Cardiac target organ damage in hypertension: Insights from epidemiology

Current Hypertension Reports

Volumn 16, Issue 7, 2014, Pages

  Lawler, Patrick R ^a   Hiremath, Pranoti ^a   Cheng, Susan ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

Author keywords

Blood pressure; Cardiac disease; Epidemiology; Hypertension

Indexed keywords

ADRENOMEDULLIN; BRADYKININ B2 RECEPTOR; BRAIN NATRIURETIC PEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE; GROWTH DIFFERENTIATION FACTOR 15; GUANYLATE CYCLASE; NATRIURETIC FACTOR;

AGE; ANTIHYPERTENSIVE THERAPY; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DISEASE COURSE; ELEVATED BLOOD PRESSURE; GENDER; HEART ATRIUM FIBRILLATION; HEART DISEASE; HEART FAILURE; HEART HYPERTROPHY; HEART INJURY; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; SMOKING; BLOOD PRESSURE; COMPLICATION; HEART DISEASES; HEART INJURIES; PHYSIOLOGY; PREVALENCE; RISK FACTOR;

BLOOD PRESSURE; HEART DISEASES; HEART INJURIES; HUMANS; HYPERTENSION; PREVALENCE; RISK FACTORS;

EID: 84902352959     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-014-0446-8     Document Type: Article

References (80)

