Activated protein C resistance: Effect of platelet activation, platelet- derived microparticles, and atherogenic lipoproteins

Blood

Volumn 93, Issue 11, 1999, Pages 3792-3797

  Taube, Janis ^a   McWilliam, Nicola ^a   Luddington, Roger ^a   Byrne, Christopher D ^a   Baglin, Trevor ^a  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 [4 (AMINOIMINOMETHYL)PHENYL] 1 PIPERAZINYL] 1 PIPERIDINEACETIC ACID; ACETYLSALICYLIC ACID;

ACTIVATED PROTEIN C RESISTANCE; ARTICLE; ATHEROGENESIS; DRUG EFFECT; HEMOSTASIS; HUMAN; HUMAN CELL; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOSIS;

EID: 0033153097     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.11.3792     Document Type: Article

References (31)

1. Dahlback B, Carlsson M, Svensson P: Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. PNAS USA 90:1004, 1993
2. Bertina R, Koeleman B, Koster T, Rosendaal F, Dirven R, de Ronde H, van der Velden P, Reitsma P: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64, 1994
3. Voorberg J, Roelse J, Koopman R, Buller H, Berends F, Ten Cate J, Mertens K, Van-Mourik J: Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet 343:1535, 1994
4. Greengard J, Sun X, Xu X, Fernandez J, Griffin J, Evatt B: Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet 343:1361, 1994
5. Zoller B, Dahlback B: Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 343:1536, 1994
6. 306 to Thr) associated with resistance to activated protein C. Blood 91:1140, 1998
7. Zoller B, Svensson P, He X, Dahlback B: Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 94:2521, 1994
8. Koster T, Rosendaal F, de Ronde H, Briet E, Vandenbrouke J, Bertina R: Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 342:1503, 1993
9. Ridker P, Hennekens C, Lindpaintner K, Stampfer M, Eisenberg P, Miletich J: Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men. N Engl J Med 332:912, 1995
10. van der Bom J, Bots M, Haverkate F, Slagboom P, Meijer P, de Jong P, Hofman A, Grobee D, Kluft C: Reduced response to activated protein C is associated with increased risk for cerebrovascular disease. Ann Intern Med 125:265, 1996
11. Sidelmann J, Gram J, Pedersen O, Jespersen J: Influence of plasma platelets on activated protein C resistance assay. Thromb Haemost 74:993, 1995
12. Shizuka R, Kanda T, Amagai H, Kobayashi I: False-positive activated protein C (APC) sensitivity ratio caused by freezing and by contamination of plasma with platelets. Thromb Res 78:189, 1995
13. Luddington R, Brown K, Baglin T: Effect of platelet phospholipid exposure on activated protein C resistance: Implications for thrombophilia screening. Br J Haematol 92:744, 1996
14. Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C. Blood 91:2818, 1998
15. Rota S, McWilliam N, Baglin T, Byrne C: Atherogenic lipoproteins support assembly of the prothrombinase complex and thrombin generation. Blood 91:508, 1998
16. Schacterle G, Pollack R: A simplified method for the quantitative assay of small amounts of protein in biologic material. Anal Biochem 51:654, 1973
17. Tangen O, Berman H, Marfey P: Gel filtration. A new technique for separation of blood platelets from plasma. Thromb Diathesis Haemorrhagica 25:268, 1971
18. Jane S, Mitchell C, Salem H: Inhibition of activated protein C by platelets. J Clin Invest 83:222, 1989
19. Camire R, Kalafatis M, Cushman M, Tracy R, Mann K, Tracy P: The mechanism of inactivation of human platelet factor Va from normal and activated protein C-resistant individuals. J Biol Chem 270:20794, 1995
20. Bajzar L, Nesheim M, Tracy P: The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 88:2093, 1996
21. Born G, Richardson P: Activation time of blood platelets. J Membr Biol 57:87, 1980
22. Nesheim M, Nichols W, Cole T, Houston J, Schenk R, Mann K, Bowie E: Isolation and study of an acquired inhibitor of human coagulation factor V. J Clin Invest 77:1986, 1986
23. Tracy P, Eide L, Bowie E, Mann K: Radioimmunoassay of factor V in human plasma and platelets. Blood 60:59, 1982
24. Weiss H, Tschopp T, Baumgartner H: Impaired interaction (adhesion-aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. N Engl J Med 293:619, 1975
25. Wester J, Sixma J, Geuze J, van der Veen J: Morphology of the early haemostasis in human skin wounds: Influence of acetylsalicylic acid. Lab Invest 39:298, 1978
26. Szczeklik A, Kranowski M, Gora P, Radwan J: Antiplatelet drugs and generation of thrombin in clotting blood. Blood 80:2006, 1992
27. Comfurius P, Bevers E, Zwaal R: The involvement of cytoskeleton in the regulation of transbilayer movement of phospholipids in human blood platelets. Biochim Biophys Acta 815:143, 1985
28. Rota S, Flynn P, Wareham N, Baglin T, Byrne C: Is platelet phospholipid-dependent thrombin generation altered by acute myocardial infarction or aspirin? Thromb Res 83:329, 1996
29. Herault J, Peyrou V, Savi P, Bernat A, Herbert J: Effect of SR121566A, a potent GP IIb-IIIa antagonist on platelet-mediated thrombin generation in vitro and in vivo. Thromb Haemost 79:383, 1998
30. Coller B: Platelet GPIIb/IIIa antagonists: The first anti-integrin receptor therapeutics. J Clin Invest 100:S57, 1997 (suppl)
31. Frelinger A, Du X, Plow E, Ginsberg M: Monoclonal antibodies to ligand-occupied conformers of integrin aIIbβ3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity and function. J Biol Chem 266:17106, 1991