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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 14, 2014, Pages 3168-3174

Trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-α

(7) Wu, Chunyan a Jia, Yaoyao a Lee, Ji Hae a Jun, Hee Jin b Lee, Hae Seung c Hwang, Kwang Yeon a Lee, Sung Joon a

a Korea University (South Korea)

b PENNINGTON BIOMEDICAL RESEARCH CENTER (United States)

c Eulji University (South Korea)

Author keywords

Hepatocyte; Lipid metabolism; PPAR ; trans Caryophyllene

Indexed keywords

ACYL COENZYME A OXIDASE; CARNITINE PALMITOYLTRANSFERASE I; CARYOPHYLLENE; FATTY ACID; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; SESQUITERPENE; 2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIGAND BINDING; LUCIFERASE ASSAY; MOLECULAR INTERACTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE; UPREGULATION; AGONISTS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; LIPID METABOLISM; OXIDATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PPAR ALPHA; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902545309 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.04.112 Document Type: Article

Times cited : (42)

References (43)

1
- 0032567990
- M.A. Austin, J.E. Hokanson, and K.L. Edwards Am. J. Cardiol. 81 1998 7B
- (1998) Am. J. Cardiol. , vol.81
- Austin, M.A.¹ Hokanson, J.E.² Edwards, K.L.³

2
- 33846637379
- N. Sarwar, J. Danesh, G. Eiriksdottir, G. Sigurdsson, N. Wareham, S. Bingham, S.M. Boekholdt, K.T. Khaw, and V. Gudnason Circulation 115 2007 450
- (2007) Circulation , vol.115 , pp. 450
- Sarwar, N.¹ Danesh, J.² Eiriksdottir, G.³ Sigurdsson, G.⁴ Wareham, N.⁵ Bingham, S.⁶ Boekholdt, S.M.⁷ Khaw, K.T.⁸ Gudnason, V.⁹

3
- 0025030698
- Y. Ito, N. Azrolan, A. O'Connell, A. Walsh, and J.L. Breslow Science 249 1990 790
- (1990) Science , vol.249 , pp. 790
- Ito, Y.¹ Azrolan, N.² O'Connell, A.³ Walsh, A.⁴ Breslow, J.L.⁵

4
- 0033551397
- S.M. Grundy Am. J. Cardiol. 83 1999 25F
- (1999) Am. J. Cardiol. , vol.83
- Grundy, S.M.¹

5
- 0024438108
- J.C. Chamberlain, J.A. Thorn, K. Oka, D.J. Galton, and J. Stocks Atherosclerosis 79 1989 85
- (1989) Atherosclerosis , vol.79 , pp. 85
- Chamberlain, J.C.¹ Thorn, J.A.² Oka, K.³ Galton, D.J.⁴ Stocks, J.⁵

6
- 0022387832
- A. Rees, J. Stocks, C.R. Sharpe, M.A. Vella, C.C. Shoulders, J. Katz, N.I. Jowett, F.E. Baralle, and D.J. Galton J. Clin. Invest. 76 1985 1090
- (1985) J. Clin. Invest. , vol.76 , pp. 1090
- Rees, A.¹ Stocks, J.² Sharpe, C.R.³ Vella, M.A.⁴ Shoulders, C.C.⁵ Katz, J.⁶ Jowett, N.I.⁷ Baralle, F.E.⁸ Galton, D.J.⁹

7
- 0033615353
- B.B. Lowell Cell 99 1999 239
- (1999) Cell , vol.99 , pp. 239
- Lowell, B.B.¹

8
- 10044223533
- A.C. Li, and C.K. Glass J. Lipid Res. 45 2004 2161
- (2004) J. Lipid Res. , vol.45 , pp. 2161
- Li, A.C.¹ Glass, C.K.²

9
- 47949094965
- S.J. Bensinger, and P. Tontonoz Nature 454 2008 470
- (2008) Nature , vol.454 , pp. 470
- Bensinger, S.J.¹ Tontonoz, P.²

