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Volumn 108, Issue , 2014, Pages 198-208

Proteomic analysis of the soluble proteomes of miltefosine-sensitive and -resistant Leishmania infantum chagasi isolates obtained from Brazilian patients with different treatment outcomes

Author keywords

2D DIGE; L. infantum chagasi; Miltefosine resistance; MS MS; Proteome

Indexed keywords

2,4 DIHYDROXYHEPT 2 ENE 1,7 DIOIC ACID ALDOLASE; ACTIN; ALCOHOL DEHYDROGENASE; CHAPERONIN; CHAPERONIN 60; METHIONINE ADENOSYLTRANSFERASE; MILTEFOSINE; NITRILASE; PEROXIREDOXIN; PROTEIN; PROTEOME; RNA HELICASE; SPERMIDINE SYNTHASE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; PHOSPHORYLCHOLINE; PROTOZOAL PROTEIN;

EID: 84902474838     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2014.05.010     Document Type: Article
Times cited : (32)

References (53)
  • 1
    • 0030051907 scopus 로고    scopus 로고
    • Clinical spectrum of Leishmaniasis
    • Pearson R.D., Sousa A.Q. Clinical spectrum of Leishmaniasis. Clin Infect Dis 1996, 22:1-13.
    • (1996) Clin Infect Dis , vol.22 , pp. 1-13
    • Pearson, R.D.1    Sousa, A.Q.2
  • 2
    • 33749350345 scopus 로고    scopus 로고
    • Miltefosine, the story of a successful partnership: disease endemic country - TDR - pharmaceutical industry (Zentaris)
    • Engel J. Miltefosine, the story of a successful partnership: disease endemic country - TDR - pharmaceutical industry (Zentaris). TDR News 2002, 68:5.
    • (2002) TDR News , vol.68 , pp. 5
    • Engel, J.1
  • 5
    • 84864488072 scopus 로고    scopus 로고
    • Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use
    • Sundar S., Singh A., Rai M., Prajapati V.K., Singh A.K., Ostyn B., et al. Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use. Clin Infect Dis 2012, 55:543-550.
    • (2012) Clin Infect Dis , vol.55 , pp. 543-550
    • Sundar, S.1    Singh, A.2    Rai, M.3    Prajapati, V.K.4    Singh, A.K.5    Ostyn, B.6
  • 6
    • 0041767590 scopus 로고    scopus 로고
    • Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug
    • Perez-Victoria F.J., Castanys S., Gamarro F. Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug. Antimicrob Agents Chemother 2003, 47:2397-2403.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2397-2403
    • Perez-Victoria, F.J.1    Castanys, S.2    Gamarro, F.3
  • 7
    • 0346118937 scopus 로고    scopus 로고
    • Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance
    • Perez-Victoria F.J., Gamarro F., Ouellette M., Castanys S. Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance. J Biol Chem 2003, 278:49965-49971.
    • (2003) J Biol Chem , vol.278 , pp. 49965-49971
    • Perez-Victoria, F.J.1    Gamarro, F.2    Ouellette, M.3    Castanys, S.4
  • 8
    • 33747639280 scopus 로고    scopus 로고
    • Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites
    • Perez-Victoria F.J., Sanchez-Canete M.P., Castanys S., Gamarro F. Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites. J Biol Chem 2006, 281:23766-23775.
