Cigarettes with different nicotine levels affect sensory perception and levels of biomarkers of exposure in adult smokers

Nicotine and Tobacco Research

Volumn 16, Issue 7, 2014, Pages 948-960

  McKinney, Diana L ^a   Frost Pineda, Kimberly ^a   Oldham, Michael J ^a   Fisher, Michael T ^a   Wang, Jingzhu ^a   Gogova, Maria ^a   Kobal, Gerd ^a  

^a Altria Client Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYPYRENE; 3 HYDROXYPROPYL MERCAPTURIC ACID; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; BIOLOGICAL MARKER; CARBOXYHEMOGLOBIN; COTININE; NICOTINE; UNCLASSIFIED DRUG; 1-HYDROXYPYRENE; 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTAN-1-OL; NITROSAMINE; PYRENE DERIVATIVE; PYRIDINE DERIVATIVE; TAR;

ADULT; AGED; ARTICLE; BLOOD LEVEL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; PILOT STUDY; PRIORITY JOURNAL; SENSORY SYSTEM; SMOKING; URINARY EXCRETION; ANALYSIS; BLOOD; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PERCEPTION; RANDOMIZED CONTROLLED TRIAL; TOBACCO; URINE; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; CARBOXYHEMOGLOBIN; COTININE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINE; NITROSAMINES; PERCEPTION; PILOT PROJECTS; PYRENES; PYRIDINES; SMOKING; TARS; TOBACCO PRODUCTS; YOUNG ADULT;

EID: 84902506207     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntu009     Document Type: Article

References (50)

