Augmented cellular trafficking and endosomal escape of porous silicon nanoparticles via zwitterionic bilayer polymer surface engineering

Biomaterials

Volumn 35, Issue 26, 2014, Pages 7488-7500

  Shahbazi, Mohammad Ali ^a   Almeida, Patrick V ^a   Mäkilä, Ermei M ^a,b   Kaasalainen, Martti H ^b   Salonen, Jarno J ^b   Hirvonen, Jouni T ^a   Santos, Hélder A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Cellular uptake; Endosomal escape; Poly(methyl vinyl ether co maleic acid); Polyethyleneimine; Porous silicon nanoparticles; Surface functionalization

Indexed keywords

CYTOTOXICITY; DRUG DELIVERY; MEDICAL NANOTECHNOLOGY; NANOCOMPOSITES; NANOPARTICLES; PLASMA STABILITY; POLYMERS; POROUS SILICON; TOXICITY;

CELLULAR UPTAKE; ENDOSOMAL ESCAPES; POLY(METHYL VINYL ETHER-CO-MALEIC ACID); POLYETHYLENEIMINE; SILICON NANOPARTICLES; SURFACE FUNCTIONALIZATION;

CONJUGATED POLYMERS;

1 ETHYL 3 [3 DIMETHYLAMINOPROPYL]CARBODIIMIDE; 10 UNDECENOIC ACID; AMINE; AMPHOLYTE; CARBOXYLIC ACID; COPOLYMER; MALEIC ACID DERIVATIVE; METHOTREXATE; NANOCOMPOSITE; NANOCONJUGATE; NANOPARTICLE; POLYETHYLENEIMINE; SILICON; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; DELAYED RELEASE FORMULATION; ION; POLYETHYLENE DERIVATIVE; POLYMER; POLYMETHYLVINYLETHER-CO-MALEIC ANHYDRIDE;

ANTIPROLIFERATIVE ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BILAYER MEMBRANE; BIOCOMPATIBILITY; CANCER CELL; CELL INTERACTION; CELL MIGRATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; DRUG CYTOTOXICITY; DRUG RELEASE; DRUG STABILITY; ENDOSOME; FEMALE; HUMAN; HUMAN CELL; HYDROPHILICITY; INTERNALIZATION; MOLECULAR MECHANICS; NANOENGINEERING; PRIORITY JOURNAL; SURFACE PROPERTY; ZETA POTENTIAL; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; MCF 7 CELL LINE; METABOLISM; POROSITY; TUMOR CELL LINE; ULTRASTRUCTURE;

ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DELAYED-ACTION PREPARATIONS; ENDOSOMES; FEMALE; HUMANS; IONS; MALEATES; MCF-7 CELLS; METHOTREXATE; NANOPARTICLES; POLYETHYLENEIMINE; POLYETHYLENES; POLYMERS; POROSITY; SILICON; SURFACE PROPERTIES;

EID: 84902549746     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.05.020     Document Type: Article

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