    • (2006) J Biol Chem , vol.281 , pp. 23766-23775
    • Perez-Victoria, F.J.1    Sanchez-Canete, M.P.2    Castanys, S.3    Gamarro, F.4
  • 9
    • 65649096220 scopus 로고    scopus 로고
    • Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug
    • Sanchez-Canete M.P., Carvalho L., Perez-Victoria F.J., Gamarro F., Castanys S. Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug. Antimicrob Agents Chemother 2009, 53:1305-1313.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1305-1313
    • Sanchez-Canete, M.P.1    Carvalho, L.2    Perez-Victoria, F.J.3    Gamarro, F.4    Castanys, S.5
  • 10
    • 0034863516 scopus 로고    scopus 로고
    • Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator
    • Perez-Victoria J.M., Perez-Victoria F.J., Parodi-Talice A., Jimenez I.A., Ravelo A.G., Castanys S., et al. Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator. Antimicrob Agents Chemother 2001, 45:2468-2474.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2468-2474
    • Perez-Victoria, J.M.1    Perez-Victoria, F.J.2    Parodi-Talice, A.3    Jimenez, I.A.4    Ravelo, A.G.5    Castanys, S.6
  • 11
    • 21444457549 scopus 로고    scopus 로고
    • Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions
    • Rakotomanga M., Saint-Pierre-Chazalet M., Loiseau P.M. Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions. Antimicrob Agents Chemother 2005, 49:2677-2686.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2677-2686
    • Rakotomanga, M.1    Saint-Pierre-Chazalet, M.2    Loiseau, P.M.3
  • 12
    • 33846554383 scopus 로고    scopus 로고
    • A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death
    • Vergnes B., Gourbal B., Girard I., Sundar S., Drummelsmith J., Ouellette M. A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death. Mol Cell Proteomics 2007, 6:88-101.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 88-101
    • Vergnes, B.1    Gourbal, B.2    Girard, I.3    Sundar, S.4    Drummelsmith, J.5    Ouellette, M.6
  • 13
    • 1442349131 scopus 로고    scopus 로고
    • Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes
    • Paris C., Loiseau P.M., Bories C., Breard J. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob Agents Chemother 2004, 48:852-859.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 852-859
    • Paris, C.1    Loiseau, P.M.2    Bories, C.3    Breard, J.4
  • 14
    • 1642565127 scopus 로고    scopus 로고
    • PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis
    • Volpini A.C., Passos V.M., Oliveira G.C., Romanha A.J. PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis. Acta Trop 2004, 90:31-37.
    • (2004) Acta Trop , vol.90 , pp. 31-37
    • Volpini, A.C.1    Passos, V.M.2    Oliveira, G.C.3    Romanha, A.J.4
  • 16
    • 0023931883 scopus 로고
    • Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250
    • Neuhoff V., Arold N., Taube D., Ehrhardt W. Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250. Electrophoresis 1988, 9:255-262.
    • (1988) Electrophoresis , vol.9 , pp. 255-262
    • Neuhoff, V.1    Arold, N.2    Taube, D.3    Ehrhardt, W.4
  • 17
    • 13844256061 scopus 로고    scopus 로고
    • Characterisation of proteins differentially present in the plasma of Biomphalaria glabrata susceptible or resistant to Echinostoma caproni
    • Vergote D., Bouchut A., Sautiere P.E., Roger E., Galinier R., Rognon A., et al. Characterisation of proteins differentially present in the plasma of Biomphalaria glabrata susceptible or resistant to Echinostoma caproni. Int J Parasitol 2005, 35:215-224.
    • (2005) Int J Parasitol , vol.35 , pp. 215-224
    • Vergote, D.1    Bouchut, A.2    Sautiere, P.E.3    Roger, E.4    Galinier, R.5    Rognon, A.6
  • 20
    • 80051783081 scopus 로고    scopus 로고
    • Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovani
    • Biyani N., Singh A.K., Mandal S., Chawla B., Madhubala R. Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovani. Mol Biochem Parasitol 2011, 179:91-99.
    • (2011) Mol Biochem Parasitol , vol.179 , pp. 91-99
    • Biyani, N.1    Singh, A.K.2    Mandal, S.3    Chawla, B.4    Madhubala, R.5
  • 21
    • 84856321253 scopus 로고    scopus 로고
    • Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism
    • Daneshvar H., Wyllie S., Phillips S., Hagan P., Burchmore R. Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. J Proteomics 2012, 75:1463-1471.
    • (2012) J Proteomics , vol.75 , pp. 1463-1471
    • Daneshvar, H.1    Wyllie, S.2    Phillips, S.3    Hagan, P.4    Burchmore, R.5
  • 22
    • 0141909066 scopus 로고    scopus 로고
    • Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms
    • Drummelsmith J., Brochu V., Girard I., Messier N., Ouellette M. Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms. Mol Cell Proteomics 2003, 2:146-155.
