The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy

Journal of Neuroinflammation

Volumn 11, Issue , 2014, Pages

  Bi, Dan ^a,e   Chen, Mingjie ^b   Zhang, Xiaoli ^a   Wang, Honglian ^b   Xia, Lei ^a   Shang, Qing ^c   Li, Tongchuan ^a   Zhu, Dengna ^a   Blomgren, Klas ^d,e   He, Lin ^b,f   Wang, Xiaoyang ^a,e   Xing, Qinghe ^b   Zhu, Changlian ^a,e  

^a ZHENGZHOU UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c ZHENGZHOU CHILDREN S HOSPITAL   (China)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cytokine; Inflammation; Periventricular leukomalacia; Single nucleotide polymorphisms

Indexed keywords

DNA; INTERLEUKIN 6; CYTOKINE;

ARTICLE; BLOOD SAMPLING; CEREBRAL PALSY; CHILD; CHINESE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENCEPHALOMALACIA; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC REGULATION; GENOTYPE; HUMAN; IL 6 GENE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; GENETIC PREDISPOSITION; GENETICS; INFANT; METABOLISM; PRESCHOOL CHILD; SEXUAL DEVELOPMENT;

CEREBRAL PALSY; CHILD, PRESCHOOL; CYTOKINES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; INTERLEUKIN-6; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS;

EID: 84902535292     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-11-100     Document Type: Article

References (46)

