High-dose phenobarbital or erythropoietin for the treatment of perinatal asphyxia in term newborns

Pediatrics International

Volumn 55, Issue 5, 2013, Pages 589-593

  Avasiloaiei, Andreea ^a   Dimitriu, Cristina ^a   Moscalu, Mihaela ^a   Paduraru, Luminita ^a   Stamatin, Maria ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

erythropoietin; high dose phenobarbital; neuroprotective strategies; oxidative stress; perinatal asphyxia

Indexed keywords

ANTIOXIDANT; ERYTHROPOIETIN; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; PHENOBARBITAL; SUPEROXIDE DISMUTASE;

APGAR SCORE; ARTICLE; BIRTH WEIGHT; BLOOD PH; COGNITION; CONSERVATIVE TREATMENT; CONTROLLED STUDY; DRUG MEGADOSE; FOLLOW UP; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; NEUROLOGIC EXAMINATION; NEWBORN; PERINATAL ASPHYXIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; UMBILICAL CORD BLOOD;

ERYTHROPOIETIN; HIGH-DOSE PHENOBARBITAL; NEUROPROTECTIVE STRATEGIES; OXIDATIVE STRESS; PERINATAL ASPHYXIA;

ASPHYXIA NEONATORUM; BIRTH WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN; FEMALE; FOLLOW-UP STUDIES; GESTATIONAL AGE; HEMATINICS; HUMANS; HYPNOTICS AND SEDATIVES; INFANT, NEWBORN; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; OXIDATIVE STRESS; PHENOBARBITAL; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 84886091681     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/ped.12121     Document Type: Article

References (33)

1. Hill A,. Neurological and Neuromuscular Disorders in Avery's Pathophysiology and Management of the Newborn, 6th edn. Williams and Wilkins, Lippincott, 2005.
2. Barks JD, Silverstein FS,. Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury. Brain Pathol. 1992; 2: 235-243.
3. Halliwell B,. Reactive oxygen species and the central nervous system. J. Neurochem. 1992; 59: 1609-1623.
4. Vento M, Asensi M, Sastre J, Lloret A, García-Sala F, Vina J,. Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen. J. Pediatr. 2003; 142: 240-246. (Pubitemid 36338004)
5. Conner EM, Grisham MB,. Inflammation, free radicals and antioxidants. Nutrition 1996; 12: 274-277. (Pubitemid 26286465)
6. Mates JM, Perez-Gomez C, Nunez de Castro I,. Antioxidant enzymes and human diseases. Clin. Biochem. 1999; 32: 595-603. (Pubitemid 30039087)
7. Fridovich I,. Oxygen toxicity: A radical explanation. J. Exp. Biol. 1998; 201: 1203-1209. (Pubitemid 28278324)
8. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med. 2005; 353: 1574-1584. (Pubitemid 41434636)
9. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomized trial. Lancet 2005; 365: 663-670. (Pubitemid 40260887)
10. Azzopardi DV, Strohm B, Edwards D, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N. Engl. J. Med. 2009; 361: 1349-1358.
11. Jacobs SE, Morlin CJ, Inder TE, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy. Arch. Pediatr. Adolesc. Med. 2011; 165: 692-700.
12. Gathwala G, Marwah A, Gahlaut V, Marwah P,. Effect of high-dose phenobarbital on oxidative stress in perinatal asphyxia: An open label randomized controlled trial. Indian Pediatr. 2010; 47: e1-e5.
13. Elmahdy H, El-Mashad AR, El-Bahrawy H, et al. Human recombinant erythropoietin in asphyxia neonatorum: Pilot trial. Pediatrics 2010; 125: e1135.
14. McPherson RJ, Juul SE,. Erythropoietin for infants with hypoxic-ischemic encephalopathy. Curr. Opin. Pediatr. 2010; 22: 139-145.
15. American College of Obstetrics and Gynecology, Task Force on Neonatal Encephalopathy and Cerebral Palsy; American Academy of Pediatrics. Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology. American College of Obstetricians and Gynecologists, Washington, DC, 2003.
16. Arthur JR, Boyne R,. Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle. Life Sci. 1985; 36: 1569-1575. (Pubitemid 15108041)
17. Paglia DE, Valentine W,. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Chem. Med. 1967; 70: 158-169.
18. Ohkawa H, Ohishi N, Yagi K,. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Ann. Biochem. 1979; 95: 351-358. (Pubitemid 9194347)
19. Kurinczuk JJ, White-Koning M, Badawi N,. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum. Dev. 2010; 86: 329-338.
20. Vannucci RC,. Hypoxic-ischemic encephalopathy. Am. J. Perinatol. 2000; 17: 113-120.
21. Villa P, Bigini P, Mennini T, et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J. Exp. Med. 2003; 198: 971-975. (Pubitemid 37152934)
22. Juul S, Felderhoff-Mueser U,. Epo and other hematopoietic factors. Semin. Fetal Neonatal Med. 2007; 12: 250-258. (Pubitemid 46875056)
23. Kumar A, Ramakrishna SVK, Basu S, Koteshwara Rao GR,. Oxidative stress in perinatal asphyxia. Pediatr. Neurol. 2008; 38: 181-185. (Pubitemid 351221225)
24. Juul SE,. Erythropoietin as a neonatal neuroprotectant: Basic and clinical studies. Hematol. Rep. 2006; 2: 108-112.
25. Kumral A, Baskin H, Gokmen N, et al. Selective inhibition of nitric oxide in hypoxic-ischemic brain model in newborn rats: Is it an explanation for the protective role of erythropoietin? Biol. Neonate 2004; 85: 51-54. (Pubitemid 38437648)
26. Sun Y, Zhou C, Polk P, Nanda A, Zhang JH,. Mechanisms of erythropoietin-induced brain protection in neonatal hypoxia-ischemia rat model. J. Cereb. Blood Flow Metab. 2004; 24: 259-270. (Pubitemid 38199119)
27. Demers EJ, McPherson RJ, Juul SE,. Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcomes in juvenile rats after neonatal hypoxia-ischemia. Pediatr. Res. 2005; 58: 297-301. (Pubitemid 41099877)
28. Kumral A, Gonenc S, Acikgoz O, et al. Erythropoietin increases glutathione peroxidase enzyme activity and decreases lipid peroxidation levels in hypoxic-ischemic brain injury in neonatal rats. Biol. Neonate 2005; 87: 15-18. (Pubitemid 40091371)
29. Kumral A, Genc S, Ozer E, et al. Erythropoietin downregulates bax and DP5 proapoptotic gene expression in neonatal hypoxic-ischemic brain injury. Biol. Neonate 2006; 89: 205-210.
30. Wei L, Han BH, Li Y, Keogh CL, Holtzman DM, Yu SP,. Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. J. Pharmacol. Exp. Ther. 2006; 317: 109-116.
31. Chang YS, Mu D, Wendland M, et al. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr. Res. 2005; 58: 106-111. (Pubitemid 40967438)
32. Ment LR, Vohr B, Allan W, et al. Change in cognitive function over time in very low-birth-weight infants. JAMA 2003; 289: 705-711. (Pubitemid 37430364)
33. Hall RT, Hall FK, Daily DK,. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. J. Pediatr. 1998; 132: 345-348. (Pubitemid 28125193)