Inhibition of thrombin generation by protein S at low procoagulant stimuli: Implications for maintenance of the hemostatic balance

Blood

Volumn 104, Issue 12, 2004, Pages 3624-3630

  Seré, Kristin M ^a   Rosing, Jan ^a   Hackeng, Tilman M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; APC PROTEIN; PHOSPHOLIPID; PROTEIN S; PROTHROMBIN; THROMBOPLASTIN;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HEMOSTASIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN S DEFICIENCY; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE DIAGNOSIS; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; STIMULUS RESPONSE;

EID: 9444273450     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-03-1146     Document Type: Article

References (31)

1. Di Scipio RG, Hermodson MA, Yates SG, Davie EW. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S. Biochemistry. 1977;16:698-706.
2. Di Scipio R, Davie E. Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma. Biochemistry. 1979;18:899-904.
3. Walker FJ. Regulation of activated protein C by a new protein: a possible function for bovine protein S. J Biol Chem. 1980;255:5521-5524.
4. Walker FJ. Regulation of activated protein C by protein S: the role of phospholipid in factor Va inactivation. J Biol Chem. 1981;256:11128-11131.
5. Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J. 1992;6: 2561-2567.
6. Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem. 1994;269:31869-31880.
7. Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor Villa: identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem. 1991;266:20139-20145.
8. Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem. 1993; 268:2872-2877.
9. Hackeng TM, van't Veer C, Meijers JC, Bouma BN. Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa. J Biol Chem. 1994;269:21051-21058.
10. Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci USA. 1994;91: 2728-2732.
11. van't Veer C, Hackeng TM, Biesbroeck D, Sixma JJ, Bouma BN. Increased prothrombin activation in protein S-deficient plasma under flow conditions on endothelial cell matrix: an independent anticoagulant function of protein S in plasma. Blood. 1995;85:1815-1821.
12. Heeb MJ, Kojima Y, Rosing J, Tans G, Griffin JH. C-terminal residues 621-635 of protein S are essential for binding to factor Va. J Biol Chem. 1999;274:36187-36192.
13. Stenberg Y, Muranyi A, Steen C, Thulin E, Drakenberg T, Stenflo J. EGF-like module pair 3-4 in vitamin K-dependent protein S: modulation of calcium affinity of module 4 by module 3, and interaction with factor X. J Mol Biol. 1999;293:653-665.
14. Dahlbäck B, Hildebrand B, Malm J. Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies. J Biol Chem. 1990;265:8127-8135.
15. Hackeng TM, Hessing M, van't Veer C, et al. Protein S binding to human endothelial cells is required for expression of cofactor activity for activated protein C. J Biol Chem. 1993;268:3993-4000.
16. van't Veer C, Butenas S, Golden N, Mann K. Regulation of prothrombinase activity by protein S. Thromb Haemost. 1999;82:80-87.
17. van Wijnen M, Stam JG, van't Veer C, et al. The interaction of protein S with the phospholipid surface is essential for the activated protein C-independent activity of protein S. Thromb Haemost. 1996;76:397-403.
18. Sere KM, Janssen MP, Willems GM, Tans G, Rosing J, Hackeng TM. Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity. Biochemistry. 2001;40:8852-8860.
19. Comp PC, Nixon RR, Cooper MR, Esmon CT. Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest. 1984;74: 2082-2088.
20. Schwarz H, Fischer M, Hopmeier P, Batard M, Griffin J. Plasma protein S deficiency in familial thrombotic disease. Blood. 1984;64:1297-1300.
21. van Wijnen M, van't Veer C, Meijers JC, Bertina RM, Bouma BN. A plasma coagulation assay for an activated protein C-independent anticoagulant activity of protein S. Thromb Haemost. 1998;80: 930-935.
22. Koenen RR, Tans G, van Oerle R, Hamulyak K, Rosing J, Hackeng TM. The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation. Blood. 2003; 102:1686-1692.
23. Rosing J, Bakker HM, Thomassen MC, Hemker HC, Tans G. Characterization of two forms of human factor Va with different cofactor activities. J Biol Chem. 1993;268:21130-21136.
24. Koedam JA, Meijers JC, Sixma JJ, Bouma BN. Inactivation of human factor VIII by activated protein C: cofactor activity of protein S and protective effect of von Willebrand factor. J Clin Invest. 1988;82:1236-1243.
25. Hemker HC, Giesen P, Al Dieri R, et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb. 2003;33:4-15.
26. Gruber A, Griffin JH. Direct detection of activated protein C in blood from human subjects. Blood. 1992;79:2340-2348.
27. Nelsestuen GL. Role of gamma-carboxyglutamic acid: an unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid. J Biol Chem. 1976;251:5648-5656.
28. Nelsestuen GL, Broderius M, Martin G. Role of gamma-carboxyglutamic acid: cation specificity of prothrombin and factor X-phospholipid binding. J Biol Chem. 1976;251:6886-6893.
29. Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Blood. 2004;103:1192-1201.
30. Giesen PL, Willems GM, Hermens WT. Production of thrombin by the prothrombinase complex is regulated by membrane-mediated transport of prothrombin. J Biol Chem. 1991;266:1379-1382.
31. Giesen PL, Rauch U, Bohrmann B, et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci USA. 1999;96:2311-2315.