1. Ayya, N., & Beauchamp, G. K. (1992). Short-term effects of diet on salt taste preference. Appetite, 18, 77-82. doi:10.1016/0195-6663(92)90212-O.
2. Baldinger, B., Hasenfratz, M., & Bättig, K. (1995). Switching to ultralow nicotine cigarettes: Effects of different tar yields and blocking of olfactory cues. Pharmacology, Biochemistry, and Behavior, 50, 233-239. doi:10.1016/0091-3057(94)00302-Y.
3. Becker, K. M., Rose, J. E., & Albino, A. P. (2008). A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation. Nicotine & Tobacco Research, 10, 1139-1148. doi:10.1080/14622200802123294.
4. Benowitz, N. L. (1999). Biomarkers of environmental tobacco smoke exposure. Environmental Health Perspectives, 107(Suppl. 2), 349-355. doi:10.2307/3434427.
5. Benowitz, N. L., Dains, K. M., Hall, S. M., Stewart, S., Wilson, M., Dempsey, D., & Jacob, P., III. (2009). Progressive commercial cigarette yield reduction: Biochemical exposure and behavioral assessment. Cancer Epidemiology, Biomarkers & Prevention, 18, 876-883. doi:10.1158/1055-9965. EPI-08-0731.
6. Benowitz, N. L., Dains, K. M., Hall, S. M., Stewart, S., Wilson, M., Dempsey, D., & Jacob, P., III. (2012). Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettes. Cancer Epidemiology Biomarkers and Prevention, 21, 761-769. doi:10.1158/1055-9965.
7. Benowitz, N. L., Hall, S. M., Stewart, S., Wilson, M., Dempsey, D., & Jacob, P., III. (2007). Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Cancer Epidemiology, Biomarkers & Prevention, 16, 2479-2485. doi:10.1158/1055-9965.EPI-07-0393.
8. Benowitz, N. L., Jacob, P., III, & Herrera, B. (2006). Nicotine intake and dose response when smoking reduced-nicotine content cigarettes. Clinical Pharmacology and Therapeutics, 80, 703-714. doi:10.1016/j.clpt.2006.09.007.
9. Breland, A. B., Acosta, M. C., & Eissenberg, T. (2003). Tobacco specific nitrosamines and potential reduced exposure products for smokers: A preliminary evaluation of Advance™. Tobacco Control, 12, 317-321. doi:10.1136/tc.12.3.317.
10. Breland, A. B., Kleykamp, B. A., & Eissenberg, T. (2006). Clinical laboratory evaluation of potential reduced exposure products for smokers. Nicotine & Tobacco Research, 8, 727-738. doi:10.1080/14622200600789585.
11. Butschky, M. F., Bailey, D., Henningfield, J. E., & Pickworth, W. B. (1995). Smoking without nicotine delivery decreases withdrawal in 12-hour abstinent smokers. Pharmacology, Biochemistry and Behavior, 50, 91-96. doi:10.1016/0091-3057(94)00269-O.
12. Carmella, S. G., Borukhova, A., Desai, D., & Hecht, S. S. (1997). Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis, 18, 587-592. doi:10.1093/carcin/18.3.587.
13. Dallery, J., Houtsmuller, E. J., Pickworth, W. B., & Stitzer, M. L. (2003). Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking. Psychopharmacology, 165, 172-180. doi:10.1007/s00213-002-1242-8.
14. Dixon, M., Kochhar, N., Prasad, K., Shepperd, J., & Warburton, D. M. (2003). The influence of changing nicotine to tar ratios on human puffing behaviour and perceived sensory response. Psychopharmacology, 170, 434-442. doi:10.1007/s00213-003-1541-8.
15. Donny, E. C., Houtsmuller, E., & Stitzer, M. L. (2007). Smoking in the absence of nicotine: Behavioral, subjective and physiological effects over 11 days. Addiction (Abingdon, England), 102, 324-334. doi:10.1111/j.1360-0443.2006.01670.x.
16. Donny, E. C., & Jones, M. (2009). Prolonged exposure to denicotinized cigarettes with or without transdermal nicotine. Drug and Alcohol Dependence, 104, 23-33. doi:10.1016/j. drugalcdep.2009.01.021.
17. Dunn, P. J., & Freiesleben, E. R. (1978). The effects of nicotine-enhanced cigarettes on human smoking parameters and alveolar carbon monoxide levels. In R. E. Thornton (Ed.), Smoking behaviour: Physiological and psychological influences (pp. 195-202). London: Churchill-Livingstone.
18. Fagerström, K. O. (1982). Effects of a nicotine-enriched cigarette on nicotine titration, daily cigarette consumption, and levels of carbon monoxide, cotinine, and nicotine. Psychopharmacology, 77, 164-167. doi:10.1007/BF00431941.
19. Fischer, S., Spiegelhalder, B., Eisenbarth, J., & Preussmann, R. (1990). Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis, 11, 723-730. doi:10.1093/carcin/11.5.723.
20. Goldfarb, T., Gritz, E. R., Jarvik, M. E., & Stolerman, I. P. (1976). Reactions to cigarettes as a function of nicotine and "tar". Clinical Pharmacology and Therapeutics, 19, 767-772. Retrieved from http://pubmed.gov.
21. Goniewicz, M. L., Havel, C. M., Peng, M. W., Jacob, P., III, Dempsey, D., Yu, L.,. Benowitz, N. L. (2009). Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Cancer Epidemiology, Biomarkers & Prevention, 18, 3421-3425. doi:10.1158/1055-9965.EPI-09-0874.
22. Hatsukami, D. K., Dahlgren, L., Zimmerman, R., & Hughes, J. R. (1988). Symptoms of tobacco withdrawal from total cigarette cessation versus partial cigarette reduction. Psychopharmacology, 94, 242-247. doi:10.1007/BF00176853.
23. Hatsukami, D. K., Heishman, S. J., Vogel, R. I., Denlinger, R. L., Roper-Batker, A. N., Mackowick, K. M.,. Donny, E. (2012). Dose-response effects of Spectrum research cigarettes. Nicotine & Tobacco Research. Advance Access published on November 22, 2012. doi:10.1093/ntr/nts247.
24. Hatsukami, D. K., Kotlyar, M., Hertsgaard, L. A., Zhang, Y., Carmella, S. G., Jensen, J. A.,. Hecht, S. S. (2010). Reduced nicotine content cigarettes: Effects on toxicant exposure, dependence and cessation. Addiction, 105, 343-355. doi:10.1111/j.1360-0443.2009.02780.x.
25. Heatherton, T. F., Kozlowski, L. T., Frecker, R. C., & Fagerström, K. O. (1991). The Fagerström Test for Nicotine Dependence: A revision of the Fagerström Tolerance Questionnaire. British Journal of Addiction, 86, 1119-1127. doi:10.1111/j.1360-0443.1991.tb01879.x.