1. .• Lawes CM, Vander Hoorn S, Rodgers A. Global burden of blood-pressure-related disease, 2001. Lancet. 2008;371:1513-8. This study illustrates the scope of the hypertension problem worldwide, and underscores the far-reaching and multinational implications of this global pandemic. (Pubitemid 351626187)
2. Echouffo-Tcheugui JB, Batty GD, Kivimaki M, Kengne AP. Risk models to predict hypertension: a systematic review. PLoS ONE. 2013;8:e67370.
3. Wang TJ, Gona P, Larson MG, Levy D, Benjamin EJ, Tofler GH, et al. Multiple biomarkers and the risk of incident hypertension. Hypertension. 2007;49:432-8.
4. Velagaleti RS, Gona P, Larson MG, Wang TJ, Levy D, Benjamin EJ, et al. Multimarker approach for the prediction of heart failure incidence in the community. Circulation. 2010;122:1700-6.
5. Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med. 2006;355:2631-9. (Pubitemid 44969122)
6. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41:677-87.
7. • Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-9. This large genome-wide association study of systolic and diastolic blood pressure used a multi-stage design in 200,000 individuals of European descent to identify 16 novel loci associated with prevelant hypertension. Six of these loci harbored genes previously known or postulated to regulate BP (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3). Intriguingly, the other 10 were not previously implicated in BP regulation, and therefore suggest potential novel pathways.
8. Schnabel RB. Common genetic variation of blood pressure traits and their relation to end-organ damage. Circ Cardiovasc Genet. 2011;4:712-3.
9. Cheng S, Fernandes VR, Bluemke DA, McClelland RL, Kronmal RA, Lima JA. Age-related left ventricular remodeling and associated risk for cardiovascular outcomes: the multi-ethnic study of atherosclerosis. Circ Cardiovasc Imaging. 2009;2:191-8.
10. .• Cheng S, Xanthakis V, Sullivan LM, Lieb W, Massaro J, Aragam J, et al. Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study. Circulation. 2010;122:570-8. This study followed individuals in the Framingham Heart Study for asymptomatic progressive cardiac remodeling. The investigators showed that with advancing age, patterns of increasing LV wall thickness, decreasing LV dimensions, and increasing fractional shortening emerge. Hypertension, along with female sex and diabetes mellitus, influenced this pattern of remodeling.
11. Lieb W, Xanthakis V, Sullivan LM, Aragam J, Pencina MJ, Larson MG, et al. Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the Framingham offspring study. Circulation. 2009;119:3085-92.
12. Drazner MH. The progression of hypertensive heart disease. Circulation. 2011;123:327-34.
13. Daniels SD, Meyer RA, Loggie JM. Determinants of cardiac involvement in children and adolescents with essential hypertension. Circulation. 1990;82:1243-8.
14. Post WS, Larson MG, Levy D. Impact of left ventricular structure on the incidence of hypertension. The Framingham Heart Study. Circulation. 1994;90:179-85. (Pubitemid 24203678)
15. Mazzolai L, Nussberger J, Aubert JF, Brunner DB, Gabbiani G, Brunner HR, et al. Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension. 1998;31:1324-30. (Pubitemid 28248835)
16. Masaki T, Kimura S, Yanagisawa M, Goto K. Molecular and cellular mechanism of endothelin regulation. Implications for vascular function. Circulation. 1991;84:1457-68.
17. Ichikawa KI, Hidai C, Okuda C, Kimata SI, Matsuoka R, Hosoda S, et al. Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium. J Am Coll Cardiol. 1996;27:1286-91. (Pubitemid 26117726)
18. Hua L, Li C, Xia D, Qu P, Li Z, Zhang W, et al. Relationship between hypertensive left ventricular hypertrophy and levels of endothelin and nitric oxide. Hypertens Res. 2000;23:377-80. (Pubitemid 30445001)
19. Schlaich MP, Kaye DM, Lambert E, Sommerville M, Socratous F, Esler MD. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation. 2003;108:560-5. (Pubitemid 36961170)
20. Greenwood JP, Scott EM, Stoker JB, Mary DA. Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive. J Am Coll Cardiol. 2001;38:1711-7. (Pubitemid 33065459)
21. Schunkert H, Hense HW, Holmer SR, Stender M, Perz S, Keil U, et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med. 1994;330:1634-8.
22. Brull D, Dhamrait S, Myerson S, Erdmann J, Woods D, World M, et al. Bradykinin B2BKR receptor polymorphism and left-ventricular growth response. Lancet. 2001;358:1155-6. (Pubitemid 32971851)
23. Xanthakis V, Larson MG, Wollert KC, Aragam J, Cheng S, Ho J, et al. Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: Implications for screening. J Am Heart Assoc. 2013;2:e000399.
24. Lind L, Wallentin L, Kempf T, Tapken H, Quint A, Lindahl B, et al. Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: Results from the prospective investigation of the vasculature in Uppsala seniors (pivus) study. Eur Heart J. 2009;30:2346-53.
25. Pauriah M, Khan F, Lim TK, Elder DH, Godfrey V, Kennedy G, et al. B-type natriuretic peptide is an independent predictor of endothelial function in man. Clin Sci (Lond). 2012;123:307-12.
