-
2
-
-
84859778293
-
mTOR signaling in growth control and disease
-
M. Laplante, D. M. Sabatini, mTOR signaling in growth control and disease. Cell 149, 274-293 (2012).
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
3
-
-
32044465506
-
TOR signaling in growth and metabolism
-
S. Wullschleger, R. Loewith, M. N. Hall, TOR signaling in growth and metabolism. Cell 124, 471-484 (2006).
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
4
-
-
33745150462
-
Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
-
I. Ruvinsky, O. Meyuhas, Ribosomal protein S6 phosphorylation: From protein synthesis to cell size. Trends Biochem. Sci. 31, 342-348 (2006).
-
(2006)
Trends Biochem. Sci.
, vol.31
, pp. 342-348
-
-
Ruvinsky, I.1
Meyuhas, O.2
-
5
-
-
84860305782
-
Phosphoinositide 3-kinases and leukocyte migration
-
S. G. Ward, Phosphoinositide 3-kinases and leukocyte migration. Curr. Immunol. Rev. 8, 154-160 (2013).
-
(2013)
Curr. Immunol. Rev.
, vol.8
, pp. 154-160
-
-
Ward, S.G.1
-
6
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
L. V. Sinclair, D. Finlay, C. Feijoo, G. H. Cornish, A. Gray, A. Ager, K. Okkenhaug, T. J. Hagenbeek, H. Spits, D. A. Cantrell, Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat. Immunol. 9, 513-521 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
Okkenhaug, K.7
Hagenbeek, T.J.8
Spits, H.9
Cantrell, D.A.10
-
7
-
-
29144438951
-
Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
-
S. Sulic, L. Panic, M. Barkic, M. Mercep, M. Uzelac, S. Volarevic, Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev. 19, 3070-3082 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 3070-3082
-
-
Sulic, S.1
Panic, L.2
Barkic, M.3
Mercep, M.4
Uzelac, M.5
Volarevic, S.6
-
8
-
-
0037716820
-
Regulation and function of serine kinase networks in lymphocytes
-
D. A. Cantrell, Regulation and function of serine kinase networks in lymphocytes. Curr. Opin. Immunol. 15, 294-298 (2003).
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 294-298
-
-
Cantrell, D.A.1
-
9
-
-
40149099723
-
Critical roles of the PI3K/Akt signaling pathway in T cell development
-
M. M. Juntilla, G. A. Koretzky, Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunol. Lett. 116, 104-110 (2008).
-
(2008)
Immunol. Lett.
, vol.116
, pp. 104-110
-
-
Juntilla, M.M.1
Koretzky, G.A.2
-
10
-
-
0038578823
-
The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3
-
L. P. Kane, A. Weiss, The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3. Immunol. Rev. 192, 7-20 (2003).
-
(2003)
Immunol. Rev.
, vol.192
, pp. 7-20
-
-
Kane, L.P.1
Weiss, A.2
-
11
-
-
79951745387
-
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
-
A. N. Macintyre, D. Finlay, G. Preston, L. V. Sinclair, C. M. Waugh, P. Tamas, C. Feijoo, K. Okkenhaug, D. A. Cantrell, Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34, 224-236 (2011).
-
(2011)
Immunity
, vol.34
, pp. 224-236
-
-
Macintyre, A.N.1
Finlay, D.2
Preston, G.3
Sinclair, L.V.4
Waugh, C.M.5
Tamas, P.6
Feijoo, C.7
Okkenhaug, K.8
Cantrell, D.A.9
-
12
-
-
33846235557
-
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway
-
M. Blonska, B. P. Pappu, R. Matsumoto, H. Li, B. Su, D. Wang, X. Lin, The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity 26, 55-66 (2007).
