BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

Journal of Cell Science

Volumn 124, Issue 20, 2011, Pages 3428-3440

  Shu, Bing ^a,b   Zhang, Ming ^a   Xie, Rong ^a   Wang, Meina ^a   Jin, Hongting ^c   Hou, Wei ^b   Tang, Dezhi ^b   Harris, Stephen E ^d   Mishina, Yuji ^e   O'Keefe, Regis J ^a   Hilton, Matthew J ^a   Wang, Yongjun ^b   Chen, Di ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bmp2; Bmp4; Chondrocyte; Endochondral bone formation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CYCLIN DEPENDENT KINASE 4; TRANSCRIPTION FACTOR RUNX2; BMP2 PROTEIN, MOUSE; BMP4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; CARTILAGE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CHONDRODYSPLASIA; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; ENDOCHONDRAL BONE DEVELOPMENT; FEMALE; GENE DELETION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; CELL CULTURE; CELL GROWTH; GENE EXPRESSION REGULATION; GENETICS; GROWTH PLATE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PROTEIN PROCESSING;

ANIMALS; APOPTOSIS; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELLS, CULTURED; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CYCLIN-DEPENDENT KINASE 4; GENE EXPRESSION REGULATION; GROWTH PLATE; MICE; MICE, KNOCKOUT; OSTEOCHONDRODYSPLASIAS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION;

EID: 84856795723     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.083659     Document Type: Article

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