    • (2003) Mol Cell Proteomics , vol.2 , pp. 146-155
    • Drummelsmith, J.1    Brochu, V.2    Girard, I.3    Messier, N.4    Ouellette, M.5
  • 23
    • 4043094169 scopus 로고    scopus 로고
    • Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance
    • Drummelsmith J., Girard I., Trudel N., Ouellette M. Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance. J Biol Chem 2004, 279:33273-33280.
    • (2004) J Biol Chem , vol.279 , pp. 33273-33280
    • Drummelsmith, J.1    Girard, I.2    Trudel, N.3    Ouellette, M.4
  • 24
    • 84859612403 scopus 로고    scopus 로고
    • Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis
    • Walker J., Gongora R., Vasquez J.J., Drummelsmith J., Burchmore R., Roy G., et al. Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis. Mol Biochem Parasitol 2012, 183:166-176.
    • (2012) Mol Biochem Parasitol , vol.183 , pp. 166-176
    • Walker, J.1    Gongora, R.2    Vasquez, J.J.3    Drummelsmith, J.4    Burchmore, R.5    Roy, G.6
  • 25
    • 79955814700 scopus 로고    scopus 로고
    • Analysis of Leishmania chagasi by 2-D difference gel electrophoresis (2-D DIGE) and immunoproteomic: identification of novel candidate antigens for diagnostic tests and vaccine
    • Costa M.M., Andrade H.M., Bartholomeu D.C., Freitas L.M., Pires S.F., Chapeaurouge A.D., et al. Analysis of Leishmania chagasi by 2-D difference gel electrophoresis (2-D DIGE) and immunoproteomic: identification of novel candidate antigens for diagnostic tests and vaccine. J Proteome Res 2011, 10:2172-2184.
    • (2011) J Proteome Res , vol.10 , pp. 2172-2184
    • Costa, M.M.1    Andrade, H.M.2    Bartholomeu, D.C.3    Freitas, L.M.4    Pires, S.F.5    Chapeaurouge, A.D.6
  • 27
    • 3242879188 scopus 로고    scopus 로고
    • "The stress of dying": the role of heat shock proteins in the regulation of apoptosis
    • Beere H.M. "The stress of dying": the role of heat shock proteins in the regulation of apoptosis. J Cell Sci 2004, 117:2641-2651.
    • (2004) J Cell Sci , vol.117 , pp. 2641-2651
    • Beere, H.M.1
  • 28
    • 34250351297 scopus 로고    scopus 로고
    • A postgenomic view of the heat shock proteins in kinetoplastids
    • Folgueira C., Requena J.M. A postgenomic view of the heat shock proteins in kinetoplastids. FEMS Microbiol Rev 2007, 31:359-377.
    • (2007) FEMS Microbiol Rev , vol.31 , pp. 359-377
    • Folgueira, C.1    Requena, J.M.2
  • 29
    • 84886907764 scopus 로고    scopus 로고
    • Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines
    • Matrangolo F.S., Liarte D.B., Andrade L.C., de Melo M.F., Andrade J.M., Ferreira R.F., et al. Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines. Mol Biochem Parasitol 2013, 190:63-75.
    • (2013) Mol Biochem Parasitol , vol.190 , pp. 63-75
    • Matrangolo, F.S.1    Liarte, D.B.2    Andrade, L.C.3    de Melo, M.F.4    Andrade, J.M.5    Ferreira, R.F.6
  • 30
    • 0342398231 scopus 로고    scopus 로고
    • The genomic organization of the HSP83 gene locus is conserved in three Leishmania species
    • Hubel A., Clos J. The genomic organization of the HSP83 gene locus is conserved in three Leishmania species. Exp Parasitol 1996, 82:225-228.
    • (1996) Exp Parasitol , vol.82 , pp. 225-228
    • Hubel, A.1    Clos, J.2
  • 31
    • 84874974453 scopus 로고    scopus 로고
    • The Hsp90-Sti1 interaction is critical for Leishmania donovani proliferation in both life cycle stages
    • Hombach A., Ommen G., Chrobak M., Clos J. The Hsp90-Sti1 interaction is critical for Leishmania donovani proliferation in both life cycle stages. Cell Microbiol 2012, 15(4):585-600.