-
(2007)
Immunity
, vol.26
, pp. 55-66
-
-
Blonska, M.1
Pappu, B.P.2
Matsumoto, R.3
Li, H.4
Su, B.5
Wang, D.6
Lin, X.7
-
13
-
-
1942469524
-
MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-κB activation
-
T. Che, Y. You, D. Wang, M. J. Tanner, V. M. Dixit, X. Lin, MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-κB activation. J. Biol. Chem. 279, 15870-15876 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15870-15876
-
-
Che, T.1
You, Y.2
Wang, D.3
Tanner, M.J.4
Dixit, V.M.5
Lin, X.6
-
14
-
-
0036707522
-
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-[κ]B activation
-
O. Gaide, B. Favier, D. F. Legler, D. Bonnet, B. Brissoni, S. Valitutti, C. Bron, J. Tschopp, M. Thome, CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-[κ]B activation. Nat. Immunol. 3, 836-843 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 836-843
-
-
Gaide, O.1
Favier, B.2
Legler, D.F.3
Bonnet, D.4
Brissoni, B.5
Valitutti, S.6
Bron, C.7
Tschopp, J.8
Thome, M.9
-
15
-
-
17744386318
-
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure
-
J. r. Ruland, G. S. Duncan, A. Elia, I. del Barco Barrantes, L. Nguyen, S. Plyte, D. G. Millar, D. Bouchard, A. Wakeham, P. S. Ohashi, T. W. Mak, Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure. Cell 104, 33-42 (2001).
-
(2001)
Cell
, vol.104
, pp. 33-42
-
-
Ruland, J.R.1
Duncan, G.S.2
Elia, A.3
Del Barco Barrantes, I.4
Nguyen, L.5
Plyte, S.6
Millar, D.G.7
Bouchard, D.8
Wakeham, A.9
Ohashi, P.S.10
Mak, T.W.11
-
16
-
-
41149136296
-
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
-
G. Lenz, R. E. Davis, V. N. Ngo, L. Lam, T. C. George, G. W. Wright, S. S. Dave, H. Zhao, W. Xu, A. Rosenwald, G. Ott, H. K. Muller-Hermelink, R. D. Gascoyne, J. M. Connors, L. M. Rimsza, E. Campo, E. S. Jaffe, J. Delabie, E. B. Smeland, R. I. Fisher, W. C. Chan, L. M. Staudt, Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 319, 1676-1679 (2008).
-
(2008)
Science
, vol.319
, pp. 1676-1679
-
-
Lenz, G.1
Davis, R.E.2
Ngo, V.N.3
Lam, L.4
George, T.C.5
Wright, G.W.6
Dave, S.S.7
Zhao, H.8
Xu, W.9
Rosenwald, A.10
Ott, G.11
Muller-Hermelink, H.K.12
Gascoyne, R.D.13
Connors, J.M.14
Rimsza, L.M.15
Campo, E.16
Jaffe, E.S.17
Delabie, J.18
Smeland, E.B.19
Fisher, R.I.20
Chan, W.C.21
Staudt, L.M.22
more..
-
17
-
-
51649111684
-
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
-
G. Lenz, G. W. Wright, N. C. T. Emre, H. Kohlhammer, S. S. Dave, R. E. Davis, S. Carty, L. T. Lam, A. L. Shaffer, W. Xiao, J. Powell, A. Rosenwald, G. Ott, H. K. Muller-Hermelink, R. D. Gascoyne, J. M. Connors, E. Campo, E. S. Jaffe, J. Delabie, E. B. Smeland, L. M. Rimsza, R. I. Fisher, D. D. Weisenburger, W. C. Chan, L. M. Staudt, Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc. Natl. Acad. Sci. U.S.A. 105, 13520-13525 (2008).
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 13520-13525
-
-
Lenz, G.1
Wright, G.W.2
Emre, N.C.T.3
Kohlhammer, H.4
Dave, S.S.5
Davis, R.E.6
Carty, S.7
Lam, L.T.8
Shaffer, A.L.9
Xiao, W.10
Powell, J.11
Rosenwald, A.12
Ott, G.13
Muller-Hermelink, H.K.14
Gascoyne, R.D.15
Connors, J.M.16
Campo, E.17
Jaffe, E.S.18
Delabie, J.19
Smeland, E.B.20
Rimsza, L.M.21
Fisher, R.I.22
Weisenburger, D.D.23
Chan, W.C.24
Staudt, L.M.25
more..
-
18
-
-
33645306041
-
A loss-of-function RNA interference screen for molecular targets in cancer
-
V. N. Ngo, R. E. Davis, L. Lamy, X. Yu, H. Zhao, G. Lenz, L. T. Lam, S. Dave, L. Yang, J. Powell, L. M. Staudt, A loss-of-function RNA interference screen for molecular targets in cancer. Nature 441, 106-110 (2006).
