Tailored protein release from biodegradable poly(ε-caprolactone-PEG)- b-poly(ε-caprolactone) multiblock-copolymer implants

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 2, 2014, Pages 329-337

  Stanković, Milica ^a   Tomar, Jasmine ^a   Hiemstra, Christine ^b   Steendam, Rob ^b   Frijlink, Henderik W ^a   Hinrichs, Wouter L J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b InnoCore Technologies BV   (Netherlands)

Author keywords

Controlled release; Hot melt extrusion; Multiblock copolymers; PEG content; Peptide protein molecular weight; Polymer implants

Indexed keywords

ALBUMIN; CARBONATE DEHYDRATASE; COPOLYMER; GOSERELIN; INULIN; LYSOZYME; MACROGOL; POLY(EPSILON CAPROLACTONE ETHYLENE GLYCOL) CO POLY(EPSILON CAPROLACTONE); POLYCAPROLACTONE; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; DRUG CARRIER; DRUG IMPLANT; MACROGOL DERIVATIVE; POLY(EPSILON-CAPROLACTONE)-B-POLY(ETHYLENEGLYCOL)-B-POLY(EPSILON-CAPROLACTONE); POLYESTER; PROTEIN;

AEROSOL; ARTICLE; BIODEGRADABLE IMPLANT; CONTROLLED DRUG RELEASE; DRUG FORMULATION; DRUG IMPLANT; IN VITRO STUDY; MELTING POINT; MOLECULAR WEIGHT; PARTICLE SIZE; POWDER; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN STABILITY; SPRAY DRYING; THERMOGRAPHY; WATER TRANSPORT; WETTABILITY; CHEMISTRY; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; TRANSITION TEMPERATURE;

ABSORBABLE IMPLANTS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG IMPLANTS; KINETICS; MOLECULAR WEIGHT; POLYESTERS; POLYETHYLENE GLYCOLS; PROTEIN STABILITY; PROTEINS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE;

EID: 84902359058     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.02.012     Document Type: Article

References (35)