    • (2012) Cell Microbiol , vol.15 , Issue.4 , pp. 585-600
    • Hombach, A.1    Ommen, G.2    Chrobak, M.3    Clos, J.4
  • 32
    • 0031036746 scopus 로고    scopus 로고
    • Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases
    • Lassle M., Blatch G.L., Kundra V., Takatori T., Zetter B.R. Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases. J Biol Chem 1997, 272:1876-1884.
    • (1997) J Biol Chem , vol.272 , pp. 1876-1884
    • Lassle, M.1    Blatch, G.L.2    Kundra, V.3    Takatori, T.4    Zetter, B.R.5
  • 33
    • 33947102605 scopus 로고    scopus 로고
    • Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction
    • Verma N.K., Singh G., Dey C.S. Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction. Exp Parasitol 2007, 116:1-13.
    • (2007) Exp Parasitol , vol.116 , pp. 1-13
    • Verma, N.K.1    Singh, G.2    Dey, C.S.3
  • 34
    • 3342943546 scopus 로고    scopus 로고
    • Possible mechanism of miltefosine-mediated death of Leishmania donovani
    • Verma N.K., Dey C.S. Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob Agents Chemother 2004, 48:3010-3015.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3010-3015
    • Verma, N.K.1    Dey, C.S.2
  • 35
    • 0034255209 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
    • Nathan C., Shiloh M.U. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci U S A 2000, 97:8841-8848.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 8841-8848
    • Nathan, C.1    Shiloh, M.U.2
  • 36
    • 0036545912 scopus 로고    scopus 로고
    • The plasma redox state and ageing
    • Droge W. The plasma redox state and ageing. Ageing Res Rev 2002, 1:257-278.
    • (2002) Ageing Res Rev , vol.1 , pp. 257-278
    • Droge, W.1
  • 37
    • 0242668686 scopus 로고    scopus 로고
    • Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling
    • Wood Z.A., Poole L.B., Karplus P.A. Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 2003, 300:650-653.
    • (2003) Science , vol.300 , pp. 650-653
    • Wood, Z.A.1    Poole, L.B.2    Karplus, P.A.3
  • 39
    • 0034678059 scopus 로고    scopus 로고
    • Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi
    • Wilkinson S.R., Temperton N.J., Mondragon A., Kelly J.M. Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. J Biol Chem 2000, 275:8220-8225.
    • (2000) J Biol Chem , vol.275 , pp. 8220-8225
    • Wilkinson, S.R.1    Temperton, N.J.2    Mondragon, A.3    Kelly, J.M.4
  • 40
    • 33646909087 scopus 로고    scopus 로고
    • Expression of a mitochondrial peroxiredoxin prevents programmed cell death in Leishmania donovani
    • Harder S., Bente M., Isermann K., Bruchhaus I. Expression of a mitochondrial peroxiredoxin prevents programmed cell death in Leishmania donovani. Eukaryot Cell 2006, 5:861-870.
    • (2006) Eukaryot Cell , vol.5 , pp. 861-870
    • Harder, S.1    Bente, M.2    Isermann, K.3    Bruchhaus, I.4
  • 41
    • 84884591986 scopus 로고    scopus 로고
    • Miltefosine unresponsive Leishmania donovani has better ability of resist reactive oxygen species
    • Das M., Saudagar P., Sundar S., Dubey V.K. Miltefosine unresponsive Leishmania donovani has better ability of resist reactive oxygen species. FEBS J 2013, 280(19):4807-4815.
    • (2013) FEBS J , vol.280 , Issue.19 , pp. 4807-4815
    • Das, M.1    Saudagar, P.2    Sundar, S.3    Dubey, V.K.4
  • 42
    • 0028212644 scopus 로고
    • Molecular characterization of microbial alcohol dehydrogenases
    • Reid M.F., Fewson C.A. Molecular characterization of microbial alcohol dehydrogenases. Crit Rev Microbiol 1994, 20:13-56.
    • (1994) Crit Rev Microbiol , vol.20 , pp. 13-56
    • Reid, M.F.1    Fewson, C.A.2
  • 43
    • 24644494767 scopus 로고    scopus 로고
    • Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism
    • Gomes R.A., Sousa Silva M., Vicente Miranda H., Ferreira A.E., Cordeiro C.A., Freire A.P. Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism. FEBS J 2005, 272:4521-4531.