-
(2006)
Nature
, vol.441
, pp. 106-110
-
-
Ngo, V.N.1
Davis, R.E.2
Lamy, L.3
Yu, X.4
Zhao, H.5
Lenz, G.6
Lam, L.T.7
Dave, S.8
Yang, L.9
Powell, J.10
Staudt, L.M.11
-
19
-
-
0036884169
-
Lymphoid malignancies: The dark side of B-cell differentiation
-
A. L. Shaffer, A. Rosenwald, L. M. Staudt, Lymphoid malignancies: The dark side of B-cell differentiation. Nat. Rev. Immunol. 2, 920-932 (2002).
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 920-932
-
-
Shaffer, A.L.1
Rosenwald, A.2
Staudt, L.M.3
-
20
-
-
39449131430
-
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-κB inhibitor A20
-
B. Coornaert, M. Baens, K. Heyninck, T. Bekaert, M. Haegman, J. Staal, L. Sun, Z. J. Chen, P. Marynen, R. Beyaert, T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-κB inhibitor A20. Nat. Immunol. 9, 263-271 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 263-271
-
-
Coornaert, B.1
Baens, M.2
Heyninck, K.3
Bekaert, T.4
Haegman, M.5
Staal, J.6
Sun, L.7
Chen, Z.J.8
Marynen, P.9
Beyaert, R.10
-
21
-
-
39449085547
-
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
-
F. Rebeaud, S. Hailfinger, A. Posevitz-Fejfar, M. Tapernoux, R. Moser, D. Rueda, O. Gaide, M. Guzzardi, E. M. Iancu, N. Rufer, N. Fasel, M. Thome, The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat. Immunol. 9, 272-281 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 272-281
-
-
Rebeaud, F.1
Hailfinger, S.2
Posevitz-Fejfar, A.3
Tapernoux, M.4
Moser, R.5
Rueda, D.6
Gaide, O.7
Guzzardi, M.8
Iancu, E.M.9
Rufer, N.10
Fasel, N.11
Thome, M.12
-
22
-
-
78650883911
-
Regulation of NF-κB signaling by caspases and MALT1 paracaspase
-
J. Staal, T. Bekaert, R. Beyaert, Regulation of NF-κB signaling by caspases and MALT1 paracaspase. Cell Res. 21, 40-54 (2011).
-
(2011)
Cell Res
, vol.21
, pp. 40-54
-
-
Staal, J.1
Bekaert, T.2
Beyaert, R.3
-
23
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
S. M. Schieke, D. Phillips, J. P. McCoy, A. M. Aponte, R. F. Shen, R. S. Balaban, T. Finkel, The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 281, 27643-27652 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 27643-27652
-
-
Schieke, S.M.1
Phillips, D.2
McCoy, J.P.3
Aponte, A.M.4
Shen, R.F.5
Balaban, R.S.6
Finkel, T.7
-
24
-
-
84874226167
-
mTOR and metabolic pathways in T cell quiescence and functional activation
-
K. Yang, H. Chi, mTOR and metabolic pathways in T cell quiescence and functional activation. Semin. Immunol. 24, 421-428 (2012).
-
(2012)
Semin. Immunol.
, vol.24
, pp. 421-428
-
-
Yang, K.1
Chi, H.2
-
25
-
-
33644772836
-
CARMA1 is required for Akt-mediated NF-κB activation in T cells
-
P. Narayan, B. Holt, R. Tosti, L. Kane, CARMA1 is required for Akt-mediated NF-κB activation in T cells. Mol. Cell. Biol. 26, 2327-2336 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 2327-2336
-
-
Narayan, P.1
Holt, B.2
Tosti, R.3
Kane, L.4
-
26
-
-
0036707520
-
A requirement for CARMA1 in TCR-induced NF-κB activation
-
D. Wang, Y. You, S. M. Case, L. M. McAllister-Lucas, L. Wang, P. S. DiStefano, G. Nuñez, J. Bertin, X. Lin, A requirement for CARMA1 in TCR-induced NF-κB activation. Nat. Immunol. 3, 830-835 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 830-835