1. Wu YW, Croen LA, Vanderwerf A, Gelfand AA, Torres AR. Candidate genes and risk for CP: a population-based study. Pediatr Res 2011, 70:642-646. 3210921, 21857382.
2. Cheng X, Li T, Wang H, Zhu D, Ma C, Ma B, Wang Y, Zhang J, Guo L, Wang L, Yun L, Chen S, Jiang Z, He L, Zhu C, Xing Q. Methylenetetrahydrofolate reductase gene polymorphisms and cerebral palsy in Chinese infants. J Hum Genet 2011, 56:17-21. 10.1038/jhg.2010.127, 20962791.
3. Pennington L, Virella D, Mjoen T, Da Graca AM, Murray J, Colver A, Himmelmann K, Rackauskaite G, Greitane A, Prasauskiene A, Andersen G, de la Cruz J. Development of The Viking Speech Scale to classify the speech of children with cerebral palsy. Res Dev Disabil 2013, 34:3202-3210. 10.1016/j.ridd.2013.06.035, 23891732.
4. Tator C, Bray G, Morin D. The CBANCH report-the burden of neurological diseases, disorders, and injuries in Canada. Can J Neuro Sci 2007, 34:268-269.
5. Tatla SK, Sauve K, Virji-Babul N, Holsti L, Butler C, Van Der Loos HF. Evidence for outcomes of motivational rehabilitation interventions for children and adolescents with cerebral palsy: an American Academy for cerebral palsy and developmental medicine systematic review. Dev Med Child Neurol 2013, 55:593-601. 10.1111/dmcn.12147, 23550896.
6. Jacobsson B, Hagberg G. Antenatal risk factors for cerebral palsy. Best Pract Res Clin Obstet Gynaecol 2004, 18:425-436. 10.1016/j.bpobgyn.2004.02.011, 15183137.
7. Elovitz MA, Brown AG, Breen K, Anton L, Maubert M, Burd I. Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury. Int J Dev Neurosci 2011, 29:663-671. 10.1016/j.ijdevneu.2011.02.011, 3140629, 21382466.
8. Djukic M, Gibson CS, Maclennan AH, Goldwater PN, Haan EA, McMichael G, Priest K, Dekker GA, Hague WM, Chan A, Rudzki Z, VAN Essen P, Khong TY, Morton MR, Ranieri E, Scott H, Tapp H, Casey G. Genetic susceptibility to viral exposure may increase the risk of cerebral palsy. Aust N Z J Obstet Gynaecol 2009, 49:247-253. 10.1111/j.1479-828X.2009.00999.x, 19566553.
9. Resch B, Radinger A, Mannhalter C, Horvath B, Binder A, Zenz W, Walcher W, Haas J, Muller WD, Pertl B. Maternal interleukin-6 (-174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant. J Perinatol 2010, 30:712-716. 10.1038/jp.2010.30, 20237486.
10. Chen M, Li T, Lin S, Bi D, Zhu D, Shang Q, Ma C, Wang H, Wang L, Zhang Y, Zhang Y, He L, Zhu C, Xing Q. Association of interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study. Cytokine 2013, 61:826-830. 10.1016/j.cyto.2013.01.011, 23415255.
11. Harding DR, Dhamrait S, Whitelaw A, Humphries SE, Marlow N, Montgomery HE. Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?. Pediatrics 2004, 114:941-947. 10.1542/peds.2003-0494-F, 15466088.
12. Wu YW, Croen LA, Torres AR, Van De Water J, Grether JK, Hsu NN. Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants. Ann Neurol 2009, 66:663-670. 10.1002/ana.21766, 19938160.
13. Kapitanovic Vidak H, Catela Ivkovic T, Jokic M, Spaventi R, Kapitanovic S. The association between proinflammatory cytokine polymorphisms and cerebral palsy in very preterm infants. Cytokine 2012, 58:57-64. 10.1016/j.cyto.2011.12.018, 22266275.
14. Sellier E, Surman G, Himmelmann K, Andersen G, Colver A, Krageloh-Mann I, De-la-Cruz J, Cans C. Trends in prevalence of cerebral palsy in children born with a birthweight of 2,500 g or over in Europe from 1980 to 1998. Eur J Epidemiol 2010, 25:635-642. 10.1007/s10654-010-9474-0, 20532622.
15. Avasiloaiei A, Dimitriu C, Moscalu M, Paduraru L, Stamatin M. High-dose phenobarbital or erythropoietin for the treatment of perinatal asphyxia in term newborns. Pediatr Int 2013, 55:589-593. 10.1111/ped.12121, 23659666.
16. Zhu C, Kang W, Xu F, Cheng X, Zhang Z, Jia L, Ji L, Guo X, Xiong H, Simbruner G, Blomgren K, Wang X. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics 2009, 124:e218-e226. 10.1542/peds.2008-3553, 19651565.
17. Soraisham AS, Trevenen C, Wood S, Singhal N, Sauve R. Histological chorioamnionitis and neurodevelopmental outcome in preterm infants. J Perinatol 2013, 33:70-75. 10.1038/jp.2012.49, 22555781.
18. Ferrell G, Lu M, Stoddard P, Sammel MD, Romero R, Strauss JF, Matthews CA. A single nucleotide polymorphism in the promoter of the LOXL1 gene and its relationship to pelvic organ prolapse and preterm premature rupture of membranes. Reprod Sci 2009, 16:438-446. 10.1177/1933719108330567, 2668743, 19182211.
19. Practice ACoO ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002, 77:67-75. Practice ACoO.
20. Campbell MK, Cartier S, Xie B, Kouniakis G, Huang W, Han V. Determinants of small for gestational age birth at term. Paediatr Perinat Epidemiol 2012, 26:525-533. 10.1111/j.1365-3016.2012.01319.x, 23061688.
21. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 2007, 27:10695-10702. 10.1523/JNEUROSCI.2178-07.2007, 2387067, 17913903.
22. Yoon BH, Park CW, Chaiworapongsa T. Intrauterine infection and the development of cerebral palsy. BJOG 2003, 110(Suppl 20):124-127.
23. Ahlin K, Himmelmann K, Hagberg G, Kacerovsky M, Cobo T, Wennerholm UB, Jacobsson B. Cerebral palsy and perinatal infection in children born at term. Obstet Gynecol 2013, 122:41-49. 10.1097/AOG.0b013e318297f37f, 23743468.
