Discovery and optimization of novel 3-piperazinylcoumarin antagonist Of chemokine-like factor 1 with oral antiasthma activity in mice

Journal of Medicinal Chemistry

Volumn 53, Issue 4, 2010, Pages 1741-1754

  Li, Gang ^a   Wang, Dongmei ^a   Sun, Mingna ^a   Li, Guangyan ^a   Hu, Jinfeng ^a   Zhang, Yun ^a   Yuan, Yuhe ^a   Ji, Haijie ^a   Chen, Naihong ^a   Liu, Gang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5,7 DIHYDROXY 4 METHYL 3 (4 METHYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; ANTIASTHMATIC AGENT; CHEMOKINE; CHEMOKINE LIKE FACTOR 1; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BINDING ASSAY; CALCIUM MOBILIZATION; CHEMOTAXIS; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BINDING, COMPETITIVE; CALCIUM; CELL LINE; CHEMOKINES; CHEMOTAXIS; COUMARINS; FIBROSIS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LUNG; MICE; NF-KAPPA B; PEPTIDE FRAGMENTS; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, CCR4; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77649197278     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901652p     Document Type: Article

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