Effect of Smad7 on transforming growth factorβ1-induced alveolar epithelial to mesenchymal transition

National Medical Journal of China

Volumn 87, Issue 27, 2007, Pages 1918-1923

  Xu, Guo Ping ^a   Li, Qing Quan ^b   Cao, Xi Xi ^b   Chen, Qi ^b   Zhao, Zhong Hua ^b   Diao, Zi Qiang ^b   Xu, Zu De ^b  

^a FUDAN UNIVERSITY   (China)

^b NONE

Author keywords

Epithelial cells; Stromal cells; Transfection; Transforming growth factor beta

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOKERATIN 19; FIBRONECTIN; LIPOFECTAMINE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEGENERATION; CELL DIFFERENTIATION; CELL STRUCTURE; CELL TRANSFORMATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; ELECTRON MICROSCOPY; EPITHELIUM CELL; GENE TRANSFER; GENETIC TRANSFECTION; IN VITRO STUDY; INHIBITION KINETICS; LAMELLAR BODY; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; MESENCHYME CELL; MYOFIBROBLAST; NONHUMAN; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CADHERINS; CELL LINE; CELL TRANSDIFFERENTIATION; EPITHELIAL CELLS; FIBRONECTINS; KERATIN-19; MESODERM; MICROSCOPY, ELECTRON, TRANSMISSION; PULMONARY ALVEOLI; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMAD7 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN;

EID: 34948817278     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Hashimoto N, Jin H, Liu T, et al. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest, 2004, 113: 243-252.
2. Yao HW, Xie QM, Chen JQ, et al. TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro. Life Sci, 2004, 76: 29-37.
3. Chinese source.
4. Maasague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J, 2000, 19:1745-1754.
5. Chinese source.
6. Hayashi H, Abdollah S, Qiu Y, et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell, 1997, 89:1165-1173.
7. Greenburg G, Hay ED. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol, 1982, 95:333-339.
8. Stoker M, Perryman M. An epithelial scatter factor released by embryo fibroblasts. J Cell Sci, 1985, 77:209-223.
9. Miettinen PJ, Ebner R, Lopez AR, et al. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol, 1994, 127: 2021-2036.
10. Kalluri R, Neilson EG. Epithelial mesenchymal transition and its implications for fibrosis. J Clin Invest, 2003, 112:1776-1784.
11. Chinese source.