24. Odding E, Roebroeck ME, Stam HJ. The epidemiology of cerebral palsy: incidence, impairments and risk factors. Disabil Rehabil 2006, 28:183-191. 10.1080/09638280500158422, 16467053.
25. Crider KS, Whitehead N, Buus RM. Genetic variation associated with preterm birth: a HuGE review. Genet Med 2005, 7:593-604. 10.1097/01.gim.0000187223.69947.db, 16301860.
26. International HapMap Consortium The International HapMap Project. Nature 2003, 426:789-796. 10.1038/nature02168, 14685227, International HapMap Consortium.
27. He MX, Yang WL, Zhang MM, Lian YJ, Hua HY, Zeng JS, Zhang LR. Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease. Neurol Sci 2010, 31:165-168.
28. Ma Y, Tang RK, Yang X, Peng GG, Liu Y, Wang XM, Wu BH, Yu JM. Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis. Hum Immunol 2011, 72:641-651. 10.1016/j.humimm.2011.03.019, 21536090.
29. Combarros O, Van Duijn CM, Hammond N, Belbin O, Arias-Vasquez A, Cortina-Borja M, Lehmann MG, Aulchenko YS, Schuur M, Kolsch H, Heun R, Wilcock GK, Brown K, Kehoe PG, Harrison R, Coto E, Alvarez V, Deloukas P, Mateo I, Gwilliam R, Morgan K, Warden DR, Smith AD, Lehmann DJ. Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease. J Neuroinflammation 2009, 6:22. 10.1186/1742-2094-6-22, 2744667, 19698145.
30. Manso H, Krug T, Sobral J, Albergaria I, Gaspar G, Ferro JM, Oliveira SA, Vicente AM. Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility through main effects and gene-gene interactions. J Cereb Blood Flow Metab 2011, 31:1751-1759. 10.1038/jcbfm.2011.27, 3170942, 21407237.
31. Cenit MC, Simeon CP, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Blanco FJ, Narvaez J, Tolosa C, Roman-Ivorra JA, Gómez-García I, García-Hernández FJ, Gallego M, García-Portales R, Egurbide MV, Fonollosa V, García de la Peña P, López-Longo FJ, González-Gay MA, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Fonseca C, Denton C, Nordin A, Palm O, , et al. Spanish Scleroderma Group Influence of the IL6 gene in susceptibility to systemic sclerosis. J Rheumatol 2012, 39:2294-2302. 10.3899/jrheum.120506, 23027890, Spanish Scleroderma Group.
32. Fornage M, Chiang YA, O'Meara ES, Psaty BM, Reiner AP, Siscovick DS, Tracy RP, Longstreth WT. Biomarkers of inflammation and MRI-Defined small vessel disease of the brain: the Cardiovascular Health Study. Stroke 2008, 39:1952-1959. 10.1161/STROKEAHA.107.508135, 2888487, 18436879.
33. Esser C, Tomluk J. Reporting Hardy-Weinberg tests in case-control studies: reasons for caution but not for panic reactions. J Invest Dermatol 2005, 124:1082-1083. 10.1111/j.0022-202X.2005.23709.x, 15854056.
34. Gu W, Du DY, Huang J, Zhang LY, Liu Q, Zhu PF, Wang ZG, Jiang JX. Identification of interleukin-6 promoter polymorphisms in the Chinese Han population and their functional significance. Crit Care Med 2008, 36:1437-1443. 10.1097/CCM.0b013e31816a0adb, 18434913.
35. Tosun A, Gokben S, Serdaroglu G, Polat M, Tekgul H. Changing views of cerebral palsy over 35 years: the experience of a center. Turk J Pediatr 2013, 55:8-15.
36. Serdaroglu A, Cansu A, Ozkan S, Tezcan S. Prevalence of cerebral palsy in Turkish children between the ages of 2 and 16 years. Dev Med Child Neurol 2006, 48:413-416. 10.1017/S0012162206000910, 16700929.
37. Himmelmann K, Hagberg G, Beckung E, Hagberg B, Uvebrant P. The changing panorama of cerebral palsy in Sweden. IX. Prevalence and origin in the birth-year period 1995-1998. Acta Paediatr 2005, 94:287-294. 10.1111/j.1651-2227.2005.tb03071.x, 16028646.
38. Stelmach T, Pisarev H, Talvik T. Ante- and perinatal factors for cerebral palsy: case-control study in Estonia. J Child Neurol 2005, 20:654-660. 10.1177/08830738050200080401, 16225810.
39. Lang JT, McCullough LD. Pathways to ischemic neuronal cell death: are sex differences relevant?. J Transl Med 2008, 6:33. 10.1186/1479-5876-6-33, 2459157, 18573200.
40. Johnston MV, Hagberg H. Sex and the pathogenesis of cerebral palsy. Dev Med Child Neurol 2007, 49:74-78.
41. Golomb MR, Fullerton HJ, Nowak-Gottl U, Deveber G, . International Pediatric Stroke Study G Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study. Stroke 2009, 40:52-57. 10.1161/STROKEAHA.108.521203, 18787197, International Pediatric Stroke Study G.
42. Zhang L, Li PP, Feng X, Barker JL, Smith SV, Rubinow DR. Sex-related differences in neuronal cell survival and signaling in rats. Neurosci Lett 2003, 337:65-68. 10.1016/s0304-3940(02)01179-5, 12527389.
43. Romero R, Gotsch F, Pineles B, Kusanovic JP. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev 2007, 65:S194-S202. 10.1301/nr.2007.dec.S194-S202, 18240548.
44. Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF. Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet 2004, 13:2659-2669. 10.1093/hmg/ddh287, 15367487.
45. Jacobsson B, Hagberg G, Hagberg B, Ladfors L, Niklasson A, Hagberg H. Cerebral palsy in preterm infants: a population-based case-control study of antenatal and intrapartal risk factors. Acta Paediatr 2002, 91:946-951. 10.1111/j.1651-2227.2002.tb02860.x, 12222720.
46. McElrath TF, Allred EN, Boggess KA, Kuban K, O'Shea TM, Paneth N, Leviton A, Investigators ES. Maternal antenatal complications and the risk of neonatal cerebral white matter damage and later cerebral palsy in children born at an extremely low gestational age. Am J Epidemiol 2009, 170:819-828. 10.1093/aje/kwp206, 2765357, 19713285.