Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1

Stem Cells and Development

Volumn 23, Issue 13, 2014, Pages 1464-1478

  Saitta, Biagio ^a   Passarini, Jenna ^a   Sareen, Dhruv ^a   Ornelas, Loren ^a   Sahabian, Anais ^a   Argade, Shilpa ^a   Krakow, Deborah ^b   Cohn, Daniel H ^b   Svendsen, Clive N ^a   Rimoin, David L ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN 2; COL10A1 PROTEIN; COL2A1 PROTEIN; COLLAGEN; COLLAGEN TYPE 1; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER 3; PROTEIN P53; SINAPULTIDE; STAGE SPECIFIC EMBRYO ANTIGEN 4; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; BIOLOGICAL MARKER; BMP2 PROTEIN, HUMAN; COLLAGEN TYPE I, ALPHA 1 CHAIN; TGFB1 PROTEIN, HUMAN; TRPV4 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ARTICLE; BONE DEVELOPMENT; BONE DYSPLASIA; CARTILAGE CELL; CELL DIFFERENTIATION; CHONDROGENESIS; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENOMIC INSTABILITY; GROWTH PLATE; HUMAN; HUMAN CELL; IN VITRO STUDY; NEWBORN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; UPREGULATION; CELL CULTURE; CHONDRODYSPLASIA; DWARFISM; GENE EXPRESSION; GENETICS; METABOLISM; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY;

BASE SEQUENCE; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROGENESIS; COLLAGEN TYPE I; DNA MUTATIONAL ANALYSIS; DWARFISM; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MUTATION, MISSENSE; OSTEOCHONDRODYSPLASIAS; TRANSFORMING GROWTH FACTOR BETA1; TRPV CATION CHANNELS;

EID: 84902535531     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0014     Document Type: Article

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