1. G. Walsh Biopharmaceutical benchmarks 2010 Nat. Biotechnol. 28 2010 917 924
2. J.L. Cleland, R. Langer, Formulation and delivery of proteins and peptides, in: J.L. Cleland, R. Langer (Eds.), Formul. Deliv. Proteins Pept., 1994, pp. 1-19.
3. A. Kovalchuk, W. Fischer, and M. Epple Controlled release of goserelin from microporous polyglycolide and polylactide Macromol. Biosci. 5 2005 289 298
4. H. Okada One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate Adv. Drug Deliv. Rev. 28 1997 43 70
5. L.S. Nair, and C.T. Laurencin Biodegradable polymers as biomaterials Prog. Polym. Sci. 32 2007 762 798
6. J.C. Wright, and A.S. Hoffman Long acting injections and implants J.C. Wright, D.J. Burgess, Adv. Deliv. Sci. Technol. 2012 Springer US, Boston, MA 11 25
7. < http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/019726s054, 020578s032lbl.pdf >. NDA 019726/S-054 Zoladex (goserelin acetate implant), (n.d.).
8. M.A. Repka, S. Majumdar, S.K. Battu, R. Srirangam, and S.B. Upadhye Applications of hot-melt extrusion in drug delivery Exp. Opin. Drug Deliv. 5 2008 1357 1376
9. M. Stanković, H. De Waard, R. Steendam, C. Hiemstra, J. Zuidema, and H. Frijlink et al. Low temperature extruded implants based on novel hydrophilic multiblock copolymer for long-term protein delivery Eur. J. Pharm. Sci. 49 2013 578 587
10. D. Blanco, and M.J. Alonso Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants Eur. J. Pharm. Biopharm. 45 1998 285 294
11. D. Bodmer, T. Kissel, and E. Traechslin Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems J. Control. Release 21 1992 129 137
12. L. Youxin, C. Volland, and T. Kissel In-vitro degradation and bovine serum albumin release of the ABA triblock copolymers consisting of poly (l(+) lactic acid), or poly(l(+) lactic acid-co-glycolic acid) A-blocks attached to central polyoxyethylene B-blocks J. Control. Release 32 1994 121 128
13. M. Lück, K.F. Pistel, Y.X. Li, T. Blunk, R.H. Müller, and T. Kissel Plasma protein adsorption on biodegradable microspheres consisting of poly(d,l-lactide-co-glycolide), poly(l-lactide) or ABA triblock copolymers containing poly(oxyethylene). Influence of production method and polymer composition J. Control. Release 55 1998 107 120
14. E.A. Appel, X.J. Loh, S.T. Jones, C.a. Dreiss, and O.a. Scherman Sustained release of proteins from high water content supramolecular polymer hydrogels Biomaterials 33 2012 4646 4652
15. M. Sandor, D. Enscore, P. Weston, and E. Mathiowitz Effect of protein molecular weight on release from micron-sized PLGA microspheres J. Control. Release 76 2001 297 311
16. D.M. Lavin, L. Zhang, S. Furtado, R.a. Hopkins, and E. Mathiowitz Effects of protein molecular weight on the intrinsic material properties and release kinetics of wet spun polymeric microfiber delivery systems Acta Biomater. 9 2013 4569 4578
17. P.L. Ritger, and N.A. Peppas A simple equation for description of soulte release from swellable devices J. Control. Release 5 1987 37 42
18. P. Costa, and J.M. Sousa Lobo Modeling and comparison of dissolution profiles Eur. J. Pharm. Sci. 13 2001 123 133
19. N. Thomas, and A.H. Windle A theory of case II diffusion Polymer (Guildf) 23 1982 529 542
20. B.K. Nyambura, I.W. Kellaway, and K.M.G. Taylor Insulin nanoparticles: stability and aerosolization from pressurized metered dose inhalers Int. J. Pharm. 375 2009 114 122
21. G. Gorin, S.-F. Wang, and L. Papapavlou Assay of lysozyme by its lytic action on M. lysodeikticus cells Anal. Biochem. 39 1971 113 127
22. K.M. Wilbur, and N.G. Anderson Electrometric and colorimetric determination of Carbonic Anhidrase J. Biol. Chem. 1948 147 154
23. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 1970 680 685
24. S. Verheyen, N. Blaton, R. Kinget, and G. Van den Mooter Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions Int. J. Pharm. 249 2002 45 58
25. V. Crescenzi, G. Manzini, G. Calzolari, and C. Borri Thermodynamics of fusion of poly-β-propiolactone and poly-ε-caprolactone. Comparative analysis of the melting of aliphatic polylactone and polyester chains Eur. Polym. J. 8 1972 449 463
26. H. Larhrib, J.I. Wells, M.H. Rubinstein, and G. Ricart Characterization of PEGs using matrix-assisted laser desorption/ionisation mass spectrometry and other related techniques Int. J. Pharm. 147 1997 187 198
27. H. Sun, L. Mei, C. Song, X. Cui, and P. Wang The in vivo degradation, absorption and excretion of PCL-based implant Biomaterials 27 2006 1735 1740
28. M.A. Woodruff, and D.W. Hutmacher The return of a forgotten polymer - polycaprolactone in the 21st century Prog. Polym. Sci. 35 2010 1217 1256
29. J.-P. Amorij, J. Meulenaar, W.L.J. Hinrichs, T. Stegmann, A. Huckriede, and F. Coenen et al. Rational design of an influenza subunit vaccine powder with sugar glass technology: preventing conformational changes of haemagglutinin during freezing and freeze-drying Vaccine 25 2007 6447 6457
30. W.L.J. Hinrichs, M.G. Prinsen, and H.W. Frijlink Inulin glasses for the stabilization of therapeutic proteins Int. J. Pharm. 215 2001 163 174
31. N. Grasmeijer, M. Stankovic, H. de Waard, H.W. Frijlink, and W.L.J. Hinrichs Unraveling protein stabilization mechanisms: vitrification and water replacement in a glass transition temperature controlled system Biochim. Biophys. Acta 1834 2013 763 769
32. F. Yao, and W.J. Kao Drug release kinetics and transport mechanisms of nondegradable and degradable polymeric delivery systems Exp. Opin Drug Deliv. 7 2011 429 444
33. R. van Dijkhuizen-Radersma, S. Métairie, J.R. Roosma, K. de Groot, and J.M. Bezemer Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers J. Control. Release 101 2005 175 186
34. A. Bertz, S. Wöhl-Bruhn, S. Miethe, B. Tiersch, J. Koetz, and M. Hust et al. Encapsulation of proteins in hydrogel carrier systems for controlled drug delivery: influence of network structure and drug size on release rate J. Biotechnol. 163 2013 243 249
35. J.M. Bezemer, D.W. Grijpma, P.J. Dijkstra, C.a. van Blitterswijk, and J. Feijen A controlled release system for proteins based on poly(ether ester) block-copolymers: polymer network characterization J. Control. Release 62 1999 393 405