10
- 17444442152
- R. Mukherjee, P.J. Davies, D.L. Crombie, E.D. Bischoff, R.M. Cesario, L. Jow, L.G. Hamann, M.F. Boehm, C.E. Mondon, A.M. Nadzan, J.R. Paterniti Jr., and R.A. Heyman Nature 386 1997 407
- (1997) Nature , vol.386 , pp. 407
- Mukherjee, R.¹ Davies, P.J.² Crombie, D.L.³ Bischoff, E.D.⁴ Cesario, R.M.⁵ Jow, L.⁶ Hamann, L.G.⁷ Boehm, M.F.⁸ Mondon, C.E.⁹ Nadzan, A.M.¹⁰ Paterniti, Jr.J.R.¹¹ Heyman, R.A.¹²

11
- 0034993832
- I.P. Torra, G. Chinetti, C. Duval, J.C. Fruchart, and B. Staels Curr. Opin. Lipidol. 12 2001 245
- (2001) Curr. Opin. Lipidol. , vol.12 , pp. 245
- Torra, I.P.¹ Chinetti, G.² Duval, C.³ Fruchart, J.C.⁴ Staels, B.⁵

12
- 0034678088
- P. Escher, and W. Wahli Mutat. Res. 448 2000 121
- (2000) Mutat. Res. , vol.448 , pp. 121
- Escher, P.¹ Wahli, W.²

13
- 3042634455
- B.D. Hegarty, S.M. Furler, N.D. Oakes, E.W. Kraegen, and G.J. Cooney Endocrinology 145 2004 3158
- (2004) Endocrinology , vol.145 , pp. 3158
- Hegarty, B.D.¹ Furler, S.M.² Oakes, N.D.³ Kraegen, E.W.⁴ Cooney, G.J.⁵

14
- 0030985318
- G. Krey, O. Braissant, F. L'Horset, E. Kalkhoven, M. Perroud, M.G. Parker, and W. Wahli Mol. Endocrinol. 11 1997 779
- (1997) Mol. Endocrinol. , vol.11 , pp. 779
- Krey, G.¹ Braissant, O.² L'Horset, F.³ Kalkhoven, E.⁴ Perroud, M.⁵ Parker, M.G.⁶ Wahli, W.⁷

15
- 1842864853
- L.A. Pennacchio, M. Olivier, J.A. Hubacek, R.M. Krauss, E.M. Rubin, and J.C. Cohen Hum. Mol. Gen. 11 2002 3031
- (2002) Hum. Mol. Gen. , vol.11 , pp. 3031
- Pennacchio, L.A.¹ Olivier, M.² Hubacek, J.A.³ Krauss, R.M.⁴ Rubin, E.M.⁵ Cohen, J.C.⁶

16
- 0032054839
- J.C. Fruchart, B. Brewer, E. Leitersdorf, M. Brochier, G. Brown, C. Calvo, R. Carmena, R. Ceska, W.C. Loy-Soong, J. Davignon, A. Gotto, S. Grundy, A. Hamsten, A. Keech, Y. Matsuzawa, J.R. Patch, R. Paoletti, K. Raslova, V. Smirnov, G. Steiner, G. Thompson, and J.R. Zhu Am. J. Cardiol. 81 1998 912
- (1998) Am. J. Cardiol. , vol.81 , pp. 912
- Fruchart, J.C.¹ Brewer, B.² Leitersdorf, E.³ Brochier, M.⁴ Brown, G.⁵ Calvo, C.⁶ Carmena, R.⁷ Ceska, R.⁸ Loy-Soong, W.C.⁹ Davignon, J.¹⁰ Gotto, A.¹¹ Grundy, S.¹² Hamsten, A.¹³ Keech, A.¹⁴ Matsuzawa, Y.¹⁵ Patch, J.R.¹⁶ Paoletti, R.¹⁷ Raslova, K.¹⁸ Smirnov, V.¹⁹ Steiner, G.²⁰ Thompson, G.²¹ Zhu, J.R.²² more..

