Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets

Vox Sanguinis

Volumn 100, Issue 2, 2011, Pages 187-195

  Hou, J ^a   Fu, Y ^a   Zhou, J ^a   Li, W ^a   Xie, R ^a   Cao, F ^a   Gilbert, G E ^b   Shi, J ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Lactadherin; Microparticles; Phosphatidylserine; Procoagulant activity; Stored platelets

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; INTRINSIC FACTOR; LACTADHERIN; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROCOAGULANT; THROMBIN; THROMBOCYTE CONCENTRATE;

ARTICLE; BLOOD CLOTTING TIME; CONFOCAL MICROSCOPY; ENZYME ASSAY; FLOW CYTOMETRY; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN FUNCTION; THROMBOCYTE;

ANNEXIN A5; ANTICOAGULANTS; ANTIGENS, SURFACE; HUMANS; MILK PROTEINS; PHOSPHATIDYLSERINES; PRESERVATION, BIOLOGICAL;

EID: 78651314081     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2010.01375.x     Document Type: Article

References (35)

1. Snyder EL: Activation during preparation and storage of platelet concentrates. Transfusion 1992; 32:500-502
2. Seghatchian J, Krailadsiri P: The platelet storage lesion. Transfus Med Rev 1997; 11:130-144
3. Shapira S, Friedman Z, Shapiro H, et al. The effect of storage on the expression of platelet membrane phosphatidylserine and the subsequent impaction the coagulant function of stored platelets. Transfusion 2000; 40:1257-1263
4. Keuren JF, Magdeleyns EJ, Govers-Riemslag JW, et al. Effects of storage-induced platelet microparticles on the initiation and propagation phase of blood coagulation. Br J Haematol 2006; 134:307-313
5. Turner CP, Sutherland J, Wadhwa M, et al. In vitro function of platelet concentrates prepared after filtration of whole blood or buffy coat pools. Vox Sang 2005; 88:164-171
6. Vance JE, Steenbergen R: Metabolism and functions of phosphatidylserine. Prog Lipid Res 2005; 44:207-234
7. Koopman G, Reutelingsperger CP, Kuijten GA, et al. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84:1415-1420
8. Vermes I, Haanen C, Steffens-Nakken H, et al. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995; 184:39-51
9. Shi J, Shi Y, Waehrens LN, et al. Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death. Cytometry A 2006; 69:1193-1201
10. Balasubramanian K, Bevers EM, Willems GM, et al. Binding of annexin V to membrane products of lipid peroxidation. Biochemistry 2001; 40:8672-8676
11. Ida M, Satoh A, Matsumoto I, et al. Human annexin V binds to sulfatide: contribution to regulation of blood coagulation. J Biochem 2004; 135:583-588
12. Kenis H, van Genderen H, Bennaghmouch A, et al. Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry. J Biol Chem 2004; 279:52623-52629
13. van Tilborg GA, Geelen T, Duimel H, et al. Internalization of annexin A5-functionalized iron oxide particles by apoptotic Jurkat cells. Contrast Media Mol Imaging 2009; 4:24-32
14. Shi J, Pipe SW, Rasmussen JT, et al. Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure. J Thromb Haemost 2008; 6:1167-1174
15. Stubbs JD, Lekutis C, Singer KL, et al. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc Natl Acad Sci USA 1990; 87:8417-8421
16. Waehrens LN, Heegaard CW, Gilbert GE, et al. Bovine Lactadherin as a Calcium-independent Imaging Agent of Phosphatidylserine Expressed on the Surface of Apoptotic HeLa Cells. J Histochem Cytochem 2009; 57:907-914
17. Albanyan AM, Murphy MF, Rasmussen JT, et al. Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin V. Transfusion 2009; 49:99-107
18. Shi J, Heegaard CW, Rasmussen JT, et al. Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta 2004; 1667:82-90
19. Shi J, Gilbert GE: Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites. Blood 2003; 101:2628-2636
20. Hvarregaard J, Andersen MH, Berglund L, et al. Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. Eur J Biochem 1996; 240:628-636
21. Kim DH, Kanno C, Mizokami Y: Purification and characterization of major glycoproteins, PAS-6 and PAS-7, from bovine milk fat globule membrane. Biochim Biophys Acta 1992; 1122:203-211
22. van Beers EJ, Schaap MC, Berckmans RJ, et al. Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease. Haematologica 2009; 94:1513-1519
23. Dale GL, Remenyi G, Friese P: Quantitation of microparticles released from coated-platelets. J Thromb Haemost 2005; 3:2081-2088
24. Lechner D, Kollars M, Gleiss A, et al. Chemotherapy-induced thrombin generation via procoagulant endothelial microparticles is independent of tissue factor activity. J Thromb Haemost 2007; 5:2445-2452
25. Robert S, Poncelet P, Lacroix R, et al. Standardization of platelet-derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer: a first step towards multicenter studies? J Thromb Haemost 2009; 7:190-197
26. Langen R, Isas JM, Hubbell WL, et al. A transmembrane form of annexin XII detected by site-directed spin labeling. Proc Natl Acad Sci USA 1998; 95:14060-14065
27. Bode AP, Orton SM, Frye MJ, et al. Vesiculation of platelets during in vitro aging. Blood 1991; 77:887-895
28. Berckmans RJ, Neiuwland R, Böing AN, et al. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost 2001; 85:639-646
29. Piccin A, Murphy WG, Smith OP: Circulating microparticles: pathophysiology and clinical implications. Blood Rev 2007; 21:157-171
30. Simak J, Gelderman MP: Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers. Transfus Med Rev 2006; 20:1-26
31. Ravichandran KS, Lorenz U: Engulfment of apoptotic cells: signals for a good meal. Nat Rev Immunol 2007; 7:964-974
32. Snyder EL, Moroff G, Simon T, et al. Recommended methods for conducting radiolabeled platelet survival studies. Transfusion 1986; 26:37-42
33. Badlou BA, Wu YP, Smid WM, et al. Platelet binding and phagocytosis by macrophages. Transfusion 2006; 46:1432-1443
34. Diedrich B, Ringdén O, Watz E, et al. A randomized study of buffy coat platelets in platelet additive solution stored 1-5 versus 6-7 days prior to prophylactic transfusion of allogeneic haematopoietic progenitor cell transplant recipients. Vox Sang 2009; 97:254-259
35. Matsubayashi H, Weidner J, Miraglia CC, et al. Platelet membrane early activation markers during prolonged storage. Thromb Res 1999; 93:151-160