Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model

Matrix Biology

Volumn 31, Issue 3, 2012, Pages 214-226

  Lewis, Renate ^a   Ravindran, Soumya ^a   Wirthlin, Louisa ^a   Traeger, Geoffrey ^b   Fernandes, Russell J ^b   McAlinden, Audrey ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alternative splicing; Cartilage; Chondrocyte; Knock in mutation; Precursor (pre ) mRNA; Splice site; Transgenic mouse; Type II procollagen

Indexed keywords

MESSENGER RNA; NUCLEOTIDE; PROCOLLAGEN; PROCOLLAGEN TYPE 2; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CONSENSUS SEQUENCE; CONTROLLED STUDY; EPIPHYSEAL CARTILAGE; EXON; FEMALE; GENE TARGETING; HINDLIMB; HOMOZYGOTE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUTATION; NONHUMAN; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL;

ALTERNATIVE SPLICING; ANIMALS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CHIMERA; CHONDROCYTES; COLLAGEN TYPE II; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; EXONS; FEMALE; GENE KNOCK-IN TECHNIQUES; HEK293 CELLS; HOMOZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; RNA ISOFORMS; RNA PRECURSORS; RNA SPLICE SITES; RNA, MESSENGER;

MUS; MUS MUSCULUS;

EID: 84857782771     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2011.12.004     Document Type: Article

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