Disease stage determines the efficacy of treatment of a paediatric neurodegenerative disease

European Journal of Neuroscience

Volumn 39, Issue 12, 2014, Pages 2139-2150

  Hassiotis, Sofia ^a   Beard, Helen ^a   Luck, Amanda ^b   Trim, Paul J ^a   King, Barbara ^a   Snel, Marten F ^a   Hopwood, John J ^a   Hemsley, Kim M ^a  

^a SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

Lysosomal storage disorder; Mouse; Reversibility; Sanfilippo; Sulphamidase

Indexed keywords

GANGLIOSIDE GM3; GLIAL FIBRILLARY ACIDIC PROTEIN; LYSOSOMAL INTEGRAL MEMBRANE PROTEIN II; MEMBRANE PROTEIN; RECOMBINANT ENZYME; RECOMBINANT N SULFOGLUCOSAMINE SULFOHYDROLASE; UNCLASSIFIED DRUG; HYDROLASE; N-SULFOGLUCOSAMINE SULFOHYDROLASE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CEREBROSPINAL FLUID; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE CLASSIFICATION; DISEASE COURSE; EARLY INTERVENTION; ENZYME REPLACEMENT; FEMALE; GLIOSIS; HISTOPATHOLOGY; MALE; MOUSE; MOUSE MODEL; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SANFILIPPO SYNDROME; STAGING; TANDEM MASS SPECTROMETRY; ANIMAL; ASTROCYTE; BRAIN; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; HUMAN; MICROGLIA; MUCOPOLYSACCHARIDOSIS III; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SPINAL CORD;

ANIMALS; ASTROCYTES; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME REPLACEMENT THERAPY; FEMALE; GLIOSIS; HUMANS; HYDROLASES; MALE; MICE, INBRED C57BL; MICROGLIA; MUCOPOLYSACCHARIDOSIS III; NEURODEGENERATIVE DISEASES; RECOMBINANT PROTEINS; SPINAL CORD;

EID: 84902548162     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12557     Document Type: Article

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