejewski, J P ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; JANUS KINASE 2; RETICULIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR RUNX;

ARTICLE; GENE MUTATION; HUMAN; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTOSIS; UNIPARENTAL DISOMY;

EID: 62549153137     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.249     Document Type: Article

References (8)

1. Szpurka H, Tiu R, Murugesan G, Aboudola S, Hsi ED, Theil KS et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. Blood 2006; 108: 2173-2181.
2. Pardanani AD, Levine RL, Lasho T, Pikman Y, Mesa RA, Wadleigh M et al MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006; 108: 3472-3476.
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7. Schnittger S, Bacher U, Haferlach C, Dengler R, Krober A, Kern W et al. Detection of an MPLW515 mutation in a case with features of both essential thrombocythemia and refractory anemia with ringed sideroblasts and thrombocytosis. Leukemia 2008; 22: 453-455.
8. Schmitt-Graeff AH, Teo SS, Olschewski M, Schaub F, Haxelmans S, Kim A et al. JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Haematologica 2008; 93: 34-40.