Protein S and factor v in regulation of coagulation on platelet microparticles by activated protein C

Thrombosis Research

Volumn 134, Issue 1, 2014, Pages 144-152

  Somajo, Sofia ^a   Koshiar, Ruzica Livaja ^a   Norström, Eva ^a   Dahlbäck, Björn ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Activated protein C; Coagulation; Factor V; Factor VIII; Microparticles; Protein S

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8A; CALCIMYCIN; COLLAGEN; LACTADHERIN; PHOSPHATIDYLSERINE; PROTEIN S; THROMBIN; PROTEIN C;

ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBOCYTE ACTIVATION; WESTERN BLOTTING; DRUG EFFECTS; KINETICS; MEMBRANE MICROPARTICLE; METABOLISM; THROMBOCYTE;

BLOOD COAGULATION; BLOOD PLATELETS; CELL-DERIVED MICROPARTICLES; FACTOR V; HUMANS; KINETICS; PLATELET ACTIVATION; PROTEIN C; PROTEIN S; THROMBIN;

EID: 84902535266     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.04.031     Document Type: Article

References (57)

1. J.M. Inal, E.A. Ansa-Addo, D. Stratton, S. Kholia, S.S. Antwi-Baffour, and S. Jorfi et al. Microvesicles in health and disease Arch Immunol Ther Exp 60 2012 107 121
2. L. Burnier, P. Fontana, B.R. Kwak, and A. Angelillo-Scherrer Cell-derived microparticles in haemostasis and vascular medicine Thromb Haemost 101 2009 439 451
3. L.L. Horstman, and Y.S. Ahn Platelet microparticles: a wide-angle perspective Crit Rev Oncol Hematol 30 1999 111 142
4. P.J. Sims, T. Wiedmer, C.T. Esmon, H.J. Weiss, and S.J. Shattil Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity J Biol Chem 264 1989 17049 17057
5. G. Tans, J. Rosing, M.C. Thomassen, M.J. Heeb, R.F. Zwaal, and J.H. Griffin Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles Blood 77 1991 2641 2648
6. M. Hoffman, D.M. Monroe, and H.R. Roberts Coagulation factor IXa binding to activated platelets and platelet-derived microparticles: a flow cytometric study Thromb Haemost 68 1992 74 78
7. G.E. Gilbert, P.J. Sims, T. Wiedmer, B. Furie, B.C. Furie, and S.J. Shattil Platelet-derived microparticles express high affinity receptors for factor VIII J Biol Chem 266 1991 17261 17268
8. S.S. Ahmad, F.S. London, and P.N. Walsh Binding studies of the enzyme (factor IXa) with the cofactor (factor VIIIa) in the assembly of factor-X activating complex on the activated platelet surface J Thromb Haemost 1 2003 2348 2355
9. P.B. Tracy, L.L. Eide, E.J. Bowie, and K.G. Mann Radioimmunoassay of factor V in human plasma and platelets Blood 60 1982 59 63
10. J. Rosing, G. Tans, J.W. Govers-Riemslag, R.F. Zwaal, and H.C. Hemker The role of phospholipids and factor Va in the prothrombinase complex J Biol Chem 255 1980 274 283
11. G. van Dieijen, G. Tans, J. Rosing, and H.C. Hemker The role of phospholipid and factor VIIIa in the activation of bovine factor X J Biol Chem 256 1981 3433 3442
12. B. Dahlback, and B.O. Villoutreix The anticoagulant protein C pathway FEBS Lett 579 2005 3310 3316
13. P.J. Fay, T.M. Smudzin, and F.J. Walker Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity J Biol Chem 266 1991 20139 20145
14. M. Kalafatis, M.D. Rand, and K.G. Mann The mechanism of inactivation of human factor V and human factor Va by activated protein C J Biol Chem 269 1994 31869 31880
15. B. Dahlback Factor V, and protein S as cofactors to activated protein C Haematologica 82 1997 91 95
16. B. Dahlback, and B.O. Villoutreix Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition Arterioscler Thromb Vasc Biol 25 2005 1311 1320
17. B. Dahlback, and J. Stenflo High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein Proc Natl Acad Sci U S A 78 1981 2512 2516
18. L.F. Maurissen, M.C. Thomassen, G.A. Nicolaes, B. Dahlback, G. Tans, and J. Rosing et al. Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation Blood 111 2008 3034 3041
19. T.J. Cramer, and A.J. Gale The anticoagulant function of coagulation factor V Thromb Haemost 107 2012 15 21
20. G.A. Nicolaes, and B. Dahlback Factor V and thrombotic disease: description of a janus-faced protein Arterioscler Thromb Vasc Biol 22 2002 530 538
21. H.P. Schwarz, M.J. Heeb, J.D. Wencel-Drake, and J.H. Griffin Identification and quantitation of protein S in human platelets Blood 66 1985 1452 1455
22. B. Dahlback Advances in understanding pathogenic mechanisms of thrombophilic disorders Blood 112 2008 19 27
23. R. Grant, E. Ansa-Addo, D. Stratton, S. Antwi-Baffour, S. Jorfi, and S. Kholia et al. A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma J Immunol Methods 371 2011 143 151
24. J. Pereira, G. Alfaro, M. Goycoolea, T. Quiroga, M. Ocqueteau, and L. Massardo et al. Circulating platelet-derived microparticles in systemic lupus erythematosus. Association with increased thrombin generation and procoagulant state Thromb Haemost 95 2006 94 99
25. D. Varon, and E. Shai Role of platelet-derived microparticles in angiogenesis and tumor progression Discov Med 8 2009 237 241
26. J. Sellam, V. Proulle, A. Jungel, M. Ittah, C. Miceli Richard, and J.E. Gottenberg et al. Increased levels of circulating microparticles in primary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity Arthritis Res Ther 11 2009 R156