17
- 84976446656
- G. Buchbauer, and A. Ilic J. Nat. Prod. 2013 4109
- (2013) J. Nat. Prod. , pp. 4109
- Buchbauer, G.¹ Ilic, A.²

18
- 77958523765
- B. Adorjan, and G. Buchbauer Flavour Frag. J. 25 2010 407
- (2010) Flavour Frag. J. , vol.25 , pp. 407
- Adorjan, B.¹ Buchbauer, G.²

19
- 84355162228
- G.R. Lang, and G. Buchbauer Flavour Frag. J. 27 2012 13
- (2012) Flavour Frag. J. , vol.27 , pp. 13
- Lang, G.R.¹ Buchbauer, G.²

20
- 48249115990
- J. Gertsch, M. Leonti, S. Raduner, I. Racz, J.Z. Chen, X.Q. Xie, K.H. Altmann, M. Karsak, and A. Zimmer Proc. Natl. Acad. Sci. U.S.A. 105 2008 9099
- (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 9099
- Gertsch, J.¹ Leonti, M.² Raduner, S.³ Racz, I.⁴ Chen, J.Z.⁵ Xie, X.Q.⁶ Altmann, K.H.⁷ Karsak, M.⁸ Zimmer, A.⁹

21
- 79952752154
- A.F. Bento, R. Marcon, R.C. Dutra, R.F. Claudino, M. Cola, D.F. Pereira Leite, and J.B. Calixto Am. J. Pathol. 178 2011 1153
- (2011) Am. J. Pathol. , vol.178 , pp. 1153
- Bento, A.F.¹ Marcon, R.² Dutra, R.C.³ Claudino, R.F.⁴ Cola, M.⁵ Pereira Leite, D.F.⁶ Calixto, J.B.⁷

22
- 67649394135
- M. Mueller, and A. Jungbauer Food Chem. 117 2009 660
- (2009) Food Chem. , vol.117 , pp. 660
- Mueller, M.¹ Jungbauer, A.²

23
- 34447107008
- M.J. Chung, A.Y. Kang, S.O. Park, K.W. Park, H.J. Jun, and S.J. Lee Food Chem. Toxicol. 45 2007 1400
- (2007) Food Chem. Toxicol. , vol.45 , pp. 1400
- Chung, M.J.¹ Kang, A.Y.² Park, S.O.³ Park, K.W.⁴ Jun, H.J.⁵ Lee, S.J.⁶

24
- 47349099996
- L.Y. Lin, C.C. Peng, Y.J. Liang, W.T. Yeh, H.E. Wang, T.H. Yu, and R.Y. Peng J. Agric. Food Chem. 56 2008 4435
- (2008) J. Agric. Food Chem. , vol.56 , pp. 4435
- Lin, L.Y.¹ Peng, C.C.² Liang, Y.J.³ Yeh, W.T.⁴ Wang, H.E.⁵ Yu, T.H.⁶ Peng, R.Y.⁷

25
- 80455125864
- I. Vallianou, N. Peroulis, P. Pantazis, and M. Hadzopoulou-Cladaras PloS One 6 2011 e20516
- (2011) PloS One , vol.6 , pp. 20516
- Vallianou, I.¹ Peroulis, N.² Pantazis, P.³ Hadzopoulou-Cladaras, M.⁴

26
- 84862286884
- J.H. Lee, H.J. Jun, M.H. Hoang, Y. Jia, X.H. Han, D.H. Lee, H.J. Lee, B.Y. Hwang, and S.J. Lee Biochem. Biophys. Res. Commun. 422 2012 568
- (2012) Biochem. Biophys. Res. Commun. , vol.422 , pp. 568
- Lee, J.H.¹ Jun, H.J.² Hoang, M.H.³ Jia, Y.⁴ Han, X.H.⁵ Lee, D.H.⁶ Lee, H.J.⁷ Hwang, B.Y.⁸ Lee, S.J.⁹

27
- 79953651662
- F. Loiodice, and G. Pochetti Curr. Top. Med. Chem. 11 2011 819
- (2011) Curr. Top. Med. Chem. , vol.11 , pp. 819
- Loiodice, F.¹ Pochetti, G.²

