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Volumn 289, Issue 24, 2014, Pages 17043-17053

Desmoglein 2 compensates for desmoglein 3 but does not control cell adhesion via regulation of p38 mitogen-activated protein kinase in keratinocytes

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; CELLS; KERATIN; LAKES; MOLECULES;

EID: 84902455483     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.489336     Document Type: Article
Times cited : (37)

References (42)
  • 2
    • 44449092953 scopus 로고    scopus 로고
    • The desmosome and pemphigus
    • Waschke, J. (2008) The desmosome and pemphigus. Histochem. Cell Biol. 130, 21-54
    • (2008) Histochem. Cell Biol. , vol.130 , pp. 21-54
    • Waschke, J.1
  • 3
    • 84862804462 scopus 로고    scopus 로고
    • Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris
    • Tsang, S. M., Brown, L., Lin, K., Liu, L., Piper, K., O'Toole, E. A., Grose, R., Hart, I. R., Garrod, D. R., Fortune, F., and Wan, H. (2012) Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J. Pathol. 227, 81-93
    • (2012) J. Pathol. , vol.227 , pp. 81-93
    • Tsang, S.M.1    Brown, L.2    Lin, K.3    Liu, L.4    Piper, K.5    O'Toole, E.A.6    Grose, R.7    Hart, I.R.8    Garrod, D.R.9    Fortune, F.10    Wan, H.11
  • 4
    • 84871280700 scopus 로고    scopus 로고
    • New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease
    • Kitajima, Y. (2013) New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease. Kaohsiung J. Med. Sci. 29, 1-13
    • (2013) Kaohsiung J. Med. Sci. , vol.29 , pp. 1-13
    • Kitajima, Y.1
  • 5
    • 33750320914 scopus 로고    scopus 로고
    • Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome
    • DOI 10.1056/NEJMra061111
    • Stanley, J. R., and Amagai, M. (2006) Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N. Engl. J. Med. 355, 1800-1810 (Pubitemid 44631364)
    • (2006) New England Journal of Medicine , vol.355 , Issue.17 , pp. 1800-1810
    • Stanley, J.R.1    Amagai, M.2
  • 6
    • 34548863639 scopus 로고    scopus 로고
    • Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3
    • DOI 10.2353/ajpath.2007.070028
    • Spindler, V., Drenckhahn, D., Zillikens, D., and Waschke, J. (2007) Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3. Am. J. Pathol. 171, 906-916 (Pubitemid 47440989)
    • (2007) American Journal of Pathology , vol.171 , Issue.3 , pp. 906-916
    • Spindler, V.1    Drenckhahn, D.2    Zillikens, D.3    Waschke, J.4
  • 7
    • 69149094112 scopus 로고    scopus 로고
    • Apoptolysis: A novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis
    • Grando, S. A., Bystryn, J. C., Chernyavsky, A. I., Frusić-Zlotkin, M., Gniadecki, R., Lotti, R., Milner, Y., Pittelkow, M. R., and Pincelli, C. (2009) Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis. Exp. Dermatol. 18, 764-770
    • (2009) Exp. Dermatol. , vol.18 , pp. 764-770
    • Grando, S.A.1    Bystryn, J.C.2    Chernyavsky, A.I.3    Frusić-Zlotkin, M.4    Gniadecki, R.5    Lotti, R.6    Milner, Y.7    Pittelkow, M.R.8    Pincelli, C.9
  • 9
    • 77953585901 scopus 로고    scopus 로고
    • From cell signaling to novel therapeutic concepts: International pemphigus meeting on advances in pemphigus research and therapy
    • Getsios, S., Waschke, J., Borradori, L., Hertl, M., and Müller, E. J. (2010) From cell signaling to novel therapeutic concepts: international pemphigus meeting on advances in pemphigus research and therapy. J. Invest. Dermatol. 130, 1764-1768
    • (2010) J. Invest. Dermatol. , vol.130 , pp. 1764-1768
    • Getsios, S.1    Waschke, J.2    Borradori, L.3    Hertl, M.4    Müller, E.J.5
  • 10
    • 79955785245 scopus 로고    scopus 로고
    • Role of Rho GTPases in desmosomal adhesion and pemphigus pathogenesis
    • Spindler, V., and Waschke, J. (2011) Role of Rho GTPases in desmosomal adhesion and pemphigus pathogenesis. Ann. Anat. 193, 177-180
    • (2011) Ann. Anat. , vol.193 , pp. 177-180
    • Spindler, V.1    Waschke, J.2
  • 11
    • 78650630568 scopus 로고    scopus 로고
    • Protective endogenous cyclic adenosine 5′-monophosphate signaling triggered by pemphigus autoantibodies
    • Spindler, V., Vielmuth, F., Schmidt, E., Rubenstein, D. S., and Waschke, J. (2010) Protective endogenous cyclic adenosine 5′-monophosphate signaling triggered by pemphigus autoantibodies. J. Immunol. 185, 6831-6838
    • (2010) J. Immunol. , vol.185 , pp. 6831-6838
    • Spindler, V.1    Vielmuth, F.2    Schmidt, E.3    Rubenstein, D.S.4    Waschke, J.5