26. Okin PM, Gerdts E, Kjeldsen SE, Julius S, Edelman JM, Dahlof B, et al. Gender differences in regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy. Hypertension. 2008;52:100-6.
27. Flack JM, Gardin JM, Yunis C, Liu K. Static and pulsatile blood pressure correlates of left ventricular structure and function in black and white young adults: the cardia study. Am Heart J. 1999;138:856-64. (Pubitemid 29523272)
28. Lorber R, Gidding SS, Daviglus ML, Colangelo LA, Liu K, Gardin JM. Influence of systolic blood pressure and body mass index on left ventricular structure in healthy african-american and white young adults: the cardia study. J Am Coll Cardiol. 2003;41:955-60. (Pubitemid 36315536)
29. Arnett DK, Rautaharju P, Crow R, Folsom AR, Ekelund LG, Hutchinson R, et al. Black-white differences in electrocardiographic left ventricular mass and its association with blood pressure (the ARIC study). Atherosclerosis Risk in Communities. Am J Cardiol. 1994;74:247-52. (Pubitemid 24239046)
30. Wang TJ, Evans JC, Benjamin EJ, Levy D, LeRoy EC, Vasan RS. Natural history of asymptomatic left ventricular systolic dysfunction in the community. Circulation. 2003;108:977-82. (Pubitemid 37048228)
31. Kuznetsova T, Herbots L, Jin Y, Stolarz-Skrzypek K, Staessen JA. Systolic and diastolic left ventricular dysfunction: from risk factors to overt heart failure. Expert Rev Cardiovasc Ther. 2010;8:251-8.
32. Fischer M, Baessler A, Hense HW, Hengstenberg C, Muscholl M, Holmer S, et al. Prevalence of left ventricular diastolic dysfunction in the community. Results from a Doppler echocardiographic-based survey of a population sample. Eur Heart J. 2003;24:320-8. (Pubitemid 36215965)
33. Kuznetsova T, Herbots L, Lopez B, Jin Y, Richart T, Thijs L, et al. Prevalence of left ventricular diastolic dysfunction in a general population. Circ Heart Fail. 2009;2:105-12.
34. Fernandes VR, Polak JF, Cheng S, Rosen BD, Carvalho B, Nasir K, et al. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:194-201.
35. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005;112:2254-62. (Pubitemid 41464567)
36. Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Cardiol Clin. 2011;29:447-59.
37. Rosen BD, Saad MF, Shea S, Nasir K, Edvardsen T, Burke G, et al. Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic: individuals the multi-ethnic study of atherosclerosis. J Am Coll Cardiol. 2006;47:1150-8.
38. Cheng S, Larson MG, McCabe EL, Osypiuk E, Lehman BT, Stanchev P, et al. Age- and sex-based reference limits and clinical correlates of myocardial strain and synchrony: the Framingham Heart Study. Circ Cardiovasc Imaging. 2013;6:692-9.
39. Rosen BD, Edvardsen T, Lai S, Castillo E, Pan L, Jerosch-Herold M, et al. Left ventricular concentric remodeling is associated with decreased global and regional systolic function: the Multi-Ethnic Study of Atherosclerosis. Circulation. 2005;112:984-91. (Pubitemid 41170266)
40. Rosen BD, Fernandes VR, Nasir K, Helle-Valle T, Jerosch-Herold M, Bluemke DA, et al. Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: the multiethnic study of atherosclerosis. Circulation. 2009;120:859-66.
41. Kannel WB, Wolf PA. Framinghamstudy insights on the hazards of elevated blood pressure. JAMA. 2008;300:2545-7.
42. Lloyd-Jones DM, Evans JC, Levy D. Hypertension in adults across the age spectrum: current outcomes and control in the community. JAMA. 2005;294:466-72. (Pubitemid 41124179)
43. Frost PH, Davis BR, Burlando AJ, Curb JD, Guthrie GP, Isaacsohn JL, et al. Coronary heart disease risk factors in men and women aged 60 years and older: findings from the systolic hypertension in the elderly program. Circulation. 1996;94:26-34. (Pubitemid 126426396)
44. Lowe LP, Greenland P, Ruth KJ, Dyer AR, Stamler R, Stamler J. Impact of major cardiovascular disease risk factors, particularly in combination, on 22-year mortality in women and men. Arch Intern Med. 1998;158:2007-14. (Pubitemid 28465625)
45. Conroy RM, Pyorala K, Fitzgerald AP, Sans S, Menotti A, De Backer G, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the score project. Eur Heart J. 2003;24:987-1003. (Pubitemid 36712275)
46. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, et al. Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: Prospective observational studies corrected for the regression dilution bias. Lancet. 1990;335:765-74. (Pubitemid 20106689)
47. O'Donnell CJ, Ridker PM, Glynn RJ, Berger K, Ajani U, Manson JE, et al. Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians. Circulation. 1997;95:1132-7. (Pubitemid 27097822)
48. Miura K, Daviglus ML, Dyer AR, Liu K, Garside DB, Stamler J, et al. Relationship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases, and all causes in young adult men: the Chicago Heart Association Detection Project in Industry. Arch Intern Med. 2001;161:1501-8. (Pubitemid 32679562)
49. Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA. 1996;275:1571-6. (Pubitemid 26154243)