28
- 0033998334
- T.M. Willson, P.J. Brown, D.D. Sternbach, and B.R. Henke J. Med. Chem. 43 2000 527
- (2000) J. Med. Chem. , vol.43 , pp. 527
- Willson, T.M.¹ Brown, P.J.² Sternbach, D.D.³ Henke, B.R.⁴

29
- 36949030830
- P. Markt, D. Schuster, J. Kirchmair, C. Laggner, and T.J. Langer Comput. Aid. Mol. Des. 21 2007 575
- (2007) Comput. Aid. Mol. Des. , vol.21 , pp. 575
- Markt, P.¹ Schuster, D.² Kirchmair, J.³ Laggner, C.⁴ Langer, T.J.⁵

30
- 20444371592
- C.Z. Liao, B. Liu, L.M. Shi, J.J. Zhou, and X.P. Lu Eur. J. Med. Chem. 40 2005 632
- (2005) Eur. J. Med. Chem. , vol.40 , pp. 632
- Liao, C.Z.¹ Liu, B.² Shi, L.M.³ Zhou, J.J.⁴ Lu, X.P.⁵

31
- 84873451171
- Y.Y. Jia, J.Y. Kim, H.J. Jun, S.J. Kim, J.H. Lee, M.H. Hoang, H.S. Kim, H.I. Chang, K.Y. Hwang, S.J. Um, and S.J. Lee BBA-Mol. Cell Biol. Lipids 1831 2013 698
- (2013) BBA-Mol. Cell Biol. Lipids , vol.1831 , pp. 698
- Jia, Y.Y.¹ Kim, J.Y.² Jun, H.J.³ Kim, S.J.⁴ Lee, J.H.⁵ Hoang, M.H.⁶ Kim, H.S.⁷ Chang, H.I.⁸ Hwang, K.Y.⁹ Um, S.J.¹⁰ Lee, S.J.¹¹

32
- 80054007230
- K.R. Do, J.A. Jeun, S.J. Houng, H.J. Jun, J.H. Lee, Y. Jia, and S.J. Lee Food Sci. Biotechnol. 20 2011 1171
- (2011) Food Sci. Biotechnol. , vol.20 , pp. 1171
- Do, K.R.¹ Jeun, J.A.² Houng, S.J.³ Jun, H.J.⁴ Lee, J.H.⁵ Jia, Y.⁶ Lee, S.J.⁷

33
- 0026442356
- E.E. Furth, H. Sprecher, E.A. Fisher, H.D. Fleishman, and M. Laposata J. Lipid Res. 33 1992 1719
- (1992) J. Lipid Res. , vol.33 , pp. 1719
- Furth, E.E.¹ Sprecher, H.² Fisher, E.A.³ Fleishman, H.D.⁴ Laposata, M.⁵

34
- 80053940494
- H.J. Jun, M. Roh, H.W. Kim, S.J. Houng, B. Cho, E.J. Yun, M.A. Hossain, H. Lee, K.H. Kim, and S.J. Lee Food Sci. Biotechnol. 20 2011 1051
- (2011) Food Sci. Biotechnol. , vol.20 , pp. 1051
- Jun, H.J.¹ Roh, M.² Kim, H.W.³ Houng, S.J.⁴ Cho, B.⁵ Yun, E.J.⁶ Hossain, M.A.⁷ Lee, H.⁸ Kim, K.H.⁹ Lee, S.J.¹⁰

35
- 79959232357
- M.H. Hoang, S.J. Houng, H.J. Jun, J.H. Lee, J.W. Choi, S.H. Kim, Y.R. Kim, and S.J. Lee J. Agric. Food Chem. 59 2011 6798
- (2011) J. Agric. Food Chem. , vol.59 , pp. 6798
- Hoang, M.H.¹ Houng, S.J.² Jun, H.J.³ Lee, J.H.⁴ Choi, J.W.⁵ Kim, S.H.⁶ Kim, Y.R.⁷ Lee, S.J.⁸