-
-
Wang, D.1
You, Y.2
Case, S.M.3
McAllister-Lucas, L.M.4
Wang, L.5
DiStefano, P.S.6
Nuñez, G.7
Bertin, J.8
Lin, X.9
-
28
-
-
70350418625
-
mTOR signaling at a glance
-
M. Laplante, D. M. Sabatini, mTOR signaling at a glance. J. Cell Sci. 122, 3589-3594 (2009).
-
(2009)
J. Cell Sci.
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
29
-
-
79953211540
-
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
-
I. Tato, R. Bartrons, F. Ventura, J. L. Rosa, Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J. Biol. Chem. 286, 6128-6142 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6128-6142
-
-
Tato, I.1
Bartrons, R.2
Ventura, F.3
Rosa, J.L.4
-
30
-
-
0024328679
-
Mechanisms of T cell activation by the calcium ionophore ionomycin
-
T. Chatila, L. Silverman, R. Miller, R. Geha, Mechanisms of T cell activation by the calcium ionophore ionomycin. J. Immunol. 143, 1283-1289 (1989).
-
(1989)
J. Immunol.
, vol.143
, pp. 1283-1289
-
-
Chatila, T.1
Silverman, L.2
Miller, R.3
Geha, R.4
-
31
-
-
0037490078
-
The MAGUK family protein CARD11 is essential for lymphocyte activation
-
H. Hara, T. Wada, C. Bakal, I. Kozieradzki, S. Suzuki, N. Suzuki, M. Nghiem, E. K. Griffiths, C. Krawczyk, B. Bauer, F. D'Acquisto, S. Ghosh, W. C. Yeh, G. Baier, R. Rottapel, J. M. Penninger, The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 18, 763-775 (2003).
-
(2003)
Immunity
, vol.18
, pp. 763-775
-
-
Hara, H.1
Wada, T.2
Bakal, C.3
Kozieradzki, I.4
Suzuki, S.5
Suzuki, N.6
Nghiem, M.7
Griffiths, E.K.8
Krawczyk, C.9
Bauer, B.10
D'Acquisto, F.11
Ghosh, S.12
Yeh, W.C.13
Baier, G.14
Rottapel, R.15
Penninger, J.M.16
-
32
-
-
77957054466
-
The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
-
J. D. Powell, G. M. Delgoffe, The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism. Immunity 33, 301-311 (2010).
-
(2010)
Immunity
, vol.33
, pp. 301-311
-
-
Powell, J.D.1
Delgoffe, G.M.2
-
33
-
-
34249284512
-
mTOR at the crossroads of T cell proliferation and tolerance
-
A. Mondino, D. L. Mueller, mTOR at the crossroads of T cell proliferation and tolerance. Semin. Immunol. 19, 162-172 (2007).
-
(2007)
Semin. Immunol.
, vol.19
, pp. 162-172
-
-
Mondino, A.1
Mueller, D.L.2
-
34
-
-
33747819801
-
mTOR and cancer: Insights into a complex relationship
-
D. M. Sabatini, mTOR and cancer: Insights into a complex relationship. Nat. Rev. Cancer 6, 729-734 (2006).
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
35
-
-
34249694900
-
Post-translational modifications regulate distinct functions of CARMA1 and BCL10
-
M. Thome, R. Weil, Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends Immunol. 28, 281-288 (2007).
-
(2007)
Trends Immunol
, vol.28
, pp. 281-288
-
-
Thome, M.1
Weil, R.2
-
36
-
-
19944433628
-
Identification and characterization of pleckstrin-homology-domain- dependent and isoenzyme-specific Akt inhibitors
-
S. F. Barnett, D. Defeo-Jones, S. Fu, P. J. Hancock, K. M. Haskell, R. E. Jones, J. A. Kahana, A. M. Kral, K. Leander, L. L. Lee, J. Malinowski, E. M. McAvoy, D. D. Nahas, R. G. Robinson, H. E. Huber, Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385, 399-408 (2005).
-
(2005)
Biochem. J.