27. S. Omoto, S. Nomura, A. Shouzu, M. Nishikawa, S. Fukuhara, and T. Iwasaka Detection of monocyte-derived microparticles in patients with Type II diabetes mellitus Diabetologia 45 2002 550 555
28. Z. Mallat, H. Benamer, B. Hugel, J. Benessiano, P.G. Steg, and J.M. Freyssinet et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes Circulation 101 2000 841 843
29. E.J. Magdeleyns, J.F. Keuren, and J. Curvers Factor Va, bound to microparticles released during platelet storage, is resistant to inactivation by activated protein C Transfusion 47 2007 1880 1888
30. W.R. Gould, J.R. Silveira, and P.B. Tracy Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va J Biol Chem 279 2004 2383 2393
31. R.M. Camire, M. Kalafatis, P. Simioni, A. Girolami, and P.B. Tracy Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C Blood 91 1998 2818 2829
32. J. Taube, N. McWilliam, R. Luddington, C.D. Byrne, and T. Baglin Activated protein C resistance: effect of platelet activation, platelet-derived microparticles, and atherogenic lipoproteins Blood 93 1999 3792 3797
33. B. Dahlback, T. Wiedmer, and P.J. Sims Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles Biochemistry 31 1992 12769 12777
34. B. Dahlback Human coagluation factor V purification and thrombin-catalyzed activation J Clin Invest 66 1980 583 591
35. K. Fujikawa, M.E. Legaz, and E.W. Davie Bovine factors X 1 and X 2 (Stuart factor). Isolation and characterization Biochemistry 11 1972 4882 4891
36. G.L. Nelsestuen, and J.W. Suttie The mode of action of vitamin K. Isolation of a peptide containing the vitamin K-dependent portion of prothrombin Proc Natl Acad Sci U S A 70 1973 3366 3370
37. L. Shen, A.M. Shah, B. Dahlback, and G.L. Nelsestuen Enhancing the activity of protein C by mutagenesis to improve the membrane-binding site: studies related to proline-10 Biochemistry 36 1997 16025 16031
38. R.L. Lundblad, L.C. Uhteg, C.N. Vogel, H.S. Kingdon, and K.G. Mann Preparation and partial characterization of two forms of bovine thrombin Biochem Biophys Res Commun 66 1975 482 489
39. J. Hou, Y. Fu, J. Zhou, W. Li, R. Xie, and F. Cao et al. Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets Vox Sang 100 2011 187 195
40. E. Norstrom, E. Thorelli, and B. Dahlback Functional characterization of recombinant FV Hong Kong and FV Cambridge Blood 100 2002 524 530
41. G.A. Nicolaes, G. Tans, M.C. Thomassen, H.C. Hemker, I. Pabinger, and K. Varadi et al. Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C J Biol Chem 270 1995 21158 21166
42. Y.H. Sun, S. Tran, E.A. Norstrom, and B. Dahlback Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C J Biol Chem 279 2004 47528 47535
43. B. Dahlback, B. Hildebrand, and J. Malm Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies J Biol Chem 265 1990 8127 8135
44. A.P. Owens III, and N. Mackman Microparticles in hemostasis and thrombosis Circ Res 108 2011 1284 1297
45. J. Rosing, L. Hoekema, G.A. Nicolaes, M.C. Thomassen, H.C. Hemker, and K. Varadi et al. Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C J Biol Chem 270 1995 27852 27858
46. S. Tran, E. Norstrom, and B. Dahlback Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va J Biol Chem 283 2008 6648 6655
47. A.F. Orozco, and D.E. Lewis Flow cytometric analysis of circulating microparticles in plasma Cytometry A 77 2010 502 514
48. S. Robert, R. Lacroix, P. Poncelet, K. Harhouri, T. Bouriche, and C. Judicone et al. High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles-brief report Arterioscler Thromb Vasc Biol 32 2012 1054 1058
49. C.A. Mitchell, and H.H. Salem Cleavage of protein S by a platelet membrane protease J Clin Invest 79 1987 374 379
50. E.A. Norstrom, M. Steen, S. Tran, and B. Dahlback Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va J Biol Chem 278 2003 24904 24911
51. N. Fernandes, L.O. Mosnier, L. Tonnu, and M.J. Heeb Zn(2)(+) -containing protein S inhibits extrinsic factor X-activating complex independently of tissue factor pathway inhibitor J Thromb Haemost 8 2010 1976 1985
52. M.J. Heeb, D. Prashun, J.H. Griffin, and B.N. Bouma Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor FASEB J 23 2009 2244 2253
53. F. Stavenuiter, N.F. Davis, E. Duan, A.J. Gale, and M.J. Heeb Platelet protein S directly inhibits procoagulant activity on platelets and microparticles Thromb Haemost 109 2013 229 237
54. T.M. Hackeng, K.M. Sere, G. Tans, and J. Rosing Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor Proc Natl Acad Sci U S A 103 2006 3106 3111
55. K.M. Sere, J. Rosing, and T.M. Hackeng Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance Blood 104 2004 3624 3630
56. E. Castoldi, P. Simioni, D. Tormene, J. Rosing, and T.M. Hackeng Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma J Thromb Haemost 8 2010 294 300
57. L.M. Vincent, S. Tran, R. Livaja, T.A. Bensend, D.M. Milewicz, and B. Dahlback Coagulation factor V(A2440G) causes east Texas bleeding disorder via TFPIalpha J Clin Invest 123 2013 3777 3787