36
- 0029791412
- K. Schoonjans, J. PeinadoOnsurbe, A.M. Lefebvre, R.A. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx EMBO J. 15 1996 5336
- (1996) EMBO J. , vol.15 , pp. 5336
- Schoonjans, K.¹ Peinadoonsurbe, J.² Lefebvre, A.M.³ Heyman, R.A.⁴ Briggs, M.⁵ Deeb, S.⁶ Staels, B.⁷ Auwerx, J.⁸

37
- 21644436821
- D.H. van Raalte, M. Li, P.H. Pritchard, and K.M. Wasan Pharm. Res. 21 2004 1531
- (2004) Pharm. Res. , vol.21 , pp. 1531
- Van Raalte, D.H.¹ Li, M.² Pritchard, P.H.³ Wasan, K.M.⁴

38
- 0032037738
- G. Martin, K. Schoonjans, B. Staels, and J. Auwerx Atherosclerosis 137 1998 S75
- (1998) Atherosclerosis , vol.137 , pp. 75
- Martin, G.¹ Schoonjans, K.² Staels, B.³ Auwerx, J.⁴

39
- 12444256363
- T. Yoshikawa, T. Ide, H. Shimano, N. Yahagi, M. Amemiya-Kudo, T. Matsuzaka, S. Yatoh, T. Kitamine, H. Okazaki, Y. Tamura, M. Sekiya, A. Takahashi, A.H. Hasty, R. Sato, H. Sone, J.I. Osuga, S. Ishibashi, and N. Yamada Mol. Endocrinol. 17 2003 1240
- (2003) Mol. Endocrinol. , vol.17 , pp. 1240
- Yoshikawa, T.¹ Ide, T.² Shimano, H.³ Yahagi, N.⁴ Amemiya-Kudo, M.⁵ Matsuzaka, T.⁶ Yatoh, S.⁷ Kitamine, T.⁸ Okazaki, H.⁹ Tamura, Y.¹⁰ Sekiya, M.¹¹ Takahashi, A.¹² Hasty, A.H.¹³ Sato, R.¹⁴ Sone, H.¹⁵ Osuga, J.I.¹⁶ Ishibashi, S.¹⁷ Yamada, N.¹⁸

40
- 0029920693
- I.J. Goldberg J. Lipid Res. 37 1996 693
- (1996) J. Lipid Res. , vol.37 , pp. 693
- Goldberg, I.J.¹

41
- 4544231849
- M. Miyazaki, A. Dobrzyn, H. Sampath, S.H. Lee, W.C. Man, K. Chu, J.M. Peters, F.J. Gonzalez, and J.M. Ntambi J. Biol. Chem. 279 2004 35017
- (2004) J. Biol. Chem. , vol.279 , pp. 35017
- Miyazaki, M.¹ Dobrzyn, A.² Sampath, H.³ Lee, S.H.⁴ Man, W.C.⁵ Chu, K.⁶ Peters, J.M.⁷ Gonzalez, F.J.⁸ Ntambi, J.M.⁹

42
- 0032506273
- B. Staels, J. Dallongeville, J. Auwerx, K. Schoonjans, E. Leitersdorf, and J.C. Fruchart Circulation 98 1998 2088
- (1998) Circulation , vol.98 , pp. 2088
- Staels, B.¹ Dallongeville, J.² Auwerx, J.³ Schoonjans, K.⁴ Leitersdorf, E.⁵ Fruchart, J.C.⁶

43
- 0028817459
- B. Staels, N. Vudac, V.A. Kosykh, R. Saladin, J.C. Fruchart, J. Dallongeville, and J. Auwerx J. Clin. Invest. 95 1995 705
- (1995) J. Clin. Invest. , vol.95 , pp. 705
- Staels, B.¹ Vudac, N.² Kosykh, V.A.³ Saladin, R.⁴ Fruchart, J.C.⁵ Dallongeville, J.⁶ Auwerx, J.⁷

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