    • (2005) FEBS J , vol.272 , pp. 4521-4531
    • Gomes, R.A.1    Sousa Silva, M.2    Vicente Miranda, H.3    Ferreira, A.E.4    Cordeiro, C.A.5    Freire, A.P.6
  • 44
    • 10444255569 scopus 로고    scopus 로고
    • Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity
    • Vickers T.J., Wyllie S., Fairlamb A.H. Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity. J Biol Chem 2004, 279:49003-49009.
    • (2004) J Biol Chem , vol.279 , pp. 49003-49009
    • Vickers, T.J.1    Wyllie, S.2    Fairlamb, A.H.3
  • 45
    • 4444278762 scopus 로고    scopus 로고
    • A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major
    • Vickers T.J., Greig N., Fairlamb A.H. A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major. Proc Natl Acad Sci U S A 2004, 101:13186-13191.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13186-13191
    • Vickers, T.J.1    Greig, N.2    Fairlamb, A.H.3
  • 46
    • 78751591332 scopus 로고    scopus 로고
    • Polyamine metabolism in Leishmania: from arginine to trypanothione
    • Colotti G., Ilari A. Polyamine metabolism in Leishmania: from arginine to trypanothione. Amino Acids 2011, 40:269-285.
    • (2011) Amino Acids , vol.40 , pp. 269-285
    • Colotti, G.1    Ilari, A.2
  • 47
    • 77956577653 scopus 로고    scopus 로고
    • Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani
    • Kumar A., Sisodia B., Misra P., Sundar S., Shasany A.K., Dube A. Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani. Br J Clin Pharmacol 2010, 70:609-617.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 609-617
    • Kumar, A.1    Sisodia, B.2    Misra, P.3    Sundar, S.4    Shasany, A.K.5    Dube, A.6
  • 48
    • 0035930633 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase
    • Zhang X., Moye-Rowley W.S. Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase. J Biol Chem 2001, 276:47844-47852.
    • (2001) J Biol Chem , vol.276 , pp. 47844-47852
    • Zhang, X.1    Moye-Rowley, W.S.2
  • 49
    • 42049091432 scopus 로고    scopus 로고
    • Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials
    • Wyllie S., Vickers T.J., Fairlamb A.H. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob Agents Chemother 2008, 52:1359-1365.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1359-1365
    • Wyllie, S.1    Vickers, T.J.2    Fairlamb, A.H.3
  • 50
    • 68049132858 scopus 로고    scopus 로고
    • Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen
    • El Fadili K., Drummelsmith J., Roy G., Jardim A., Ouellette M. Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen. Exp Parasitol 2009, 123:51-57.
    • (2009) Exp Parasitol , vol.123 , pp. 51-57
    • El Fadili, K.1    Drummelsmith, J.2    Roy, G.3    Jardim, A.4    Ouellette, M.5
  • 51
    • 80055037796 scopus 로고    scopus 로고
    • Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible -resistant Leishmania donovani
    • Chawla B., Jhingran A., Panigrahi A., Stuart K.D., Madhubala R. Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible -resistant Leishmania donovani. PLoS One 2011, 6:e26660.
    • (2011) PLoS One , vol.6
    • Chawla, B.1    Jhingran, A.2    Panigrahi, A.3    Stuart, K.D.4    Madhubala, R.5
  • 52
    • 70349968083 scopus 로고    scopus 로고
    • Proteomic analysis of wild type and arsenite-resistant Leishmania donovani
    • Sharma S., Singh G., Chavan H.D., Dey C.S. Proteomic analysis of wild type and arsenite-resistant Leishmania donovani. Exp Parasitol 2009, 123:369-376.
    • (2009) Exp Parasitol , vol.123 , pp. 369-376
    • Sharma, S.1    Singh, G.2    Chavan, H.D.3    Dey, C.S.4
  • 53
    • 80053395366 scopus 로고    scopus 로고
    • Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania
    • Moreira W., Leprohon P., Ouellette M. Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania. Cell Death Dis 2011, 2:e201.
    • (2011) Cell Death Dis , vol.2
    • Moreira, W.1    Leprohon, P.2    Ouellette, M.3


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