26. Hecht, S. S., Hatsukami, D. K., Bonilla, L. E., & Hochalter, J. B. (1999). Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism. Chemical Research in Toxicology, 12, 172-179. doi:10.1021/tx980214i.
27. Hecht, S. S., Hochalter, J. B., Villalta, P. W., & Murphy, S. E. (2000). 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogen precursor. Proceedings of the National Academy of Sciences of the United States of America, 97, 12493-12497. doi:10.1073/pnas.220207697.
28. Henningfield, J. E., Benowitz, N. L., Slade, J., Houston, T. P., Davis, R. M., & Deitchman, S. E. (1998). Reducing the addictiveness of cigarettes. For the Council on Scientific Affairs, American Medical Association. Tobacco Control, 7, 281-293. Retrieved from www.ncbi.nlm.nih.gov/pmc/articles/PMC1763900/pdf/v007p00281.pdf.
29. Herning, R. I., Jones, R. T., Bachman, J., & Mines, A. H. (1981). Puff volume increases when low-nicotine cigarettes are smoked. British Medical Journal, 283, 187-189. doi:10.1136/bmj.283.6285.187.
30. Kassel, J. D., Greenstein, J. E., Evatt, D. P., Wardle, M. C., Yates, M. C., Veilleux, J. C., & Eissenberg, T. (2007). Smoking topography in response to denicotinized and high-yield nicotine cigarettes in adolescent smokers. Journal of Adolescent Health, 40, 54-60. doi:10.1016/j.jadohealth.2006.08.006.
31. Muhammad-Kah, R., Liang, Q., Frost-Pineda, K., Mendes, P. E., Roethig, H. J., & Sarkar, M. (2011). Factors affecting exposure to nicotine and carbon monoxide in adult cigarette smokers. Regulatory Toxicology and Pharmacology, 61, 129-136. doi:10.1016/j.yrtph.2011.07.003.
32. Pickworth, W. B., Fant, R. V., Nelson, R. A., Rohrer, M. S., & Henningfield, J. E. (1999). Pharmacodynamic effects of new de-nicotinized cigarettes. Nicotine & Tobacco Research, 1, 357-364. doi:10.1080/14622299050011491.
33. Richter, E., Engl, J., Friesenegger, S., & Tricker, A. R. (2009). Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man. Chemical Research in Toxicology, 22, 1008-1017. doi:10.1021/tx800461d.
34. Richter, E., & Tricker, A. R. (1994). Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats. Carcinogenesis, 15, 1061-1064. doi:10.1093/carcin/15.5.1061.
35. Robinson, J. H., Pritchard, W. S., & Davis, R. A. (1992). Psychopharmacological effects of smoking a cigarette with typical "tar" and carbon monoxide yields but minimal nicotine. Psychopharmacology, 108, 466-472. Retrieved from http://pubmed.gov.
36. Roethig, H. J., Kinser, R. D., Lau, R. W., Walk, R. A., & Wang, N. (2005). Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking. Journal of Clinical Pharmacology, 45, 133-145. doi:10.1177/0091270004271253.
37. Roethig, H. J., Zedler, B. K., Kinser, R. D., Feng, S., Nelson, B. L., & Liang, Q. (2007). Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system. Journal of Clinical Pharmacology, 47, 518-530. doi:10.1177/0091270006297686.
38. Rose, J. E., & Behm, F. M. (2004). Effects of low nicotine content cigarettes on smoke intake. Nicotine and Tobacco Research, 6, 309-319. Erratum in (2004) Nicotine and Tobacco Research, 6, 575. doi:10.1080/146222004100016 76378.
39. Rose, J. E., Behm, F. M., & Levin, E. D. (1993). Role of nicotine dose and sensory cues in the regulation of smoke intake. Pharmacology, Biochemistry and Behavior, 44, 891-900. doi:10.1016/0091-3057(93)90021-K.
40. Russell, M. A. H., Jarvis, M., Iyer, R., & Feyerabend, C. (1980). Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. British Medical Journal, 280, 972-976.
41. Scherer, G. (1999). Smoking behaviour and compensation: A review of the literature. Psychopharmacology, 145, 1-20. doi:10.1007/s002130051027.
42. Scherer, G. (2005). Biomonitoring of inhaled complex mixtures-Ambient air, diesel exhaust and cigarette smoke. Experimental and Toxicologic Pathology, 57, 75-110. doi:10.1016/j.etp.2005.05.007.
43. St. Helen, G., Goniewicz, M. L., Dempsey, D., Wilson, M., Jacob, P., III, & Benowitz, N. L. (2012). Exposure and kinetics of polycyclic aromatic hydrocarbons (PAHs) in cigarette smokers. Chemical Research in Toxicology, 25, 952-964. doi:10.1021/tx300043k.
44. Stepney, R. (1981). Would a medium-nicotine, low-tar cigarette be less hazardous to health? British Medical Journal, 283, 1292-1296. doi:10.1136/bmj.283.6302.1292.
45. Strasser, A. A., Lerman, C., Sanborn, P. M., Pickworth, W. B., & Feldman, E. A. (2007). New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Drug and Alcohol Dependence, 86, 294-300. doi:10.1016/j.drugalcdep.2006.06.017.
46. Tricker, A. R. (2003). Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour. Toxicology, 183, 151-173. doi:10.1016/S0300-483X(02)00513-9.
47. U.S. Food and Drug Administration. (2001). Guidance for industry: Bioanalytical method validation. Rockville, MD: U.S. Department of Health and Human Services, FDA, Center for Drug Evaluation and Research. Retrieved from www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf.
48. Van Vleet, T. R., Bombick, D. W., & Coulombe, R. A., Jr. (2001). Inhibition of human cytochrome P450 2E1 by nicotine, cotinine, and aqueous cigarette tar extract in vitro. Toxicological Sciences, 64, 185-191. doi:10.1093/toxsci/64.2.185.
49. Woodman, G., Newman, S. P., Pavia, D., & Clarke, S. W. (1987). Inhaled smoke volume and puff indices with cigarettes of different tar and nicotine levels. European Journal of Respiratory Diseases, 70, 187-192. Retrieved from pubmed. gov.
50. Zedler, B. K., Kinser, R., Oey, J., Nelson, B., Roethig, H. J., Walk, R. A.,. Tricker, A. R. (2006). Biomarkers of exposure and potential harm in adult smokers of 3-7 mg tar yield (Federal Trade Commission) cigarettes and in adult non-smokers. Biomarkers, 11, 201-220. doi:10.1080/13547500600576260.