Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 2, 2010, Pages 294-300

  Castoldi, E ^a   Simioni, P ^b   Tormene, D ^b   Rosing, J ^a   Hackeng, T M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

Oral anticoagulant therapy; Oral contraceptives; Protein S deficiency; TFPI; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ORAL CONTRACEPTIVE AGENT; PROTEIN S; THROMBIN; TISSUE FACTOR PATHWAY INHIBITOR;

ACQUIRED PROTEIN S DEFICIENCY; ADULT; ANTICOAGULANT THERAPY; ARTICLE; CONTROLLED STUDY; FEMALE; HEREDITARY PROTEIN S DEFICIENCY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL CONTRACEPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; PROTEIN S DEFICIENCY; SURFACE PLASMON RESONANCE; THROMBOSIS;

ADMINISTRATION, ORAL; ADULT; AGED; ANTICOAGULANTS; BLOOD COAGULATION; CASE-CONTROL STUDIES; CONTRACEPTIVES, ORAL; DOWN-REGULATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; LIPOPROTEINS; MALE; MIDDLE AGED; PROTEIN BINDING; PROTEIN S; PROTEIN S DEFICIENCY; RISK FACTORS; THROMBIN; THROMBOPLASTIN; TIME FACTORS; YOUNG ADULT;

EID: 74749084650     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2009.03712.x     Document Type: Article

References (30)

1. García de Frutos P, Fuentes-Prior P, Hurtado B, Sala N. Molecular basis of protein S deficiency. Thromb Haemost 2007, 98:543-56.
2. Castoldi E, Hackeng TM. Regulation of coagulation by protein S. Curr Opin Hematol 2008, 15:529-36.
3. Walker FJ. Protein S and the regulation of activated protein C. Semin Thromb Hemost 1984, 10:131-8.
4. Hackeng TM, Seré KM, Tans G, Rosing J. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proc Natl Acad Sci USA 2006, 103:3106-11.
5. Ndonwi M, Broze G. Protein S enhances the TFPI inhibition of factor Xa but not its inhibition of factor VIIa/tissue factor. J Thromb Haemost 2008, 6:1044-6.
6. Comp PC, Esmon CT. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med 1984, 311:1525-8.
7. Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. Plasma protein S deficiency in familial thrombotic disease. Blood 1984, 64:1297-300.
8. Dykes AC, Walker ID, McMahon AD, Islam SI, Tait RC. A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state. Br J Haematol 2001, 113:636-41.
9. Huisveld IA, Hospers JE, Meijers JC, Starkenburg AE, Erich WB, Bouma BN. Oral contraceptives reduce total protein S, but not free protein S. Thromb Res 1987, 45:109-14.
10. Boerger LM, Morris PC, Thurnau GR, Esmon CT, Comp PC. Oral contraceptives and gender affect protein S status. Blood 1987, 69:692-4.
11. D'Angelo A, Viganò-D'Angelo S, Esmon CT, Comp PC. Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation. J Clin Invest 1988, 81:1445-54.
12. Lwaleed BA, Bass PS. Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol 2006, 208:327-39.
13. Crawley JT, Lane DA. The haemostatic role of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol 2008, 28:233-42.
14. Broze GJ, Lange GW, Duffin KL, MacPhail L. Heterogeneity of plasma tissue factor pathway inhibitor. Blood Coagul Fibrinolysis 1994, 5:551-9.
15. Wesselschmidt R, Likert K, Girard T, Wun TC, Broze GJ. Tissue factor pathway inhibitor: the carboxy-terminus is required for optimal inhibition of factor Xa. Blood 1992, 79:2004-10.
16. Dahm A, Van Hylckama Vlieg A, Bendz B, Rosendaal F, Bertina RM, Sandset PM. Low levels of tissue factor pathway inhibitor (TFPI) increase the risk of venous thrombosis. Blood 2003, 101:4387-92.
17. Duckers C, Simioni P, Spiezia L, Radu C, Gavasso S, Rosing J, Castoldi E. Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency. Blood 2008, 112:3615-23.
18. Dahm AE, Sandset PM, Rosendaal FR. The association between protein S levels and anticoagulant activity of tissue factor pathway inhibitor type 1. J Thromb Haemost 2008, 6:393-5.
19. Simioni P, Sanson BJ, Prandoni P, Tormene D, Friederich PW, Girolami B, Gavasso S, Huisman MV, Büller HR, ten Cate JW, Girolami A, Prins MH. Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost 1999, 81:198-202.
20. Castoldi E, Simioni P, Tormene D, Thomassen MC, Spiezia L, Gavasso S, Rosing J. Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia. J Thromb Haemost 2007, 5:971-9.
21. Hemker HC, Giesen P, AlDieri R, Regnault V, de Smed E, Wagenvoord R, Lecompte T, Béguin S. The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability. Pathophysiol Haemost Thromb 2002, 32:249-53.
22. Seré KM, Rosing J, Hackeng TM. Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. Blood 2004, 104:3624-30.
23. Lafeuillade A, Alessi MC, Poizot-Martin I, Dhiver C, Quilichini R, Aubert L, Gastaut JA, Juhan-Vague I. Protein S deficiency and HIV infection. N Engl J Med 1991, 324:1220.
24. Nguyên P, Reynaud J, Pouzol P, Munzer M, Richard O, Francois P. Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children. Eur J Pediatr 1994, 153:646-9.
25. Forastiero RR, Kordich L, Basilotta E, Carreras LO. Differences in protein S and C4b-binding protein levels in different groups of patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis 1994, 5:609-16.
26. Guermazi S, Regnault V, Gorgi Y, Ayed K, Lecompte T, Dellagi K. Further evidence for the presence of anti-protein S autoantibodies in patients with systemic lupus erythematosus. Blood Coagul Fibrinolysis 2000, 11:491-8.
27. Marchetti M, Castoldi E, Spronk HM, van Oerle R, Balducci D, Barbui T, Rosing J, Ten Cate H, Falanga A. Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera. Blood 2008, 112:4061-8.
28. Hackeng TM, Maurissen LF, Castoldi E, Rosing J. Regulation of TFPI function by protein S. J Thromb Haemost 2009, 7(Suppl. 1):165-8.
29. Carlsson SU, Dahlbäck B. Importance of protein S for expression of the C4B-binding protein -beta-chain. J Thromb Haemost 2009, 7(Suppl. 2):259. [abstract]
30. Heeb MJ, Prashun D, Griffin JH, Bouma BN. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J 2009, 23:2244-53.