, vol.385
, pp. 399-408
-
-
Barnett, S.F.1
Defeo-Jones, D.2
Fu, S.3
Hancock, P.J.4
Haskell, K.M.5
Jones, R.E.6
Kahana, J.A.7
Kral, A.M.8
Leander, K.9
Lee, L.L.10
Malinowski, J.11
McAvoy, E.M.12
Nahas, D.D.13
Robinson, R.G.14
Huber, H.E.15
-
37
-
-
2442612540
-
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
-
M. Thome, CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat. Rev. Immunol. 4, 348-359 (2004).
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 348-359
-
-
Thome, M.1
-
38
-
-
78650862297
-
Antigen receptor signaling to NF-κB via CARMA1, BCL10, and MALT1
-
M. Thome, J. E. Charton, C. Pelzer, S. Hailfinger, Antigen receptor signaling to NF-κB via CARMA1, BCL10, and MALT1. Cold Spring Harb. Perspect. Biol. 2, a003004 (2010).
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
-
-
Thome, M.1
Charton, J.E.2
Pelzer, C.3
Hailfinger, S.4
-
39
-
-
42949098959
-
NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation
-
C. J. Wu, J. D. Ashwell, NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation. Proc. Natl. Acad. Sci. U.S.A. 105, 3023-3028 (2008).
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 3023-3028
-
-
Wu, C.J.1
Ashwell, J.D.2
-
40
-
-
73949114883
-
Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
-
S. Hailfinger, G. Lenz, V. Ngo, A. Posvitz-Fejfar, F. Rebeaud, M. Guzzardi, E. M. M. Penas, J. Dierlamm, W. C. Chan, L. M. Staudt, M. Thome, Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proc. Natl. Acad. Sci. U.S.A. 106, 19946-19951 (2009).
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 19946-19951
-
-
Hailfinger, S.1
Lenz, G.2
Ngo, V.3
Posvitz-Fejfar, A.4
Rebeaud, F.5
Guzzardi, M.6
Penas, E.M.M.7
Dierlamm, J.8
Chan, W.C.9
Staudt, L.M.10
Thome, M.11
-
41
-
-
2342629277
-
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
-
L. Sun, L. Deng, C. K. Ea, Z. P. Xia, Z. J. Chen, The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14, 289-301 (2004).
-
(2004)
Mol. Cell
, vol.14
, pp. 289-301
-
-
Sun, L.1
Deng, L.2
Ea, C.K.3
Xia, Z.P.4
Chen, Z.J.5
-
42
-
-
0023219739
-
Interleukin 2 and diacylglycerol stimulate phosphorylation of 40 S ribosomal S6 protein. Correlation with increased protein synthesis and S6 kinase activation
-
S. W. Evans, W. L. Farrar, Interleukin 2 and diacylglycerol stimulate phosphorylation of 40 S ribosomal S6 protein. Correlation with increased protein synthesis and S6 kinase activation. J. Biol. Chem. 262, 4624-4630 (1987).
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 4624-4630
-
-
Evans, S.W.1
Farrar, W.L.2
-
43
-
-
77953534607
-
Metabolism in T cell activation and differentiation
-
E. L. Pearce, Metabolism in T cell activation and differentiation. Curr. Opin. Immunol. 22, 314-320 (2010).
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 314-320
-
-
Pearce, E.L.1
-
44
-
-
0033635249
-
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
-
J. C. Rathmell, M. G. V. Heiden, M. H. Harris, K. A. Frauwirth, C. B. Thompson, In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6, 683-692 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 683-692
-
-
Rathmell, J.C.1
Heiden, M.G.V.2
Harris, M.H.3
Frauwirth, K.A.4
Thompson, C.B.5
-
45
-
-
0036320205
-
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
-
A. L. Edinger, C. B. Thompson, Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell 13, 2276-2288 (2002).
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 2276-2288
-
-
Edinger, A.L.1
Thompson, C.B.2
-
46
-
-
78649955075
-
The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN
-
R. L. Lamason, A. Kupfer, J. L. Pomerantz, The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN. Mol. Cell 40, 798-809 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 798-809
-
-
Lamason, R.L.1
Kupfer, A.2
Pomerantz, J.L.3
-
47
-
-
0034731443
-
CARD9 is a novel caspase recruitment domain containing protein that interacts with BCL10/CLAP and activates NF-κB
-
J. Bertin, Y. Guo, L. Wang, S. M. Srinivasula, M. D. Jacobson, J. L. Poyet, S. Merriam, M. Q. Du, M. J. S. Dyer, K. E. Robison, P. S. DiStefano, E. S. Alnemri, CARD9 is a novel caspase recruitment domain containing protein that interacts with BCL10/CLAP and activates NF-κB. J. Biol. Chem. 275, 41082-41086 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 41082-41086
-
-
Bertin, J.1
Guo, Y.2
Wang, L.3
Srinivasula, S.M.4
Jacobson, M.D.5
Poyet, J.L.6
Merriam, S.7
Du, M.Q.8
Dyer, M.J.S.9
Robison, K.E.10
DiStefano, P.S.11
Alnemri, E.S.12
-
48
-
-
0030905166
-
Target of rapamycin proteins and their kinase activities are required for meiosis
-
X. F. Zheng, S. L. Schreiber, Target of rapamycin proteins and their kinase activities are required for meiosis. Proc. Natl. Acad. Sci. U.S.A. 94, 3070-3075 (1997).