  • 12
    • 0030890618 scopus 로고    scopus 로고
    • Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes
    • Osada, K., Seishima, M., and Kitajima, Y. (1997) Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/ cytoskeleton fractions in human keratinocytes. J. Invest. Dermatol. 108, 482-487 (Pubitemid 27148285)
    • (1997) Journal of Investigative Dermatology , vol.108 , Issue.4 , pp. 482-487
    • Osada, K.1    Seishima, M.2    Kitajima, Y.3
  • 13
    • 0035858871 scopus 로고    scopus 로고
    • A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris
    • DOI 10.1083/jcb.153.4.823
    • Caldelari, R., de Bruin, A., Baumann, D., Suter, M. M., Bierkamp, C., Balmer, V., and Müller, E. (2001) A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. J. Cell Biol. 153, 823-834 (Pubitemid 34286113)
    • (2001) Journal of Cell Biology , vol.153 , Issue.4 , pp. 823-834
    • Caldelari, R.1    De Bruin, A.2    Baumann, D.3    Suter, M.M.4    Bierkamp, C.5    Balmer, V.6    Muller, E.7
  • 14
    • 84875969766 scopus 로고    scopus 로고
    • A pathophysiologic role for epidermal growth factor receptor in pemphigus acantholysis
    • Bektas, M., Jolly, P. S., Berkowitz, P., Amagai, M., and Rubenstein, D. S. (2013) A pathophysiologic role for epidermal growth factor receptor in pemphigus acantholysis. J. Biol. Chem. 288, 9447-9456
    • (2013) J. Biol. Chem. , vol.288 , pp. 9447-9456
    • Bektas, M.1    Jolly, P.S.2    Berkowitz, P.3    Amagai, M.4    Rubenstein, D.S.5
  • 15
    • 59649096544 scopus 로고    scopus 로고
    • Pemphigus vulgaris IgG cause loss of desmoglein-mediated adhesion and keratinocyte dissociation independent of epidermal growth factor receptor
    • Heupel, W.-M., Engerer, P., Schmidt, E., and Waschke, J. (2009) Pemphigus vulgaris IgG cause loss of desmoglein-mediated adhesion and keratinocyte dissociation independent of epidermal growth factor receptor. Am. J. Pathol. 174, 475-485
    • (2009) Am. J. Pathol. , vol.174 , pp. 475-485
    • Heupel, W.-M.1    Engerer, P.2    Schmidt, E.3    Waschke, J.4
  • 17
    • 77950590873 scopus 로고    scopus 로고
    • p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis
    • Jolly, P. S., Berkowitz, P., Bektas, M., Lee, H. E., Chua, M., Diaz, L. A., and Rubenstein, D. S. (2010) p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis. J. Biol. Chem. 285, 8936-8941
    • (2010) J. Biol. Chem. , vol.285 , pp. 8936-8941
    • Jolly, P.S.1    Berkowitz, P.2    Bektas, M.3    Lee, H.E.4    Chua, M.5    Diaz, L.A.6    Rubenstein, D.S.7
  • 19
    • 21244476854 scopus 로고    scopus 로고
    • Desmosome signaling: Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization
    • DOI 10.1074/jbc.M501365200
    • Berkowitz, P., Hu, P., Liu, Z., Diaz, L. A., Enghild, J. J., Chua, M. P., and Rubenstein, D. S. (2005) Desmosome signaling: inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J. Biol. Chem. 280, 23778-23784 (Pubitemid 40884862)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.25 , pp. 23778-23784
    • Berkowitz, P.1    Hu, P.2    Liu, Z.3    Diaz, L.A.4    Enghild, J.J.5    Chua, M.P.6    Rubenstein, D.S.7
  • 25
    • 84872224315 scopus 로고    scopus 로고
    • Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion
    • Hartlieb, E., Kempf, B., Partilla, M., Vigh, B., Spindler, V., and Waschke, J. (2013) Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. PLoS ONE 8, e53739
    • (2013) PLoS ONE , vol.8
    • Hartlieb, E.1    Kempf, B.2    Partilla, M.3    Vigh, B.4    Spindler, V.5    Waschke, J.6
  • 26
    • 0030902370 scopus 로고    scopus 로고
    • Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
    • DOI 10.1083/jcb.137.5.1091
    • Koch, P. J., Mahoney, M. G., Ishikawa, H., Pulkkinen, L., Uitto, J., Shultz, L., Murphy, G. F., Whitaker-Menezes, D., and Stanley, J. R. (1997) Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J. Cell Biol. 137, 1091-1102 (Pubitemid 27251044)
    • (1997) Journal of Cell Biology , vol.137 , Issue.5 , pp. 1091-1102
    • Koch, P.J.1    Mahoney, M.G.2    Ishikawa, H.3    Pulkkinen, L.4    Uitto, J.5    Shultz, L.6    Murphy, G.F.7    Whitaker-Menezes, D.8    Stanley, J.R.9
  • 27
    • 0033557198 scopus 로고    scopus 로고
    • Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
    • Mahoney, M. G., Wang, Z., Rothenberger, K., Koch, P. J., Amagai, M., and Stanley, J. R. (1999) Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J. Clin. Invest. 103, 461-468 (Pubitemid 29094045)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.4 , pp. 461-468