50. Stokes 3rd J, Kannel WB, Wolf PA, D'Agostino RB, Cupples LA. Blood pressure as a risk factor for cardiovascular disease. The Framingham study - 30 years of follow-up. Hypertension. 1989;13:I13-8.
51. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-13. (Pubitemid 35472129)
52. Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation. 2001;103:1245-9. (Pubitemid 32221347)
53. Lloyd-Jones DM, Leip EP, Larson MG, Vasan RS, Levy D. Novel approach to examining first cardiovascular events after hypertension onset. Hypertension. 2005;45:39-45. (Pubitemid 40066411)
54. Cheng S, Gupta DK, Claggett B, Sharrett AR, Shah AM, Skali H, et al. Differential influence of distinct components of increased blood pressure on cardiovascular outcomes: from the Atherosclerosis Risk in Communities study. Hypertension. 2013;62:492-8.
55. Escobar E. Hypertension and coronary heart disease. J Hum Hypertens. 2002;16 Suppl 1:S61-3. (Pubitemid 34441139)
56. Taddei S, Salvetti A. Pathogenetic factors in hypertension. Endothelial factors. Clin Exp Hypertens. 1996;18:323-35.
57. Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol. 2009;157:527-36.
58. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665.
59. Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275:1557-62. (Pubitemid 26154241)
60. Richards AM, Nicholls MG, Troughton RW, Lainchbury JG, Elliott J, Frampton C, et al. Antecedent hypertension and heart failure after myocardial infarction. J Am Coll Cardiol. 2002;39:1182-8. (Pubitemid 34267423)
61. Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, et al. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham Heart Study of the National Heart, Lung, and Blood Institute. Circulation. 2009;119:3070-7.
62. Ho JE, Gona P, Pencina MJ, Tu JV, Austin PC, Vasan RS, et al. Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community. Eur Heart J. 2012;33:1734-41.
63. Lee DS, Massaro JM, Wang TJ, Kannel WB, Benjamin EJ, Kenchaiah S, et al. Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life. Hypertension. 2007;50:869-76. (Pubitemid 350287528)
64. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D'Agostino RB, Kannel WB, et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation. 2002;106:3068-72. (Pubitemid 35440290)
65. Ekundayo OJ, Allman RM, Sanders PW, Aban I, Love TE, Arnett D, et al. Isolated systolic hypertension and incident heart failure in older adults: a propensity-matched study. Hypertension. 2009;53:458-65.
66. Butler J, Kalogeropoulos AP, Georgiopoulou VV, Bibbins-Domingo K, Najjar SS, Sutton-Tyrrell KC, et al. Systolic blood pressure and incident heart failure in the elderly. The cardiovascular health study and the health, ageing and body composition study. Heart. 2011;97:1304-11.
67. Haider AW, Larson MG, Franklin SS, Levy D. Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study. Ann Intern Med. 2003;138:10-6. (Pubitemid 36232089)
68. Kass DA. Age-related changes in venticular-arterial coupling: pathophysiologic implications. Heart Fail Rev. 2002;7:51-62. (Pubitemid 34154899)
69. Chae CU, Pfeffer MA, Glynn RJ, Mitchell GF, Taylor JO, Hennekens CH. Increased pulse pressure and risk of heart failure in the elderly. JAMA. 1999;281:634-9. (Pubitemid 29098064)
70. Kane GC, Karon BL, Mahoney DW, Redfield MM, Roger VL, Burnett Jr JC, et al. Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA. 2011;306:856-63.
71. de Simone G, Gottdiener JS, Chinali M, Maurer MS. Left ventricular mass predicts heart failure not related to previous myocardial infarction: the cardiovascular health study. Eur Heart J. 2008;29:741-7. (Pubitemid 351431013)
72. Gradman AH, Alfayoumi F. From left ventricular hypertrophy to congestive heart failure:management of hypertensive heart disease. Prog Cardiovasc Dis. 2006;48:326-41.
73. Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D'Agostino Sr RB, et al. Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet. 2009;373:739-45.
74. Healey JS, Connolly SJ. Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic target. Am J Cardiol. 2003;91:9G-14.
75. Mitchell GF, Vasan RS, Keyes MJ, Parise H, Wang TJ, Larson MG, et al. Pulse pressure and risk of new-onset atrial fibrillation. JAMA. 2007;297:709-15. (Pubitemid 46294560)
76. Go O, Rosendorff C. Hypertension and atrial fibrillation. Curr Cardiol Rep. 2009;11:430-5.
77. Benjamin EJ, Levy D, Vaziri SM, D'Agostino RB, Belanger AJ, Wolf PA. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA. 1994;271:840-4.
78. Psaty BM, Manolio TA, Kuller LH, Kronmal RA, Cushman M, Fried LP, et al. Incidence of and risk factors for atrial fibrillation in older adults. Circulation. 1997;96:2455-61. (Pubitemid 27425856)
79. Thomas MC, Dublin S, Kaplan RC, Glazer NL, Lumley T, Longstreth Jr WT, et al. Blood pressure control and risk of incident atrial fibrillation. Am J Hypertens. 2008;21:1111-6.
80. Milan A, Caserta MA, Dematteis A, Naso D, Pertusio A, Magnino C, et al. Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients. J Hum Hypertens. 2009;23:743-50.