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 3070-3075
-
-
Zheng, X.F.1
Schreiber, S.L.2
-
49
-
-
80052282195
-
Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines
-
S. Hailfinger, H. Nogai, C. Pelzer, M. Jaworski, K. Cabalzar, J. E. Charton, M. Guzzardi, C. Dacaillet, M. Grau, B. Durken, P. Lenz, G. Lenz, M. Thome, Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines. Proc. Natl. Acad. Sci. U.S.A. 108, 14596-14601 (2011).
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 14596-14601
-
-
Hailfinger, S.1
Nogai, H.2
Pelzer, C.3
Jaworski, M.4
Cabalzar, K.5
Charton, J.E.6
Guzzardi, M.7
Dacaillet, C.8
Grau, M.9
Durken, B.10
Lenz, P.11
Lenz, G.12
Thome, M.13
-
50
-
-
48349125069
-
The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation
-
H. Kawadler, M. A. Gantz, J. L. Riley, X. Yang, The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation. Mol. Cell 31, 415-421 (2008).
-
(2008)
Mol. Cell
, vol.31
, pp. 415-421
-
-
Kawadler, H.1
Gantz, M.A.2
Riley, J.L.3
Yang, X.4
-
51
-
-
38449096218
-
A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2
-
A. F. Arechiga, B. D. Bell, S. Leverrier, B. M. Weist, M. Porter, Z. Wu, Y. Kanno, S. J. Ramos, S. T. Ong, R. Siegel, C. M. Walsh, A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2. J. Immunol. 179, 5291-5300 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 5291-5300
-
-
Arechiga, A.F.1
Bell, B.D.2
Leverrier, S.3
Weist, B.M.4
Porter, M.5
Wu, Z.6
Kanno, Y.7
Ramos, S.J.8
Ong, S.T.9
Siegel, R.10
Walsh, C.M.11
-
52
-
-
79955592698
-
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
-
J. Staal, Y. Driege, T. Bekaert, A. Demeyer, D. Muyllaert, P. Van Damme, K. Gevaert, R. Beyaert, T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J. 30, 1742-1752 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 1742-1752
-
-
Staal, J.1
Driege, Y.2
Bekaert, T.3
Demeyer, A.4
Muyllaert, D.5
Van Damme, P.6
Gevaert, K.7
Beyaert, R.8
-
53
-
-
84878315256
-
+ helper T cells regulates immune activation
-
+ helper T cells regulates immune activation. Cell 153, 1036-1049 (2013).
-
(2013)
Cell
, vol.153
, pp. 1036-1049
-
-
Uehata, T.1
Iwasaki, H.2
Vandenbon, A.3
Matsushita, K.4
Hernandez-Cuellar, E.5
Kuniyoshi, K.6
Satoh, T.7
Mino, T.8
Suzuki, Y.9
Standley, D.M.10
Tsujimura, T.11
Rakugi, H.12
Isaka, Y.13
Takeuchi, O.14
Akira, S.15
-
54
-
-
0142084679
-
Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation
-
J. Faridi, J. Fawcett, L. Wang, R. A. Roth, Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation. Am. J. Physiol. Endocrinol. Metab. 285, E964-E972 (2003).
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.285
-
-
Faridi, J.1
Fawcett, J.2
Wang, L.3
Roth, R.A.4
-
55
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
D. C. Fingar, S. Salama, C. Tsou, E. Harlow, J. Blenis, Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16, 1472-1487 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
56
-
-
77649213114
-
Tissue-microarray based immunohistochemical analysis of survival pathways in nodular sclerosing classical Hodgkin lymphoma as compared with Non-Hodgkin's lymphoma
-
J. De, R. Brown, Tissue-microarray based immunohistochemical analysis of survival pathways in nodular sclerosing classical Hodgkin lymphoma as compared with Non-Hodgkin's lymphoma. Int. J. Clin. Exp. Med. 3, 55-68 (2010).