    • Mahoney, M.G.1    Wang, Z.2    Rothenberger, K.3    Koch, P.J.4    Amagai, M.5    Stanley, J.R.6
  • 28
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 30
    • 49649084477 scopus 로고    scopus 로고
    • Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction
    • Heupel, W. M., Zillikens, D., Drenckhahn, D., and Waschke, J. (2008) Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction. J. Immunol. 181, 1825-1834
    • (2008) J. Immunol. , vol.181 , pp. 1825-1834
    • Heupel, W.M.1    Zillikens, D.2    Drenckhahn, D.3    Waschke, J.4
  • 31
    • 67649846396 scopus 로고    scopus 로고
    • Peptides Targeting the desmoglein 3 adhesive interface prevent autoantibody-induced acantholysis in pemphigus
    • Heupel, W. M., Müller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., and Waschke, J. (2009) Peptides Targeting the desmoglein 3 adhesive interface prevent autoantibody-induced acantholysis in pemphigus. J. Biol. Chem. 284, 8589-8595
    • (2009) J. Biol. Chem. , vol.284 , pp. 8589-8595
    • Heupel, W.M.1    Müller, T.2    Efthymiadis, A.3    Schmidt, E.4    Drenckhahn, D.5    Waschke, J.6
  • 32
    • 84888702640 scopus 로고
    • Pemphigus
    • Lever, W. F. (1953) Pemphigus. Medicine 32, 1-123
    • (1953) Medicine , vol.32 , pp. 1-123
    • Lever, W.F.1
  • 33
    • 84869784358 scopus 로고    scopus 로고
    • Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice
    • Baron, S., Hoang, A., Vogel, H., and Attardi, L. D. (2012) Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. PLoS ONE 7, e50024
    • (2012) PLoS ONE , vol.7
    • Baron, S.1    Hoang, A.2    Vogel, H.3    Attardi, L.D.4
  • 34
    • 78649497210 scopus 로고    scopus 로고
    • Superficial dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins
    • Brennan, D., Hu, Y., Medhat, W., Dowling, A., and Mahoney, M. G. (2010) Superficial dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins. Dermatol. Res. Pract. 2010, 410278
    • (2010) Dermatol. Res. Pract. , vol.2010 , pp. 410278
    • Brennan, D.1    Hu, Y.2    Medhat, W.3    Dowling, A.4    Mahoney, M.G.5
  • 35
    • 66749130153 scopus 로고    scopus 로고
    • Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study
    • Brennan, D., and Mahoney, M. G. (2009) Increased expression of Dsg2 in malignant skin carcinomas: a tissue-microarray based study. Cell Adh. Migr. 3, 148-154
    • (2009) Cell Adh. Migr. , vol.3 , pp. 148-154
    • Brennan, D.1    Mahoney, M.G.2
  • 37
    • 79954610504 scopus 로고    scopus 로고
    • Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling
    • Kolegraff, K., Nava, P., Helms, M. N., Parkos, C. A., and Nusrat, A. (2011) Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling. Mol. Biol. Cell 22, 1121-1134
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1121-1134
    • Kolegraff, K.1    Nava, P.2    Helms, M.N.3    Parkos, C.A.4    Nusrat, A.5
  • 39
    • 84900848540 scopus 로고    scopus 로고
    • Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling
    • 10.1038/jid.2014.21
    • Spindler, V., Dehner, C., Hubner, S., and Waschke, J. (2014) Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. J. Invest. Dermatol. 10.1038/jid.2014.21
    • (2014) J. Invest. Dermatol.
    • Spindler, V.1    Dehner, C.2    Hubner, S.3    Waschke, J.4
  • 40
    • 34249903066 scopus 로고    scopus 로고
    • p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells
    • DOI 10.1083/jcb.200703174
    • Wöll, S., Windoffer, R., and Leube, R. E. (2007) p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells. J. Cell Biol. 177, 795-807 (Pubitemid 46873086)
    • (2007) Journal of Cell Biology , vol.177 , Issue.5 , pp. 795-807
    • Woll, S.1    Windoffer, R.2    Leube, R.E.3
  • 41
    • 39149091017 scopus 로고    scopus 로고
    • Outside-in signaling through integrins and cadherins: A central mechanism to control epidermal growth and differentiation?
    • DOI 10.1038/sj.jid.5701248, PII 5701248
    • Müller, E. J., Williamson, L., Kolly, C., and Suter, M. M. (2008) Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation? J. Invest. Dermatol. 128, 501-516 (Pubitemid 351252683)
    • (2008) Journal of Investigative Dermatology , vol.128 , Issue.3 , pp. 501-516
    • Muller, E.J.1    Williamson, L.2    Kolly, C.3    Suter, M.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.