-
(2010)
Int. J. Clin. Exp. Med.
, vol.3
, pp. 55-68
-
-
De, J.1
Brown, R.2
-
57
-
-
77954605430
-
Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: Therapeutic implications
-
L. V. Pham, A. T. Tamayo, C. Li, W. Bornmann, W. Priebe, R. J. Ford, Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: Therapeutic implications. Mol. Cancer Ther. 9, 2026-2036 (2010).
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 2026-2036
-
-
Pham, L.V.1
Tamayo, A.T.2
Li, C.3
Bornmann, W.4
Priebe, W.5
Ford, R.J.6
-
59
-
-
34547208593
-
Notch-induced T cell development requires phosphoinositide-dependent kinase 1
-
A. P. Kelly, D. K. Finlay, H. J. Hinton, R. G. Clarke, E. Fiorini, F. Radtke, D. A. Cantrell, Notch-induced T cell development requires phosphoinositide-dependent kinase 1. EMBO J. 26, 3441-3450 (2007).
-
(2007)
EMBO J.
, vol.26
, pp. 3441-3450
-
-
Kelly, A.P.1
Finlay, D.K.2
Hinton, H.J.3
Clarke, R.G.4
Fiorini, E.5
Radtke, F.6
Cantrell, D.A.7
-
60
-
-
84860237060
-
Regulation and function of mTOR signalling in T cell fate decisions
-
H. Chi, Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325-338 (2012).
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 325-338
-
-
Chi, H.1
-
61
-
-
84861157343
-
Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
-
A. T. Waickman, J. D. Powell, Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J. Immunol. 188, 4721-4729 (2012).
-
(2012)
J. Immunol.
, vol.188
, pp. 4721-4729
-
-
Waickman, A.T.1
Powell, J.D.2
-
62
-
-
84879195658
-
mTOR and lymphocyte metabolism
-
H. Zeng, H. Chi, mTOR and lymphocyte metabolism. Curr. Opin. Immunol. 25, 347-355 (2013).
-
(2013)
Curr. Opin. Immunol.
, vol.25
, pp. 347-355
-
-
Zeng, H.1
Chi, H.2
-
63
-
-
80053909808
-
Akt fine-tunes NF-κB-dependent gene expression during T cell activation
-
J. Cheng, B. Phong, D. C. Wilson, R. Hirsch, L. P. Kane, Akt fine-tunes NF-κB-dependent gene expression during T cell activation. J. Biol. Chem. 286, 36076-36085 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36076-36085
-
-
Cheng, J.1
Phong, B.2
Wilson, D.C.3
Hirsch, R.4
Kane, L.P.5
-
64
-
-
80053608320
-
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways
-
J. Lee, E. W. Su, C. Zhu, S. Hainline, J. Phuah, J. A. Moroco, T. E. Smithgall, V. K. Kuchroo, L. P. Kane, Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Mol. Cell. Biol. 31, 3963-3974 (2011).
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3963-3974
-
-
Lee, J.1
Su, E.W.2
Zhu, C.3
Hainline, S.4
Phuah, J.5
Moroco, J.A.6
Smithgall, T.E.7
Kuchroo, V.K.8
Kane, L.P.9
-
65
-
-
33746047673
-
Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity
-
T. van Meerten, R. S. van Rijn, S. Hol, A. Hagenbeek, S. B. Ebeling, Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity. Clin. Cancer Res. 12, 4027-4035 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4027-4035
-
-
Van Meerten, T.1
Van Rijn, R.S.2
Hol, S.3
Hagenbeek, A.4
Ebeling, S.B.5
-
66
-
-
84887446052
-
Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation
-
M. E. Heid, P. A. Keyel, C. Kamga, S. Shiva, S. C. Watkins, R. D. Salter, Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J. Immunol. 191, 5230-5238 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 5230-5238
-
-
Heid, M.E.1
Keyel, P.A.2
Kamga, C.3
Shiva, S.4
Watkins, S.C.5
Salter, R.D.6
|